PMC:1564426 / 37352-50938 JSON TXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id	Subject	Object	Predicate	Lexical cue
T19066	15-17	VBZ	denotes	is
T19065	18-28	VBN	denotes	implicated
T19067	29-31	IN	denotes	in
T19068	32-35	DT	denotes	the
T19070	36-39	NN	denotes	Wnt
T19071	40-49	NN	denotes	signaling
T19069	50-57	NN	denotes	pathway
T19072	58-62	WDT	denotes	that
T19074	63-65	VBZ	denotes	is
T19073	66-74	VBN	denotes	involved
T19075	75-79	CC	denotes	both
T19076	80-82	IN	denotes	in
T19077	83-94	NN	denotes	development
T19078	95-98	CC	denotes	and
T19079	99-112	NN	denotes	tumorigenesis
T19080	112-113	.	denotes	.
T19081	113-331	sentence	denotes	Human germline mutations in APC cause FAP [4,5], which is characterized by hundreds of adenomatous colorectal polyps, with an almost inevitable progression to colorectal cancer in the third and fourth decades of life.
T19082	114-119	JJ	denotes	Human
T19084	120-128	NN	denotes	germline
T19083	129-138	NNS	denotes	mutations
T19086	139-141	IN	denotes	in
T19087	142-145	NN	denotes	APC
T19085	146-151	VBP	denotes	cause
T19088	152-155	NN	denotes	FAP
T19089	156-157	-LRB-	denotes	[
T19091	157-158	CD	denotes	4
T19092	158-159	,	denotes	,
T19090	159-160	CD	denotes	5
T19093	160-161	-RRB-	denotes	]
T19094	161-163	,	denotes	,
T19095	163-168	WDT	denotes	which
T19097	169-171	VBZ	denotes	is
T19096	172-185	VBN	denotes	characterized
T19098	186-188	IN	denotes	by
T19099	189-197	NNS	denotes	hundreds
T19100	198-200	IN	denotes	of
T19101	201-212	JJ	denotes	adenomatous
T19103	213-223	JJ	denotes	colorectal
T19102	224-230	NNS	denotes	polyps
T19104	230-232	,	denotes	,
T19105	232-236	IN	denotes	with
T19106	237-239	DT	denotes	an
T19108	240-246	RB	denotes	almost
T19109	247-257	JJ	denotes	inevitable
T19107	258-269	NN	denotes	progression
T19110	270-272	IN	denotes	to
T19111	273-283	JJ	denotes	colorectal
T19112	284-290	NN	denotes	cancer
T19113	291-293	IN	denotes	in
T19114	294-297	DT	denotes	the
T19116	298-303	JJ	denotes	third
T19117	304-307	CC	denotes	and
T19118	308-314	JJ	denotes	fourth
T19115	315-322	NNS	denotes	decades
T19119	323-325	IN	denotes	of
T19120	326-330	NN	denotes	life
T19121	330-331	.	denotes	.
T19122	331-423	sentence	denotes	The phenotypical features of FAP and its variant, Gardner's syndrome, can be very variable.
T19123	332-335	DT	denotes	The
T19125	336-348	JJ	denotes	phenotypical
T19124	349-357	NNS	denotes	features
T19127	358-360	IN	denotes	of
T19128	361-364	NN	denotes	FAP
T19129	365-368	CC	denotes	and
T19130	369-372	PRP$	denotes	its
T19131	373-380	NN	denotes	variant
T19132	380-382	,	denotes	,
T19133	382-389	NNP	denotes	Gardner
T19135	389-391	POS	denotes	's
T19134	392-400	NN	denotes	syndrome
T19136	400-402	,	denotes	,
T19137	402-405	MD	denotes	can
T19126	406-408	VB	denotes	be
T19138	409-413	RB	denotes	very
T19139	414-422	JJ	denotes	variable
T19140	422-423	.	denotes	.
T19141	423-710	sentence	denotes	As well as colorectal polyps, these individuals can develop extracolonic symptoms, among which are upper gastrointestinal tract polyps, congenital hypertrophy of the retinal pigment epithelium, desmoid tumors, disorders of the maxillary and skeletal bones, and dental abnormalities [6].
T19142	424-426	RB	denotes	As
T19144	427-431	RB	denotes	well
T19143	432-434	IN	denotes	as
T19146	435-445	JJ	denotes	colorectal
T19145	446-452	NNS	denotes	polyps
T19148	452-454	,	denotes	,
T19149	454-459	DT	denotes	these
T19150	460-471	NNS	denotes	individuals
T19151	472-475	MD	denotes	can
T19147	476-483	VB	denotes	develop
T19152	484-496	JJ	denotes	extracolonic
T19153	497-505	NNS	denotes	symptoms
T19154	505-507	,	denotes	,
T19155	507-512	IN	denotes	among
T19157	513-518	WDT	denotes	which
T19156	519-522	VBP	denotes	are
T19158	523-528	JJ	denotes	upper
T19160	529-545	JJ	denotes	gastrointestinal
T19159	546-551	NN	denotes	tract
T19161	552-558	NNS	denotes	polyps
T19162	558-560	,	denotes	,
T19163	560-570	JJ	denotes	congenital
T19164	571-582	NN	denotes	hypertrophy
T19165	583-585	IN	denotes	of
T19166	586-589	DT	denotes	the
T19168	590-597	JJ	denotes	retinal
T19169	598-605	NN	denotes	pigment
T19167	606-616	NN	denotes	epithelium
T19170	616-618	,	denotes	,
T19171	618-625	JJ	denotes	desmoid
T19172	626-632	NNS	denotes	tumors
T19173	632-634	,	denotes	,
T19174	634-643	NNS	denotes	disorders
T19175	644-646	IN	denotes	of
T19176	647-650	DT	denotes	the
T19178	651-660	JJ	denotes	maxillary
T19179	661-664	CC	denotes	and
T19180	665-673	JJ	denotes	skeletal
T19177	674-679	NNS	denotes	bones
T19181	679-681	,	denotes	,
T19182	681-684	CC	denotes	and
T19183	685-691	JJ	denotes	dental
T19184	692-705	NNS	denotes	abnormalities
T19185	706-707	-LRB-	denotes	[
T19186	707-708	CD	denotes	6
T19187	708-709	-RRB-	denotes	]
T19188	709-710	.	denotes	.
T19189	710-864	sentence	denotes	While the heterozygous knockout mice for Apc develop adenomatous polyps predominantly in small intestine, the homozygous embryos die before gastrulation.
T19190	711-716	IN	denotes	While
T19192	717-720	DT	denotes	the
T19194	721-733	JJ	denotes	heterozygous
T19195	734-742	NN	denotes	knockout
T19193	743-747	NNS	denotes	mice
T19196	748-751	IN	denotes	for
T19197	752-755	NN	denotes	Apc
T19191	756-763	VBP	denotes	develop
T19199	764-775	JJ	denotes	adenomatous
T19200	776-782	NNS	denotes	polyps
T19201	783-796	RB	denotes	predominantly
T19202	797-799	IN	denotes	in
T19203	800-805	JJ	denotes	small
T19204	806-815	NN	denotes	intestine
T19205	815-817	,	denotes	,
T19206	817-820	DT	denotes	the
T19208	821-831	JJ	denotes	homozygous
T19207	832-839	NNS	denotes	embryos
T19198	840-843	VBP	denotes	die
T19209	844-850	IN	denotes	before
T19210	851-863	NN	denotes	gastrulation
T19211	863-864	.	denotes	.
T19212	864-1190	sentence	denotes	To gain more insights into the effects of Apc loss in tissues other than gastrointestinal tract during life of animals and to circumvent the embryonic lethality associated with Apc nullizygosity, we created a mouse strain carrying a conditional allele of Apc (ApcCKO) in which exon 14 of the Apc is flanked by loxP sequences.
T19213	865-867	TO	denotes	To
T19214	868-872	VB	denotes	gain
T19216	873-877	JJR	denotes	more
T19217	878-886	NNS	denotes	insights
T19218	887-891	IN	denotes	into
T19219	892-895	DT	denotes	the
T19220	896-903	NNS	denotes	effects
T19221	904-906	IN	denotes	of
T19222	907-910	NN	denotes	Apc
T19223	911-915	NN	denotes	loss
T19224	916-918	IN	denotes	in
T19225	919-926	NNS	denotes	tissues
T19226	927-932	JJ	denotes	other
T19227	933-937	IN	denotes	than
T19228	938-954	JJ	denotes	gastrointestinal
T19229	955-960	NN	denotes	tract
T19230	961-967	IN	denotes	during
T19231	968-972	NN	denotes	life
T19232	973-975	IN	denotes	of
T19233	976-983	NNS	denotes	animals
T19234	984-987	CC	denotes	and
T19235	988-990	TO	denotes	to
T19236	991-1001	VB	denotes	circumvent
T19237	1002-1005	DT	denotes	the
T19239	1006-1015	JJ	denotes	embryonic
T19238	1016-1025	NN	denotes	lethality
T19240	1026-1036	VBN	denotes	associated
T19241	1037-1041	IN	denotes	with
T19242	1042-1045	NN	denotes	Apc
T19243	1046-1059	NN	denotes	nullizygosity
T19244	1059-1061	,	denotes	,
T19245	1061-1063	PRP	denotes	we
T19215	1064-1071	VBD	denotes	created
T19246	1072-1073	DT	denotes	a
T19248	1074-1079	NN	denotes	mouse
T19247	1080-1086	NN	denotes	strain
T19249	1087-1095	VBG	denotes	carrying
T19250	1096-1097	DT	denotes	a
T19252	1098-1109	JJ	denotes	conditional
T19251	1110-1116	NN	denotes	allele
T19253	1117-1119	IN	denotes	of
T19254	1120-1123	NN	denotes	Apc
T19255	1124-1125	-LRB-	denotes	(
T19256	1125-1131	NN	denotes	ApcCKO
T19257	1131-1132	-RRB-	denotes	)
T19258	1133-1135	IN	denotes	in
T19260	1136-1141	WDT	denotes	which
T19261	1142-1146	NN	denotes	exon
T19262	1147-1149	CD	denotes	14
T19263	1150-1152	IN	denotes	of
T19264	1153-1156	DT	denotes	the
T19265	1157-1160	NN	denotes	Apc
T19266	1161-1163	VBZ	denotes	is
T19259	1164-1171	VBN	denotes	flanked
T19267	1172-1174	IN	denotes	by
T19268	1175-1179	NN	denotes	loxP
T19269	1180-1189	NNS	denotes	sequences
T19270	1189-1190	.	denotes	.
T19271	1190-1371	sentence	denotes	The homozygous mice for the conditional allele are viable and indistinguishable to the normal mice, allowing us to study the roles of Apc in a tissue- and temporal-specific manner.
T19272	1191-1194	DT	denotes	The
T19274	1195-1205	JJ	denotes	homozygous
T19273	1206-1210	NNS	denotes	mice
T19276	1211-1214	IN	denotes	for
T19277	1215-1218	DT	denotes	the
T19279	1219-1230	JJ	denotes	conditional
T19278	1231-1237	NN	denotes	allele
T19275	1238-1241	VBP	denotes	are
T19280	1242-1248	JJ	denotes	viable
T19281	1249-1252	CC	denotes	and
T19282	1253-1270	JJ	denotes	indistinguishable
T19283	1271-1273	IN	denotes	to
T19284	1274-1277	DT	denotes	the
T19286	1278-1284	JJ	denotes	normal
T19285	1285-1289	NNS	denotes	mice
T19287	1289-1291	,	denotes	,
T19288	1291-1299	VBG	denotes	allowing
T19289	1300-1302	PRP	denotes	us
T19291	1303-1305	TO	denotes	to
T19290	1306-1311	VB	denotes	study
T19292	1312-1315	DT	denotes	the
T19293	1316-1321	NNS	denotes	roles
T19294	1322-1324	IN	denotes	of
T19295	1325-1328	NN	denotes	Apc
T19296	1329-1331	IN	denotes	in
T19297	1332-1333	DT	denotes	a
T19299	1334-1340	NN	denotes	tissue
T19301	1340-1341	HYPH	denotes	-
T19302	1342-1345	CC	denotes	and
T19303	1346-1354	JJ	denotes	temporal
T19304	1354-1355	HYPH	denotes	-
T19300	1355-1363	JJ	denotes	specific
T19298	1364-1370	NN	denotes	manner
T19305	1370-1371	.	denotes	.
T19307	1372-1374	TO	denotes	To
T19306	1372-1559	sentence	denotes	To assess the phenotypic consequences of inactivation of the Apc gene in cells that express K14, we created mice that are homozygous for the ApcCKO allele and contain a K14-cre transgene.
T19308	1375-1381	VB	denotes	assess
T19310	1382-1385	DT	denotes	the
T19312	1386-1396	JJ	denotes	phenotypic
T19311	1397-1409	NNS	denotes	consequences
T19313	1410-1412	IN	denotes	of
T19314	1413-1425	NN	denotes	inactivation
T19315	1426-1428	IN	denotes	of
T19316	1429-1432	DT	denotes	the
T19318	1433-1436	NN	denotes	Apc
T19317	1437-1441	NN	denotes	gene
T19319	1442-1444	IN	denotes	in
T19320	1445-1450	NNS	denotes	cells
T19321	1451-1455	WDT	denotes	that
T19322	1456-1463	VBP	denotes	express
T19323	1464-1467	NN	denotes	K14
T19324	1467-1469	,	denotes	,
T19325	1469-1471	PRP	denotes	we
T19309	1472-1479	VBD	denotes	created
T19326	1480-1484	NNS	denotes	mice
T19327	1485-1489	WDT	denotes	that
T19328	1490-1493	VBP	denotes	are
T19329	1494-1504	JJ	denotes	homozygous
T19330	1505-1508	IN	denotes	for
T19331	1509-1512	DT	denotes	the
T19333	1513-1519	NN	denotes	ApcCKO
T19332	1520-1526	NN	denotes	allele
T19334	1527-1530	CC	denotes	and
T19335	1531-1538	VBP	denotes	contain
T19336	1539-1540	DT	denotes	a
T19338	1541-1544	NN	denotes	K14
T19340	1544-1545	HYPH	denotes	-
T19339	1545-1548	NN	denotes	cre
T19337	1549-1558	NN	denotes	transgene
T19341	1558-1559	.	denotes	.
T19342	1559-1612	sentence	denotes	These mice failed to thrive and died before weaning.
T19343	1560-1565	DT	denotes	These
T19344	1566-1570	NNS	denotes	mice
T19345	1571-1577	VBD	denotes	failed
T19346	1578-1580	TO	denotes	to
T19347	1581-1587	VB	denotes	thrive
T19348	1588-1591	CC	denotes	and
T19349	1592-1596	VBD	denotes	died
T19350	1597-1603	IN	denotes	before
T19351	1604-1611	VBG	denotes	weaning
T19352	1611-1612	.	denotes	.
T19353	1612-1668	sentence	denotes	They also exhibited hair, tooth, and thymus phenotypes.
T19354	1613-1617	PRP	denotes	They
T19356	1618-1622	RB	denotes	also
T19355	1623-1632	VBD	denotes	exhibited
T19357	1633-1637	NN	denotes	hair
T19359	1637-1639	,	denotes	,
T19360	1639-1644	NN	denotes	tooth
T19361	1644-1646	,	denotes	,
T19362	1646-1649	CC	denotes	and
T19363	1650-1656	NN	denotes	thymus
T19358	1657-1667	NNS	denotes	phenotypes
T19364	1667-1668	.	denotes	.
T22183	1670-1673	NN	denotes	Apc
T22185	1674-1677	CC	denotes	and
T22186	1678-1682	NN	denotes	Hair
T22187	1683-1691	NN	denotes	Follicle
T22184	1692-1705	NN	denotes	Morphogenesis
T22188	1705-1978	sentence	denotes	Current models of hair follicle development suggest that the establishment of a regular array of placodes in the surface epithelium in response to the first dermal message is achieved through the competing activities of molecules that promote or repress placode fate [24].
T22189	1706-1713	JJ	denotes	Current
T22190	1714-1720	NNS	denotes	models
T22192	1721-1723	IN	denotes	of
T22193	1724-1728	NN	denotes	hair
T22194	1729-1737	NN	denotes	follicle
T22195	1738-1749	NN	denotes	development
T22191	1750-1757	VBP	denotes	suggest
T22196	1758-1762	IN	denotes	that
T22198	1763-1766	DT	denotes	the
T22199	1767-1780	NN	denotes	establishment
T22200	1781-1783	IN	denotes	of
T22201	1784-1785	DT	denotes	a
T22203	1786-1793	JJ	denotes	regular
T22202	1794-1799	NN	denotes	array
T22204	1800-1802	IN	denotes	of
T22205	1803-1811	NNS	denotes	placodes
T22206	1812-1814	IN	denotes	in
T22207	1815-1818	DT	denotes	the
T22209	1819-1826	NN	denotes	surface
T22208	1827-1837	NN	denotes	epithelium
T22210	1838-1840	IN	denotes	in
T22211	1841-1849	NN	denotes	response
T22212	1850-1852	IN	denotes	to
T22213	1853-1856	DT	denotes	the
T22215	1857-1862	JJ	denotes	first
T22216	1863-1869	JJ	denotes	dermal
T22214	1870-1877	NN	denotes	message
T22217	1878-1880	VBZ	denotes	is
T22197	1881-1889	VBN	denotes	achieved
T22218	1890-1897	IN	denotes	through
T22219	1898-1901	DT	denotes	the
T22221	1902-1911	VBG	denotes	competing
T22220	1912-1922	NNS	denotes	activities
T22222	1923-1925	IN	denotes	of
T22223	1926-1935	NNS	denotes	molecules
T22224	1936-1940	WDT	denotes	that
T22225	1941-1948	VBP	denotes	promote
T22226	1949-1951	CC	denotes	or
T22227	1952-1959	VBP	denotes	repress
T22228	1960-1967	NN	denotes	placode
T22229	1968-1972	NN	denotes	fate
T22230	1973-1974	-LRB-	denotes	[
T22231	1974-1976	CD	denotes	24
T22232	1976-1977	-RRB-	denotes	]
T22233	1977-1978	.	denotes	.
T22234	1978-2125	sentence	denotes	There is accumulating evidence that activation of the Wnt signaling pathway in the dermis may be involved in establishing the first dermal signal.
T22235	1979-1984	EX	denotes	There
T22236	1985-1987	VBZ	denotes	is
T22237	1988-2000	VBG	denotes	accumulating
T22238	2001-2009	NN	denotes	evidence
T22239	2010-2014	IN	denotes	that
T22241	2015-2025	NN	denotes	activation
T22242	2026-2028	IN	denotes	of
T22243	2029-2032	DT	denotes	the
T22245	2033-2036	NN	denotes	Wnt
T22246	2037-2046	NN	denotes	signaling
T22244	2047-2054	NN	denotes	pathway
T22247	2055-2057	IN	denotes	in
T22248	2058-2061	DT	denotes	the
T22249	2062-2068	NN	denotes	dermis
T22250	2069-2072	MD	denotes	may
T22251	2073-2075	VB	denotes	be
T22240	2076-2084	VBN	denotes	involved
T22252	2085-2087	IN	denotes	in
T22253	2088-2100	VBG	denotes	establishing
T22254	2101-2104	DT	denotes	the
T22256	2105-2110	JJ	denotes	first
T22257	2111-2117	JJ	denotes	dermal
T22255	2118-2124	NN	denotes	signal
T22258	2124-2125	.	denotes	.
T22259	2125-2363	sentence	denotes	Experimental activation of epithelial β-catenin signaling (by expression of N-terminal–truncated, constitutively stabilized forms of β-catenin or ectopic expression of Lef1) induces ectopic follicles in both mouse and chick skin [25–27].
T22260	2126-2138	JJ	denotes	Experimental
T22261	2139-2149	NN	denotes	activation
T22263	2150-2152	IN	denotes	of
T22264	2153-2163	JJ	denotes	epithelial
T22266	2164-2165	NN	denotes	β
T22268	2165-2166	HYPH	denotes	-
T22267	2166-2173	NN	denotes	catenin
T22265	2174-2183	NN	denotes	signaling
T22269	2184-2185	-LRB-	denotes	(
T22270	2185-2187	IN	denotes	by
T22271	2188-2198	NN	denotes	expression
T22272	2199-2201	IN	denotes	of
T22273	2202-2203	NN	denotes	N
T22275	2203-2204	HYPH	denotes	-
T22274	2204-2212	NN	denotes	terminal
T22277	2212-2213	HYPH	denotes	–
T22276	2213-2222	JJ	denotes	truncated
T22279	2222-2224	,	denotes	,
T22280	2224-2238	RB	denotes	constitutively
T22281	2239-2249	VBN	denotes	stabilized
T22278	2250-2255	NNS	denotes	forms
T22282	2256-2258	IN	denotes	of
T22283	2259-2260	NN	denotes	β
T22285	2260-2261	HYPH	denotes	-
T22284	2261-2268	NN	denotes	catenin
T22286	2269-2271	CC	denotes	or
T22287	2272-2279	JJ	denotes	ectopic
T22288	2280-2290	NN	denotes	expression
T22289	2291-2293	IN	denotes	of
T22290	2294-2298	NN	denotes	Lef1
T22291	2298-2299	-RRB-	denotes	)
T22262	2300-2307	VBZ	denotes	induces
T22292	2308-2315	JJ	denotes	ectopic
T22293	2316-2325	NNS	denotes	follicles
T22294	2326-2328	IN	denotes	in
T22295	2329-2333	CC	denotes	both
T22296	2334-2339	NN	denotes	mouse
T22298	2340-2343	CC	denotes	and
T22299	2344-2349	NN	denotes	chick
T22297	2350-2354	NN	denotes	skin
T22300	2355-2356	-LRB-	denotes	[
T22301	2356-2358	CD	denotes	25
T22302	2358-2359	SYM	denotes	–
T22303	2359-2361	CD	denotes	27
T22304	2361-2362	-RRB-	denotes	]
T22305	2362-2363	.	denotes	.
T22306	2363-2603	sentence	denotes	Conversely, down-regulation of β-catenin signaling (through Lef1 knock-out, ectopic expression of Wnt inhibitor Dkk1 or conditional deletion of β-catenin in epidermis) results in loss of vibrissae and some pelage follicles in mice [28–30].
T22307	2364-2374	RB	denotes	Conversely
T22309	2374-2376	,	denotes	,
T22310	2376-2380	JJ	denotes	down
T22312	2380-2381	HYPH	denotes	-
T22311	2381-2391	NN	denotes	regulation
T22313	2392-2394	IN	denotes	of
T22314	2395-2396	NN	denotes	β
T22316	2396-2397	HYPH	denotes	-
T22315	2397-2404	NN	denotes	catenin
T22317	2405-2414	NN	denotes	signaling
T22318	2415-2416	-LRB-	denotes	(
T22319	2416-2423	IN	denotes	through
T22320	2424-2428	NN	denotes	Lef1
T22321	2429-2434	VB	denotes	knock
T22323	2434-2435	HYPH	denotes	-
T22324	2435-2438	RP	denotes	out
T22325	2438-2440	,	denotes	,
T22326	2440-2447	JJ	denotes	ectopic
T22322	2448-2458	NN	denotes	expression
T22327	2459-2461	IN	denotes	of
T22328	2462-2465	NN	denotes	Wnt
T22329	2466-2475	NN	denotes	inhibitor
T22330	2476-2480	NN	denotes	Dkk1
T22331	2481-2483	CC	denotes	or
T22332	2484-2495	JJ	denotes	conditional
T22333	2496-2504	NN	denotes	deletion
T22334	2505-2507	IN	denotes	of
T22335	2508-2509	NN	denotes	β
T22337	2509-2510	HYPH	denotes	-
T22336	2510-2517	NN	denotes	catenin
T22338	2518-2520	IN	denotes	in
T22339	2521-2530	NN	denotes	epidermis
T22340	2530-2531	-RRB-	denotes	)
T22308	2532-2539	VBZ	denotes	results
T22341	2540-2542	IN	denotes	in
T22342	2543-2547	NN	denotes	loss
T22343	2548-2550	IN	denotes	of
T22344	2551-2560	NNS	denotes	vibrissae
T22345	2561-2564	CC	denotes	and
T22346	2565-2569	DT	denotes	some
T22348	2570-2576	NN	denotes	pelage
T22347	2577-2586	NNS	denotes	follicles
T22349	2587-2589	IN	denotes	in
T22350	2590-2594	NNS	denotes	mice
T22351	2595-2596	-LRB-	denotes	[
T22352	2596-2598	CD	denotes	28
T22353	2598-2599	SYM	denotes	–
T22354	2599-2601	CD	denotes	30
T22355	2601-2602	-RRB-	denotes	]
T22356	2602-2603	.	denotes	.
T22357	2603-3097	sentence	denotes	Our finding that K14-driven Apc loss in embryonic ectoderm resulted in irregularly spaced and often tightly clustered abnormal hair placode initiation and follicle morphogenesis (Figures 4F, 5B, 5D, and 5F) as well as in the development of multiple tooth buds (Figure 4O and 4P), is in line with the effects seen in activation of epithelial β-catenin signaling during placode formation, indicating the role of Apc in specification of embryonic ectodermal stem cells to produce a hair follicle.
T22358	2604-2607	PRP$	denotes	Our
T22359	2608-2615	NN	denotes	finding
T22361	2616-2620	IN	denotes	that
T22363	2621-2624	NN	denotes	K14
T22365	2624-2625	HYPH	denotes	-
T22364	2625-2631	VBN	denotes	driven
T22367	2632-2635	NN	denotes	Apc
T22366	2636-2640	NN	denotes	loss
T22368	2641-2643	IN	denotes	in
T22369	2644-2653	JJ	denotes	embryonic
T22370	2654-2662	NN	denotes	ectoderm
T22362	2663-2671	VBD	denotes	resulted
T22371	2672-2674	IN	denotes	in
T22372	2675-2686	RB	denotes	irregularly
T22373	2687-2693	VBN	denotes	spaced
T22375	2694-2697	CC	denotes	and
T22376	2698-2703	RB	denotes	often
T22378	2704-2711	RB	denotes	tightly
T22377	2712-2721	VBN	denotes	clustered
T22379	2722-2730	JJ	denotes	abnormal
T22380	2731-2735	NN	denotes	hair
T22381	2736-2743	NN	denotes	placode
T22374	2744-2754	NN	denotes	initiation
T22382	2755-2758	CC	denotes	and
T22383	2759-2767	NN	denotes	follicle
T22384	2768-2781	NN	denotes	morphogenesis
T22385	2782-2783	-LRB-	denotes	(
T22387	2783-2790	NNS	denotes	Figures
T22386	2791-2793	NN	denotes	4F
T22388	2793-2795	,	denotes	,
T22389	2795-2797	NN	denotes	5B
T22390	2797-2799	,	denotes	,
T22391	2799-2801	NN	denotes	5D
T22392	2801-2803	,	denotes	,
T22393	2803-2806	CC	denotes	and
T22394	2807-2809	NN	denotes	5F
T22395	2809-2810	-RRB-	denotes	)
T22396	2811-2813	RB	denotes	as
T22398	2814-2818	RB	denotes	well
T22397	2819-2821	IN	denotes	as
T22399	2822-2824	IN	denotes	in
T22400	2825-2828	DT	denotes	the
T22401	2829-2840	NN	denotes	development
T22402	2841-2843	IN	denotes	of
T22403	2844-2852	JJ	denotes	multiple
T22405	2853-2858	NN	denotes	tooth
T22404	2859-2863	NNS	denotes	buds
T22406	2864-2865	-LRB-	denotes	(
T22408	2865-2871	NN	denotes	Figure
T22407	2872-2874	NN	denotes	4O
T22409	2875-2878	CC	denotes	and
T22410	2879-2881	NN	denotes	4P
T22411	2881-2882	-RRB-	denotes	)
T22412	2882-2884	,	denotes	,
T22360	2884-2886	VBZ	denotes	is
T22413	2887-2889	IN	denotes	in
T22414	2890-2894	NN	denotes	line
T22415	2895-2899	IN	denotes	with
T22416	2900-2903	DT	denotes	the
T22417	2904-2911	NNS	denotes	effects
T22418	2912-2916	VBN	denotes	seen
T22419	2917-2919	IN	denotes	in
T22420	2920-2930	NN	denotes	activation
T22421	2931-2933	IN	denotes	of
T22422	2934-2944	JJ	denotes	epithelial
T22424	2945-2946	NN	denotes	β
T22426	2946-2947	HYPH	denotes	-
T22425	2947-2954	NN	denotes	catenin
T22423	2955-2964	NN	denotes	signaling
T22427	2965-2971	IN	denotes	during
T22428	2972-2979	NN	denotes	placode
T22429	2980-2989	NN	denotes	formation
T22430	2989-2991	,	denotes	,
T22431	2991-3001	VBG	denotes	indicating
T22432	3002-3005	DT	denotes	the
T22433	3006-3010	NN	denotes	role
T22434	3011-3013	IN	denotes	of
T22435	3014-3017	NN	denotes	Apc
T22436	3018-3020	IN	denotes	in
T22437	3021-3034	NN	denotes	specification
T22438	3035-3037	IN	denotes	of
T22439	3038-3047	JJ	denotes	embryonic
T22441	3048-3058	JJ	denotes	ectodermal
T22442	3059-3063	NN	denotes	stem
T22440	3064-3069	NNS	denotes	cells
T22443	3070-3072	TO	denotes	to
T22444	3073-3080	VB	denotes	produce
T22445	3081-3082	DT	denotes	a
T22447	3083-3087	NN	denotes	hair
T22446	3088-3096	NN	denotes	follicle
T22448	3096-3097	.	denotes	.
T22449	3097-3431	sentence	denotes	Given the role of Apc in down-regulation of β-catenin, loss of Apc would inevitably lead to altered expression of β-catenin in ectodermal cells during the hair placode formation, giving rise to aberrant follicular growth throughout the embryonic epidermis, including the footpads, where normally hairless (Figure 5B, 5D, 5F, and 5H).
T22450	3098-3103	VBN	denotes	Given
T22452	3104-3107	DT	denotes	the
T22453	3108-3112	NN	denotes	role
T22454	3113-3115	IN	denotes	of
T22455	3116-3119	NN	denotes	Apc
T22456	3120-3122	IN	denotes	in
T22457	3123-3127	RB	denotes	down
T22459	3127-3128	HYPH	denotes	-
T22458	3128-3138	NN	denotes	regulation
T22460	3139-3141	IN	denotes	of
T22461	3142-3143	NN	denotes	β
T22463	3143-3144	HYPH	denotes	-
T22462	3144-3151	NN	denotes	catenin
T22464	3151-3153	,	denotes	,
T22465	3153-3157	NN	denotes	loss
T22466	3158-3160	IN	denotes	of
T22467	3161-3164	NNP	denotes	Apc
T22468	3165-3170	MD	denotes	would
T22469	3171-3181	RB	denotes	inevitably
T22451	3182-3186	VB	denotes	lead
T22470	3187-3189	IN	denotes	to
T22471	3190-3197	JJ	denotes	altered
T22472	3198-3208	NN	denotes	expression
T22473	3209-3211	IN	denotes	of
T22474	3212-3213	NN	denotes	β
T22476	3213-3214	HYPH	denotes	-
T22475	3214-3221	NN	denotes	catenin
T22477	3222-3224	IN	denotes	in
T22478	3225-3235	JJ	denotes	ectodermal
T22479	3236-3241	NNS	denotes	cells
T22480	3242-3248	IN	denotes	during
T22481	3249-3252	DT	denotes	the
T22483	3253-3257	NN	denotes	hair
T22484	3258-3265	NN	denotes	placode
T22482	3266-3275	NN	denotes	formation
T22485	3275-3277	,	denotes	,
T22486	3277-3283	VBG	denotes	giving
T22487	3284-3288	NN	denotes	rise
T22488	3289-3291	IN	denotes	to
T22489	3292-3300	JJ	denotes	aberrant
T22491	3301-3311	JJ	denotes	follicular
T22490	3312-3318	NN	denotes	growth
T22492	3319-3329	IN	denotes	throughout
T22493	3330-3333	DT	denotes	the
T22495	3334-3343	JJ	denotes	embryonic
T22494	3344-3353	NN	denotes	epidermis
T22496	3353-3355	,	denotes	,
T22497	3355-3364	VBG	denotes	including
T22498	3365-3368	DT	denotes	the
T22499	3369-3377	NNS	denotes	footpads
T22500	3377-3379	,	denotes	,
T22501	3379-3384	WRB	denotes	where
T22503	3385-3393	RB	denotes	normally
T22502	3394-3402	JJ	denotes	hairless
T22504	3403-3404	-LRB-	denotes	(
T22506	3404-3410	NN	denotes	Figure
T22505	3411-3413	NN	denotes	5B
T22507	3413-3415	,	denotes	,
T22508	3415-3417	NN	denotes	5D
T22509	3417-3419	,	denotes	,
T22510	3419-3421	NN	denotes	5F
T22511	3421-3423	,	denotes	,
T22512	3423-3426	CC	denotes	and
T22513	3427-3429	NN	denotes	5H
T22514	3429-3430	-RRB-	denotes	)
T22515	3430-3431	.	denotes	.
T22516	3431-3678	sentence	denotes	Of interest are the phenotypic similarities and differences between our KA mutant mice and the previously described K14-ΔN87βcat transgenic mice expressing stable β-catenin under the control of K14 promoter [25] and K14-Lef1 transgenic mice [27].
T22517	3432-3434	IN	denotes	Of
T22519	3435-3443	NN	denotes	interest
T22518	3444-3447	VBP	denotes	are
T22520	3448-3451	DT	denotes	the
T22522	3452-3462	JJ	denotes	phenotypic
T22521	3463-3475	NNS	denotes	similarities
T22523	3476-3479	CC	denotes	and
T22524	3480-3491	NNS	denotes	differences
T22525	3492-3499	IN	denotes	between
T22526	3500-3503	PRP$	denotes	our
T22528	3504-3506	NN	denotes	KA
T22529	3507-3513	JJ	denotes	mutant
T22527	3514-3518	NNS	denotes	mice
T22530	3519-3522	CC	denotes	and
T22531	3523-3526	DT	denotes	the
T22533	3527-3537	RB	denotes	previously
T22534	3538-3547	VBN	denotes	described
T22535	3548-3551	NN	denotes	K14
T22537	3551-3552	HYPH	denotes	-
T22536	3552-3560	NN	denotes	ΔN87βcat
T22538	3561-3571	JJ	denotes	transgenic
T22532	3572-3576	NNS	denotes	mice
T22539	3577-3587	VBG	denotes	expressing
T22540	3588-3594	JJ	denotes	stable
T22542	3595-3596	NN	denotes	β
T22543	3596-3597	HYPH	denotes	-
T22541	3597-3604	NN	denotes	catenin
T22544	3605-3610	IN	denotes	under
T22545	3611-3614	DT	denotes	the
T22546	3615-3622	NN	denotes	control
T22547	3623-3625	IN	denotes	of
T22548	3626-3629	NN	denotes	K14
T22549	3630-3638	NN	denotes	promoter
T22550	3639-3640	-LRB-	denotes	[
T22551	3640-3642	CD	denotes	25
T22552	3642-3643	-RRB-	denotes	]
T22553	3644-3647	CC	denotes	and
T22554	3648-3651	NN	denotes	K14
T22556	3651-3652	HYPH	denotes	-
T22555	3652-3656	NN	denotes	Lef1
T22558	3657-3667	JJ	denotes	transgenic
T22557	3668-3672	NNS	denotes	mice
T22559	3673-3674	-LRB-	denotes	[
T22560	3674-3676	CD	denotes	27
T22561	3676-3677	-RRB-	denotes	]
T22562	3677-3678	.	denotes	.
T22563	3678-3795	sentence	denotes	Surprisingly, our mutant mice shared more similarities with the K14-Lef1 mice than the K14-ΔN87βcat transgenic mice.
T22564	3679-3691	RB	denotes	Surprisingly
T22566	3691-3693	,	denotes	,
T22567	3693-3696	PRP$	denotes	our
T22569	3697-3703	JJ	denotes	mutant
T22568	3704-3708	NNS	denotes	mice
T22565	3709-3715	VBD	denotes	shared
T22570	3716-3720	JJR	denotes	more
T22571	3721-3733	NNS	denotes	similarities
T22572	3734-3738	IN	denotes	with
T22573	3739-3742	DT	denotes	the
T22575	3743-3746	NN	denotes	K14
T22577	3746-3747	HYPH	denotes	-
T22576	3747-3751	NN	denotes	Lef1
T22574	3752-3756	NNS	denotes	mice
T22578	3757-3761	IN	denotes	than
T22579	3762-3765	DT	denotes	the
T22581	3766-3769	NN	denotes	K14
T22583	3769-3770	HYPH	denotes	-
T22582	3770-3778	NN	denotes	ΔN87βcat
T22584	3779-3789	JJ	denotes	transgenic
T22580	3790-3794	NNS	denotes	mice
T22585	3794-3795	.	denotes	.
T22586	3795-3936	sentence	denotes	For example, the KA mutant mice displayed the disoriented and short, curly whiskers seen in K14-Lef1but not in K14-ΔN87βcat transgenic mice.
T22587	3796-3799	IN	denotes	For
T22589	3800-3807	NN	denotes	example
T22590	3807-3809	,	denotes	,
T22591	3809-3812	DT	denotes	the
T22593	3813-3815	NN	denotes	KA
T22594	3816-3822	JJ	denotes	mutant
T22592	3823-3827	NNS	denotes	mice
T22588	3828-3837	VBD	denotes	displayed
T22595	3838-3841	DT	denotes	the
T22597	3842-3853	JJ	denotes	disoriented
T22598	3854-3857	CC	denotes	and
T22599	3858-3863	JJ	denotes	short
T22600	3863-3865	,	denotes	,
T22601	3865-3870	JJ	denotes	curly
T22596	3871-3879	NNS	denotes	whiskers
T22602	3880-3884	VBN	denotes	seen
T22603	3885-3887	IN	denotes	in
T22604	3888-3891	NN	denotes	K14
T22606	3891-3892	HYPH	denotes	-
T22605	3892-3899	NN	denotes	Lef1but
T22607	3900-3903	RB	denotes	not
T22608	3904-3906	IN	denotes	in
T22609	3907-3910	NN	denotes	K14
T22611	3910-3911	HYPH	denotes	-
T22610	3911-3919	NN	denotes	ΔN87βcat
T22613	3920-3930	JJ	denotes	transgenic
T22612	3931-3935	NNS	denotes	mice
T22614	3935-3936	.	denotes	.
T22615	3936-4222	sentence	denotes	In addition, KA mutant mice displayed a disorganized hair coat beginning with the emergence of neonatal hairs, similar to that observed in K14-Lef1 mice, whereas in K14-ΔN87βcat mice, embryonic hair follicle morphogenesis was unaffected and other skin changes only emerged postnatally.
T22616	3937-3939	IN	denotes	In
T22618	3940-3948	NN	denotes	addition
T22619	3948-3950	,	denotes	,
T22620	3950-3952	NN	denotes	KA
T22622	3953-3959	JJ	denotes	mutant
T22621	3960-3964	NNS	denotes	mice
T22617	3965-3974	VBD	denotes	displayed
T22623	3975-3976	DT	denotes	a
T22625	3977-3989	JJ	denotes	disorganized
T22626	3990-3994	NN	denotes	hair
T22624	3995-3999	NN	denotes	coat
T22627	4000-4009	VBG	denotes	beginning
T22628	4010-4014	IN	denotes	with
T22629	4015-4018	DT	denotes	the
T22630	4019-4028	NN	denotes	emergence
T22631	4029-4031	IN	denotes	of
T22632	4032-4040	JJ	denotes	neonatal
T22633	4041-4046	NNS	denotes	hairs
T22634	4046-4048	,	denotes	,
T22635	4048-4055	JJ	denotes	similar
T22636	4056-4058	IN	denotes	to
T22637	4059-4063	DT	denotes	that
T22638	4064-4072	VBN	denotes	observed
T22639	4073-4075	IN	denotes	in
T22640	4076-4079	NN	denotes	K14
T22642	4079-4080	HYPH	denotes	-
T22641	4080-4084	NN	denotes	Lef1
T22643	4085-4089	NNS	denotes	mice
T22644	4089-4091	,	denotes	,
T22645	4091-4098	IN	denotes	whereas
T22647	4099-4101	IN	denotes	in
T22648	4102-4105	NN	denotes	K14
T22650	4105-4106	HYPH	denotes	-
T22649	4106-4114	NN	denotes	ΔN87βcat
T22651	4115-4119	NNS	denotes	mice
T22652	4119-4121	,	denotes	,
T22653	4121-4130	JJ	denotes	embryonic
T22655	4131-4135	NN	denotes	hair
T22656	4136-4144	NN	denotes	follicle
T22654	4145-4158	NN	denotes	morphogenesis
T22646	4159-4162	VBD	denotes	was
T22657	4163-4173	JJ	denotes	unaffected
T22658	4174-4177	CC	denotes	and
T22659	4178-4183	JJ	denotes	other
T22661	4184-4188	NN	denotes	skin
T22660	4189-4196	NNS	denotes	changes
T22663	4197-4201	RB	denotes	only
T22662	4202-4209	VBD	denotes	emerged
T22664	4210-4221	RB	denotes	postnatally
T22665	4221-4222	.	denotes	.
T22666	4222-4327	sentence	denotes	The reason for this difference could be attributed to one or all of three possible contributing factors.
T22667	4223-4226	DT	denotes	The
T22668	4227-4233	NN	denotes	reason
T22670	4234-4237	IN	denotes	for
T22671	4238-4242	DT	denotes	this
T22672	4243-4253	NN	denotes	difference
T22673	4254-4259	MD	denotes	could
T22674	4260-4262	VB	denotes	be
T22669	4263-4273	VBN	denotes	attributed
T22675	4274-4276	IN	denotes	to
T22676	4277-4280	CD	denotes	one
T22677	4281-4283	CC	denotes	or
T22678	4284-4287	DT	denotes	all
T22679	4288-4290	IN	denotes	of
T22680	4291-4296	CD	denotes	three
T22682	4297-4305	JJ	denotes	possible
T22683	4306-4318	VBG	denotes	contributing
T22681	4319-4326	NNS	denotes	factors
T22684	4326-4327	.	denotes	.
T22685	4327-4554	sentence	denotes	(1) Although the K14 promoter itself is known to initiate the expression at E9.5 and elevated dramatically by E13.5–E14.5 [19,31], many factors could influence the expression of promoter/transgene construct in transgenic mice.
T22686	4328-4329	-LRB-	denotes	(
T22687	4329-4330	LS	denotes	1
T22689	4330-4331	-RRB-	denotes	)
T22690	4332-4340	IN	denotes	Although
T22692	4341-4344	DT	denotes	the
T22694	4345-4348	NN	denotes	K14
T22693	4349-4357	NN	denotes	promoter
T22695	4358-4364	PRP	denotes	itself
T22696	4365-4367	VBZ	denotes	is
T22691	4368-4373	VBN	denotes	known
T22697	4374-4376	TO	denotes	to
T22698	4377-4385	VB	denotes	initiate
T22699	4386-4389	DT	denotes	the
T22700	4390-4400	NN	denotes	expression
T22701	4401-4403	IN	denotes	at
T22702	4404-4408	NN	denotes	E9.5
T22703	4409-4412	CC	denotes	and
T22704	4413-4421	VBN	denotes	elevated
T22705	4422-4434	RB	denotes	dramatically
T22706	4435-4437	IN	denotes	by
T22707	4438-4443	NN	denotes	E13.5
T22708	4443-4444	SYM	denotes	–
T22709	4444-4449	NN	denotes	E14.5
T22710	4450-4451	-LRB-	denotes	[
T22712	4451-4453	CD	denotes	19
T22713	4453-4454	,	denotes	,
T22711	4454-4456	CD	denotes	31
T22714	4456-4457	-RRB-	denotes	]
T22715	4457-4459	,	denotes	,
T22716	4459-4463	JJ	denotes	many
T22717	4464-4471	NNS	denotes	factors
T22718	4472-4477	MD	denotes	could
T22688	4478-4487	VB	denotes	influence
T22719	4488-4491	DT	denotes	the
T22720	4492-4502	NN	denotes	expression
T22721	4503-4505	IN	denotes	of
T22722	4506-4514	NN	denotes	promoter
T22724	4514-4515	HYPH	denotes	/
T22723	4515-4524	NN	denotes	transgene
T22725	4525-4534	NN	denotes	construct
T22726	4535-4537	IN	denotes	in
T22727	4538-4548	JJ	denotes	transgenic
T22728	4549-4553	NNS	denotes	mice
T22729	4553-4554	.	denotes	.
T22730	4554-4669	sentence	denotes	One of the most important considerations has to do with the integration site of the transgene in the mouse genome.
T22731	4555-4558	CD	denotes	One
T22733	4559-4561	IN	denotes	of
T22734	4562-4565	DT	denotes	the
T22736	4566-4570	RBS	denotes	most
T22737	4571-4580	JJ	denotes	important
T22735	4581-4595	NNS	denotes	considerations
T22732	4596-4599	VBZ	denotes	has
T22738	4600-4602	TO	denotes	to
T22739	4603-4605	VB	denotes	do
T22740	4606-4610	IN	denotes	with
T22741	4611-4614	DT	denotes	the
T22743	4615-4626	NN	denotes	integration
T22742	4627-4631	NN	denotes	site
T22744	4632-4634	IN	denotes	of
T22745	4635-4638	DT	denotes	the
T22746	4639-4648	NN	denotes	transgene
T22747	4649-4651	IN	denotes	in
T22748	4652-4655	DT	denotes	the
T22750	4656-4661	NN	denotes	mouse
T22749	4662-4668	NN	denotes	genome
T22751	4668-4669	.	denotes	.
T22752	4669-4792	sentence	denotes	Depending on the location of integration, the transcriptional activity of even the same transgene could vary considerably.
T22753	4670-4679	VBG	denotes	Depending
T22755	4680-4682	IN	denotes	on
T22756	4683-4686	DT	denotes	the
T22757	4687-4695	NN	denotes	location
T22758	4696-4698	IN	denotes	of
T22759	4699-4710	NN	denotes	integration
T22760	4710-4712	,	denotes	,
T22761	4712-4715	DT	denotes	the
T22763	4716-4731	JJ	denotes	transcriptional
T22762	4732-4740	NN	denotes	activity
T22764	4741-4743	IN	denotes	of
T22765	4744-4748	RB	denotes	even
T22767	4749-4752	DT	denotes	the
T22768	4753-4757	JJ	denotes	same
T22766	4758-4767	NN	denotes	transgene
T22769	4768-4773	MD	denotes	could
T22754	4774-4778	VB	denotes	vary
T22770	4779-4791	RB	denotes	considerably
T22771	4791-4792	.	denotes	.
T22772	4792-4981	sentence	denotes	It is possible that the apparent lack of ΔN87βcat function in embryogenesis could be due to the delayed or weak expression of the K14-ΔN87βcat transgene compared to the intrinsic promoter.
T22773	4793-4795	PRP	denotes	It
T22774	4796-4798	VBZ	denotes	is
T22775	4799-4807	JJ	denotes	possible
T22776	4808-4812	IN	denotes	that
T22778	4813-4816	DT	denotes	the
T22780	4817-4825	JJ	denotes	apparent
T22779	4826-4830	NN	denotes	lack
T22781	4831-4833	IN	denotes	of
T22782	4834-4842	NN	denotes	ΔN87βcat
T22783	4843-4851	NN	denotes	function
T22784	4852-4854	IN	denotes	in
T22785	4855-4868	NN	denotes	embryogenesis
T22786	4869-4874	MD	denotes	could
T22777	4875-4877	VB	denotes	be
T22787	4878-4881	IN	denotes	due
T22788	4882-4884	IN	denotes	to
T22789	4885-4888	DT	denotes	the
T22791	4889-4896	VBN	denotes	delayed
T22792	4897-4899	CC	denotes	or
T22793	4900-4904	JJ	denotes	weak
T22790	4905-4915	NN	denotes	expression
T22794	4916-4918	IN	denotes	of
T22795	4919-4922	DT	denotes	the
T22797	4923-4926	NN	denotes	K14
T22799	4926-4927	HYPH	denotes	-
T22798	4927-4935	NN	denotes	ΔN87βcat
T22796	4936-4945	NN	denotes	transgene
T22800	4946-4954	VBN	denotes	compared
T22801	4955-4957	IN	denotes	to
T22802	4958-4961	DT	denotes	the
T22804	4962-4971	JJ	denotes	intrinsic
T22803	4972-4980	NN	denotes	promoter
T22805	4980-4981	.	denotes	.
T22806	4981-5237	sentence	denotes	In contrast, Cre-mediated recombination is seen in E13.5 skin of K14-cre transgenic mice used in this study [16] and K14-cre–mediated truncation of the Apc gene is likely to have occurred by then, in time for the second wave of hair follicle morphgenesis.
T22807	4982-4984	IN	denotes	In
T22809	4985-4993	NN	denotes	contrast
T22810	4993-4995	,	denotes	,
T22811	4995-4998	NN	denotes	Cre
T22813	4998-4999	HYPH	denotes	-
T22812	4999-5007	JJ	denotes	mediated
T22814	5008-5021	NN	denotes	recombination
T22815	5022-5024	VBZ	denotes	is
T22808	5025-5029	VBN	denotes	seen
T22816	5030-5032	IN	denotes	in
T22817	5033-5038	NN	denotes	E13.5
T22818	5039-5043	NN	denotes	skin
T22819	5044-5046	IN	denotes	of
T22820	5047-5050	NN	denotes	K14
T22822	5050-5051	HYPH	denotes	-
T22821	5051-5054	NN	denotes	cre
T22824	5055-5065	JJ	denotes	transgenic
T22823	5066-5070	NNS	denotes	mice
T22825	5071-5075	VBN	denotes	used
T22826	5076-5078	IN	denotes	in
T22827	5079-5083	DT	denotes	this
T22828	5084-5089	NN	denotes	study
T22829	5090-5091	-LRB-	denotes	[
T22830	5091-5093	CD	denotes	16
T22831	5093-5094	-RRB-	denotes	]
T22832	5095-5098	CC	denotes	and
T22833	5099-5102	NN	denotes	K14
T22835	5102-5103	HYPH	denotes	-
T22834	5103-5106	NN	denotes	cre
T22837	5106-5107	HYPH	denotes	–
T22836	5107-5115	JJ	denotes	mediated
T22838	5116-5126	NN	denotes	truncation
T22840	5127-5129	IN	denotes	of
T22841	5130-5133	DT	denotes	the
T22843	5134-5137	NN	denotes	Apc
T22842	5138-5142	NN	denotes	gene
T22839	5143-5145	VBZ	denotes	is
T22844	5146-5152	JJ	denotes	likely
T22845	5153-5155	TO	denotes	to
T22847	5156-5160	VB	denotes	have
T22846	5161-5169	VBN	denotes	occurred
T22848	5170-5172	IN	denotes	by
T22849	5173-5177	RB	denotes	then
T22850	5177-5179	,	denotes	,
T22851	5179-5181	IN	denotes	in
T22852	5182-5186	NN	denotes	time
T22853	5187-5190	IN	denotes	for
T22854	5191-5194	DT	denotes	the
T22856	5195-5201	JJ	denotes	second
T22855	5202-5206	NN	denotes	wave
T22857	5207-5209	IN	denotes	of
T22858	5210-5214	NN	denotes	hair
T22859	5215-5223	NN	denotes	follicle
T22860	5224-5236	NN	denotes	morphgenesis
T22861	5236-5237	.	denotes	.
T22862	5237-5456	sentence	denotes	(2) Another important fact is that in the aforementioned transgenic model the overexpression of transgene is confined to the basal cells of the epidermis and the ORS of hair follicles, where the K14 promoter is active.
T22863	5238-5239	-LRB-	denotes	(
T22864	5239-5240	LS	denotes	2
T22866	5240-5241	-RRB-	denotes	)
T22867	5242-5249	DT	denotes	Another
T22869	5250-5259	JJ	denotes	important
T22868	5260-5264	NN	denotes	fact
T22865	5265-5267	VBZ	denotes	is
T22870	5268-5272	IN	denotes	that
T22872	5273-5275	IN	denotes	in
T22873	5276-5279	DT	denotes	the
T22875	5280-5294	JJ	denotes	aforementioned
T22876	5295-5305	JJ	denotes	transgenic
T22874	5306-5311	NN	denotes	model
T22877	5312-5315	DT	denotes	the
T22878	5316-5330	NN	denotes	overexpression
T22879	5331-5333	IN	denotes	of
T22880	5334-5343	NN	denotes	transgene
T22881	5344-5346	VBZ	denotes	is
T22871	5347-5355	VBN	denotes	confined
T22882	5356-5358	IN	denotes	to
T22883	5359-5362	DT	denotes	the
T22885	5363-5368	JJ	denotes	basal
T22884	5369-5374	NNS	denotes	cells
T22886	5375-5377	IN	denotes	of
T22887	5378-5381	DT	denotes	the
T22888	5382-5391	NN	denotes	epidermis
T22889	5392-5395	CC	denotes	and
T22890	5396-5399	DT	denotes	the
T22891	5400-5403	NN	denotes	ORS
T22892	5404-5406	IN	denotes	of
T22893	5407-5411	NN	denotes	hair
T22894	5412-5421	NNS	denotes	follicles
T22895	5421-5423	,	denotes	,
T22896	5423-5428	WRB	denotes	where
T22898	5429-5432	DT	denotes	the
T22900	5433-5436	NN	denotes	K14
T22899	5437-5445	NN	denotes	promoter
T22897	5446-5448	VBZ	denotes	is
T22901	5449-5455	JJ	denotes	active
T22902	5455-5456	.	denotes	.
T22903	5456-5565	sentence	denotes	The expression of transgene is hence transient and stops once K14-expressing cells terminally differentiate.
T22904	5457-5460	DT	denotes	The
T22905	5461-5471	NN	denotes	expression
T22907	5472-5474	IN	denotes	of
T22908	5475-5484	NN	denotes	transgene
T22906	5485-5487	VBZ	denotes	is
T22909	5488-5493	RB	denotes	hence
T22910	5494-5503	JJ	denotes	transient
T22911	5504-5507	CC	denotes	and
T22912	5508-5513	VBZ	denotes	stops
T22913	5514-5518	IN	denotes	once
T22915	5519-5522	NN	denotes	K14
T22917	5522-5523	HYPH	denotes	-
T22916	5523-5533	VBG	denotes	expressing
T22918	5534-5539	NNS	denotes	cells
T22919	5540-5550	RB	denotes	terminally
T22914	5551-5564	VBP	denotes	differentiate
T22920	5564-5565	.	denotes	.
T22921	5565-5781	sentence	denotes	In contrast, in our model, K14-cre–mediated deletion of Apc would result in Apc mutation not only in K14 promoter active cells, but remain so in all cell layers that derived from the K14 promoter active progenitors.
T22922	5566-5568	IN	denotes	In
T22924	5569-5577	NN	denotes	contrast
T22925	5577-5579	,	denotes	,
T22926	5579-5581	IN	denotes	in
T22927	5582-5585	PRP$	denotes	our
T22928	5586-5591	NN	denotes	model
T22929	5591-5593	,	denotes	,
T22930	5593-5596	NN	denotes	K14
T22932	5596-5597	HYPH	denotes	-
T22931	5597-5600	NN	denotes	cre
T22934	5600-5601	HYPH	denotes	–
T22933	5601-5609	JJ	denotes	mediated
T22935	5610-5618	NN	denotes	deletion
T22936	5619-5621	IN	denotes	of
T22937	5622-5625	NN	denotes	Apc
T22938	5626-5631	MD	denotes	would
T22923	5632-5638	VB	denotes	result
T22939	5639-5641	IN	denotes	in
T22940	5642-5645	NN	denotes	Apc
T22941	5646-5654	NN	denotes	mutation
T22942	5655-5658	RB	denotes	not
T22944	5659-5663	RB	denotes	only
T22943	5664-5666	IN	denotes	in
T22945	5667-5670	NN	denotes	K14
T22947	5671-5679	NN	denotes	promoter
T22948	5680-5686	JJ	denotes	active
T22946	5687-5692	NNS	denotes	cells
T22949	5692-5694	,	denotes	,
T22950	5694-5697	CC	denotes	but
T22951	5698-5704	VBP	denotes	remain
T22952	5705-5707	RB	denotes	so
T22953	5708-5710	IN	denotes	in
T22954	5711-5714	DT	denotes	all
T22956	5715-5719	NN	denotes	cell
T22955	5720-5726	NNS	denotes	layers
T22957	5727-5731	WDT	denotes	that
T22958	5732-5739	VBN	denotes	derived
T22959	5740-5744	IN	denotes	from
T22960	5745-5748	DT	denotes	the
T22962	5749-5752	NN	denotes	K14
T22963	5753-5761	NN	denotes	promoter
T22964	5762-5768	JJ	denotes	active
T22961	5769-5780	NNS	denotes	progenitors
T22965	5780-5781	.	denotes	.
T22966	5781-5880	sentence	denotes	These derivatives include the suprabasal epidermis and the entire epithelium of the hair follicle.
T22967	5782-5787	DT	denotes	These
T22968	5788-5799	NNS	denotes	derivatives
T22969	5800-5807	VBP	denotes	include
T22970	5808-5811	DT	denotes	the
T22972	5812-5822	JJ	denotes	suprabasal
T22971	5823-5832	NN	denotes	epidermis
T22973	5833-5836	CC	denotes	and
T22974	5837-5840	DT	denotes	the
T22976	5841-5847	JJ	denotes	entire
T22975	5848-5858	NN	denotes	epithelium
T22977	5859-5861	IN	denotes	of
T22978	5862-5865	DT	denotes	the
T22980	5866-5870	NN	denotes	hair
T22979	5871-5879	NN	denotes	follicle
T22981	5879-5880	.	denotes	.
T22982	5880-5994	sentence	denotes	Stabilization of β-catenin in a broader population of cells could account for some of the phenotypic differences.
T22983	5881-5894	NN	denotes	Stabilization
T22985	5895-5897	IN	denotes	of
T22986	5898-5899	NN	denotes	β
T22988	5899-5900	HYPH	denotes	-
T22987	5900-5907	NN	denotes	catenin
T22989	5908-5910	IN	denotes	in
T22990	5911-5912	DT	denotes	a
T22992	5913-5920	JJR	denotes	broader
T22991	5921-5931	NN	denotes	population
T22993	5932-5934	IN	denotes	of
T22994	5935-5940	NNS	denotes	cells
T22995	5941-5946	MD	denotes	could
T22984	5947-5954	VB	denotes	account
T22996	5955-5958	IN	denotes	for
T22997	5959-5963	DT	denotes	some
T22998	5964-5966	IN	denotes	of
T22999	5967-5970	DT	denotes	the
T23001	5971-5981	JJ	denotes	phenotypic
T23000	5982-5993	NNS	denotes	differences
T23002	5993-5994	.	denotes	.
T23003	5994-6131	sentence	denotes	However, we did not detect any elevated β-catenin expression in either K1- or K6-positive differentiated cells in postnatal mutant skin.
T23004	5995-6002	RB	denotes	However
T23006	6002-6004	,	denotes	,
T23007	6004-6006	PRP	denotes	we
T23008	6007-6010	VBD	denotes	did
T23009	6011-6014	RB	denotes	not
T23005	6015-6021	VB	denotes	detect
T23010	6022-6025	DT	denotes	any
T23012	6026-6034	JJ	denotes	elevated
T23013	6035-6036	NN	denotes	β
T23015	6036-6037	HYPH	denotes	-
T23014	6037-6044	NN	denotes	catenin
T23011	6045-6055	NN	denotes	expression
T23016	6056-6058	IN	denotes	in
T23017	6059-6065	CC	denotes	either
T23019	6066-6068	NN	denotes	K1
T23021	6068-6069	HYPH	denotes	-
T23022	6070-6072	CC	denotes	or
T23023	6073-6075	NN	denotes	K6
T23024	6075-6076	HYPH	denotes	-
T23020	6076-6084	JJ	denotes	positive
T23025	6085-6099	VBN	denotes	differentiated
T23018	6100-6105	NNS	denotes	cells
T23026	6106-6108	IN	denotes	in
T23027	6109-6118	JJ	denotes	postnatal
T23029	6119-6125	JJ	denotes	mutant
T23028	6126-6130	NN	denotes	skin
T23030	6130-6131	.	denotes	.
T23031	6131-6371	sentence	denotes	This indicates that despite the absence of Apc and potential stabilization of β-catenin in derivatives of K14-expressing progenitors, elevated β-catenin expression, and subsequent cell fate determination may only take place in basal cells.
T23032	6132-6136	DT	denotes	This
T23033	6137-6146	VBZ	denotes	indicates
T23034	6147-6151	IN	denotes	that
T23036	6152-6159	IN	denotes	despite
T23037	6160-6163	DT	denotes	the
T23038	6164-6171	NN	denotes	absence
T23039	6172-6174	IN	denotes	of
T23040	6175-6178	NN	denotes	Apc
T23041	6179-6182	CC	denotes	and
T23042	6183-6192	JJ	denotes	potential
T23043	6193-6206	NN	denotes	stabilization
T23044	6207-6209	IN	denotes	of
T23045	6210-6211	NN	denotes	β
T23047	6211-6212	HYPH	denotes	-
T23046	6212-6219	NN	denotes	catenin
T23048	6220-6222	IN	denotes	in
T23049	6223-6234	NNS	denotes	derivatives
T23050	6235-6237	IN	denotes	of
T23051	6238-6241	NN	denotes	K14
T23053	6241-6242	HYPH	denotes	-
T23052	6242-6252	VBG	denotes	expressing
T23054	6253-6264	NNS	denotes	progenitors
T23055	6264-6266	,	denotes	,
T23056	6266-6274	JJ	denotes	elevated
T23058	6275-6276	NN	denotes	β
T23060	6276-6277	HYPH	denotes	-
T23059	6277-6284	NN	denotes	catenin
T23057	6285-6295	NN	denotes	expression
T23061	6295-6297	,	denotes	,
T23062	6297-6300	CC	denotes	and
T23063	6301-6311	JJ	denotes	subsequent
T23065	6312-6316	NN	denotes	cell
T23066	6317-6321	NN	denotes	fate
T23064	6322-6335	NN	denotes	determination
T23067	6336-6339	MD	denotes	may
T23068	6340-6344	RB	denotes	only
T23035	6345-6349	VB	denotes	take
T23069	6350-6355	NN	denotes	place
T23070	6356-6358	IN	denotes	in
T23071	6359-6364	JJ	denotes	basal
T23072	6365-6370	NNS	denotes	cells
T23073	6370-6371	.	denotes	.
T23074	6371-6586	sentence	denotes	(3) We cannot exclude the possibility that given the multifunctional properties of Apc, disruption of its functions other than down-regulation of β-catenin may also have contributed to the observed overt phenotype.
T23075	6372-6373	-LRB-	denotes	(
T23076	6373-6374	LS	denotes	3
T23078	6374-6375	-RRB-	denotes	)
T23079	6376-6378	PRP	denotes	We
T23080	6379-6382	MD	denotes	can
T23081	6382-6385	RB	denotes	not
T23077	6386-6393	VB	denotes	exclude
T23082	6394-6397	DT	denotes	the
T23083	6398-6409	NN	denotes	possibility
T23084	6410-6414	IN	denotes	that
T23086	6415-6420	VBN	denotes	given
T23087	6421-6424	DT	denotes	the
T23089	6425-6440	JJ	denotes	multifunctional
T23088	6441-6451	NNS	denotes	properties
T23090	6452-6454	IN	denotes	of
T23091	6455-6458	NN	denotes	Apc
T23092	6458-6460	,	denotes	,
T23093	6460-6470	NN	denotes	disruption
T23094	6471-6473	IN	denotes	of
T23095	6474-6477	PRP$	denotes	its
T23096	6478-6487	NNS	denotes	functions
T23097	6488-6493	JJ	denotes	other
T23098	6494-6498	IN	denotes	than
T23099	6499-6503	RB	denotes	down
T23101	6503-6504	HYPH	denotes	-
T23100	6504-6514	NN	denotes	regulation
T23102	6515-6517	IN	denotes	of
T23103	6518-6519	NN	denotes	β
T23105	6519-6520	HYPH	denotes	-
T23104	6520-6527	NN	denotes	catenin
T23106	6528-6531	MD	denotes	may
T23107	6532-6536	RB	denotes	also
T23108	6537-6541	VB	denotes	have
T23085	6542-6553	VBN	denotes	contributed
T23109	6554-6556	IN	denotes	to
T23110	6557-6560	DT	denotes	the
T23112	6561-6569	VBN	denotes	observed
T23113	6570-6575	JJ	denotes	overt
T23111	6576-6585	NN	denotes	phenotype
T23114	6585-6586	.	denotes	.
T23115	6586-6712	sentence	denotes	While some features of our mutant mice were similar to these transgenic mice, other phenotypic aspects were largely distinct.
T23116	6587-6592	IN	denotes	While
T23118	6593-6597	DT	denotes	some
T23119	6598-6606	NNS	denotes	features
T23120	6607-6609	IN	denotes	of
T23121	6610-6613	PRP$	denotes	our
T23123	6614-6620	JJ	denotes	mutant
T23122	6621-6625	NNS	denotes	mice
T23117	6626-6630	VBD	denotes	were
T23125	6631-6638	JJ	denotes	similar
T23126	6639-6641	IN	denotes	to
T23127	6642-6647	DT	denotes	these
T23129	6648-6658	JJ	denotes	transgenic
T23128	6659-6663	NNS	denotes	mice
T23130	6663-6665	,	denotes	,
T23131	6665-6670	JJ	denotes	other
T23133	6671-6681	JJ	denotes	phenotypic
T23132	6682-6689	NNS	denotes	aspects
T23124	6690-6694	VBD	denotes	were
T23134	6695-6702	RB	denotes	largely
T23135	6703-6711	JJ	denotes	distinct
T23136	6711-6712	.	denotes	.
T23137	6712-6947	sentence	denotes	In addition to aberrant hair follicle morphogenesis, K14-driven loss of Apc caused formation of multiple tooth buds that, like hair follicles, were known to develop through inductive interactions between the epithelium and mesenchyme.
T23138	6713-6715	IN	denotes	In
T23140	6716-6724	NN	denotes	addition
T23141	6725-6727	IN	denotes	to
T23142	6728-6736	JJ	denotes	aberrant
T23144	6737-6741	NN	denotes	hair
T23145	6742-6750	NN	denotes	follicle
T23143	6751-6764	NN	denotes	morphogenesis
T23146	6764-6766	,	denotes	,
T23147	6766-6769	NN	denotes	K14
T23149	6769-6770	HYPH	denotes	-
T23148	6770-6776	JJ	denotes	driven
T23150	6777-6781	NN	denotes	loss
T23151	6782-6784	IN	denotes	of
T23152	6785-6788	NN	denotes	Apc
T23139	6789-6795	VBD	denotes	caused
T23153	6796-6805	NN	denotes	formation
T23154	6806-6808	IN	denotes	of
T23155	6809-6817	JJ	denotes	multiple
T23157	6818-6823	NN	denotes	tooth
T23156	6824-6828	NNS	denotes	buds
T23158	6829-6833	WDT	denotes	that
T23160	6833-6835	,	denotes	,
T23161	6835-6839	IN	denotes	like
T23162	6840-6844	NN	denotes	hair
T23163	6845-6854	NNS	denotes	follicles
T23164	6854-6856	,	denotes	,
T23165	6856-6860	VBD	denotes	were
T23159	6861-6866	VBN	denotes	known
T23166	6867-6869	TO	denotes	to
T23167	6870-6877	VB	denotes	develop
T23168	6878-6885	IN	denotes	through
T23169	6886-6895	JJ	denotes	inductive
T23170	6896-6908	NNS	denotes	interactions
T23171	6909-6916	IN	denotes	between
T23172	6917-6920	DT	denotes	the
T23173	6921-6931	NN	denotes	epithelium
T23174	6932-6935	CC	denotes	and
T23175	6936-6946	NN	denotes	mesenchyme
T23176	6946-6947	.	denotes	.
T23177	6947-7279	sentence	denotes	This observation was similar to the ectopic tooth buds found in animals misexpressing Lef1 [27], but more severe and was also present at birth, indicating the effect of Apc loss during the initiation of embryonic tooth development, which was evident by aberrant Shh expression in E15.5 embryonic oral epithelium (unpublished data).
T23178	6948-6952	DT	denotes	This
T23179	6953-6964	NN	denotes	observation
T23180	6965-6968	VBD	denotes	was
T23181	6969-6976	JJ	denotes	similar
T23182	6977-6979	IN	denotes	to
T23183	6980-6983	DT	denotes	the
T23185	6984-6991	JJ	denotes	ectopic
T23186	6992-6997	NN	denotes	tooth
T23184	6998-7002	NNS	denotes	buds
T23187	7003-7008	VBN	denotes	found
T23188	7009-7011	IN	denotes	in
T23189	7012-7019	NNS	denotes	animals
T23190	7020-7033	VBG	denotes	misexpressing
T23191	7034-7038	NN	denotes	Lef1
T23192	7039-7040	-LRB-	denotes	[
T23193	7040-7042	CD	denotes	27
T23194	7042-7043	-RRB-	denotes	]
T23195	7043-7045	,	denotes	,
T23196	7045-7048	CC	denotes	but
T23197	7049-7053	RBR	denotes	more
T23198	7054-7060	JJ	denotes	severe
T23199	7061-7064	CC	denotes	and
T23200	7065-7068	VBD	denotes	was
T23201	7069-7073	RB	denotes	also
T23202	7074-7081	JJ	denotes	present
T23203	7082-7084	IN	denotes	at
T23204	7085-7090	NN	denotes	birth
T23205	7090-7092	,	denotes	,
T23206	7092-7102	VBG	denotes	indicating
T23207	7103-7106	DT	denotes	the
T23208	7107-7113	NN	denotes	effect
T23209	7114-7116	IN	denotes	of
T23210	7117-7120	NN	denotes	Apc
T23211	7121-7125	NN	denotes	loss
T23212	7126-7132	IN	denotes	during
T23213	7133-7136	DT	denotes	the
T23214	7137-7147	NN	denotes	initiation
T23215	7148-7150	IN	denotes	of
T23216	7151-7160	JJ	denotes	embryonic
T23218	7161-7166	NN	denotes	tooth
T23217	7167-7178	NN	denotes	development
T23219	7178-7180	,	denotes	,
T23220	7180-7185	WDT	denotes	which
T23221	7186-7189	VBD	denotes	was
T23222	7190-7197	JJ	denotes	evident
T23223	7198-7200	IN	denotes	by
T23224	7201-7209	JJ	denotes	aberrant
T23226	7210-7213	NN	denotes	Shh
T23225	7214-7224	NN	denotes	expression
T23227	7225-7227	IN	denotes	in
T23228	7228-7233	NN	denotes	E15.5
T23230	7234-7243	JJ	denotes	embryonic
T23231	7244-7248	JJ	denotes	oral
T23229	7249-7259	NN	denotes	epithelium
T23232	7260-7261	-LRB-	denotes	(
T23234	7261-7272	JJ	denotes	unpublished
T23233	7273-7277	NNS	denotes	data
T23235	7277-7278	-RRB-	denotes	)
T23236	7278-7279	.	denotes	.
T23237	7279-7451	sentence	denotes	It should be noted that although multiple tooth buds were histologically visible (Figure 4O and 4P), these teeth never broke out and the KA mutant mice appeared toothless.
T23238	7280-7282	PRP	denotes	It
T23240	7283-7289	MD	denotes	should
T23241	7290-7292	VB	denotes	be
T23239	7293-7298	VBN	denotes	noted
T23242	7299-7303	IN	denotes	that
T23244	7304-7312	IN	denotes	although
T23246	7313-7321	JJ	denotes	multiple
T23248	7322-7327	NN	denotes	tooth
T23247	7328-7332	NNS	denotes	buds
T23245	7333-7337	VBD	denotes	were
T23249	7338-7352	RB	denotes	histologically
T23250	7353-7360	JJ	denotes	visible
T23251	7361-7362	-LRB-	denotes	(
T23253	7362-7368	NN	denotes	Figure
T23252	7369-7371	NN	denotes	4O
T23254	7372-7375	CC	denotes	and
T23255	7376-7378	NN	denotes	4P
T23256	7378-7379	-RRB-	denotes	)
T23257	7379-7381	,	denotes	,
T23258	7381-7386	DT	denotes	these
T23259	7387-7392	NNS	denotes	teeth
T23260	7393-7398	RB	denotes	never
T23243	7399-7404	VBD	denotes	broke
T23261	7405-7408	RP	denotes	out
T23262	7409-7412	CC	denotes	and
T23263	7413-7416	DT	denotes	the
T23265	7417-7419	NN	denotes	KA
T23266	7420-7426	JJ	denotes	mutant
T23264	7427-7431	NNS	denotes	mice
T23267	7432-7440	VBD	denotes	appeared
T23268	7441-7450	JJ	denotes	toothless
T23269	7450-7451	.	denotes	.
T23270	7451-7516	sentence	denotes	This unusual severe tooth defect is unique to these mutant mice.
T23271	7452-7456	DT	denotes	This
T23273	7457-7464	JJ	denotes	unusual
T23274	7465-7471	JJ	denotes	severe
T23275	7472-7477	NN	denotes	tooth
T23272	7478-7484	NN	denotes	defect
T23276	7485-7487	VBZ	denotes	is
T23277	7488-7494	JJ	denotes	unique
T23278	7495-7497	IN	denotes	to
T23279	7498-7503	DT	denotes	these
T23281	7504-7510	JJ	denotes	mutant
T23280	7511-7515	NNS	denotes	mice
T23282	7515-7516	.	denotes	.
T23283	7516-7613	sentence	denotes	In addition, neither of the two transgenic mice was postnatally lethal as in the KA mutant mice.
T23284	7517-7519	IN	denotes	In
T23286	7520-7528	NN	denotes	addition
T23287	7528-7530	,	denotes	,
T23288	7530-7537	DT	denotes	neither
T23289	7538-7540	IN	denotes	of
T23290	7541-7544	DT	denotes	the
T23292	7545-7548	CD	denotes	two
T23293	7549-7559	JJ	denotes	transgenic
T23291	7560-7564	NNS	denotes	mice
T23285	7565-7568	VBD	denotes	was
T23294	7569-7580	RB	denotes	postnatally
T23295	7581-7587	JJ	denotes	lethal
T23296	7588-7590	IN	denotes	as
T23297	7591-7593	IN	denotes	in
T23298	7594-7597	DT	denotes	the
T23300	7598-7600	NN	denotes	KA
T23301	7601-7607	JJ	denotes	mutant
T23299	7608-7612	NNS	denotes	mice
T23302	7612-7613	.	denotes	.
T23303	7613-7747	sentence	denotes	We did not find any obvious histopathological abnormalities in the internal organs of KA mice that could contribute to the lethality.
T23304	7614-7616	PRP	denotes	We
T23306	7617-7620	VBD	denotes	did
T23307	7621-7624	RB	denotes	not
T23305	7625-7629	VB	denotes	find
T23308	7630-7633	DT	denotes	any
T23310	7634-7641	JJ	denotes	obvious
T23311	7642-7659	JJ	denotes	histopathological
T23309	7660-7673	NNS	denotes	abnormalities
T23312	7674-7676	IN	denotes	in
T23313	7677-7680	DT	denotes	the
T23315	7681-7689	JJ	denotes	internal
T23314	7690-7696	NNS	denotes	organs
T23316	7697-7699	IN	denotes	of
T23317	7700-7702	NN	denotes	KA
T23318	7703-7707	NNS	denotes	mice
T23319	7708-7712	WDT	denotes	that
T23321	7713-7718	MD	denotes	could
T23320	7719-7729	VB	denotes	contribute
T23322	7730-7732	IN	denotes	to
T23323	7733-7736	DT	denotes	the
T23324	7737-7746	NN	denotes	lethality
T23325	7746-7747	.	denotes	.
T23326	7747-7929	sentence	denotes	However, the fact that all the mutants had lower weight (Figure 2F) with hardly any evidence of solid food in their stomach indicates that the mutants might have died of starvation.
T23327	7748-7755	RB	denotes	However
T23329	7755-7757	,	denotes	,
T23330	7757-7760	DT	denotes	the
T23331	7761-7765	NN	denotes	fact
T23332	7766-7770	IN	denotes	that
T23334	7771-7774	PDT	denotes	all
T23336	7775-7778	DT	denotes	the
T23335	7779-7786	NNS	denotes	mutants
T23333	7787-7790	VBD	denotes	had
T23337	7791-7796	JJR	denotes	lower
T23338	7797-7803	NN	denotes	weight
T23339	7804-7805	-LRB-	denotes	(
T23341	7805-7811	NN	denotes	Figure
T23340	7812-7814	NN	denotes	2F
T23342	7814-7815	-RRB-	denotes	)
T23343	7816-7820	IN	denotes	with
T23344	7821-7827	RB	denotes	hardly
T23346	7828-7831	DT	denotes	any
T23345	7832-7840	NN	denotes	evidence
T23347	7841-7843	IN	denotes	of
T23348	7844-7849	JJ	denotes	solid
T23349	7850-7854	NN	denotes	food
T23350	7855-7857	IN	denotes	in
T23351	7858-7863	PRP$	denotes	their
T23352	7864-7871	NN	denotes	stomach
T23328	7872-7881	VBZ	denotes	indicates
T23353	7882-7886	IN	denotes	that
T23355	7887-7890	DT	denotes	the
T23356	7891-7898	NNS	denotes	mutants
T23357	7899-7904	MD	denotes	might
T23358	7905-7909	VB	denotes	have
T23354	7910-7914	VBN	denotes	died
T23359	7915-7917	IN	denotes	of
T23360	7918-7928	NN	denotes	starvation
T23361	7928-7929	.	denotes	.
T23362	7929-8048	sentence	denotes	Dermal fat was reduced in the mutant skin, possibly as a consequence of poor nutrition caused by the absence of teeth.
T23363	7930-7936	JJ	denotes	Dermal
T23364	7937-7940	NN	denotes	fat
T23366	7941-7944	VBD	denotes	was
T23365	7945-7952	VBN	denotes	reduced
T23367	7953-7955	IN	denotes	in
T23368	7956-7959	DT	denotes	the
T23370	7960-7966	JJ	denotes	mutant
T23369	7967-7971	NN	denotes	skin
T23371	7971-7973	,	denotes	,
T23372	7973-7981	RB	denotes	possibly
T23373	7982-7984	IN	denotes	as
T23374	7985-7986	DT	denotes	a
T23375	7987-7998	NN	denotes	consequence
T23376	7999-8001	IN	denotes	of
T23377	8002-8006	JJ	denotes	poor
T23378	8007-8016	NN	denotes	nutrition
T23379	8017-8023	VBN	denotes	caused
T23380	8024-8026	IN	denotes	by
T23381	8027-8030	DT	denotes	the
T23382	8031-8038	NN	denotes	absence
T23383	8039-8041	IN	denotes	of
T23384	8042-8047	NNS	denotes	teeth
T23385	8047-8048	.	denotes	.
T23386	8048-8261	sentence	denotes	Since the weight loss in KA mutants started from P8–P10 while pups were still nursed by their mothers, starvation due to lack of teeth cannot be the sole cause of death, but is likely to be a contributing factor.
T23387	8049-8054	IN	denotes	Since
T23389	8055-8058	DT	denotes	the
T23391	8059-8065	NN	denotes	weight
T23390	8066-8070	NN	denotes	loss
T23392	8071-8073	IN	denotes	in
T23393	8074-8076	NN	denotes	KA
T23394	8077-8084	NNS	denotes	mutants
T23388	8085-8092	VBN	denotes	started
T23396	8093-8097	IN	denotes	from
T23397	8098-8100	NN	denotes	P8
T23398	8100-8101	SYM	denotes	–
T23399	8101-8104	NN	denotes	P10
T23400	8105-8110	IN	denotes	while
T23402	8111-8115	NNS	denotes	pups
T23403	8116-8120	VBD	denotes	were
T23404	8121-8126	RB	denotes	still
T23401	8127-8133	VBN	denotes	nursed
T23405	8134-8136	IN	denotes	by
T23406	8137-8142	PRP$	denotes	their
T23407	8143-8150	NNS	denotes	mothers
T23408	8150-8152	,	denotes	,
T23409	8152-8162	NN	denotes	starvation
T23410	8163-8166	IN	denotes	due
T23411	8167-8169	IN	denotes	to
T23412	8170-8174	NN	denotes	lack
T23413	8175-8177	IN	denotes	of
T23414	8178-8183	NNS	denotes	teeth
T23415	8184-8187	MD	denotes	can
T23416	8187-8190	RB	denotes	not
T23395	8191-8193	VB	denotes	be
T23417	8194-8197	DT	denotes	the
T23419	8198-8202	JJ	denotes	sole
T23418	8203-8208	NN	denotes	cause
T23420	8209-8211	IN	denotes	of
T23421	8212-8217	NN	denotes	death
T23422	8217-8219	,	denotes	,
T23423	8219-8222	CC	denotes	but
T23424	8223-8225	VBZ	denotes	is
T23425	8226-8232	JJ	denotes	likely
T23426	8233-8235	TO	denotes	to
T23427	8236-8238	VB	denotes	be
T23428	8239-8240	DT	denotes	a
T23430	8241-8253	VBG	denotes	contributing
T23429	8254-8260	NN	denotes	factor
T23431	8260-8261	.	denotes	.
T23432	8261-8458	sentence	denotes	Absence of teeth and mammary glands have been observed in mice deficient in Lef1 and ectopically expressing Dkk1 [29,30] but their absence was due to the block in development before the bud stage.
T23433	8262-8269	NN	denotes	Absence
T23435	8270-8272	IN	denotes	of
T23436	8273-8278	NNS	denotes	teeth
T23437	8279-8282	CC	denotes	and
T23438	8283-8290	JJ	denotes	mammary
T23439	8291-8297	NNS	denotes	glands
T23440	8298-8302	VBP	denotes	have
T23441	8303-8307	VBN	denotes	been
T23434	8308-8316	VBN	denotes	observed
T23442	8317-8319	IN	denotes	in
T23443	8320-8324	NNS	denotes	mice
T23444	8325-8334	JJ	denotes	deficient
T23445	8335-8337	IN	denotes	in
T23446	8338-8342	NN	denotes	Lef1
T23447	8343-8346	CC	denotes	and
T23448	8347-8358	RB	denotes	ectopically
T23449	8359-8369	VBG	denotes	expressing
T23450	8370-8374	NN	denotes	Dkk1
T23451	8375-8376	-LRB-	denotes	[
T23453	8376-8378	CD	denotes	29
T23454	8378-8379	,	denotes	,
T23452	8379-8381	CD	denotes	30
T23455	8381-8382	-RRB-	denotes	]
T23456	8383-8386	CC	denotes	but
T23457	8387-8392	PRP$	denotes	their
T23458	8393-8400	NN	denotes	absence
T23459	8401-8404	VBD	denotes	was
T23460	8405-8408	IN	denotes	due
T23461	8409-8411	IN	denotes	to
T23462	8412-8415	DT	denotes	the
T23463	8416-8421	NN	denotes	block
T23464	8422-8424	IN	denotes	in
T23465	8425-8436	NN	denotes	development
T23466	8437-8443	IN	denotes	before
T23467	8444-8447	DT	denotes	the
T23469	8448-8451	NN	denotes	bud
T23468	8452-8457	NN	denotes	stage
T23470	8457-8458	.	denotes	.
T23471	8458-8596	sentence	denotes	Hence, neither loss nor excess of tooth bud formation allows proper development of teeth for mice to have a healthy diet and normal life.
T23472	8459-8464	RB	denotes	Hence
T23474	8464-8466	,	denotes	,
T23475	8466-8473	CC	denotes	neither
T23476	8474-8478	NN	denotes	loss
T23477	8479-8482	CC	denotes	nor
T23478	8483-8489	NN	denotes	excess
T23479	8490-8492	IN	denotes	of
T23480	8493-8498	JJ	denotes	tooth
T23481	8499-8502	NN	denotes	bud
T23482	8503-8512	NN	denotes	formation
T23473	8513-8519	VBZ	denotes	allows
T23483	8520-8526	JJ	denotes	proper
T23484	8527-8538	NN	denotes	development
T23485	8539-8541	IN	denotes	of
T23486	8542-8547	NNS	denotes	teeth
T23487	8548-8551	IN	denotes	for
T23489	8552-8556	NNS	denotes	mice
T23490	8557-8559	TO	denotes	to
T23488	8560-8564	VB	denotes	have
T23491	8565-8566	DT	denotes	a
T23493	8567-8574	JJ	denotes	healthy
T23492	8575-8579	NN	denotes	diet
T23494	8580-8583	CC	denotes	and
T23495	8584-8590	JJ	denotes	normal
T23496	8591-8595	NN	denotes	life
T23497	8595-8596	.	denotes	.
T23498	8596-8722	sentence	denotes	Mechanistic studies to understand how increased levels of β-catenin leads to altered skin and tooth phenotypes are under way.
T23499	8597-8608	JJ	denotes	Mechanistic
T23500	8609-8616	NNS	denotes	studies
T23502	8617-8619	TO	denotes	to
T23503	8620-8630	VB	denotes	understand
T23504	8631-8634	WRB	denotes	how
T23506	8635-8644	VBN	denotes	increased
T23507	8645-8651	NNS	denotes	levels
T23508	8652-8654	IN	denotes	of
T23509	8655-8656	NN	denotes	β
T23511	8656-8657	HYPH	denotes	-
T23510	8657-8664	NN	denotes	catenin
T23505	8665-8670	VBZ	denotes	leads
T23512	8671-8673	IN	denotes	to
T23513	8674-8681	JJ	denotes	altered
T23515	8682-8686	NN	denotes	skin
T23516	8687-8690	CC	denotes	and
T23517	8691-8696	NN	denotes	tooth
T23514	8697-8707	NNS	denotes	phenotypes
T23501	8708-8711	VBP	denotes	are
T23518	8712-8717	IN	denotes	under
T23519	8718-8721	NN	denotes	way
T23520	8721-8722	.	denotes	.
T25417	8724-8727	NN	denotes	Apc
T25418	8728-8731	CC	denotes	and
T25419	8732-8738	NN	denotes	Thymus
T25420	8739-8752	NN	denotes	Organogenesis
T25421	8752-9008	sentence	denotes	In this study, we observed that K14-driven loss of Apc resulted in a small thymus with severe squamous metaplasia leading to the formation of numerous pyogranuloma and loss of proper meshwork structure for thymocyte maturation, rendering the mice athymic.
T25422	8753-8755	IN	denotes	In
T25424	8756-8760	DT	denotes	this
T25425	8761-8766	NN	denotes	study
T25426	8766-8768	,	denotes	,
T25427	8768-8770	PRP	denotes	we
T25423	8771-8779	VBD	denotes	observed
T25428	8780-8784	IN	denotes	that
T25430	8785-8788	NN	denotes	K14
T25432	8788-8789	HYPH	denotes	-
T25431	8789-8795	VBN	denotes	driven
T25433	8796-8800	NN	denotes	loss
T25434	8801-8803	IN	denotes	of
T25435	8804-8807	NN	denotes	Apc
T25429	8808-8816	VBD	denotes	resulted
T25436	8817-8819	IN	denotes	in
T25437	8820-8821	DT	denotes	a
T25439	8822-8827	JJ	denotes	small
T25438	8828-8834	NN	denotes	thymus
T25440	8835-8839	IN	denotes	with
T25441	8840-8846	JJ	denotes	severe
T25443	8847-8855	JJ	denotes	squamous
T25442	8856-8866	NN	denotes	metaplasia
T25444	8867-8874	VBG	denotes	leading
T25445	8875-8877	IN	denotes	to
T25446	8878-8881	DT	denotes	the
T25447	8882-8891	NN	denotes	formation
T25448	8892-8894	IN	denotes	of
T25449	8895-8903	JJ	denotes	numerous
T25450	8904-8916	NN	denotes	pyogranuloma
T25451	8917-8920	CC	denotes	and
T25452	8921-8925	NN	denotes	loss
T25453	8926-8928	IN	denotes	of
T25454	8929-8935	JJ	denotes	proper
T25456	8936-8944	NN	denotes	meshwork
T25455	8945-8954	NN	denotes	structure
T25457	8955-8958	IN	denotes	for
T25458	8959-8968	NN	denotes	thymocyte
T25459	8969-8979	NN	denotes	maturation
T25460	8979-8981	,	denotes	,
T25461	8981-8990	VBG	denotes	rendering
T25462	8991-8994	DT	denotes	the
T25463	8995-8999	NNS	denotes	mice
T25464	9000-9007	JJ	denotes	athymic
T25465	9007-9008	.	denotes	.
T25466	9008-9226	sentence	denotes	Previous studies have shown that in normal adult thymus K14 expression is found together with K5 in the stellate medullary TECs, but not in association with K5+ TECs in the cortex or at the cortico-medullary junction.
T25467	9009-9017	JJ	denotes	Previous
T25468	9018-9025	NNS	denotes	studies
T25470	9026-9030	VBP	denotes	have
T25469	9031-9036	VBN	denotes	shown
T25471	9037-9041	IN	denotes	that
T25473	9042-9044	IN	denotes	in
T25474	9045-9051	JJ	denotes	normal
T25476	9052-9057	JJ	denotes	adult
T25475	9058-9064	NN	denotes	thymus
T25477	9065-9068	NN	denotes	K14
T25478	9069-9079	NN	denotes	expression
T25479	9080-9082	VBZ	denotes	is
T25472	9083-9088	VBN	denotes	found
T25480	9089-9097	RB	denotes	together
T25482	9098-9102	IN	denotes	with
T25483	9103-9105	NN	denotes	K5
T25484	9106-9108	IN	denotes	in
T25485	9109-9112	DT	denotes	the
T25487	9113-9121	JJ	denotes	stellate
T25488	9122-9131	JJ	denotes	medullary
T25486	9132-9136	NNS	denotes	TECs
T25489	9136-9138	,	denotes	,
T25490	9138-9141	CC	denotes	but
T25491	9142-9145	RB	denotes	not
T25481	9146-9148	IN	denotes	in
T25492	9149-9160	NN	denotes	association
T25493	9161-9165	IN	denotes	with
T25494	9166-9168	NN	denotes	K5
T25496	9168-9169	SYM	denotes	+
T25495	9170-9174	NNS	denotes	TECs
T25497	9175-9177	IN	denotes	in
T25498	9178-9181	DT	denotes	the
T25499	9182-9188	NN	denotes	cortex
T25500	9189-9191	CC	denotes	or
T25501	9192-9194	IN	denotes	at
T25502	9195-9198	DT	denotes	the
T25504	9199-9206	JJ	denotes	cortico
T25506	9206-9207	HYPH	denotes	-
T25505	9207-9216	JJ	denotes	medullary
T25503	9217-9225	NN	denotes	junction
T25507	9225-9226	.	denotes	.
T25508	9226-9418	sentence	denotes	In addition, it has been demonstrated that K14+ TECs do not coexpress K8; hence, there are two distinct medullary subsets, namely a K8−K14+ stellate subset and a K8+K14− globular subset [32].
T25509	9227-9229	IN	denotes	In
T25511	9230-9238	NN	denotes	addition
T25512	9238-9240	,	denotes	,
T25513	9240-9242	PRP	denotes	it
T25514	9243-9246	VBZ	denotes	has
T25515	9247-9251	VBN	denotes	been
T25510	9252-9264	VBN	denotes	demonstrated
T25517	9265-9269	IN	denotes	that
T25519	9270-9273	NN	denotes	K14
T25521	9273-9274	SYM	denotes	+
T25520	9275-9279	NNS	denotes	TECs
T25522	9280-9282	VBP	denotes	do
T25523	9283-9286	RB	denotes	not
T25518	9287-9296	VB	denotes	coexpress
T25524	9297-9299	NN	denotes	K8
T25525	9299-9300	:	denotes	;
T25526	9301-9306	RB	denotes	hence
T25527	9306-9308	,	denotes	,
T25528	9308-9313	EX	denotes	there
T25516	9314-9317	VBP	denotes	are
T25529	9318-9321	CD	denotes	two
T25531	9322-9330	JJ	denotes	distinct
T25532	9331-9340	JJ	denotes	medullary
T25530	9341-9348	NNS	denotes	subsets
T25533	9348-9350	,	denotes	,
T25534	9350-9356	RB	denotes	namely
T25536	9357-9358	DT	denotes	a
T25537	9359-9361	NN	denotes	K8
T25538	9361-9362	HYPH	denotes	−
T25539	9362-9365	NN	denotes	K14
T25540	9365-9366	SYM	denotes	+
T25541	9367-9375	JJ	denotes	stellate
T25535	9376-9382	NN	denotes	subset
T25542	9383-9386	CC	denotes	and
T25543	9387-9388	DT	denotes	a
T25545	9389-9391	NN	denotes	K8
T25546	9391-9392	SYM	denotes	+
T25547	9392-9395	NN	denotes	K14
T25548	9395-9396	SYM	denotes	−
T25549	9397-9405	JJ	denotes	globular
T25544	9406-9412	NN	denotes	subset
T25550	9413-9414	-LRB-	denotes	[
T25551	9414-9416	CD	denotes	32
T25552	9416-9417	-RRB-	denotes	]
T25553	9417-9418	.	denotes	.
T25554	9418-9620	sentence	denotes	In agreement with the previous results, in P3 normal thymus K14 expression was restricted to stellate medullary TECs (Figure 6D), whereas K8 expression was found throughout the TECs (unpublished data).
T25555	9419-9421	IN	denotes	In
T25557	9422-9431	NN	denotes	agreement
T25558	9432-9436	IN	denotes	with
T25559	9437-9440	DT	denotes	the
T25561	9441-9449	JJ	denotes	previous
T25560	9450-9457	NNS	denotes	results
T25562	9457-9459	,	denotes	,
T25563	9459-9461	IN	denotes	in
T25564	9462-9464	NN	denotes	P3
T25566	9465-9471	JJ	denotes	normal
T25565	9472-9478	NN	denotes	thymus
T25567	9479-9482	NN	denotes	K14
T25568	9483-9493	NN	denotes	expression
T25569	9494-9497	VBD	denotes	was
T25556	9498-9508	VBN	denotes	restricted
T25570	9509-9511	IN	denotes	to
T25571	9512-9520	JJ	denotes	stellate
T25573	9521-9530	JJ	denotes	medullary
T25572	9531-9535	NNS	denotes	TECs
T25574	9536-9537	-LRB-	denotes	(
T25576	9537-9543	NN	denotes	Figure
T25575	9544-9546	NN	denotes	6D
T25577	9546-9547	-RRB-	denotes	)
T25578	9547-9549	,	denotes	,
T25579	9549-9556	IN	denotes	whereas
T25581	9557-9559	NN	denotes	K8
T25582	9560-9570	NN	denotes	expression
T25583	9571-9574	VBD	denotes	was
T25580	9575-9580	VBN	denotes	found
T25584	9581-9591	IN	denotes	throughout
T25585	9592-9595	DT	denotes	the
T25586	9596-9600	NNS	denotes	TECs
T25587	9601-9602	-LRB-	denotes	(
T25589	9602-9613	JJ	denotes	unpublished
T25588	9614-9618	NNS	denotes	data
T25590	9618-9619	-RRB-	denotes	)
T25591	9619-9620	.	denotes	.
T25592	9620-9727	sentence	denotes	We could not clarify whether these two keratins were coexpressed in the same TECs without double-staining.
T25593	9621-9623	PRP	denotes	We
T25595	9624-9629	MD	denotes	could
T25596	9630-9633	RB	denotes	not
T25594	9634-9641	VB	denotes	clarify
T25597	9642-9649	IN	denotes	whether
T25599	9650-9655	DT	denotes	these
T25601	9656-9659	CD	denotes	two
T25600	9660-9668	NNS	denotes	keratins
T25602	9669-9673	VBD	denotes	were
T25598	9674-9685	VBN	denotes	coexpressed
T25603	9686-9688	IN	denotes	in
T25604	9689-9692	DT	denotes	the
T25606	9693-9697	JJ	denotes	same
T25605	9698-9702	NNS	denotes	TECs
T25607	9703-9710	IN	denotes	without
T25608	9711-9717	NN	denotes	double
T25610	9717-9718	HYPH	denotes	-
T25609	9718-9726	NN	denotes	staining
T25611	9726-9727	.	denotes	.
T25612	9727-10015	sentence	denotes	There were individual differences among mutants and these were prominently reflected in the histological abnormalities of the thymus at P3, but as the older surviving mutants all showed the same histopathologies of the thymus, the mutant thymi eventually seem to result in the same fate.
T25613	9728-9733	EX	denotes	There
T25614	9734-9738	VBD	denotes	were
T25615	9739-9749	JJ	denotes	individual
T25616	9750-9761	NNS	denotes	differences
T25617	9762-9767	IN	denotes	among
T25618	9768-9775	NNS	denotes	mutants
T25619	9776-9779	CC	denotes	and
T25620	9780-9785	DT	denotes	these
T25622	9786-9790	VBD	denotes	were
T25623	9791-9802	RB	denotes	prominently
T25621	9803-9812	VBN	denotes	reflected
T25624	9813-9815	IN	denotes	in
T25625	9816-9819	DT	denotes	the
T25627	9820-9832	JJ	denotes	histological
T25626	9833-9846	NNS	denotes	abnormalities
T25628	9847-9849	IN	denotes	of
T25629	9850-9853	DT	denotes	the
T25630	9854-9860	NN	denotes	thymus
T25631	9861-9863	IN	denotes	at
T25632	9864-9866	NN	denotes	P3
T25633	9866-9868	,	denotes	,
T25634	9868-9871	CC	denotes	but
T25635	9872-9874	IN	denotes	as
T25637	9875-9878	DT	denotes	the
T25639	9879-9884	JJR	denotes	older
T25640	9885-9894	VBG	denotes	surviving
T25638	9895-9902	NNS	denotes	mutants
T25641	9903-9906	DT	denotes	all
T25636	9907-9913	VBD	denotes	showed
T25643	9914-9917	DT	denotes	the
T25645	9918-9922	JJ	denotes	same
T25644	9923-9939	NNS	denotes	histopathologies
T25646	9940-9942	IN	denotes	of
T25647	9943-9946	DT	denotes	the
T25648	9947-9953	NN	denotes	thymus
T25649	9953-9955	,	denotes	,
T25650	9955-9958	DT	denotes	the
T25652	9959-9965	JJ	denotes	mutant
T25651	9966-9971	NNS	denotes	thymi
T25653	9972-9982	RB	denotes	eventually
T25642	9983-9987	VBP	denotes	seem
T25654	9988-9990	TO	denotes	to
T25655	9991-9997	VB	denotes	result
T25656	9998-10000	IN	denotes	in
T25657	10001-10004	DT	denotes	the
T25659	10005-10009	JJ	denotes	same
T25658	10010-10014	NN	denotes	fate
T25660	10014-10015	.	denotes	.
T25661	10015-10485	sentence	denotes	It is unclear when K14-cre induction actually takes place in the mutant thymus, but as the population of cells showing a strong nuclear β-catenin staining as well as the cells expressing K14 were small and thymic epithelial compartments still existed in a mild P3 mutant thymus (Figure 6E and 6F), it seems that initial differentiation to medullary and cortical TECs and thymocyte colonization have already taken place prior to the major effects of K14-driven Apc loss.
T25662	10016-10018	PRP	denotes	It
T25663	10019-10021	VBZ	denotes	is
T25664	10022-10029	JJ	denotes	unclear
T25665	10030-10034	WRB	denotes	when
T25667	10035-10038	NN	denotes	K14
T25669	10038-10039	HYPH	denotes	-
T25668	10039-10042	NN	denotes	cre
T25670	10043-10052	NN	denotes	induction
T25671	10053-10061	RB	denotes	actually
T25666	10062-10067	VBZ	denotes	takes
T25672	10068-10073	NN	denotes	place
T25673	10074-10076	IN	denotes	in
T25674	10077-10080	DT	denotes	the
T25676	10081-10087	JJ	denotes	mutant
T25675	10088-10094	NN	denotes	thymus
T25677	10094-10096	,	denotes	,
T25678	10096-10099	CC	denotes	but
T25679	10100-10102	IN	denotes	as
T25681	10103-10106	DT	denotes	the
T25682	10107-10117	NN	denotes	population
T25683	10118-10120	IN	denotes	of
T25684	10121-10126	NNS	denotes	cells
T25685	10127-10134	VBG	denotes	showing
T25686	10135-10136	DT	denotes	a
T25688	10137-10143	JJ	denotes	strong
T25689	10144-10151	JJ	denotes	nuclear
T25690	10152-10153	NN	denotes	β
T25692	10153-10154	HYPH	denotes	-
T25691	10154-10161	NN	denotes	catenin
T25687	10162-10170	NN	denotes	staining
T25693	10171-10173	RB	denotes	as
T25695	10174-10178	RB	denotes	well
T25694	10179-10181	IN	denotes	as
T25696	10182-10185	DT	denotes	the
T25697	10186-10191	NNS	denotes	cells
T25698	10192-10202	VBG	denotes	expressing
T25699	10203-10206	NN	denotes	K14
T25680	10207-10211	VBD	denotes	were
T25701	10212-10217	JJ	denotes	small
T25702	10218-10221	CC	denotes	and
T25703	10222-10228	JJ	denotes	thymic
T25705	10229-10239	JJ	denotes	epithelial
T25704	10240-10252	NNS	denotes	compartments
T25707	10253-10258	RB	denotes	still
T25706	10259-10266	VBD	denotes	existed
T25708	10267-10269	IN	denotes	in
T25709	10270-10271	DT	denotes	a
T25711	10272-10276	JJ	denotes	mild
T25712	10277-10279	NN	denotes	P3
T25713	10280-10286	JJ	denotes	mutant
T25710	10287-10293	NN	denotes	thymus
T25714	10294-10295	-LRB-	denotes	(
T25716	10295-10301	NN	denotes	Figure
T25715	10302-10304	NN	denotes	6E
T25717	10305-10308	CC	denotes	and
T25718	10309-10311	NN	denotes	6F
T25719	10311-10312	-RRB-	denotes	)
T25720	10312-10314	,	denotes	,
T25721	10314-10316	PRP	denotes	it
T25700	10317-10322	VBZ	denotes	seems
T25722	10323-10327	IN	denotes	that
T25724	10328-10335	JJ	denotes	initial
T25725	10336-10351	NN	denotes	differentiation
T25726	10352-10354	IN	denotes	to
T25727	10355-10364	JJ	denotes	medullary
T25729	10365-10368	CC	denotes	and
T25730	10369-10377	JJ	denotes	cortical
T25728	10378-10382	NNS	denotes	TECs
T25731	10383-10386	CC	denotes	and
T25732	10387-10396	NN	denotes	thymocyte
T25733	10397-10409	NN	denotes	colonization
T25734	10410-10414	VBP	denotes	have
T25735	10415-10422	RB	denotes	already
T25723	10423-10428	VBN	denotes	taken
T25736	10429-10434	NN	denotes	place
T25737	10435-10440	JJ	denotes	prior
T25738	10441-10443	IN	denotes	to
T25739	10444-10447	DT	denotes	the
T25741	10448-10453	JJ	denotes	major
T25740	10454-10461	NNS	denotes	effects
T25742	10462-10464	IN	denotes	of
T25743	10465-10468	NN	denotes	K14
T25745	10468-10469	HYPH	denotes	-
T25744	10469-10475	VBN	denotes	driven
T25747	10476-10479	NN	denotes	Apc
T25746	10480-10484	NN	denotes	loss
T25748	10484-10485	.	denotes	.
T25749	10485-10688	sentence	denotes	However, cells with nuclear β-catenin and K8+K14+ double-positive epithelial cells increased subsequently, associated with active proliferation in the latter group of cells and loss of TEC compartments.
T25750	10486-10493	RB	denotes	However
T25752	10493-10495	,	denotes	,
T25753	10495-10500	NNS	denotes	cells
T25754	10501-10505	IN	denotes	with
T25755	10506-10513	JJ	denotes	nuclear
T25757	10514-10515	NN	denotes	β
T25758	10515-10516	HYPH	denotes	-
T25756	10516-10523	NN	denotes	catenin
T25760	10524-10527	CC	denotes	and
T25761	10528-10530	NN	denotes	K8
T25763	10530-10531	SYM	denotes	+
T25764	10531-10534	NN	denotes	K14
T25765	10534-10535	SYM	denotes	+
T25766	10536-10542	JJ	denotes	double
T25767	10542-10543	HYPH	denotes	-
T25762	10543-10551	JJ	denotes	positive
T25768	10552-10562	JJ	denotes	epithelial
T25759	10563-10568	NNS	denotes	cells
T25751	10569-10578	VBD	denotes	increased
T25769	10579-10591	RB	denotes	subsequently
T25770	10591-10593	,	denotes	,
T25771	10593-10603	JJ	denotes	associated
T25772	10604-10608	IN	denotes	with
T25773	10609-10615	JJ	denotes	active
T25774	10616-10629	NN	denotes	proliferation
T25775	10630-10632	IN	denotes	in
T25776	10633-10636	DT	denotes	the
T25778	10637-10643	JJ	denotes	latter
T25777	10644-10649	NN	denotes	group
T25779	10650-10652	IN	denotes	of
T25780	10653-10658	NNS	denotes	cells
T25781	10659-10662	CC	denotes	and
T25782	10663-10667	NN	denotes	loss
T25783	10668-10670	IN	denotes	of
T25784	10671-10674	NN	denotes	TEC
T25785	10675-10687	NNS	denotes	compartments
T25786	10687-10688	.	denotes	.
T25787	10688-10979	sentence	denotes	With age, β-catenin expression pattern became more diffuse and fewer epithelial cells showed nuclear localization but K8+K14+ cells remained, forming concentric structures of epithelial cells filled with hard keratin deposits and infiltrated with vast number of neutrophils and macrophages.
T25788	10689-10693	IN	denotes	With
T25790	10694-10697	NN	denotes	age
T25791	10697-10699	,	denotes	,
T25792	10699-10700	NN	denotes	β
T25794	10700-10701	HYPH	denotes	-
T25793	10701-10708	NN	denotes	catenin
T25796	10709-10719	NN	denotes	expression
T25795	10720-10727	NN	denotes	pattern
T25789	10728-10734	VBD	denotes	became
T25797	10735-10739	RBR	denotes	more
T25798	10740-10747	JJ	denotes	diffuse
T25799	10748-10751	CC	denotes	and
T25800	10752-10757	JJR	denotes	fewer
T25802	10758-10768	JJ	denotes	epithelial
T25801	10769-10774	NNS	denotes	cells
T25803	10775-10781	VBD	denotes	showed
T25804	10782-10789	JJ	denotes	nuclear
T25805	10790-10802	NN	denotes	localization
T25806	10803-10806	CC	denotes	but
T25807	10807-10809	NN	denotes	K8
T25809	10809-10810	SYM	denotes	+
T25810	10810-10813	NN	denotes	K14
T25811	10813-10814	SYM	denotes	+
T25808	10815-10820	NNS	denotes	cells
T25812	10821-10829	VBD	denotes	remained
T25813	10829-10831	,	denotes	,
T25814	10831-10838	VBG	denotes	forming
T25815	10839-10849	JJ	denotes	concentric
T25816	10850-10860	NNS	denotes	structures
T25817	10861-10863	IN	denotes	of
T25818	10864-10874	JJ	denotes	epithelial
T25819	10875-10880	NNS	denotes	cells
T25820	10881-10887	VBN	denotes	filled
T25821	10888-10892	IN	denotes	with
T25822	10893-10897	JJ	denotes	hard
T25824	10898-10905	NN	denotes	keratin
T25823	10906-10914	NNS	denotes	deposits
T25825	10915-10918	CC	denotes	and
T25826	10919-10930	VBN	denotes	infiltrated
T25827	10931-10935	IN	denotes	with
T25828	10936-10940	JJ	denotes	vast
T25829	10941-10947	NN	denotes	number
T25830	10948-10950	IN	denotes	of
T25831	10951-10962	NNS	denotes	neutrophils
T25832	10963-10966	CC	denotes	and
T25833	10967-10978	NNS	denotes	macrophages
T25834	10978-10979	.	denotes	.
T25835	10979-11074	sentence	denotes	Only a few epithelial cells were dividing and hardly any thymocytes were present by this time.
T25836	10980-10984	RB	denotes	Only
T25838	10985-10986	DT	denotes	a
T25839	10987-10990	JJ	denotes	few
T25840	10991-11001	JJ	denotes	epithelial
T25837	11002-11007	NNS	denotes	cells
T25842	11008-11012	VBD	denotes	were
T25841	11013-11021	VBG	denotes	dividing
T25843	11022-11025	CC	denotes	and
T25844	11026-11032	RB	denotes	hardly
T25846	11033-11036	DT	denotes	any
T25845	11037-11047	NNS	denotes	thymocytes
T25847	11048-11052	VBD	denotes	were
T25848	11053-11060	JJ	denotes	present
T25849	11061-11063	IN	denotes	by
T25850	11064-11068	DT	denotes	this
T25851	11069-11073	NN	denotes	time
T25852	11073-11074	.	denotes	.
T25853	11074-11359	sentence	denotes	These results suggest that with the deletion of Apc in TECs, stabililization and nuclear localization of β-catenin took place and subsequently these cells differentiated into keratinocytes that expressed both K14 and K8, similar to the basal cells of the skin, instead of TEC subsets.
T25854	11075-11080	DT	denotes	These
T25855	11081-11088	NNS	denotes	results
T25856	11089-11096	VBP	denotes	suggest
T25857	11097-11101	IN	denotes	that
T25859	11102-11106	IN	denotes	with
T25860	11107-11110	DT	denotes	the
T25861	11111-11119	NN	denotes	deletion
T25862	11120-11122	IN	denotes	of
T25863	11123-11126	NN	denotes	Apc
T25864	11127-11129	IN	denotes	in
T25865	11130-11134	NNS	denotes	TECs
T25866	11134-11136	,	denotes	,
T25867	11136-11151	NN	denotes	stabililization
T25868	11152-11155	CC	denotes	and
T25869	11156-11163	JJ	denotes	nuclear
T25870	11164-11176	NN	denotes	localization
T25871	11177-11179	IN	denotes	of
T25872	11180-11181	NN	denotes	β
T25874	11181-11182	HYPH	denotes	-
T25873	11182-11189	NN	denotes	catenin
T25858	11190-11194	VBD	denotes	took
T25875	11195-11200	NN	denotes	place
T25876	11201-11204	CC	denotes	and
T25877	11205-11217	RB	denotes	subsequently
T25879	11218-11223	DT	denotes	these
T25880	11224-11229	NNS	denotes	cells
T25878	11230-11244	VBD	denotes	differentiated
T25881	11245-11249	IN	denotes	into
T25882	11250-11263	NNS	denotes	keratinocytes
T25883	11264-11268	WDT	denotes	that
T25884	11269-11278	VBD	denotes	expressed
T25885	11279-11283	CC	denotes	both
T25886	11284-11287	NN	denotes	K14
T25887	11288-11291	CC	denotes	and
T25888	11292-11294	NN	denotes	K8
T25889	11294-11296	,	denotes	,
T25890	11296-11303	JJ	denotes	similar
T25891	11304-11306	IN	denotes	to
T25892	11307-11310	DT	denotes	the
T25894	11311-11316	JJ	denotes	basal
T25893	11317-11322	NNS	denotes	cells
T25895	11323-11325	IN	denotes	of
T25896	11326-11329	DT	denotes	the
T25897	11330-11334	NN	denotes	skin
T25898	11334-11336	,	denotes	,
T25899	11336-11343	RB	denotes	instead
T25900	11344-11346	IN	denotes	of
T25901	11347-11350	NN	denotes	TEC
T25902	11351-11358	NNS	denotes	subsets
T25903	11358-11359	.	denotes	.
T25904	11359-11617	sentence	denotes	The expansion and differentiation of these keratinocytes lead to loss of proper thymic epithelial compartments and in turn produced and deposited the hard keratins that consequently caused vast amount of neutrophils and macrophages to infiltrate the thymus.
T25905	11360-11363	DT	denotes	The
T25906	11364-11373	NN	denotes	expansion
T25908	11374-11377	CC	denotes	and
T25909	11378-11393	NN	denotes	differentiation
T25910	11394-11396	IN	denotes	of
T25911	11397-11402	DT	denotes	these
T25912	11403-11416	NNS	denotes	keratinocytes
T25907	11417-11421	VBP	denotes	lead
T25913	11422-11424	IN	denotes	to
T25914	11425-11429	NN	denotes	loss
T25915	11430-11432	IN	denotes	of
T25916	11433-11439	JJ	denotes	proper
T25918	11440-11446	JJ	denotes	thymic
T25919	11447-11457	JJ	denotes	epithelial
T25917	11458-11470	NNS	denotes	compartments
T25920	11471-11474	CC	denotes	and
T25921	11475-11477	IN	denotes	in
T25923	11478-11482	NN	denotes	turn
T25922	11483-11491	VBD	denotes	produced
T25924	11492-11495	CC	denotes	and
T25925	11496-11505	VBD	denotes	deposited
T25926	11506-11509	DT	denotes	the
T25928	11510-11514	JJ	denotes	hard
T25927	11515-11523	NNS	denotes	keratins
T25929	11524-11528	WDT	denotes	that
T25931	11529-11541	RB	denotes	consequently
T25930	11542-11548	VBD	denotes	caused
T25932	11549-11553	JJ	denotes	vast
T25933	11554-11560	NN	denotes	amount
T25935	11561-11563	IN	denotes	of
T25936	11564-11575	NNS	denotes	neutrophils
T25937	11576-11579	CC	denotes	and
T25938	11580-11591	NNS	denotes	macrophages
T25939	11592-11594	TO	denotes	to
T25934	11595-11605	VB	denotes	infiltrate
T25940	11606-11609	DT	denotes	the
T25941	11610-11616	NN	denotes	thymus
T25942	11616-11617	.	denotes	.
T25943	11617-11745	sentence	denotes	These aberrant epithelial structures eventually have overtaken the whole of the thymus and driven out the colonized thymocytes.
T25944	11618-11623	DT	denotes	These
T25946	11624-11632	JJ	denotes	aberrant
T25947	11633-11643	JJ	denotes	epithelial
T25945	11644-11654	NNS	denotes	structures
T25949	11655-11665	RB	denotes	eventually
T25950	11666-11670	VBP	denotes	have
T25948	11671-11680	VBN	denotes	overtaken
T25951	11681-11684	DT	denotes	the
T25952	11685-11690	NN	denotes	whole
T25953	11691-11693	IN	denotes	of
T25954	11694-11697	DT	denotes	the
T25955	11698-11704	NN	denotes	thymus
T25956	11705-11708	CC	denotes	and
T25957	11709-11715	VBN	denotes	driven
T25958	11716-11719	RP	denotes	out
T25959	11720-11723	DT	denotes	the
T25961	11724-11733	VBN	denotes	colonized
T25960	11734-11744	NNS	denotes	thymocytes
T25962	11744-11745	.	denotes	.
T25963	11745-12018	sentence	denotes	K14-driven loss of Apc and subsequent constitutive expression of β-catenin in TECs have therefore misdirected them to wrong epithelial cell fate, not allowing proper differentiation to either cortical or medullary TECs, which is essential for normal thymocyte development.
T25964	11746-11749	NN	denotes	K14
T25966	11749-11750	HYPH	denotes	-
T25965	11750-11756	VBN	denotes	driven
T25967	11757-11761	NN	denotes	loss
T25969	11762-11764	IN	denotes	of
T25970	11765-11768	NN	denotes	Apc
T25971	11769-11772	CC	denotes	and
T25972	11773-11783	JJ	denotes	subsequent
T25974	11784-11796	JJ	denotes	constitutive
T25973	11797-11807	NN	denotes	expression
T25975	11808-11810	IN	denotes	of
T25976	11811-11812	NN	denotes	β
T25978	11812-11813	HYPH	denotes	-
T25977	11813-11820	NN	denotes	catenin
T25979	11821-11823	IN	denotes	in
T25980	11824-11828	NNS	denotes	TECs
T25981	11829-11833	VBP	denotes	have
T25982	11834-11843	RB	denotes	therefore
T25968	11844-11855	VBN	denotes	misdirected
T25983	11856-11860	PRP	denotes	them
T25984	11861-11863	IN	denotes	to
T25985	11864-11869	JJ	denotes	wrong
T25987	11870-11880	JJ	denotes	epithelial
T25988	11881-11885	NN	denotes	cell
T25986	11886-11890	NN	denotes	fate
T25989	11890-11892	,	denotes	,
T25990	11892-11895	RB	denotes	not
T25991	11896-11904	VBG	denotes	allowing
T25992	11905-11911	JJ	denotes	proper
T25993	11912-11927	NN	denotes	differentiation
T25994	11928-11930	IN	denotes	to
T25995	11931-11937	CC	denotes	either
T25996	11938-11946	JJ	denotes	cortical
T25998	11947-11949	CC	denotes	or
T25999	11950-11959	JJ	denotes	medullary
T25997	11960-11964	NNS	denotes	TECs
T26000	11964-11966	,	denotes	,
T26001	11966-11971	WDT	denotes	which
T26002	11972-11974	VBZ	denotes	is
T26003	11975-11984	JJ	denotes	essential
T26004	11985-11988	IN	denotes	for
T26005	11989-11995	JJ	denotes	normal
T26007	11996-12005	NN	denotes	thymocyte
T26006	12006-12017	NN	denotes	development
T26008	12017-12018	.	denotes	.
T26009	12018-12211	sentence	denotes	This is not only evident from the lack of dividing thymocytes in the mutant thymus by P13, but also by the differential expression pattern of keratins, which were more skin-like than TEC-like.
T26010	12019-12023	DT	denotes	This
T26011	12024-12026	VBZ	denotes	is
T26012	12027-12030	RB	denotes	not
T26013	12031-12035	RB	denotes	only
T26014	12036-12043	JJ	denotes	evident
T26015	12044-12048	IN	denotes	from
T26016	12049-12052	DT	denotes	the
T26017	12053-12057	NN	denotes	lack
T26018	12058-12060	IN	denotes	of
T26019	12061-12069	VBG	denotes	dividing
T26020	12070-12080	NNS	denotes	thymocytes
T26021	12081-12083	IN	denotes	in
T26022	12084-12087	DT	denotes	the
T26024	12088-12094	JJ	denotes	mutant
T26023	12095-12101	NN	denotes	thymus
T26025	12102-12104	IN	denotes	by
T26026	12105-12108	NN	denotes	P13
T26027	12108-12110	,	denotes	,
T26028	12110-12113	CC	denotes	but
T26029	12114-12118	RB	denotes	also
T26030	12119-12121	IN	denotes	by
T26031	12122-12125	DT	denotes	the
T26033	12126-12138	JJ	denotes	differential
T26034	12139-12149	NN	denotes	expression
T26032	12150-12157	NN	denotes	pattern
T26035	12158-12160	IN	denotes	of
T26036	12161-12169	NNS	denotes	keratins
T26037	12169-12171	,	denotes	,
T26038	12171-12176	WDT	denotes	which
T26039	12177-12181	VBD	denotes	were
T26040	12182-12186	RBR	denotes	more
T26042	12187-12191	NN	denotes	skin
T26043	12191-12192	HYPH	denotes	-
T26041	12192-12196	JJ	denotes	like
T26044	12197-12201	IN	denotes	than
T26045	12202-12205	NN	denotes	TEC
T26047	12205-12206	HYPH	denotes	-
T26046	12206-12210	JJ	denotes	like
T26048	12210-12211	.	denotes	.
T26049	12211-12408	sentence	denotes	The importance of Apc function in thymic development has been demonstrated by thymocyte-specific loss of Apc by crossing a different strain of Apc conditional mice and LckCre transgenic mice [33].
T26050	12212-12215	DT	denotes	The
T26051	12216-12226	NN	denotes	importance
T26053	12227-12229	IN	denotes	of
T26054	12230-12233	NN	denotes	Apc
T26055	12234-12242	NN	denotes	function
T26056	12243-12245	IN	denotes	in
T26057	12246-12252	JJ	denotes	thymic
T26058	12253-12264	NN	denotes	development
T26059	12265-12268	VBZ	denotes	has
T26060	12269-12273	VBN	denotes	been
T26052	12274-12286	VBN	denotes	demonstrated
T26061	12287-12289	IN	denotes	by
T26062	12290-12299	NN	denotes	thymocyte
T26064	12299-12300	HYPH	denotes	-
T26063	12300-12308	JJ	denotes	specific
T26065	12309-12313	NN	denotes	loss
T26066	12314-12316	IN	denotes	of
T26067	12317-12320	NN	denotes	Apc
T26068	12321-12323	IN	denotes	by
T26069	12324-12332	VBG	denotes	crossing
T26070	12333-12334	DT	denotes	a
T26072	12335-12344	JJ	denotes	different
T26071	12345-12351	NN	denotes	strain
T26073	12352-12354	IN	denotes	of
T26074	12355-12358	NN	denotes	Apc
T26076	12359-12370	JJ	denotes	conditional
T26075	12371-12375	NNS	denotes	mice
T26077	12376-12379	CC	denotes	and
T26078	12380-12386	NN	denotes	LckCre
T26080	12387-12397	JJ	denotes	transgenic
T26079	12398-12402	NNS	denotes	mice
T26081	12403-12404	-LRB-	denotes	[
T26082	12404-12406	CD	denotes	33
T26083	12406-12407	-RRB-	denotes	]
T26084	12407-12408	.	denotes	.
T26085	12408-12553	sentence	denotes	Here, by K14-driven TEC-specific loss of Apc, we have demonstrated its importance in thymus development not only in thymocytes but also in TECs.
T26086	12409-12413	RB	denotes	Here
T26088	12413-12415	,	denotes	,
T26089	12415-12417	IN	denotes	by
T26090	12418-12421	NN	denotes	K14
T26092	12421-12422	HYPH	denotes	-
T26091	12422-12428	VBN	denotes	driven
T26094	12429-12432	NN	denotes	TEC
T26096	12432-12433	HYPH	denotes	-
T26095	12433-12441	JJ	denotes	specific
T26093	12442-12446	NN	denotes	loss
T26097	12447-12449	IN	denotes	of
T26098	12450-12453	NN	denotes	Apc
T26099	12453-12455	,	denotes	,
T26100	12455-12457	PRP	denotes	we
T26101	12458-12462	VBP	denotes	have
T26087	12463-12475	VBN	denotes	demonstrated
T26102	12476-12479	PRP$	denotes	its
T26103	12480-12490	NN	denotes	importance
T26104	12491-12493	IN	denotes	in
T26105	12494-12500	NN	denotes	thymus
T26106	12501-12512	NN	denotes	development
T26107	12513-12516	RB	denotes	not
T26109	12517-12521	RB	denotes	only
T26108	12522-12524	IN	denotes	in
T26110	12525-12535	NNS	denotes	thymocytes
T26111	12536-12539	CC	denotes	but
T26112	12540-12544	RB	denotes	also
T26113	12545-12547	IN	denotes	in
T26114	12548-12552	NNS	denotes	TECs
T26115	12552-12553	.	denotes	.
T26116	12553-12781	sentence	denotes	It is of interest that dental abnormalities, such as supernumerary and impacted teeth similar to those observed in our mutant mice, are frequently seen in patients with Gardner's syndrome, carriers of APC germline mutation [6].
T26117	12554-12556	PRP	denotes	It
T26118	12557-12559	VBZ	denotes	is
T26119	12560-12562	IN	denotes	of
T26120	12563-12571	NN	denotes	interest
T26121	12572-12576	IN	denotes	that
T26123	12577-12583	JJ	denotes	dental
T26124	12584-12597	NNS	denotes	abnormalities
T26125	12597-12599	,	denotes	,
T26126	12599-12603	JJ	denotes	such
T26127	12604-12606	IN	denotes	as
T26128	12607-12620	JJ	denotes	supernumerary
T26130	12621-12624	CC	denotes	and
T26131	12625-12633	JJ	denotes	impacted
T26129	12634-12639	NNS	denotes	teeth
T26132	12640-12647	JJ	denotes	similar
T26133	12648-12650	IN	denotes	to
T26134	12651-12656	DT	denotes	those
T26135	12657-12665	VBN	denotes	observed
T26136	12666-12668	IN	denotes	in
T26137	12669-12672	PRP$	denotes	our
T26139	12673-12679	JJ	denotes	mutant
T26138	12680-12684	NNS	denotes	mice
T26140	12684-12686	,	denotes	,
T26141	12686-12689	VBP	denotes	are
T26142	12690-12700	RB	denotes	frequently
T26122	12701-12705	VBN	denotes	seen
T26143	12706-12708	IN	denotes	in
T26144	12709-12717	NNS	denotes	patients
T26145	12718-12722	IN	denotes	with
T26146	12723-12730	NNP	denotes	Gardner
T26148	12730-12732	POS	denotes	's
T26147	12733-12741	NN	denotes	syndrome
T26149	12741-12743	,	denotes	,
T26150	12743-12751	NNS	denotes	carriers
T26151	12752-12754	IN	denotes	of
T26152	12755-12758	NN	denotes	APC
T26154	12759-12767	NN	denotes	germline
T26153	12768-12776	NN	denotes	mutation
T26155	12777-12778	-LRB-	denotes	[
T26156	12778-12779	CD	denotes	6
T26157	12779-12780	-RRB-	denotes	]
T26158	12780-12781	.	denotes	.
T26159	12781-12954	sentence	denotes	The importance of odonto-stomatological examinations should hence be pointed out as a means of reaching a presumptive diagnosis, whose confirmation is vital to the patient.
T26160	12782-12785	DT	denotes	The
T26161	12786-12796	NN	denotes	importance
T26163	12797-12799	IN	denotes	of
T26164	12800-12806	NN	denotes	odonto
T26166	12806-12807	HYPH	denotes	-
T26165	12807-12821	JJ	denotes	stomatological
T26167	12822-12834	NNS	denotes	examinations
T26168	12835-12841	MD	denotes	should
T26169	12842-12847	RB	denotes	hence
T26170	12848-12850	VB	denotes	be
T26162	12851-12858	VBN	denotes	pointed
T26171	12859-12862	RP	denotes	out
T26172	12863-12865	IN	denotes	as
T26173	12866-12867	DT	denotes	a
T26174	12868-12873	NN	denotes	means
T26175	12874-12876	IN	denotes	of
T26176	12877-12885	VBG	denotes	reaching
T26177	12886-12887	DT	denotes	a
T26179	12888-12899	JJ	denotes	presumptive
T26178	12900-12909	NN	denotes	diagnosis
T26180	12909-12911	,	denotes	,
T26181	12911-12916	WP$	denotes	whose
T26182	12917-12929	NN	denotes	confirmation
T26183	12930-12932	VBZ	denotes	is
T26184	12933-12938	JJ	denotes	vital
T26185	12939-12941	IN	denotes	to
T26186	12942-12945	DT	denotes	the
T26187	12946-12953	NN	denotes	patient
T26188	12953-12954	.	denotes	.
T26189	12954-13203	sentence	denotes	Further characterization of the mechanism of such developmental defects using our mouse model should provide important insights into Apc function in multiple organ systems and to give better insights into potential adverse events in human subjects.
T26190	12955-12962	JJ	denotes	Further
T26191	12963-12979	NN	denotes	characterization
T26193	12980-12982	IN	denotes	of
T26194	12983-12986	DT	denotes	the
T26195	12987-12996	NN	denotes	mechanism
T26196	12997-12999	IN	denotes	of
T26197	13000-13004	JJ	denotes	such
T26199	13005-13018	JJ	denotes	developmental
T26198	13019-13026	NNS	denotes	defects
T26200	13027-13032	VBG	denotes	using
T26201	13033-13036	PRP$	denotes	our
T26203	13037-13042	NN	denotes	mouse
T26202	13043-13048	NN	denotes	model
T26204	13049-13055	MD	denotes	should
T26192	13056-13063	VB	denotes	provide
T26205	13064-13073	JJ	denotes	important
T26206	13074-13082	NNS	denotes	insights
T26207	13083-13087	IN	denotes	into
T26208	13088-13091	NN	denotes	Apc
T26209	13092-13100	NN	denotes	function
T26210	13101-13103	IN	denotes	in
T26211	13104-13112	JJ	denotes	multiple
T26213	13113-13118	NN	denotes	organ
T26212	13119-13126	NNS	denotes	systems
T26214	13127-13130	CC	denotes	and
T26215	13131-13133	TO	denotes	to
T26216	13134-13138	VB	denotes	give
T26217	13139-13145	JJR	denotes	better
T26218	13146-13154	NNS	denotes	insights
T26219	13155-13159	IN	denotes	into
T26220	13160-13169	JJ	denotes	potential
T26222	13170-13177	JJ	denotes	adverse
T26221	13178-13184	NNS	denotes	events
T26223	13185-13187	IN	denotes	in
T26224	13188-13193	JJ	denotes	human
T26225	13194-13202	NNS	denotes	subjects
T26226	13202-13203	.	denotes	.
T26227	13203-13411	sentence	denotes	In conclusion, we have shown that loss of Apc in K14-expressing embryonic cells causes aberrant morphogenesis in various skin appendages, including hair follicles and teeth, and abnormal thymus organogensis.
T26228	13204-13206	IN	denotes	In
T26230	13207-13217	NN	denotes	conclusion
T26231	13217-13219	,	denotes	,
T26232	13219-13221	PRP	denotes	we
T26233	13222-13226	VBP	denotes	have
T26229	13227-13232	VBN	denotes	shown
T26234	13233-13237	IN	denotes	that
T26236	13238-13242	NN	denotes	loss
T26237	13243-13245	IN	denotes	of
T26238	13246-13249	NN	denotes	Apc
T26239	13250-13252	IN	denotes	in
T26240	13253-13256	NN	denotes	K14
T26242	13256-13257	HYPH	denotes	-
T26241	13257-13267	VBG	denotes	expressing
T26244	13268-13277	JJ	denotes	embryonic
T26243	13278-13283	NNS	denotes	cells
T26235	13284-13290	VBZ	denotes	causes
T26245	13291-13299	JJ	denotes	aberrant
T26246	13300-13313	NN	denotes	morphogenesis
T26247	13314-13316	IN	denotes	in
T26248	13317-13324	JJ	denotes	various
T26250	13325-13329	NN	denotes	skin
T26249	13330-13340	NNS	denotes	appendages
T26251	13340-13342	,	denotes	,
T26252	13342-13351	VBG	denotes	including
T26253	13352-13356	NN	denotes	hair
T26254	13357-13366	NNS	denotes	follicles
T26255	13367-13370	CC	denotes	and
T26256	13371-13376	NNS	denotes	teeth
T26257	13376-13378	,	denotes	,
T26258	13378-13381	CC	denotes	and
T26259	13382-13390	JJ	denotes	abnormal
T26261	13391-13397	NN	denotes	thymus
T26260	13398-13410	NN	denotes	organogensis
T26262	13410-13411	.	denotes	.
T26263	13411-13586	sentence	denotes	Our results provide genetic evidence that expression of Apc is essential for regulation of proper cell fates in these organs that require epithelial–mesenchymal interactions.
T26264	13412-13415	PRP$	denotes	Our
T26265	13416-13423	NNS	denotes	results
T26266	13424-13431	VBP	denotes	provide
T26267	13432-13439	JJ	denotes	genetic
T26268	13440-13448	NN	denotes	evidence
T26269	13449-13453	IN	denotes	that
T26271	13454-13464	NN	denotes	expression
T26272	13465-13467	IN	denotes	of
T26273	13468-13471	NN	denotes	Apc
T26270	13472-13474	VBZ	denotes	is
T26274	13475-13484	JJ	denotes	essential
T26275	13485-13488	IN	denotes	for
T26276	13489-13499	NN	denotes	regulation
T26277	13500-13502	IN	denotes	of
T26278	13503-13509	JJ	denotes	proper
T26280	13510-13514	NN	denotes	cell
T26279	13515-13520	NNS	denotes	fates
T26281	13521-13523	IN	denotes	in
T26282	13524-13529	DT	denotes	these
T26283	13530-13536	NNS	denotes	organs
T26284	13537-13541	WDT	denotes	that
T26285	13542-13549	VBP	denotes	require
T26286	13550-13560	JJ	denotes	epithelial
T26288	13560-13561	HYPH	denotes	–
T26287	13561-13572	JJ	denotes	mesenchymal
T26289	13573-13585	NNS	denotes	interactions
T26290	13585-13586	.	denotes	.
R5655	T19066	T19065	auxpass	is,implicated
R5656	T19067	T19065	prep	in,implicated
R5657	T19068	T19069	det	the,pathway
R5658	T19069	T19067	pobj	pathway,in
R5659	T19070	T19069	compound	Wnt,pathway
R5660	T19071	T19069	compound	signaling,pathway
R5661	T19072	T19073	dep	that,involved
R5662	T19073	T19069	relcl	involved,pathway
R5663	T19074	T19073	auxpass	is,involved
R5664	T19075	T19076	preconj	both,in
R5665	T19076	T19073	prep	in,involved
R5666	T19077	T19076	pobj	development,in
R5667	T19078	T19077	cc	and,development
R5668	T19079	T19077	conj	tumorigenesis,development
R5669	T19080	T19065	punct	.,implicated
R5670	T19082	T19083	amod	Human,mutations
R5671	T19083	T19085	nsubj	mutations,cause
R5672	T19084	T19083	compound	germline,mutations
R5673	T19086	T19083	prep	in,mutations
R5674	T19087	T19086	pobj	APC,in
R5675	T19088	T19085	dobj	FAP,cause
R5676	T19089	T19090	punct	[,5
R5677	T19090	T19088	parataxis	5,FAP
R5678	T19091	T19090	nummod	4,5
R5679	T19092	T19090	punct	",",5
R5680	T19093	T19090	punct	],5
R5681	T19094	T19088	punct	", ",FAP
R5682	T19095	T19096	dep	which,characterized
R5683	T19096	T19088	relcl	characterized,FAP
R5684	T19097	T19096	auxpass	is,characterized
R5685	T19098	T19096	agent	by,characterized
R5686	T19099	T19098	pobj	hundreds,by
R5687	T19100	T19099	prep	of,hundreds
R5688	T19101	T19102	amod	adenomatous,polyps
R5689	T19102	T19100	pobj	polyps,of
R5690	T19103	T19102	amod	colorectal,polyps
R5691	T19104	T19088	punct	", ",FAP
R5692	T19105	T19088	prep	with,FAP
R5693	T19106	T19107	det	an,progression
R5694	T19107	T19105	pobj	progression,with
R5695	T19108	T19109	advmod	almost,inevitable
R5696	T19109	T19107	amod	inevitable,progression
R5697	T19110	T19107	prep	to,progression
R5698	T19111	T19112	amod	colorectal,cancer
R5699	T19112	T19110	pobj	cancer,to
R5700	T19113	T19107	prep	in,progression
R5701	T19114	T19115	det	the,decades
R5702	T19115	T19113	pobj	decades,in
R5703	T19116	T19115	amod	third,decades
R5704	T19117	T19116	cc	and,third
R5705	T19118	T19116	conj	fourth,third
R5706	T19119	T19115	prep	of,decades
R5707	T19120	T19119	pobj	life,of
R5708	T19121	T19085	punct	.,cause
R5709	T19123	T19124	det	The,features
R5710	T19124	T19126	nsubj	features,be
R5711	T19125	T19124	amod	phenotypical,features
R5712	T19127	T19124	prep	of,features
R5713	T19128	T19127	pobj	FAP,of
R5714	T19129	T19128	cc	and,FAP
R5715	T19130	T19131	poss	its,variant
R5716	T19131	T19128	conj	variant,FAP
R5717	T19132	T19131	punct	", ",variant
R5718	T19133	T19134	poss	Gardner,syndrome
R5719	T19134	T19131	appos	syndrome,variant
R5720	T19135	T19133	case	's,Gardner
R5721	T19136	T19126	punct	", ",be
R5722	T19137	T19126	aux	can,be
R5723	T19138	T19139	advmod	very,variable
R5724	T19139	T19126	acomp	variable,be
R5725	T19140	T19126	punct	.,be
R5726	T19142	T19143	advmod	As,as
R5727	T19143	T19145	cc	as,polyps
R5728	T19144	T19143	advmod	well,as
R5729	T19145	T19147	dep	polyps,develop
R5730	T19146	T19145	amod	colorectal,polyps
R5731	T19148	T19147	punct	", ",develop
R5732	T19149	T19150	det	these,individuals
R5733	T19150	T19147	nsubj	individuals,develop
R5734	T19151	T19147	aux	can,develop
R5735	T19152	T19153	amod	extracolonic,symptoms
R5736	T19153	T19147	dobj	symptoms,develop
R5737	T19154	T19153	punct	", ",symptoms
R5738	T19155	T19156	prep	among,are
R5739	T19156	T19153	relcl	are,symptoms
R5740	T19157	T19155	pobj	which,among
R5741	T19158	T19159	amod	upper,tract
R5742	T19159	T19161	compound	tract,polyps
R5743	T19160	T19159	amod	gastrointestinal,tract
R5744	T19161	T19156	nsubj	polyps,are
R5745	T19162	T19161	punct	", ",polyps
R5746	T19163	T19164	amod	congenital,hypertrophy
R5747	T19164	T19161	conj	hypertrophy,polyps
R5748	T19165	T19164	prep	of,hypertrophy
R5749	T19166	T19167	det	the,epithelium
R5750	T19167	T19165	pobj	epithelium,of
R5751	T19168	T19167	amod	retinal,epithelium
R5752	T19169	T19167	compound	pigment,epithelium
R5753	T19170	T19164	punct	", ",hypertrophy
R5754	T19171	T19172	amod	desmoid,tumors
R5755	T19172	T19164	conj	tumors,hypertrophy
R5756	T19173	T19172	punct	", ",tumors
R5757	T19174	T19172	conj	disorders,tumors
R5758	T19175	T19174	prep	of,disorders
R5759	T19176	T19177	det	the,bones
R5760	T19177	T19175	pobj	bones,of
R5761	T19178	T19177	amod	maxillary,bones
R5762	T19179	T19178	cc	and,maxillary
R5763	T19180	T19178	conj	skeletal,maxillary
R5764	T19181	T19174	punct	", ",disorders
R5765	T19182	T19174	cc	and,disorders
R5766	T19183	T19184	amod	dental,abnormalities
R5767	T19184	T19174	conj	abnormalities,disorders
R5768	T19185	T19186	punct	[,6
R5769	T19186	T19147	parataxis	6,develop
R5770	T19187	T19186	punct	],6
R5771	T19188	T19147	punct	.,develop
R5772	T19190	T19191	mark	While,develop
R5773	T19191	T19198	advcl	develop,die
R5774	T19192	T19193	det	the,mice
R5775	T19193	T19191	nsubj	mice,develop
R5776	T19194	T19195	amod	heterozygous,knockout
R5777	T19195	T19193	compound	knockout,mice
R5778	T19196	T19193	prep	for,mice
R5779	T19197	T19196	pobj	Apc,for
R5780	T19199	T19200	amod	adenomatous,polyps
R5781	T19200	T19191	dobj	polyps,develop
R5782	T19201	T19202	advmod	predominantly,in
R5783	T19202	T19191	prep	in,develop
R5784	T19203	T19204	amod	small,intestine
R5785	T19204	T19202	pobj	intestine,in
R5786	T19205	T19198	punct	", ",die
R5787	T19206	T19207	det	the,embryos
R5788	T19207	T19198	nsubj	embryos,die
R5789	T19208	T19207	amod	homozygous,embryos
R5790	T19209	T19198	prep	before,die
R5791	T19210	T19209	pobj	gastrulation,before
R5792	T19211	T19198	punct	.,die
R5793	T19213	T19214	aux	To,gain
R5794	T19214	T19215	advcl	gain,created
R5795	T19216	T19217	amod	more,insights
R5796	T19217	T19214	dobj	insights,gain
R5797	T19218	T19217	prep	into,insights
R5798	T19219	T19220	det	the,effects
R5799	T19220	T19218	pobj	effects,into
R5800	T19221	T19220	prep	of,effects
R5801	T19222	T19223	compound	Apc,loss
R5802	T19223	T19221	pobj	loss,of
R5803	T19224	T19220	prep	in,effects
R5804	T19225	T19224	pobj	tissues,in
R5805	T19226	T19225	amod	other,tissues
R5806	T19227	T19226	prep	than,other
R5807	T19228	T19229	amod	gastrointestinal,tract
R5808	T19229	T19227	pobj	tract,than
R5809	T19230	T19220	prep	during,effects
R5810	T19231	T19230	pobj	life,during
R5811	T19232	T19231	prep	of,life
R5812	T19233	T19232	pobj	animals,of
R5813	T19234	T19214	cc	and,gain
R5814	T19235	T19236	aux	to,circumvent
R5815	T19236	T19214	conj	circumvent,gain
R5816	T19237	T19238	det	the,lethality
R5817	T19238	T19236	dobj	lethality,circumvent
R5818	T19239	T19238	amod	embryonic,lethality
R5819	T19240	T19238	acl	associated,lethality
R5820	T19241	T19240	prep	with,associated
R5821	T19242	T19243	compound	Apc,nullizygosity
R5822	T19243	T19241	pobj	nullizygosity,with
R5823	T19244	T19215	punct	", ",created
R5824	T19245	T19215	nsubj	we,created
R5825	T19246	T19247	det	a,strain
R5826	T19247	T19215	dobj	strain,created
R5827	T19248	T19247	compound	mouse,strain
R5828	T19249	T19247	acl	carrying,strain
R5829	T19250	T19251	det	a,allele
R5830	T19251	T19249	dobj	allele,carrying
R5831	T19252	T19251	amod	conditional,allele
R5832	T19253	T19251	prep	of,allele
R5833	T19254	T19253	pobj	Apc,of
R5834	T19255	T19256	punct	(,ApcCKO
R5835	T19256	T19251	parataxis	ApcCKO,allele
R5836	T19257	T19256	punct	),ApcCKO
R5837	T19258	T19259	prep	in,flanked
R5838	T19259	T19251	relcl	flanked,allele
R5839	T19260	T19258	pobj	which,in
R5840	T19261	T19259	nsubjpass	exon,flanked
R5841	T19262	T19261	nummod	14,exon
R5842	T19263	T19261	prep	of,exon
R5843	T19264	T19265	det	the,Apc
R5844	T19265	T19263	pobj	Apc,of
R5845	T19266	T19259	auxpass	is,flanked
R5846	T19267	T19259	agent	by,flanked
R5847	T19268	T19269	compound	loxP,sequences
R5848	T19269	T19267	pobj	sequences,by
R5849	T19270	T19215	punct	.,created
R5850	T19272	T19273	det	The,mice
R5851	T19273	T19275	nsubj	mice,are
R5852	T19274	T19273	amod	homozygous,mice
R5853	T19276	T19273	prep	for,mice
R5854	T19277	T19278	det	the,allele
R5855	T19278	T19276	pobj	allele,for
R5856	T19279	T19278	amod	conditional,allele
R5857	T19280	T19275	acomp	viable,are
R5858	T19281	T19280	cc	and,viable
R5859	T19282	T19280	conj	indistinguishable,viable
R5860	T19283	T19282	prep	to,indistinguishable
R5861	T19284	T19285	det	the,mice
R5862	T19285	T19283	pobj	mice,to
R5863	T19286	T19285	amod	normal,mice
R5864	T19287	T19275	punct	", ",are
R5865	T19288	T19275	advcl	allowing,are
R5866	T19289	T19290	nsubj	us,study
R5867	T19290	T19288	ccomp	study,allowing
R5868	T19291	T19290	aux	to,study
R5869	T19292	T19293	det	the,roles
R5870	T19293	T19290	dobj	roles,study
R5871	T19294	T19293	prep	of,roles
R5872	T19295	T19294	pobj	Apc,of
R5873	T19296	T19290	prep	in,study
R5874	T19297	T19298	det	a,manner
R5875	T19298	T19296	pobj	manner,in
R5876	T19299	T19300	npadvmod	tissue,specific
R5877	T19300	T19298	amod	specific,manner
R5878	T19301	T19299	punct	-,tissue
R5879	T19302	T19299	cc	and,tissue
R5880	T19303	T19299	conj	temporal,tissue
R5881	T19304	T19300	punct	-,specific
R5882	T19305	T19275	punct	.,are
R5883	T19307	T19308	aux	To,assess
R5884	T19308	T19309	advcl	assess,created
R5885	T19310	T19311	det	the,consequences
R5886	T19311	T19308	dobj	consequences,assess
R5887	T19312	T19311	amod	phenotypic,consequences
R5888	T19313	T19311	prep	of,consequences
R5889	T19314	T19313	pobj	inactivation,of
R5890	T19315	T19314	prep	of,inactivation
R5891	T19316	T19317	det	the,gene
R5892	T19317	T19315	pobj	gene,of
R5893	T19318	T19317	compound	Apc,gene
R5894	T19319	T19308	prep	in,assess
R5895	T19320	T19319	pobj	cells,in
R5896	T19321	T19322	dep	that,express
R5897	T19322	T19320	relcl	express,cells
R5898	T19323	T19322	dobj	K14,express
R5899	T19324	T19309	punct	", ",created
R5900	T19325	T19309	nsubj	we,created
R5901	T19326	T19309	dobj	mice,created
R5902	T19327	T19328	dep	that,are
R5903	T19328	T19326	relcl	are,mice
R5904	T19329	T19328	acomp	homozygous,are
R5905	T19330	T19329	prep	for,homozygous
R5906	T19331	T19332	det	the,allele
R5907	T19332	T19330	pobj	allele,for
R5908	T19333	T19332	compound	ApcCKO,allele
R5909	T19334	T19328	cc	and,are
R5910	T19335	T19328	conj	contain,are
R5911	T19336	T19337	det	a,transgene
R5912	T19337	T19335	dobj	transgene,contain
R5913	T19338	T19339	compound	K14,cre
R5914	T19339	T19337	compound	cre,transgene
R5915	T19340	T19339	punct	-,cre
R5916	T19341	T19309	punct	.,created
R5917	T19343	T19344	det	These,mice
R5918	T19344	T19345	nsubj	mice,failed
R5919	T19346	T19347	aux	to,thrive
R5920	T19347	T19345	xcomp	thrive,failed
R5921	T19348	T19345	cc	and,failed
R5922	T19349	T19345	conj	died,failed
R5923	T19350	T19349	prep	before,died
R5924	T19351	T19350	pobj	weaning,before
R5925	T19352	T19345	punct	.,failed
R5926	T19354	T19355	nsubj	They,exhibited
R5927	T19356	T19355	advmod	also,exhibited
R5928	T19357	T19358	nmod	hair,phenotypes
R5929	T19358	T19355	dobj	phenotypes,exhibited
R5930	T19359	T19357	punct	", ",hair
R5931	T19360	T19357	conj	tooth,hair
R5932	T19361	T19360	punct	", ",tooth
R5933	T19362	T19360	cc	and,tooth
R5934	T19363	T19360	conj	thymus,tooth
R5935	T19364	T19355	punct	.,exhibited
R5954	T22183	T22184	nmod	Apc,Morphogenesis
R5955	T22185	T22183	cc	and,Apc
R5956	T22186	T22187	compound	Hair,Follicle
R5957	T22187	T22183	conj	Follicle,Apc
R5958	T22189	T22190	amod	Current,models
R5959	T22190	T22191	nsubj	models,suggest
R5960	T22192	T22190	prep	of,models
R5961	T22193	T22194	compound	hair,follicle
R5962	T22194	T22195	compound	follicle,development
R5963	T22195	T22192	pobj	development,of
R5964	T22196	T22197	mark	that,achieved
R5965	T22197	T22191	ccomp	achieved,suggest
R5966	T22198	T22199	det	the,establishment
R5967	T22199	T22197	nsubjpass	establishment,achieved
R5968	T22200	T22199	prep	of,establishment
R5969	T22201	T22202	det	a,array
R5970	T22202	T22200	pobj	array,of
R5971	T22203	T22202	amod	regular,array
R5972	T22204	T22202	prep	of,array
R5973	T22205	T22204	pobj	placodes,of
R5974	T22206	T22202	prep	in,array
R5975	T22207	T22208	det	the,epithelium
R5976	T22208	T22206	pobj	epithelium,in
R5977	T22209	T22208	compound	surface,epithelium
R5978	T22210	T22199	prep	in,establishment
R5979	T22211	T22210	pobj	response,in
R5980	T22212	T22211	prep	to,response
R5981	T22213	T22214	det	the,message
R5982	T22214	T22212	pobj	message,to
R5983	T22215	T22214	amod	first,message
R5984	T22216	T22214	amod	dermal,message
R5985	T22217	T22197	auxpass	is,achieved
R5986	T22218	T22197	prep	through,achieved
R5987	T22219	T22220	det	the,activities
R5988	T22220	T22218	pobj	activities,through
R5989	T22221	T22220	amod	competing,activities
R5990	T22222	T22220	prep	of,activities
R5991	T22223	T22222	pobj	molecules,of
R5992	T22224	T22225	dep	that,promote
R5993	T22225	T22223	relcl	promote,molecules
R5994	T22226	T22225	cc	or,promote
R5995	T22227	T22225	conj	repress,promote
R5996	T22228	T22229	compound	placode,fate
R5997	T22229	T22227	dobj	fate,repress
R5998	T22230	T22231	punct	[,24
R5999	T22231	T22191	parataxis	24,suggest
R6000	T22232	T22231	punct	],24
R6001	T22233	T22191	punct	.,suggest
R6002	T22235	T22236	expl	There,is
R6003	T22237	T22238	amod	accumulating,evidence
R6004	T22238	T22236	attr	evidence,is
R6005	T22239	T22240	mark	that,involved
R6006	T22240	T22238	acl	involved,evidence
R6007	T22241	T22240	nsubjpass	activation,involved
R6008	T22242	T22241	prep	of,activation
R6009	T22243	T22244	det	the,pathway
R6010	T22244	T22242	pobj	pathway,of
R6011	T22245	T22244	compound	Wnt,pathway
R6012	T22246	T22244	compound	signaling,pathway
R6013	T22247	T22241	prep	in,activation
R6014	T22248	T22249	det	the,dermis
R6015	T22249	T22247	pobj	dermis,in
R6016	T22250	T22240	aux	may,involved
R6017	T22251	T22240	auxpass	be,involved
R6018	T22252	T22240	prep	in,involved
R6019	T22253	T22252	pcomp	establishing,in
R6020	T22254	T22255	det	the,signal
R6021	T22255	T22253	dobj	signal,establishing
R6022	T22256	T22255	amod	first,signal
R6023	T22257	T22255	amod	dermal,signal
R6024	T22258	T22236	punct	.,is
R6025	T22260	T22261	amod	Experimental,activation
R6026	T22261	T22262	nsubj	activation,induces
R6027	T22263	T22261	prep	of,activation
R6028	T22264	T22265	amod	epithelial,signaling
R6029	T22265	T22263	pobj	signaling,of
R6030	T22266	T22267	compound	β,catenin
R6031	T22267	T22265	compound	catenin,signaling
R6032	T22268	T22267	punct	-,catenin
R6033	T22269	T22261	punct	(,activation
R6034	T22270	T22261	prep	by,activation
R6035	T22271	T22270	pobj	expression,by
R6036	T22272	T22271	prep	of,expression
R6037	T22273	T22274	compound	N,terminal
R6038	T22274	T22276	npadvmod	terminal,truncated
R6039	T22275	T22274	punct	-,terminal
R6040	T22276	T22278	amod	truncated,forms
R6041	T22277	T22276	punct	–,truncated
R6042	T22278	T22272	pobj	forms,of
R6043	T22279	T22278	punct	", ",forms
R6044	T22280	T22281	advmod	constitutively,stabilized
R6045	T22281	T22278	amod	stabilized,forms
R6046	T22282	T22278	prep	of,forms
R6047	T22283	T22284	compound	β,catenin
R6048	T22284	T22282	pobj	catenin,of
R6049	T22285	T22284	punct	-,catenin
R6050	T22286	T22271	cc	or,expression
R6051	T22287	T22288	amod	ectopic,expression
R6052	T22288	T22271	conj	expression,expression
R6053	T22289	T22288	prep	of,expression
R6054	T22290	T22289	pobj	Lef1,of
R6055	T22291	T22262	punct	),induces
R6056	T22292	T22293	amod	ectopic,follicles
R6057	T22293	T22262	dobj	follicles,induces
R6058	T22294	T22262	prep	in,induces
R6059	T22295	T22296	preconj	both,mouse
R6060	T22296	T22297	nmod	mouse,skin
R6061	T22297	T22294	pobj	skin,in
R6062	T22298	T22296	cc	and,mouse
R6063	T22299	T22296	conj	chick,mouse
R6064	T22300	T22301	punct	[,25
R6065	T22301	T22262	parataxis	25,induces
R6066	T22302	T22303	punct	–,27
R6067	T22303	T22301	prep	27,25
R6068	T22304	T22301	punct	],25
R6069	T22305	T22262	punct	.,induces
R6070	T22307	T22308	advmod	Conversely,results
R6071	T22309	T22308	punct	", ",results
R6072	T22310	T22311	amod	down,regulation
R6073	T22311	T22308	nsubj	regulation,results
R6074	T22312	T22311	punct	-,regulation
R6075	T22313	T22311	prep	of,regulation
R6076	T22314	T22315	compound	β,catenin
R6077	T22315	T22317	compound	catenin,signaling
R6078	T22316	T22315	punct	-,catenin
R6079	T22317	T22313	pobj	signaling,of
R6080	T22318	T22311	punct	(,regulation
R6081	T22319	T22311	prep	through,regulation
R6082	T22320	T22321	npadvmod	Lef1,knock
R6083	T22321	T22322	amod	knock,expression
R6084	T22322	T22319	pobj	expression,through
R6085	T22323	T22321	punct	-,knock
R6086	T22324	T22321	prt	out,knock
R6087	T22325	T22322	punct	", ",expression
R6088	T22326	T22322	amod	ectopic,expression
R6089	T22327	T22322	prep	of,expression
R6090	T22328	T22329	compound	Wnt,inhibitor
R6091	T22329	T22327	pobj	inhibitor,of
R6092	T22330	T22329	appos	Dkk1,inhibitor
R6093	T22331	T22322	cc	or,expression
R6094	T22332	T22333	amod	conditional,deletion
R6095	T22333	T22322	conj	deletion,expression
R6096	T22334	T22333	prep	of,deletion
R6097	T22335	T22336	compound	β,catenin
R6098	T22336	T22334	pobj	catenin,of
R6099	T22337	T22336	punct	-,catenin
R6100	T22338	T22333	prep	in,deletion
R6101	T22339	T22338	pobj	epidermis,in
R6102	T22340	T22308	punct	),results
R6103	T22341	T22308	prep	in,results
R6104	T22342	T22341	pobj	loss,in
R6105	T22343	T22342	prep	of,loss
R6106	T22344	T22343	pobj	vibrissae,of
R6107	T22345	T22344	cc	and,vibrissae
R6108	T22346	T22347	det	some,follicles
R6109	T22347	T22344	conj	follicles,vibrissae
R6110	T22348	T22347	compound	pelage,follicles
R6111	T22349	T22308	prep	in,results
R6112	T22350	T22349	pobj	mice,in
R6113	T22351	T22352	punct	[,28
R6114	T22352	T22308	parataxis	28,results
R6115	T22353	T22354	punct	–,30
R6116	T22354	T22352	prep	30,28
R6117	T22355	T22352	punct	],28
R6118	T22356	T22308	punct	.,results
R6119	T22358	T22359	poss	Our,finding
R6120	T22359	T22360	nsubj	finding,is
R6121	T22361	T22362	mark	that,resulted
R6122	T22362	T22359	acl	resulted,finding
R6123	T22363	T22364	npadvmod	K14,driven
R6124	T22364	T22366	amod	driven,loss
R6125	T22365	T22364	punct	-,driven
R6126	T22366	T22362	nsubj	loss,resulted
R6127	T22367	T22366	compound	Apc,loss
R6128	T22368	T22366	prep	in,loss
R6129	T22369	T22370	amod	embryonic,ectoderm
R6130	T22370	T22368	pobj	ectoderm,in
R6131	T22371	T22362	prep	in,resulted
R6132	T22372	T22373	advmod	irregularly,spaced
R6133	T22373	T22374	amod	spaced,initiation
R6134	T22374	T22371	pobj	initiation,in
R6135	T22375	T22373	cc	and,spaced
R6136	T22376	T22377	advmod	often,clustered
R6137	T22377	T22373	conj	clustered,spaced
R6138	T22378	T22377	advmod	tightly,clustered
R6139	T22379	T22374	amod	abnormal,initiation
R6140	T22380	T22374	compound	hair,initiation
R6141	T22381	T22374	compound	placode,initiation
R6142	T22382	T22374	cc	and,initiation
R6143	T22383	T22384	compound	follicle,morphogenesis
R6144	T22384	T22374	conj	morphogenesis,initiation
R6145	T22385	T22386	punct	(,4F
R6146	T22386	T22374	parataxis	4F,initiation
R6147	T22387	T22386	compound	Figures,4F
R6148	T22388	T22386	punct	", ",4F
R6149	T22389	T22386	conj	5B,4F
R6150	T22390	T22389	punct	", ",5B
R6151	T22391	T22389	conj	5D,5B
R6152	T22392	T22391	punct	", ",5D
R6153	T22393	T22391	cc	and,5D
R6154	T22394	T22391	conj	5F,5D
R6155	T22395	T22386	punct	),4F
R6156	T22396	T22397	advmod	as,as
R6157	T22397	T22371	cc	as,in
R6158	T22398	T22397	advmod	well,as
R6159	T22399	T22371	conj	in,in
R6160	T22400	T22401	det	the,development
R6161	T22401	T22399	pobj	development,in
R6162	T22402	T22401	prep	of,development
R6163	T22403	T22404	amod	multiple,buds
R6164	T22404	T22402	pobj	buds,of
R6165	T22405	T22404	compound	tooth,buds
R6166	T22406	T22407	punct	(,4O
R6167	T22407	T22404	parataxis	4O,buds
R6168	T22408	T22407	compound	Figure,4O
R6169	T22409	T22407	cc	and,4O
R6170	T22410	T22407	conj	4P,4O
R6171	T22411	T22407	punct	),4O
R6172	T22412	T22360	punct	", ",is
R6173	T22413	T22360	prep	in,is
R6174	T22414	T22413	pobj	line,in
R6175	T22415	T22414	prep	with,line
R6176	T22416	T22417	det	the,effects
R6177	T22417	T22415	pobj	effects,with
R6178	T22418	T22417	acl	seen,effects
R6179	T22419	T22418	prep	in,seen
R6180	T22420	T22419	pobj	activation,in
R6181	T22421	T22420	prep	of,activation
R6182	T22422	T22423	amod	epithelial,signaling
R6183	T22423	T22421	pobj	signaling,of
R6184	T22424	T22425	compound	β,catenin
R6185	T22425	T22423	compound	catenin,signaling
R6186	T22426	T22425	punct	-,catenin
R6187	T22427	T22420	prep	during,activation
R6188	T22428	T22429	compound	placode,formation
R6189	T22429	T22427	pobj	formation,during
R6190	T22430	T22360	punct	", ",is
R6191	T22431	T22360	advcl	indicating,is
R6192	T22432	T22433	det	the,role
R6193	T22433	T22431	dobj	role,indicating
R6194	T22434	T22433	prep	of,role
R6195	T22435	T22434	pobj	Apc,of
R6196	T22436	T22433	prep	in,role
R6197	T22437	T22436	pobj	specification,in
R6198	T22438	T22437	prep	of,specification
R6199	T22439	T22440	amod	embryonic,cells
R6200	T22440	T22438	pobj	cells,of
R6201	T22441	T22440	amod	ectodermal,cells
R6202	T22442	T22440	compound	stem,cells
R6203	T22443	T22444	aux	to,produce
R6204	T22444	T22437	acl	produce,specification
R6205	T22445	T22446	det	a,follicle
R6206	T22446	T22444	dobj	follicle,produce
R6207	T22447	T22446	compound	hair,follicle
R6208	T22448	T22360	punct	.,is
R6209	T22450	T22451	prep	Given,lead
R6210	T22452	T22453	det	the,role
R6211	T22453	T22450	pobj	role,Given
R6212	T22454	T22453	prep	of,role
R6213	T22455	T22454	pobj	Apc,of
R6214	T22456	T22453	prep	in,role
R6215	T22457	T22458	advmod	down,regulation
R6216	T22458	T22456	pobj	regulation,in
R6217	T22459	T22458	punct	-,regulation
R6218	T22460	T22458	prep	of,regulation
R6219	T22461	T22462	compound	β,catenin
R6220	T22462	T22460	pobj	catenin,of
R6221	T22463	T22462	punct	-,catenin
R6222	T22464	T22451	punct	", ",lead
R6223	T22465	T22451	nsubj	loss,lead
R6224	T22466	T22465	prep	of,loss
R6225	T22467	T22466	pobj	Apc,of
R6226	T22468	T22451	aux	would,lead
R6227	T22469	T22451	advmod	inevitably,lead
R6228	T22470	T22451	prep	to,lead
R6229	T22471	T22472	amod	altered,expression
R6230	T22472	T22470	pobj	expression,to
R6231	T22473	T22472	prep	of,expression
R6232	T22474	T22475	compound	β,catenin
R6233	T22475	T22473	pobj	catenin,of
R6234	T22476	T22475	punct	-,catenin
R6235	T22477	T22451	prep	in,lead
R6236	T22478	T22479	amod	ectodermal,cells
R6237	T22479	T22477	pobj	cells,in
R6238	T22480	T22451	prep	during,lead
R6239	T22481	T22482	det	the,formation
R6240	T22482	T22480	pobj	formation,during
R6241	T22483	T22484	compound	hair,placode
R6242	T22484	T22482	compound	placode,formation
R6243	T22485	T22451	punct	", ",lead
R6244	T22486	T22451	advcl	giving,lead
R6245	T22487	T22486	dobj	rise,giving
R6246	T22488	T22486	prep	to,giving
R6247	T22489	T22490	amod	aberrant,growth
R6248	T22490	T22488	pobj	growth,to
R6249	T22491	T22490	amod	follicular,growth
R6250	T22492	T22486	prep	throughout,giving
R6251	T22493	T22494	det	the,epidermis
R6252	T22494	T22492	pobj	epidermis,throughout
R6253	T22495	T22494	amod	embryonic,epidermis
R6254	T22496	T22494	punct	", ",epidermis
R6255	T22497	T22494	prep	including,epidermis
R6256	T22498	T22499	det	the,footpads
R6257	T22499	T22497	pobj	footpads,including
R6258	T22500	T22499	punct	", ",footpads
R6259	T22501	T22502	advmod	where,hairless
R6260	T22502	T22499	relcl	hairless,footpads
R6261	T22503	T22502	advmod	normally,hairless
R6262	T22504	T22505	punct	(,5B
R6263	T22505	T22451	parataxis	5B,lead
R6264	T22506	T22505	compound	Figure,5B
R6265	T22507	T22505	punct	", ",5B
R6266	T22508	T22505	conj	5D,5B
R6267	T22509	T22508	punct	", ",5D
R6268	T22510	T22508	conj	5F,5D
R6269	T22511	T22510	punct	", ",5F
R6270	T22512	T22510	cc	and,5F
R6271	T22513	T22510	conj	5H,5F
R6272	T22514	T22505	punct	),5B
R6273	T22515	T22451	punct	.,lead
R6274	T22517	T22518	prep	Of,are
R6275	T22519	T22517	pobj	interest,Of
R6276	T22520	T22521	det	the,similarities
R6277	T22521	T22518	nsubj	similarities,are
R6278	T22522	T22521	amod	phenotypic,similarities
R6279	T22523	T22521	cc	and,similarities
R6280	T22524	T22521	conj	differences,similarities
R6281	T22525	T22521	prep	between,similarities
R6282	T22526	T22527	poss	our,mice
R6283	T22527	T22525	pobj	mice,between
R6284	T22528	T22527	nmod	KA,mice
R6285	T22529	T22527	amod	mutant,mice
R6286	T22530	T22527	cc	and,mice
R6287	T22531	T22532	det	the,mice
R6288	T22532	T22527	conj	mice,mice
R6289	T22533	T22534	advmod	previously,described
R6290	T22534	T22532	amod	described,mice
R6291	T22535	T22536	nmod	K14,ΔN87βcat
R6292	T22536	T22532	nmod	ΔN87βcat,mice
R6293	T22537	T22536	punct	-,ΔN87βcat
R6294	T22538	T22532	amod	transgenic,mice
R6295	T22539	T22532	acl	expressing,mice
R6296	T22540	T22541	amod	stable,catenin
R6297	T22541	T22539	dobj	catenin,expressing
R6298	T22542	T22541	compound	β,catenin
R6299	T22543	T22541	punct	-,catenin
R6300	T22544	T22539	prep	under,expressing
R6301	T22545	T22546	det	the,control
R6302	T22546	T22544	pobj	control,under
R6303	T22547	T22546	prep	of,control
R6304	T22548	T22549	compound	K14,promoter
R6305	T22549	T22547	pobj	promoter,of
R6306	T22550	T22551	punct	[,25
R6307	T22551	T22549	parataxis	25,promoter
R6308	T22552	T22551	punct	],25
R6309	T22553	T22549	cc	and,promoter
R6310	T22554	T22555	nmod	K14,Lef1
R6311	T22555	T22557	nmod	Lef1,mice
R6312	T22556	T22555	punct	-,Lef1
R6313	T22557	T22549	conj	mice,promoter
R6314	T22558	T22555	amod	transgenic,Lef1
R6315	T22559	T22560	punct	[,27
R6316	T22560	T22557	parataxis	27,mice
R6317	T22561	T22560	punct	],27
R6318	T22562	T22518	punct	.,are
R6319	T22564	T22565	advmod	Surprisingly,shared
R6320	T22566	T22565	punct	", ",shared
R6321	T22567	T22568	poss	our,mice
R6322	T22568	T22565	nsubj	mice,shared
R6323	T22569	T22568	amod	mutant,mice
R6324	T22570	T22571	amod	more,similarities
R6325	T22571	T22565	dobj	similarities,shared
R6326	T22572	T22565	prep	with,shared
R6327	T22573	T22574	det	the,mice
R6328	T22574	T22572	pobj	mice,with
R6329	T22575	T22576	compound	K14,Lef1
R6330	T22576	T22574	compound	Lef1,mice
R6331	T22577	T22576	punct	-,Lef1
R6332	T22578	T22565	prep	than,shared
R6333	T22579	T22580	det	the,mice
R6334	T22580	T22578	pobj	mice,than
R6335	T22581	T22582	nmod	K14,ΔN87βcat
R6336	T22582	T22580	nmod	ΔN87βcat,mice
R6337	T22583	T22582	punct	-,ΔN87βcat
R6338	T22584	T22580	amod	transgenic,mice
R6339	T22585	T22565	punct	.,shared
R6340	T22587	T22588	prep	For,displayed
R6341	T22589	T22587	pobj	example,For
R6342	T22590	T22588	punct	", ",displayed
R6343	T22591	T22592	det	the,mice
R6344	T22592	T22588	nsubj	mice,displayed
R6345	T22593	T22592	nmod	KA,mice
R6346	T22594	T22592	amod	mutant,mice
R6347	T22595	T22596	det	the,whiskers
R6348	T22596	T22588	dobj	whiskers,displayed
R6349	T22597	T22596	amod	disoriented,whiskers
R6350	T22598	T22597	cc	and,disoriented
R6351	T22599	T22597	conj	short,disoriented
R6352	T22600	T22596	punct	", ",whiskers
R6353	T22601	T22596	amod	curly,whiskers
R6354	T22602	T22596	acl	seen,whiskers
R6355	T22603	T22602	prep	in,seen
R6356	T22604	T22605	compound	K14,Lef1but
R6357	T22605	T22603	pobj	Lef1but,in
R6358	T22606	T22605	punct	-,Lef1but
R6359	T22607	T22603	neg	not,in
R6360	T22608	T22603	prep	in,in
R6361	T22609	T22610	nmod	K14,ΔN87βcat
R6362	T22610	T22612	nmod	ΔN87βcat,mice
R6363	T22611	T22610	punct	-,ΔN87βcat
R6364	T22612	T22608	pobj	mice,in
R6365	T22613	T22612	amod	transgenic,mice
R6366	T22614	T22588	punct	.,displayed
R6367	T22616	T22617	prep	In,displayed
R6368	T22618	T22616	pobj	addition,In
R6369	T22619	T22617	punct	", ",displayed
R6370	T22620	T22621	nmod	KA,mice
R6371	T22621	T22617	nsubj	mice,displayed
R6372	T22622	T22621	amod	mutant,mice
R6373	T22623	T22624	det	a,coat
R6374	T22624	T22617	dobj	coat,displayed
R6375	T22625	T22624	amod	disorganized,coat
R6376	T22626	T22624	compound	hair,coat
R6377	T22627	T22624	acl	beginning,coat
R6378	T22628	T22627	prep	with,beginning
R6379	T22629	T22630	det	the,emergence
R6380	T22630	T22628	pobj	emergence,with
R6381	T22631	T22630	prep	of,emergence
R6382	T22632	T22633	amod	neonatal,hairs
R6383	T22633	T22631	pobj	hairs,of
R6384	T22634	T22633	punct	", ",hairs
R6385	T22635	T22633	amod	similar,hairs
R6386	T22636	T22635	prep	to,similar
R6387	T22637	T22636	pobj	that,to
R6388	T22638	T22637	acl	observed,that
R6389	T22639	T22638	prep	in,observed
R6390	T22640	T22641	compound	K14,Lef1
R6391	T22641	T22643	compound	Lef1,mice
R6392	T22642	T22641	punct	-,Lef1
R6393	T22643	T22639	pobj	mice,in
R6394	T22644	T22617	punct	", ",displayed
R6395	T22645	T22646	mark	whereas,was
R6396	T22646	T22617	advcl	was,displayed
R6397	T22647	T22646	prep	in,was
R6398	T22648	T22649	compound	K14,ΔN87βcat
R6399	T22649	T22651	compound	ΔN87βcat,mice
R6400	T22650	T22649	punct	-,ΔN87βcat
R6401	T22651	T22647	pobj	mice,in
R6402	T22652	T22646	punct	", ",was
R6403	T22653	T22654	amod	embryonic,morphogenesis
R6404	T22654	T22646	nsubj	morphogenesis,was
R6405	T22655	T22656	compound	hair,follicle
R6406	T22656	T22654	compound	follicle,morphogenesis
R6407	T22657	T22646	acomp	unaffected,was
R6408	T22658	T22646	cc	and,was
R6409	T22659	T22660	amod	other,changes
R6410	T22660	T22662	nsubj	changes,emerged
R6411	T22661	T22660	compound	skin,changes
R6412	T22662	T22646	conj	emerged,was
R6413	T22663	T22662	advmod	only,emerged
R6414	T22664	T22662	advmod	postnatally,emerged
R6415	T22665	T22617	punct	.,displayed
R6416	T22667	T22668	det	The,reason
R6417	T22668	T22669	nsubjpass	reason,attributed
R6418	T22670	T22668	prep	for,reason
R6419	T22671	T22672	det	this,difference
R6420	T22672	T22670	pobj	difference,for
R6421	T22673	T22669	aux	could,attributed
R6422	T22674	T22669	auxpass	be,attributed
R6423	T22675	T22669	prep	to,attributed
R6424	T22676	T22675	pobj	one,to
R6425	T22677	T22676	cc	or,one
R6426	T22678	T22676	conj	all,one
R6427	T22679	T22676	prep	of,one
R6428	T22680	T22681	nummod	three,factors
R6429	T22681	T22679	pobj	factors,of
R6430	T22682	T22681	amod	possible,factors
R6431	T22683	T22681	amod	contributing,factors
R6432	T22684	T22669	punct	.,attributed
R6433	T22686	T22687	punct	(,1
R6434	T22687	T22688	meta	1,influence
R6435	T22689	T22687	punct	),1
R6436	T22690	T22691	mark	Although,known
R6437	T22691	T22688	advcl	known,influence
R6438	T22692	T22693	det	the,promoter
R6439	T22693	T22691	nsubjpass	promoter,known
R6440	T22694	T22693	compound	K14,promoter
R6441	T22695	T22693	appos	itself,promoter
R6442	T22696	T22691	auxpass	is,known
R6443	T22697	T22698	aux	to,initiate
R6444	T22698	T22691	xcomp	initiate,known
R6445	T22699	T22700	det	the,expression
R6446	T22700	T22698	dobj	expression,initiate
R6447	T22701	T22698	prep	at,initiate
R6448	T22702	T22701	pobj	E9.5,at
R6449	T22703	T22691	cc	and,known
R6450	T22704	T22691	conj	elevated,known
R6451	T22705	T22704	advmod	dramatically,elevated
R6452	T22706	T22704	prep	by,elevated
R6453	T22707	T22706	pobj	E13.5,by
R6454	T22708	T22709	punct	–,E14.5
R6455	T22709	T22707	prep	E14.5,E13.5
R6456	T22710	T22711	punct	[,31
R6457	T22711	T22704	parataxis	31,elevated
R6458	T22712	T22711	nummod	19,31
R6459	T22713	T22711	punct	",",31
R6460	T22714	T22711	punct	],31
R6461	T22715	T22688	punct	", ",influence
R6462	T22716	T22717	amod	many,factors
R6463	T22717	T22688	nsubj	factors,influence
R6464	T22718	T22688	aux	could,influence
R6465	T22719	T22720	det	the,expression
R6466	T22720	T22688	dobj	expression,influence
R6467	T22721	T22720	prep	of,expression
R6468	T22722	T22723	compound	promoter,transgene
R6469	T22723	T22725	compound	transgene,construct
R6470	T22724	T22723	punct	/,transgene
R6471	T22725	T22721	pobj	construct,of
R6472	T22726	T22688	prep	in,influence
R6473	T22727	T22728	amod	transgenic,mice
R6474	T22728	T22726	pobj	mice,in
R6475	T22729	T22688	punct	.,influence
R6476	T22731	T22732	nsubj	One,has
R6477	T22733	T22731	prep	of,One
R6478	T22734	T22735	det	the,considerations
R6479	T22735	T22733	pobj	considerations,of
R6480	T22736	T22737	advmod	most,important
R6481	T22737	T22735	amod	important,considerations
R6482	T22738	T22739	aux	to,do
R6483	T22739	T22732	xcomp	do,has
R6484	T22740	T22739	prep	with,do
R6485	T22741	T22742	det	the,site
R6486	T22742	T22740	pobj	site,with
R6487	T22743	T22742	compound	integration,site
R6488	T22744	T22742	prep	of,site
R6489	T22745	T22746	det	the,transgene
R6490	T22746	T22744	pobj	transgene,of
R6491	T22747	T22739	prep	in,do
R6492	T22748	T22749	det	the,genome
R6493	T22749	T22747	pobj	genome,in
R6494	T22750	T22749	compound	mouse,genome
R6495	T22751	T22732	punct	.,has
R6496	T22753	T22754	prep	Depending,vary
R6497	T22755	T22753	prep	on,Depending
R6498	T22756	T22757	det	the,location
R6499	T22757	T22755	pobj	location,on
R6500	T22758	T22757	prep	of,location
R6501	T22759	T22758	pobj	integration,of
R6502	T22760	T22754	punct	", ",vary
R6503	T22761	T22762	det	the,activity
R6504	T22762	T22754	nsubj	activity,vary
R6505	T22763	T22762	amod	transcriptional,activity
R6506	T22764	T22762	prep	of,activity
R6507	T22765	T22766	advmod	even,transgene
R6508	T22766	T22764	pobj	transgene,of
R6509	T22767	T22766	det	the,transgene
R6510	T22768	T22766	amod	same,transgene
R6511	T22769	T22754	aux	could,vary
R6512	T22770	T22754	advmod	considerably,vary
R6513	T22771	T22754	punct	.,vary
R6514	T22773	T22774	nsubj	It,is
R6515	T22775	T22774	acomp	possible,is
R6516	T22776	T22777	mark	that,be
R6517	T22777	T22774	ccomp	be,is
R6518	T22778	T22779	det	the,lack
R6519	T22779	T22777	nsubj	lack,be
R6520	T22780	T22779	amod	apparent,lack
R6521	T22781	T22779	prep	of,lack
R6522	T22782	T22783	compound	ΔN87βcat,function
R6523	T22783	T22781	pobj	function,of
R6524	T22784	T22779	prep	in,lack
R6525	T22785	T22784	pobj	embryogenesis,in
R6526	T22786	T22777	aux	could,be
R6527	T22787	T22777	prep	due,be
R6528	T22788	T22787	pcomp	to,due
R6529	T22789	T22790	det	the,expression
R6530	T22790	T22787	pobj	expression,due
R6531	T22791	T22790	amod	delayed,expression
R6532	T22792	T22791	cc	or,delayed
R6533	T22793	T22791	conj	weak,delayed
R6534	T22794	T22790	prep	of,expression
R6535	T22795	T22796	det	the,transgene
R6536	T22796	T22794	pobj	transgene,of
R6537	T22797	T22798	compound	K14,ΔN87βcat
R6538	T22798	T22796	compound	ΔN87βcat,transgene
R6539	T22799	T22798	punct	-,ΔN87βcat
R6540	T22800	T22790	prep	compared,expression
R6541	T22801	T22800	prep	to,compared
R6542	T22802	T22803	det	the,promoter
R6543	T22803	T22801	pobj	promoter,to
R6544	T22804	T22803	amod	intrinsic,promoter
R6545	T22805	T22774	punct	.,is
R6546	T22807	T22808	prep	In,seen
R6547	T22809	T22807	pobj	contrast,In
R6548	T22810	T22808	punct	", ",seen
R6549	T22811	T22812	npadvmod	Cre,mediated
R6550	T22812	T22814	amod	mediated,recombination
R6551	T22813	T22812	punct	-,mediated
R6552	T22814	T22808	nsubjpass	recombination,seen
R6553	T22815	T22808	auxpass	is,seen
R6554	T22816	T22808	prep	in,seen
R6555	T22817	T22818	compound	E13.5,skin
R6556	T22818	T22816	pobj	skin,in
R6557	T22819	T22818	prep	of,skin
R6558	T22820	T22821	nmod	K14,cre
R6559	T22821	T22823	nmod	cre,mice
R6560	T22822	T22821	punct	-,cre
R6561	T22823	T22819	pobj	mice,of
R6562	T22824	T22823	amod	transgenic,mice
R6563	T22825	T22823	acl	used,mice
R6564	T22826	T22825	prep	in,used
R6565	T22827	T22828	det	this,study
R6566	T22828	T22826	pobj	study,in
R6567	T22829	T22830	punct	[,16
R6568	T22830	T22808	parataxis	16,seen
R6569	T22831	T22830	punct	],16
R6570	T22832	T22808	cc	and,seen
R6571	T22833	T22834	compound	K14,cre
R6572	T22834	T22836	npadvmod	cre,mediated
R6573	T22835	T22834	punct	-,cre
R6574	T22836	T22838	amod	mediated,truncation
R6575	T22837	T22836	punct	–,mediated
R6576	T22838	T22839	nsubj	truncation,is
R6577	T22839	T22808	conj	is,seen
R6578	T22840	T22838	prep	of,truncation
R6579	T22841	T22842	det	the,gene
R6580	T22842	T22840	pobj	gene,of
R6581	T22843	T22842	compound	Apc,gene
R6582	T22844	T22839	acomp	likely,is
R6583	T22845	T22846	aux	to,occurred
R6584	T22846	T22844	xcomp	occurred,likely
R6585	T22847	T22846	aux	have,occurred
R6586	T22848	T22846	prep	by,occurred
R6587	T22849	T22848	pcomp	then,by
R6588	T22850	T22846	punct	", ",occurred
R6589	T22851	T22846	prep	in,occurred
R6590	T22852	T22851	pobj	time,in
R6591	T22853	T22852	prep	for,time
R6592	T22854	T22855	det	the,wave
R6593	T22855	T22853	pobj	wave,for
R6594	T22856	T22855	amod	second,wave
R6595	T22857	T22855	prep	of,wave
R6596	T22858	T22859	compound	hair,follicle
R6597	T22859	T22860	compound	follicle,morphgenesis
R6598	T22860	T22857	pobj	morphgenesis,of
R6599	T22861	T22808	punct	.,seen
R6600	T22863	T22864	punct	(,2
R6601	T22864	T22865	meta	2,is
R6602	T22866	T22864	punct	),2
R6603	T22867	T22868	det	Another,fact
R6604	T22868	T22865	nsubj	fact,is
R6605	T22869	T22868	amod	important,fact
R6606	T22870	T22871	mark	that,confined
R6607	T22871	T22865	ccomp	confined,is
R6608	T22872	T22871	prep	in,confined
R6609	T22873	T22874	det	the,model
R6610	T22874	T22872	pobj	model,in
R6611	T22875	T22874	amod	aforementioned,model
R6612	T22876	T22874	amod	transgenic,model
R6613	T22877	T22878	det	the,overexpression
R6614	T22878	T22871	nsubjpass	overexpression,confined
R6615	T22879	T22878	prep	of,overexpression
R6616	T22880	T22879	pobj	transgene,of
R6617	T22881	T22871	auxpass	is,confined
R6618	T22882	T22871	prep	to,confined
R6619	T22883	T22884	det	the,cells
R6620	T22884	T22882	pobj	cells,to
R6621	T22885	T22884	amod	basal,cells
R6622	T22886	T22884	prep	of,cells
R6623	T22887	T22888	det	the,epidermis
R6624	T22888	T22886	pobj	epidermis,of
R6625	T22889	T22884	cc	and,cells
R6626	T22890	T22891	det	the,ORS
R6627	T22891	T22884	conj	ORS,cells
R6628	T22892	T22891	prep	of,ORS
R6629	T22893	T22894	compound	hair,follicles
R6630	T22894	T22892	pobj	follicles,of
R6631	T22895	T22884	punct	", ",cells
R6632	T22896	T22897	advmod	where,is
R6633	T22897	T22884	relcl	is,cells
R6634	T22898	T22899	det	the,promoter
R6635	T22899	T22897	nsubj	promoter,is
R6636	T22900	T22899	compound	K14,promoter
R6637	T22901	T22897	acomp	active,is
R6638	T22902	T22865	punct	.,is
R6639	T22904	T22905	det	The,expression
R6640	T22905	T22906	nsubj	expression,is
R6641	T22907	T22905	prep	of,expression
R6642	T22908	T22907	pobj	transgene,of
R6643	T22909	T22906	advmod	hence,is
R6644	T22910	T22906	acomp	transient,is
R6645	T22911	T22906	cc	and,is
R6646	T22912	T22906	conj	stops,is
R6647	T22913	T22914	mark	once,differentiate
R6648	T22914	T22912	advcl	differentiate,stops
R6649	T22915	T22916	npadvmod	K14,expressing
R6650	T22916	T22918	amod	expressing,cells
R6651	T22917	T22916	punct	-,expressing
R6652	T22918	T22914	nsubj	cells,differentiate
R6653	T22919	T22914	advmod	terminally,differentiate
R6654	T22920	T22906	punct	.,is
R6655	T22922	T22923	prep	In,result
R6656	T22924	T22922	pobj	contrast,In
R6657	T22925	T22923	punct	", ",result
R6658	T22926	T22923	prep	in,result
R6659	T22927	T22928	poss	our,model
R6660	T22928	T22926	pobj	model,in
R6661	T22929	T22923	punct	", ",result
R6662	T22930	T22931	compound	K14,cre
R6663	T22931	T22933	npadvmod	cre,mediated
R6664	T22932	T22931	punct	-,cre
R6665	T22933	T22935	amod	mediated,deletion
R6666	T22934	T22933	punct	–,mediated
R6667	T22935	T22923	nsubj	deletion,result
R6668	T22936	T22935	prep	of,deletion
R6669	T22937	T22936	pobj	Apc,of
R6670	T22938	T22923	aux	would,result
R6671	T22939	T22923	prep	in,result
R6672	T22940	T22941	compound	Apc,mutation
R6673	T22941	T22939	pobj	mutation,in
R6674	T22942	T22943	preconj	not,in
R6675	T22943	T22923	prep	in,result
R6676	T22944	T22942	advmod	only,not
R6677	T22945	T22946	nmod	K14,cells
R6678	T22946	T22943	pobj	cells,in
R6679	T22947	T22946	nmod	promoter,cells
R6680	T22948	T22946	amod	active,cells
R6681	T22949	T22923	punct	", ",result
R6682	T22950	T22923	cc	but,result
R6683	T22951	T22923	conj	remain,result
R6684	T22952	T22951	advmod	so,remain
R6685	T22953	T22951	prep	in,remain
R6686	T22954	T22955	det	all,layers
R6687	T22955	T22953	pobj	layers,in
R6688	T22956	T22955	compound	cell,layers
R6689	T22957	T22958	dep	that,derived
R6690	T22958	T22955	relcl	derived,layers
R6691	T22959	T22958	prep	from,derived
R6692	T22960	T22961	det	the,progenitors
R6693	T22961	T22959	pobj	progenitors,from
R6694	T22962	T22963	nmod	K14,promoter
R6695	T22963	T22961	nmod	promoter,progenitors
R6696	T22964	T22961	amod	active,progenitors
R6697	T22965	T22923	punct	.,result
R6698	T22967	T22968	det	These,derivatives
R6699	T22968	T22969	nsubj	derivatives,include
R6700	T22970	T22971	det	the,epidermis
R6701	T22971	T22969	dobj	epidermis,include
R6702	T22972	T22971	amod	suprabasal,epidermis
R6703	T22973	T22971	cc	and,epidermis
R6704	T22974	T22975	det	the,epithelium
R6705	T22975	T22971	conj	epithelium,epidermis
R6706	T22976	T22975	amod	entire,epithelium
R6707	T22977	T22975	prep	of,epithelium
R6708	T22978	T22979	det	the,follicle
R6709	T22979	T22977	pobj	follicle,of
R6710	T22980	T22979	compound	hair,follicle
R6711	T22981	T22969	punct	.,include
R6712	T22983	T22984	nsubj	Stabilization,account
R6713	T22985	T22983	prep	of,Stabilization
R6714	T22986	T22987	compound	β,catenin
R6715	T22987	T22985	pobj	catenin,of
R6716	T22988	T22987	punct	-,catenin
R6717	T22989	T22983	prep	in,Stabilization
R6718	T22990	T22991	det	a,population
R6719	T22991	T22989	pobj	population,in
R6720	T22992	T22991	amod	broader,population
R6721	T22993	T22991	prep	of,population
R6722	T22994	T22993	pobj	cells,of
R6723	T22995	T22984	aux	could,account
R6724	T22996	T22984	prep	for,account
R6725	T22997	T22996	pobj	some,for
R6726	T22998	T22997	prep	of,some
R6727	T22999	T23000	det	the,differences
R6728	T23000	T22998	pobj	differences,of
R6729	T23001	T23000	amod	phenotypic,differences
R6730	T23002	T22984	punct	.,account
R6731	T23004	T23005	advmod	However,detect
R6732	T23006	T23005	punct	", ",detect
R6733	T23007	T23005	nsubj	we,detect
R6734	T23008	T23005	aux	did,detect
R6735	T23009	T23005	neg	not,detect
R6736	T23010	T23011	det	any,expression
R6737	T23011	T23005	dobj	expression,detect
R6738	T23012	T23011	amod	elevated,expression
R6739	T23013	T23014	compound	β,catenin
R6740	T23014	T23011	compound	catenin,expression
R6741	T23015	T23014	punct	-,catenin
R6742	T23016	T23005	prep	in,detect
R6743	T23017	T23018	preconj	either,cells
R6744	T23018	T23016	pobj	cells,in
R6745	T23019	T23020	npadvmod	K1,positive
R6746	T23020	T23018	amod	positive,cells
R6747	T23021	T23019	punct	-,K1
R6748	T23022	T23019	cc	or,K1
R6749	T23023	T23019	conj	K6,K1
R6750	T23024	T23020	punct	-,positive
R6751	T23025	T23018	amod	differentiated,cells
R6752	T23026	T23005	prep	in,detect
R6753	T23027	T23028	amod	postnatal,skin
R6754	T23028	T23026	pobj	skin,in
R6755	T23029	T23028	amod	mutant,skin
R6756	T23030	T23005	punct	.,detect
R6757	T23032	T23033	nsubj	This,indicates
R6758	T23034	T23035	mark	that,take
R6759	T23035	T23033	ccomp	take,indicates
R6760	T23036	T23035	prep	despite,take
R6761	T23037	T23038	det	the,absence
R6762	T23038	T23036	pobj	absence,despite
R6763	T23039	T23038	prep	of,absence
R6764	T23040	T23039	pobj	Apc,of
R6765	T23041	T23038	cc	and,absence
R6766	T23042	T23043	amod	potential,stabilization
R6767	T23043	T23038	conj	stabilization,absence
R6768	T23044	T23043	prep	of,stabilization
R6769	T23045	T23046	compound	β,catenin
R6770	T23046	T23044	pobj	catenin,of
R6771	T23047	T23046	punct	-,catenin
R6772	T23048	T23038	prep	in,absence
R6773	T23049	T23048	pobj	derivatives,in
R6774	T23050	T23049	prep	of,derivatives
R6775	T23051	T23052	npadvmod	K14,expressing
R6776	T23052	T23054	amod	expressing,progenitors
R6777	T23053	T23052	punct	-,expressing
R6778	T23054	T23050	pobj	progenitors,of
R6779	T23055	T23035	punct	", ",take
R6780	T23056	T23057	amod	elevated,expression
R6781	T23057	T23035	nsubj	expression,take
R6782	T23058	T23059	compound	β,catenin
R6783	T23059	T23057	compound	catenin,expression
R6784	T23060	T23059	punct	-,catenin
R6785	T23061	T23057	punct	", ",expression
R6786	T23062	T23057	cc	and,expression
R6787	T23063	T23064	amod	subsequent,determination
R6788	T23064	T23057	conj	determination,expression
R6789	T23065	T23066	compound	cell,fate
R6790	T23066	T23064	compound	fate,determination
R6791	T23067	T23035	aux	may,take
R6792	T23068	T23035	advmod	only,take
R6793	T23069	T23035	dobj	place,take
R6794	T23070	T23035	prep	in,take
R6795	T23071	T23072	amod	basal,cells
R6796	T23072	T23070	pobj	cells,in
R6797	T23073	T23033	punct	.,indicates
R6798	T23075	T23076	punct	(,3
R6799	T23076	T23077	meta	3,exclude
R6800	T23078	T23076	punct	),3
R6801	T23079	T23077	nsubj	We,exclude
R6802	T23080	T23077	aux	can,exclude
R6803	T23081	T23077	neg	not,exclude
R6804	T23082	T23083	det	the,possibility
R6805	T23083	T23077	dobj	possibility,exclude
R6806	T23084	T23085	mark	that,contributed
R6807	T23085	T23083	acl	contributed,possibility
R6808	T23086	T23085	prep	given,contributed
R6809	T23087	T23088	det	the,properties
R6810	T23088	T23086	pobj	properties,given
R6811	T23089	T23088	amod	multifunctional,properties
R6812	T23090	T23088	prep	of,properties
R6813	T23091	T23090	pobj	Apc,of
R6814	T23092	T23085	punct	", ",contributed
R6815	T23093	T23085	nsubj	disruption,contributed
R6816	T23094	T23093	prep	of,disruption
R6817	T23095	T23096	poss	its,functions
R6818	T23096	T23094	pobj	functions,of
R6819	T23097	T23096	amod	other,functions
R6820	T23098	T23097	prep	than,other
R6821	T23099	T23100	advmod	down,regulation
R6822	T23100	T23098	pobj	regulation,than
R6823	T23101	T23100	punct	-,regulation
R6824	T23102	T23100	prep	of,regulation
R6825	T23103	T23104	compound	β,catenin
R6826	T23104	T23102	pobj	catenin,of
R6827	T23105	T23104	punct	-,catenin
R6828	T23106	T23085	aux	may,contributed
R6829	T23107	T23085	advmod	also,contributed
R6830	T23108	T23085	aux	have,contributed
R6831	T23109	T23085	prep	to,contributed
R6832	T23110	T23111	det	the,phenotype
R6833	T23111	T23109	pobj	phenotype,to
R6834	T23112	T23111	amod	observed,phenotype
R6835	T23113	T23111	amod	overt,phenotype
R6836	T23114	T23077	punct	.,exclude
R6837	T23116	T23117	mark	While,were
R6838	T23117	T23124	advcl	were,were
R6839	T23118	T23119	det	some,features
R6840	T23119	T23117	nsubj	features,were
R6841	T23120	T23119	prep	of,features
R6842	T23121	T23122	poss	our,mice
R6843	T23122	T23120	pobj	mice,of
R6844	T23123	T23122	amod	mutant,mice
R6845	T23125	T23117	acomp	similar,were
R6846	T23126	T23125	prep	to,similar
R6847	T23127	T23128	det	these,mice
R6848	T23128	T23126	pobj	mice,to
R6849	T23129	T23128	amod	transgenic,mice
R6850	T23130	T23124	punct	", ",were
R6851	T23131	T23132	amod	other,aspects
R6852	T23132	T23124	nsubj	aspects,were
R6853	T23133	T23132	amod	phenotypic,aspects
R6854	T23134	T23135	advmod	largely,distinct
R6855	T23135	T23124	acomp	distinct,were
R6856	T23136	T23124	punct	.,were
R6857	T23138	T23139	prep	In,caused
R6858	T23140	T23138	pobj	addition,In
R6859	T23141	T23140	prep	to,addition
R6860	T23142	T23143	amod	aberrant,morphogenesis
R6861	T23143	T23141	pobj	morphogenesis,to
R6862	T23144	T23145	compound	hair,follicle
R6863	T23145	T23143	compound	follicle,morphogenesis
R6864	T23146	T23139	punct	", ",caused
R6865	T23147	T23148	npadvmod	K14,driven
R6866	T23148	T23150	amod	driven,loss
R6867	T23149	T23148	punct	-,driven
R6868	T23150	T23139	nsubj	loss,caused
R6869	T23151	T23150	prep	of,loss
R6870	T23152	T23151	pobj	Apc,of
R6871	T23153	T23139	dobj	formation,caused
R6872	T23154	T23153	prep	of,formation
R6873	T23155	T23156	amod	multiple,buds
R6874	T23156	T23154	pobj	buds,of
R6875	T23157	T23156	compound	tooth,buds
R6876	T23158	T23159	dep	that,known
R6877	T23159	T23156	relcl	known,buds
R6878	T23160	T23159	punct	", ",known
R6879	T23161	T23159	prep	like,known
R6880	T23162	T23163	compound	hair,follicles
R6881	T23163	T23161	pobj	follicles,like
R6882	T23164	T23159	punct	", ",known
R6883	T23165	T23159	auxpass	were,known
R6884	T23166	T23167	aux	to,develop
R6885	T23167	T23159	xcomp	develop,known
R6886	T23168	T23167	prep	through,develop
R6887	T23169	T23170	amod	inductive,interactions
R6888	T23170	T23168	pobj	interactions,through
R6889	T23171	T23170	prep	between,interactions
R6890	T23172	T23173	det	the,epithelium
R6891	T23173	T23171	pobj	epithelium,between
R6892	T23174	T23173	cc	and,epithelium
R6893	T23175	T23173	conj	mesenchyme,epithelium
R6894	T23176	T23139	punct	.,caused
R6895	T23178	T23179	det	This,observation
R6896	T23179	T23180	nsubj	observation,was
R6897	T23181	T23180	acomp	similar,was
R6898	T23182	T23181	prep	to,similar
R6899	T23183	T23184	det	the,buds
R6900	T23184	T23182	pobj	buds,to
R6901	T23185	T23184	amod	ectopic,buds
R6902	T23186	T23184	compound	tooth,buds
R6903	T23187	T23184	acl	found,buds
R6904	T23188	T23187	prep	in,found
R6905	T23189	T23188	pobj	animals,in
R6906	T23190	T23189	acl	misexpressing,animals
R6907	T23191	T23190	dobj	Lef1,misexpressing
R6908	T23192	T23193	punct	[,27
R6909	T23193	T23187	parataxis	27,found
R6910	T23194	T23193	punct	],27
R6911	T23195	T23181	punct	", ",similar
R6912	T23196	T23181	cc	but,similar
R6913	T23197	T23198	advmod	more,severe
R6914	T23198	T23181	conj	severe,similar
R6915	T23199	T23180	cc	and,was
R6916	T23200	T23180	conj	was,was
R6917	T23201	T23200	advmod	also,was
R6918	T23202	T23200	acomp	present,was
R6919	T23203	T23200	prep	at,was
R6920	T23204	T23203	pobj	birth,at
R6921	T23205	T23200	punct	", ",was
R6922	T23206	T23200	advcl	indicating,was
R6923	T23207	T23208	det	the,effect
R6924	T23208	T23206	dobj	effect,indicating
R6925	T23209	T23208	prep	of,effect
R6926	T23210	T23211	compound	Apc,loss
R6927	T23211	T23209	pobj	loss,of
R6928	T23212	T23211	prep	during,loss
R6929	T23213	T23214	det	the,initiation
R6930	T23214	T23212	pobj	initiation,during
R6931	T23215	T23214	prep	of,initiation
R6932	T23216	T23217	amod	embryonic,development
R6933	T23217	T23215	pobj	development,of
R6934	T23218	T23217	compound	tooth,development
R6935	T23219	T23208	punct	", ",effect
R6936	T23220	T23221	dep	which,was
R6937	T23221	T23208	relcl	was,effect
R6938	T23222	T23221	acomp	evident,was
R6939	T23223	T23221	prep	by,was
R6940	T23224	T23225	amod	aberrant,expression
R6941	T23225	T23223	pobj	expression,by
R6942	T23226	T23225	compound	Shh,expression
R6943	T23227	T23225	prep	in,expression
R6944	T23228	T23229	nmod	E15.5,epithelium
R6945	T23229	T23227	pobj	epithelium,in
R6946	T23230	T23229	amod	embryonic,epithelium
R6947	T23231	T23229	amod	oral,epithelium
R6948	T23232	T23233	punct	(,data
R6949	T23233	T23206	meta	data,indicating
R6950	T23234	T23233	amod	unpublished,data
R6951	T23235	T23233	punct	),data
R6952	T23236	T23180	punct	.,was
R6953	T23238	T23239	nsubjpass	It,noted
R6954	T23240	T23239	aux	should,noted
R6955	T23241	T23239	auxpass	be,noted
R6956	T23242	T23243	mark	that,broke
R6957	T23243	T23239	ccomp	broke,noted
R6958	T23244	T23245	mark	although,were
R6959	T23245	T23243	advcl	were,broke
R6960	T23246	T23247	amod	multiple,buds
R6961	T23247	T23245	nsubj	buds,were
R6962	T23248	T23247	compound	tooth,buds
R6963	T23249	T23250	advmod	histologically,visible
R6964	T23250	T23245	acomp	visible,were
R6965	T23251	T23252	punct	(,4O
R6966	T23252	T23245	parataxis	4O,were
R6967	T23253	T23252	compound	Figure,4O
R6968	T23254	T23252	cc	and,4O
R6969	T23255	T23252	conj	4P,4O
R6970	T23256	T23252	punct	),4O
R6971	T23257	T23243	punct	", ",broke
R6972	T23258	T23259	det	these,teeth
R6973	T23259	T23243	nsubj	teeth,broke
R6974	T23260	T23243	neg	never,broke
R6975	T23261	T23243	prt	out,broke
R6976	T23262	T23243	cc	and,broke
R6977	T23263	T23264	det	the,mice
R6978	T23264	T23267	nsubj	mice,appeared
R6979	T23265	T23264	nmod	KA,mice
R6980	T23266	T23264	amod	mutant,mice
R6981	T23267	T23243	conj	appeared,broke
R6982	T23268	T23267	oprd	toothless,appeared
R6983	T23375	T23373	pobj	consequence,as
R6984	T23376	T23375	prep	of,consequence
R6985	T23377	T23378	amod	poor,nutrition
R6986	T23378	T23376	pobj	nutrition,of
R6987	T23379	T23378	acl	caused,nutrition
R6988	T23380	T23379	agent	by,caused
R6989	T23381	T23382	det	the,absence
R6990	T23269	T23239	punct	.,noted
R6991	T23382	T23380	pobj	absence,by
R6992	T23383	T23382	prep	of,absence
R6993	T23271	T23272	det	This,defect
R6994	T23384	T23383	pobj	teeth,of
R6995	T23385	T23365	punct	.,reduced
R6996	T23272	T23276	nsubj	defect,is
R6997	T23273	T23272	amod	unusual,defect
R6998	T23387	T23388	mark	Since,started
R6999	T23274	T23272	amod	severe,defect
R7000	T23275	T23272	compound	tooth,defect
R7001	T23388	T23395	advcl	started,be
R7002	T23277	T23276	acomp	unique,is
R7003	T23278	T23277	prep	to,unique
R7004	T23279	T23280	det	these,mice
R7005	T23389	T23390	det	the,loss
R7006	T23280	T23278	pobj	mice,to
R7007	T23281	T23280	amod	mutant,mice
R7008	T23390	T23388	nsubj	loss,started
R7009	T23282	T23276	punct	.,is
R7010	T23284	T23285	prep	In,was
R7011	T23391	T23390	compound	weight,loss
R7012	T23392	T23390	prep	in,loss
R7013	T23286	T23284	pobj	addition,In
R7014	T23287	T23285	punct	", ",was
R7015	T23393	T23394	compound	KA,mutants
R7016	T23288	T23285	nsubj	neither,was
R7017	T23289	T23288	prep	of,neither
R7018	T23290	T23291	det	the,mice
R7019	T23394	T23392	pobj	mutants,in
R7020	T23291	T23289	pobj	mice,of
R7021	T23292	T23291	nummod	two,mice
R7022	T23293	T23291	amod	transgenic,mice
R7023	T23396	T23388	prep	from,started
R7024	T23294	T23295	advmod	postnatally,lethal
R7025	T23295	T23285	acomp	lethal,was
R7026	T23296	T23285	prep	as,was
R7027	T23297	T23296	prep	in,as
R7028	T23298	T23299	det	the,mice
R7029	T23299	T23297	pobj	mice,in
R7030	T23397	T23396	pobj	P8,from
R7031	T23300	T23299	nmod	KA,mice
R7032	T23301	T23299	amod	mutant,mice
R7033	T23302	T23285	punct	.,was
R7034	T23398	T23399	punct	–,P10
R7035	T23399	T23397	prep	P10,P8
R7036	T23304	T23305	nsubj	We,find
R7037	T23306	T23305	aux	did,find
R7038	T23307	T23305	neg	not,find
R7039	T23308	T23309	det	any,abnormalities
R7040	T23400	T23401	mark	while,nursed
R7041	T23309	T23305	dobj	abnormalities,find
R7042	T23310	T23309	amod	obvious,abnormalities
R7043	T23311	T23309	amod	histopathological,abnormalities
R7044	T23312	T23309	prep	in,abnormalities
R7045	T23401	T23388	advcl	nursed,started
R7046	T23313	T23314	det	the,organs
R7047	T23314	T23312	pobj	organs,in
R7048	T23315	T23314	amod	internal,organs
R7049	T23402	T23401	nsubjpass	pups,nursed
R7050	T23316	T23314	prep	of,organs
R7051	T23317	T23318	compound	KA,mice
R7052	T23318	T23316	pobj	mice,of
R7053	T23403	T23401	auxpass	were,nursed
R7054	T23319	T23320	dep	that,contribute
R7055	T23320	T23309	relcl	contribute,abnormalities
R7056	T23321	T23320	aux	could,contribute
R7057	T23404	T23401	advmod	still,nursed
R7058	T23322	T23320	prep	to,contribute
R7059	T23323	T23324	det	the,lethality
R7060	T23405	T23401	agent	by,nursed
R7061	T23324	T23322	pobj	lethality,to
R7062	T23325	T23305	punct	.,find
R7063	T23406	T23407	poss	their,mothers
R7064	T23327	T23328	advmod	However,indicates
R7065	T23407	T23405	pobj	mothers,by
R7066	T23329	T23328	punct	", ",indicates
R7067	T23330	T23331	det	the,fact
R7068	T23331	T23328	nsubj	fact,indicates
R7069	T23408	T23395	punct	", ",be
R7070	T23332	T23333	mark	that,had
R7071	T23333	T23331	acl	had,fact
R7072	T23334	T23335	predet	all,mutants
R7073	T23409	T23395	nsubj	starvation,be
R7074	T23335	T23333	nsubj	mutants,had
R7075	T23336	T23335	det	the,mutants
R7076	T23337	T23338	amod	lower,weight
R7077	T23338	T23333	dobj	weight,had
R7078	T23339	T23340	punct	(,2F
R7079	T23340	T23338	parataxis	2F,weight
R7080	T23410	T23409	prep	due,starvation
R7081	T23341	T23340	compound	Figure,2F
R7082	T23342	T23340	punct	),2F
R7083	T23343	T23338	prep	with,weight
R7084	T23411	T23410	pcomp	to,due
R7085	T23344	T23345	advmod	hardly,evidence
R7086	T23345	T23343	pobj	evidence,with
R7087	T23412	T23410	pobj	lack,due
R7088	T23346	T23345	det	any,evidence
R7089	T23347	T23345	prep	of,evidence
R7090	T23348	T23349	amod	solid,food
R7091	T23349	T23347	pobj	food,of
R7092	T23413	T23412	prep	of,lack
R7093	T23350	T23345	prep	in,evidence
R7094	T23351	T23352	poss	their,stomach
R7095	T23352	T23350	pobj	stomach,in
R7096	T23414	T23413	pobj	teeth,of
R7097	T23353	T23354	mark	that,died
R7098	T23354	T23328	ccomp	died,indicates
R7099	T23355	T23356	det	the,mutants
R7100	T23415	T23395	aux	can,be
R7101	T23356	T23354	nsubj	mutants,died
R7102	T23357	T23354	aux	might,died
R7103	T23358	T23354	aux	have,died
R7104	T23416	T23395	neg	not,be
R7105	T23359	T23354	prep	of,died
R7106	T23360	T23359	pobj	starvation,of
R7107	T23361	T23328	punct	.,indicates
R7108	T23417	T23418	det	the,cause
R7109	T23418	T23395	attr	cause,be
R7110	T23363	T23364	amod	Dermal,fat
R7111	T23419	T23418	amod	sole,cause
R7112	T23364	T23365	nsubjpass	fat,reduced
R7113	T23420	T23418	prep	of,cause
R7114	T23366	T23365	auxpass	was,reduced
R7115	T23367	T23365	prep	in,reduced
R7116	T23421	T23420	pobj	death,of
R7117	T23368	T23369	det	the,skin
R7118	T23369	T23367	pobj	skin,in
R7119	T23370	T23369	amod	mutant,skin
R7120	T23422	T23395	punct	", ",be
R7121	T23371	T23365	punct	", ",reduced
R7122	T23372	T23373	advmod	possibly,as
R7123	T23423	T23395	cc	but,be
R7124	T23373	T23365	prep	as,reduced
R7125	T23374	T23375	det	a,consequence
R7126	T23424	T23395	conj	is,be
R7127	T23425	T23424	acomp	likely,is
R7128	T23426	T23427	aux	to,be
R7129	T23427	T23425	xcomp	be,likely
R7130	T23428	T23429	det	a,factor
R7131	T23481	T23482	compound	bud,formation
R7132	T23482	T23479	pobj	formation,of
R7133	T23483	T23484	amod	proper,development
R7134	T23429	T23427	attr	factor,be
R7135	T23484	T23473	dobj	development,allows
R7136	T23485	T23484	prep	of,development
R7137	T23486	T23485	pobj	teeth,of
R7138	T23430	T23429	amod	contributing,factor
R7139	T23487	T23488	mark	for,have
R7140	T23488	T23473	advcl	have,allows
R7141	T23489	T23488	nsubj	mice,have
R7142	T23431	T23395	punct	.,be
R7143	T23490	T23488	aux	to,have
R7144	T23491	T23492	det	a,diet
R7145	T23433	T23434	nsubjpass	Absence,observed
R7146	T23492	T23488	dobj	diet,have
R7147	T23493	T23492	amod	healthy,diet
R7148	T23494	T23492	cc	and,diet
R7149	T23435	T23433	prep	of,Absence
R7150	T23495	T23496	amod	normal,life
R7151	T23496	T23492	conj	life,diet
R7152	T23497	T23473	punct	.,allows
R7153	T23499	T23500	amod	Mechanistic,studies
R7154	T23436	T23435	pobj	teeth,of
R7155	T23500	T23501	nsubj	studies,are
R7156	T23437	T23436	cc	and,teeth
R7157	T23502	T23503	aux	to,understand
R7158	T23503	T23500	advcl	understand,studies
R7159	T23504	T23505	advmod	how,leads
R7160	T23438	T23439	amod	mammary,glands
R7161	T23505	T23503	ccomp	leads,understand
R7162	T23506	T23507	amod	increased,levels
R7163	T23507	T23505	nsubj	levels,leads
R7164	T23439	T23436	conj	glands,teeth
R7165	T23508	T23507	prep	of,levels
R7166	T23509	T23510	compound	β,catenin
R7167	T23440	T23434	aux	have,observed
R7168	T23510	T23508	pobj	catenin,of
R7169	T23511	T23510	punct	-,catenin
R7170	T23512	T23505	prep	to,leads
R7171	T23441	T23434	auxpass	been,observed
R7172	T23513	T23514	amod	altered,phenotypes
R7173	T23514	T23512	pobj	phenotypes,to
R7174	T23515	T23514	nmod	skin,phenotypes
R7175	T23442	T23434	prep	in,observed
R7176	T23516	T23515	cc	and,skin
R7177	T23517	T23515	conj	tooth,skin
R7178	T23518	T23501	prep	under,are
R7179	T23443	T23442	pobj	mice,in
R7180	T23519	T23518	pobj	way,under
R7181	T23520	T23501	punct	.,are
R7182	T23444	T23443	amod	deficient,mice
R7183	T23445	T23444	prep	in,deficient
R7184	T23446	T23445	pobj	Lef1,in
R7185	T23447	T23444	cc	and,deficient
R7186	T23448	T23449	advmod	ectopically,expressing
R7187	T23449	T23444	conj	expressing,deficient
R7188	T23450	T23449	dobj	Dkk1,expressing
R7189	T23451	T23452	punct	[,30
R7190	T23452	T23434	parataxis	30,observed
R7191	T23453	T23452	nummod	29,30
R7192	T23454	T23452	punct	",",30
R7193	T23455	T23452	punct	],30
R7194	T23456	T23434	cc	but,observed
R7195	T23457	T23458	poss	their,absence
R7196	T23458	T23459	nsubj	absence,was
R7197	T23459	T23434	conj	was,observed
R7198	T23460	T23459	prep	due,was
R7199	T23461	T23460	pcomp	to,due
R7200	T23462	T23463	det	the,block
R7201	T23463	T23460	pobj	block,due
R7202	T23464	T23463	prep	in,block
R7203	T23465	T23464	pobj	development,in
R7204	T23466	T23463	prep	before,block
R7205	T23467	T23468	det	the,stage
R7206	T23468	T23466	pobj	stage,before
R7207	T23469	T23468	compound	bud,stage
R7208	T23470	T23459	punct	.,was
R7209	T23472	T23473	advmod	Hence,allows
R7210	T23474	T23473	punct	", ",allows
R7211	T23475	T23476	preconj	neither,loss
R7212	T23476	T23473	nsubj	loss,allows
R7213	T23477	T23476	cc	nor,loss
R7214	T23478	T23476	conj	excess,loss
R7215	T23479	T23476	prep	of,loss
R7216	T23480	T23481	amod	tooth,bud
R7221	T25418	T25417	cc	and,Apc
R7222	T25419	T25420	compound	Thymus,Organogenesis
R7223	T25420	T25417	conj	Organogenesis,Apc
R7224	T25422	T25423	prep	In,observed
R7225	T25424	T25425	det	this,study
R7226	T25425	T25422	pobj	study,In
R7227	T25426	T25423	punct	", ",observed
R7228	T25427	T25423	nsubj	we,observed
R7229	T25428	T25429	mark	that,resulted
R7230	T25429	T25423	ccomp	resulted,observed
R7231	T25430	T25431	npadvmod	K14,driven
R7232	T25431	T25433	amod	driven,loss
R7233	T25432	T25431	punct	-,driven
R7234	T25433	T25429	nsubj	loss,resulted
R7235	T25434	T25433	prep	of,loss
R7236	T25435	T25434	pobj	Apc,of
R7237	T25436	T25429	prep	in,resulted
R7238	T25437	T25438	det	a,thymus
R7239	T25438	T25436	pobj	thymus,in
R7240	T25439	T25438	amod	small,thymus
R7241	T25440	T25438	prep	with,thymus
R7242	T25441	T25442	amod	severe,metaplasia
R7243	T25442	T25440	pobj	metaplasia,with
R7244	T25443	T25442	amod	squamous,metaplasia
R7245	T25444	T25442	acl	leading,metaplasia
R7246	T25445	T25444	prep	to,leading
R7247	T25446	T25447	det	the,formation
R7248	T25447	T25445	pobj	formation,to
R7249	T25448	T25447	prep	of,formation
R7250	T25449	T25450	amod	numerous,pyogranuloma
R7251	T25450	T25448	pobj	pyogranuloma,of
R7252	T25451	T25447	cc	and,formation
R7253	T25452	T25447	conj	loss,formation
R7254	T25453	T25452	prep	of,loss
R7255	T25454	T25455	amod	proper,structure
R7256	T25455	T25453	pobj	structure,of
R7257	T25456	T25455	compound	meshwork,structure
R7258	T25457	T25455	prep	for,structure
R7259	T25458	T25459	compound	thymocyte,maturation
R7260	T25459	T25457	pobj	maturation,for
R7261	T25460	T25429	punct	", ",resulted
R7262	T25461	T25429	advcl	rendering,resulted
R7263	T25462	T25463	det	the,mice
R7264	T25463	T25461	dobj	mice,rendering
R7265	T25464	T25461	oprd	athymic,rendering
R7266	T25465	T25423	punct	.,observed
R7267	T25467	T25468	amod	Previous,studies
R7268	T25468	T25469	nsubj	studies,shown
R7269	T25470	T25469	aux	have,shown
R7270	T25471	T25472	mark	that,found
R7271	T25472	T25469	ccomp	found,shown
R7272	T25473	T25472	prep	in,found
R7273	T25474	T25475	amod	normal,thymus
R7274	T25475	T25473	pobj	thymus,in
R7275	T25476	T25475	amod	adult,thymus
R7276	T25477	T25478	compound	K14,expression
R7277	T25478	T25472	nsubjpass	expression,found
R7278	T25479	T25472	auxpass	is,found
R7279	T25480	T25481	advmod	together,in
R7280	T25481	T25472	prep	in,found
R7281	T25482	T25480	prep	with,together
R7282	T25483	T25482	pobj	K5,with
R7283	T25484	T25483	prep	in,K5
R7284	T25485	T25486	det	the,TECs
R7285	T25486	T25484	pobj	TECs,in
R7286	T25487	T25486	amod	stellate,TECs
R7287	T25488	T25486	amod	medullary,TECs
R7288	T25489	T25481	punct	", ",in
R7289	T25490	T25481	cc	but,in
R7290	T25491	T25490	neg	not,but
R7291	T25492	T25481	pobj	association,in
R7292	T25493	T25492	prep	with,association
R7293	T25494	T25495	nmod	K5,TECs
R7294	T25495	T25493	pobj	TECs,with
R7295	T25496	T25494	punct	+,K5
R7296	T25497	T25492	prep	in,association
R7297	T25498	T25499	det	the,cortex
R7298	T25499	T25497	pobj	cortex,in
R7299	T25500	T25497	cc	or,in
R7300	T25501	T25497	conj	at,in
R7301	T25502	T25503	det	the,junction
R7302	T25503	T25501	pobj	junction,at
R7303	T25504	T25505	amod	cortico,medullary
R7304	T25505	T25503	amod	medullary,junction
R7305	T25506	T25505	punct	-,medullary
R7306	T25507	T25469	punct	.,shown
R7307	T25509	T25510	prep	In,demonstrated
R7308	T25510	T25516	ccomp	demonstrated,are
R7309	T25511	T25509	pobj	addition,In
R7310	T25512	T25510	punct	", ",demonstrated
R7311	T25513	T25510	nsubjpass	it,demonstrated
R7312	T25514	T25510	aux	has,demonstrated
R7313	T25515	T25510	auxpass	been,demonstrated
R7314	T25517	T25518	mark	that,coexpress
R7315	T25518	T25510	ccomp	coexpress,demonstrated
R7316	T25519	T25520	nmod	K14,TECs
R7317	T25520	T25518	nsubj	TECs,coexpress
R7318	T25521	T25519	punct	+,K14
R7319	T25522	T25518	aux	do,coexpress
R7320	T25523	T25518	neg	not,coexpress
R7321	T25524	T25518	dobj	K8,coexpress
R7322	T25525	T25516	punct	;,are
R7323	T25526	T25516	advmod	hence,are
R7324	T25527	T25516	punct	", ",are
R7325	T25528	T25516	expl	there,are
R7326	T25529	T25530	nummod	two,subsets
R7327	T25530	T25516	attr	subsets,are
R7328	T25531	T25530	amod	distinct,subsets
R7329	T25532	T25530	amod	medullary,subsets
R7330	T25533	T25530	punct	", ",subsets
R7331	T25534	T25535	advmod	namely,subset
R7332	T25535	T25530	appos	subset,subsets
R7333	T25536	T25535	det	a,subset
R7334	T25537	T25535	nmod	K8,subset
R7335	T25538	T25537	punct	−,K8
R7336	T25539	T25535	nmod	K14,subset
R7337	T25540	T25539	punct	+,K14
R7338	T25541	T25535	amod	stellate,subset
R7339	T25542	T25535	cc	and,subset
R7340	T25543	T25544	det	a,subset
R7341	T25544	T25535	conj	subset,subset
R7342	T25545	T25544	nmod	K8,subset
R7343	T25546	T25545	punct	+,K8
R7344	T25547	T25544	nmod	K14,subset
R7345	T25548	T25547	punct	−,K14
R7346	T25549	T25544	amod	globular,subset
R7347	T25550	T25551	punct	[,32
R7348	T25551	T25516	parataxis	32,are
R7349	T25552	T25551	punct	],32
R7350	T25553	T25516	punct	.,are
R7351	T25555	T25556	prep	In,restricted
R7352	T25557	T25555	pobj	agreement,In
R7353	T25558	T25557	prep	with,agreement
R7354	T25559	T25560	det	the,results
R7355	T25560	T25558	pobj	results,with
R7356	T25561	T25560	amod	previous,results
R7357	T25562	T25556	punct	", ",restricted
R7358	T25563	T25556	prep	in,restricted
R7359	T25564	T25565	nmod	P3,thymus
R7360	T25565	T25563	pobj	thymus,in
R7361	T25566	T25565	amod	normal,thymus
R7362	T25567	T25568	compound	K14,expression
R7363	T25568	T25556	nsubjpass	expression,restricted
R7364	T25569	T25556	auxpass	was,restricted
R7365	T25570	T25556	prep	to,restricted
R7366	T25571	T25572	amod	stellate,TECs
R7367	T25572	T25570	pobj	TECs,to
R7368	T25573	T25572	amod	medullary,TECs
R7369	T25574	T25575	punct	(,6D
R7370	T25575	T25556	parataxis	6D,restricted
R7371	T25576	T25575	compound	Figure,6D
R7372	T25577	T25575	punct	),6D
R7373	T25578	T25556	punct	", ",restricted
R7374	T25579	T25580	mark	whereas,found
R7375	T25580	T25556	advcl	found,restricted
R7376	T25581	T25582	compound	K8,expression
R7377	T25582	T25580	nsubjpass	expression,found
R7378	T25583	T25580	auxpass	was,found
R7379	T25584	T25580	prep	throughout,found
R7380	T25585	T25586	det	the,TECs
R7381	T25586	T25584	pobj	TECs,throughout
R7382	T25587	T25588	punct	(,data
R7383	T25588	T25556	meta	data,restricted
R7384	T25589	T25588	amod	unpublished,data
R7385	T25590	T25588	punct	),data
R7386	T25591	T25556	punct	.,restricted
R7387	T25593	T25594	nsubj	We,clarify
R7388	T25595	T25594	aux	could,clarify
R7389	T25596	T25594	neg	not,clarify
R7390	T25597	T25598	mark	whether,coexpressed
R7391	T25598	T25594	ccomp	coexpressed,clarify
R7392	T25599	T25600	det	these,keratins
R7393	T25600	T25598	nsubjpass	keratins,coexpressed
R7394	T25601	T25600	nummod	two,keratins
R7395	T25602	T25598	auxpass	were,coexpressed
R7396	T25603	T25598	prep	in,coexpressed
R7397	T25604	T25605	det	the,TECs
R7398	T25605	T25603	pobj	TECs,in
R7399	T25606	T25605	amod	same,TECs
R7400	T25607	T25598	prep	without,coexpressed
R7401	T25608	T25609	compound	double,staining
R7402	T25609	T25607	pobj	staining,without
R7403	T25610	T25609	punct	-,staining
R7404	T25611	T25594	punct	.,clarify
R7405	T25613	T25614	expl	There,were
R7406	T25615	T25616	amod	individual,differences
R7407	T25616	T25614	attr	differences,were
R7408	T25617	T25614	prep	among,were
R7409	T25618	T25617	pobj	mutants,among
R7410	T25619	T25614	cc	and,were
R7411	T25620	T25621	nsubjpass	these,reflected
R7412	T25621	T25614	conj	reflected,were
R7413	T25622	T25621	auxpass	were,reflected
R7414	T25623	T25621	advmod	prominently,reflected
R7415	T25624	T25621	prep	in,reflected
R7416	T25625	T25626	det	the,abnormalities
R7417	T25626	T25624	pobj	abnormalities,in
R7418	T25627	T25626	amod	histological,abnormalities
R7419	T25628	T25626	prep	of,abnormalities
R7420	T25629	T25630	det	the,thymus
R7421	T25630	T25628	pobj	thymus,of
R7422	T25631	T25621	prep	at,reflected
R7423	T25632	T25631	pobj	P3,at
R7424	T25633	T25614	punct	", ",were
R7425	T25634	T25614	cc	but,were
R7426	T25635	T25636	mark	as,showed
R7427	T25636	T25642	advcl	showed,seem
R7428	T25637	T25638	det	the,mutants
R7429	T25638	T25636	nsubj	mutants,showed
R7430	T25639	T25638	amod	older,mutants
R7431	T25640	T25638	amod	surviving,mutants
R7432	T25641	T25638	appos	all,mutants
R7433	T25642	T25614	conj	seem,were
R7434	T25643	T25644	det	the,histopathologies
R7435	T25644	T25636	dobj	histopathologies,showed
R7436	T25645	T25644	amod	same,histopathologies
R7437	T25646	T25644	prep	of,histopathologies
R7438	T25647	T25648	det	the,thymus
R7439	T25648	T25646	pobj	thymus,of
R7440	T25649	T25642	punct	", ",seem
R7441	T25650	T25651	det	the,thymi
R7442	T25651	T25642	nsubj	thymi,seem
R7443	T25652	T25651	amod	mutant,thymi
R7444	T25653	T25642	advmod	eventually,seem
R7445	T25654	T25655	aux	to,result
R7446	T25655	T25642	xcomp	result,seem
R7447	T25656	T25655	prep	in,result
R7448	T25657	T25658	det	the,fate
R7449	T25658	T25656	pobj	fate,in
R7450	T25659	T25658	amod	same,fate
R7451	T25660	T25642	punct	.,seem
R7452	T25662	T25663	nsubj	It,is
R7453	T25664	T25663	acomp	unclear,is
R7454	T25665	T25666	advmod	when,takes
R7455	T25666	T25663	ccomp	takes,is
R7456	T25667	T25668	compound	K14,cre
R7457	T25668	T25670	compound	cre,induction
R7458	T25669	T25668	punct	-,cre
R7459	T25670	T25666	nsubj	induction,takes
R7460	T25671	T25666	advmod	actually,takes
R7461	T25672	T25666	dobj	place,takes
R7462	T25673	T25666	prep	in,takes
R7463	T25674	T25675	det	the,thymus
R7464	T25675	T25673	pobj	thymus,in
R7465	T25676	T25675	amod	mutant,thymus
R7466	T25677	T25663	punct	", ",is
R7467	T25678	T25663	cc	but,is
R7468	T25679	T25680	mark	as,were
R7469	T25680	T25700	advcl	were,seems
R7470	T25681	T25682	det	the,population
R7471	T25682	T25680	nsubj	population,were
R7472	T25683	T25682	prep	of,population
R7473	T25684	T25683	pobj	cells,of
R7474	T25685	T25684	acl	showing,cells
R7475	T25686	T25687	det	a,staining
R7476	T25687	T25685	dobj	staining,showing
R7477	T25688	T25687	amod	strong,staining
R7478	T25689	T25687	amod	nuclear,staining
R7479	T25690	T25691	compound	β,catenin
R7480	T25691	T25687	compound	catenin,staining
R7481	T25692	T25691	punct	-,catenin
R7482	T25693	T25694	advmod	as,as
R7483	T25694	T25682	cc	as,population
R7484	T25695	T25694	advmod	well,as
R7485	T25696	T25697	det	the,cells
R7486	T25697	T25682	conj	cells,population
R7487	T25698	T25697	acl	expressing,cells
R7488	T25699	T25698	dobj	K14,expressing
R7489	T25700	T25663	conj	seems,is
R7490	T25701	T25680	acomp	small,were
R7491	T25702	T25680	cc	and,were
R7492	T25703	T25704	amod	thymic,compartments
R7493	T25704	T25706	nsubj	compartments,existed
R7494	T25705	T25704	amod	epithelial,compartments
R7495	T25706	T25680	conj	existed,were
R7496	T25707	T25706	advmod	still,existed
R7497	T25708	T25706	prep	in,existed
R7498	T25709	T25710	det	a,thymus
R7499	T25710	T25708	pobj	thymus,in
R7500	T25711	T25710	amod	mild,thymus
R7501	T25712	T25710	nmod	P3,thymus
R7502	T25713	T25710	amod	mutant,thymus
R7503	T25714	T25715	punct	(,6E
R7504	T25715	T25706	parataxis	6E,existed
R7505	T25716	T25715	compound	Figure,6E
R7506	T25717	T25715	cc	and,6E
R7507	T25718	T25715	conj	6F,6E
R7508	T25719	T25715	punct	),6E
R7509	T25720	T25700	punct	", ",seems
R7510	T25721	T25700	nsubj	it,seems
R7511	T25722	T25723	mark	that,taken
R7512	T25723	T25700	ccomp	taken,seems
R7513	T25724	T25725	amod	initial,differentiation
R7514	T25725	T25723	nsubj	differentiation,taken
R7515	T25726	T25725	prep	to,differentiation
R7516	T25727	T25728	amod	medullary,TECs
R7517	T25728	T25726	pobj	TECs,to
R7518	T25729	T25727	cc	and,medullary
R7519	T25730	T25727	conj	cortical,medullary
R7520	T25731	T25728	cc	and,TECs
R7521	T25732	T25733	compound	thymocyte,colonization
R7522	T25733	T25728	conj	colonization,TECs
R7523	T25734	T25723	aux	have,taken
R7524	T25735	T25723	advmod	already,taken
R7525	T25736	T25723	dobj	place,taken
R7526	T25737	T25738	amod	prior,to
R7527	T25738	T25723	prep	to,taken
R7528	T25739	T25740	det	the,effects
R7529	T25740	T25738	pobj	effects,to
R7530	T25741	T25740	amod	major,effects
R7531	T25742	T25740	prep	of,effects
R7532	T25743	T25744	npadvmod	K14,driven
R7533	T25744	T25746	amod	driven,loss
R7534	T25745	T25744	punct	-,driven
R7535	T25746	T25742	pobj	loss,of
R7536	T25747	T25746	compound	Apc,loss
R7537	T25748	T25700	punct	.,seems
R7538	T25750	T25751	advmod	However,increased
R7539	T25752	T25751	punct	", ",increased
R7540	T25753	T25751	nsubj	cells,increased
R7541	T25754	T25753	prep	with,cells
R7542	T25755	T25756	amod	nuclear,catenin
R7543	T25756	T25759	nmod	catenin,cells
R7544	T25757	T25756	nmod	β,catenin
R7545	T25758	T25756	punct	-,catenin
R7546	T25759	T25754	pobj	cells,with
R7547	T25760	T25756	cc	and,catenin
R7548	T25761	T25762	npadvmod	K8,positive
R7549	T25762	T25756	conj	positive,catenin
R7550	T25763	T25761	punct	+,K8
R7551	T25764	T25762	npadvmod	K14,positive
R7552	T25765	T25764	punct	+,K14
R7553	T25766	T25762	amod	double,positive
R7554	T25767	T25762	punct	-,positive
R7555	T25768	T25759	amod	epithelial,cells
R7556	T25769	T25751	advmod	subsequently,increased
R7557	T25770	T25751	punct	", ",increased
R7558	T25771	T25751	advcl	associated,increased
R7559	T25772	T25771	prep	with,associated
R7560	T25773	T25774	amod	active,proliferation
R7561	T25774	T25772	pobj	proliferation,with
R7562	T25775	T25774	prep	in,proliferation
R7563	T25776	T25777	det	the,group
R7564	T25777	T25775	pobj	group,in
R7565	T25778	T25777	amod	latter,group
R7566	T25779	T25777	prep	of,group
R7567	T25780	T25779	pobj	cells,of
R7568	T25781	T25774	cc	and,proliferation
R7569	T25782	T25774	conj	loss,proliferation
R7570	T25783	T25782	prep	of,loss
R7571	T25784	T25785	compound	TEC,compartments
R7572	T25785	T25783	pobj	compartments,of
R7573	T25786	T25751	punct	.,increased
R7574	T25788	T25789	prep	With,became
R7575	T25790	T25788	pobj	age,With
R7576	T25791	T25789	punct	", ",became
R7577	T25792	T25793	compound	β,catenin
R7578	T25793	T25795	compound	catenin,pattern
R7579	T25794	T25793	punct	-,catenin
R7580	T25795	T25789	nsubj	pattern,became
R7581	T25796	T25795	compound	expression,pattern
R7582	T25797	T25798	advmod	more,diffuse
R7583	T25798	T25789	acomp	diffuse,became
R7584	T25799	T25789	cc	and,became
R7585	T25800	T25801	amod	fewer,cells
R7586	T25801	T25803	nsubj	cells,showed
R7587	T25802	T25801	amod	epithelial,cells
R7588	T25803	T25789	conj	showed,became
R7589	T25804	T25805	amod	nuclear,localization
R7590	T25805	T25803	dobj	localization,showed
R7591	T25806	T25803	cc	but,showed
R7592	T25807	T25808	nmod	K8,cells
R7593	T25808	T25812	nsubj	cells,remained
R7594	T25809	T25807	punct	+,K8
R7595	T25810	T25808	nmod	K14,cells
R7596	T25811	T25810	punct	+,K14
R7597	T25812	T25803	conj	remained,showed
R7598	T25813	T25812	punct	", ",remained
R7599	T25814	T25812	advcl	forming,remained
R7600	T25815	T25816	amod	concentric,structures
R7601	T25816	T25814	dobj	structures,forming
R7602	T25817	T25816	prep	of,structures
R7603	T25818	T25819	amod	epithelial,cells
R7604	T25819	T25817	pobj	cells,of
R7605	T25820	T25819	acl	filled,cells
R7606	T25821	T25820	agent	with,filled
R7607	T25822	T25823	amod	hard,deposits
R7608	T25823	T25821	pobj	deposits,with
R7609	T25824	T25823	compound	keratin,deposits
R7610	T25825	T25820	cc	and,filled
R7611	T25826	T25820	conj	infiltrated,filled
R7612	T25827	T25826	agent	with,infiltrated
R7613	T25828	T25829	amod	vast,number
R7614	T25829	T25827	pobj	number,with
R7615	T25830	T25829	prep	of,number
R7616	T25831	T25830	pobj	neutrophils,of
R7617	T25832	T25831	cc	and,neutrophils
R7618	T25833	T25831	conj	macrophages,neutrophils
R7619	T25834	T25789	punct	.,became
R7620	T25836	T25837	advmod	Only,cells
R7621	T25837	T25841	nsubj	cells,dividing
R7622	T25838	T25837	det	a,cells
R7623	T25839	T25837	amod	few,cells
R7624	T25840	T25837	amod	epithelial,cells
R7625	T25842	T25841	aux	were,dividing
R7626	T25843	T25841	cc	and,dividing
R7627	T25844	T25845	advmod	hardly,thymocytes
R7628	T25845	T25847	nsubj	thymocytes,were
R7629	T25846	T25845	det	any,thymocytes
R7630	T25847	T25841	conj	were,dividing
R7631	T25848	T25847	acomp	present,were
R7632	T25849	T25847	prep	by,were
R7633	T25850	T25851	det	this,time
R7634	T25851	T25849	pobj	time,by
R7635	T25852	T25847	punct	.,were
R7636	T25854	T25855	det	These,results
R7637	T25855	T25856	nsubj	results,suggest
R7638	T25857	T25858	mark	that,took
R7639	T25858	T25856	ccomp	took,suggest
R7640	T25859	T25858	prep	with,took
R7641	T25860	T25861	det	the,deletion
R7642	T25861	T25859	pobj	deletion,with
R7643	T25862	T25861	prep	of,deletion
R7644	T25863	T25862	pobj	Apc,of
R7645	T25864	T25861	prep	in,deletion
R7646	T25865	T25864	pobj	TECs,in
R7647	T25866	T25858	punct	", ",took
R7648	T25867	T25858	nsubj	stabililization,took
R7649	T25868	T25867	cc	and,stabililization
R7650	T25869	T25870	amod	nuclear,localization
R7651	T25870	T25867	conj	localization,stabililization
R7652	T25871	T25867	prep	of,stabililization
R7653	T25872	T25873	compound	β,catenin
R7654	T25873	T25871	pobj	catenin,of
R7655	T25874	T25873	punct	-,catenin
R7656	T25875	T25858	dobj	place,took
R7657	T25876	T25858	cc	and,took
R7658	T25877	T25878	advmod	subsequently,differentiated
R7659	T25878	T25858	conj	differentiated,took
R7660	T25879	T25880	det	these,cells
R7661	T25880	T25878	nsubj	cells,differentiated
R7662	T25881	T25878	prep	into,differentiated
R7663	T25882	T25881	pobj	keratinocytes,into
R7664	T25883	T25884	dep	that,expressed
R7665	T25884	T25882	relcl	expressed,keratinocytes
R7666	T25885	T25886	preconj	both,K14
R7667	T25886	T25884	dobj	K14,expressed
R7668	T25887	T25886	cc	and,K14
R7669	T25888	T25886	conj	K8,K14
R7670	T25889	T25884	punct	", ",expressed
R7671	T25890	T25884	advcl	similar,expressed
R7672	T25891	T25890	prep	to,similar
R7673	T25892	T25893	det	the,cells
R7674	T25893	T25891	pobj	cells,to
R7675	T25894	T25893	amod	basal,cells
R7676	T25895	T25893	prep	of,cells
R7677	T25896	T25897	det	the,skin
R7678	T25897	T25895	pobj	skin,of
R7679	T25898	T25884	punct	", ",expressed
R7680	T25899	T25900	advmod	instead,of
R7681	T25900	T25884	prep	of,expressed
R7682	T25901	T25902	compound	TEC,subsets
R7683	T25902	T25900	pobj	subsets,of
R7684	T25903	T25856	punct	.,suggest
R7685	T25905	T25906	det	The,expansion
R7686	T25906	T25907	nsubj	expansion,lead
R7687	T25908	T25906	cc	and,expansion
R7688	T25909	T25906	conj	differentiation,expansion
R7689	T25910	T25906	prep	of,expansion
R7690	T25911	T25912	det	these,keratinocytes
R7691	T25912	T25910	pobj	keratinocytes,of
R7692	T25913	T25907	prep	to,lead
R7693	T25914	T25913	pobj	loss,to
R7694	T25915	T25914	prep	of,loss
R7695	T25916	T25917	amod	proper,compartments
R7696	T25917	T25915	pobj	compartments,of
R7697	T25918	T25917	amod	thymic,compartments
R7698	T25919	T25917	amod	epithelial,compartments
R7699	T25920	T25907	cc	and,lead
R7700	T25921	T25922	prep	in,produced
R7701	T25922	T25907	conj	produced,lead
R7702	T25923	T25921	pobj	turn,in
R7703	T25924	T25922	cc	and,produced
R7704	T25925	T25922	conj	deposited,produced
R7705	T25926	T25927	det	the,keratins
R7706	T25927	T25925	dobj	keratins,deposited
R7707	T25928	T25927	amod	hard,keratins
R7708	T25929	T25930	dep	that,caused
R7709	T25930	T25927	relcl	caused,keratins
R7710	T25931	T25930	advmod	consequently,caused
R7711	T25932	T25933	amod	vast,amount
R7712	T25933	T25934	nsubj	amount,infiltrate
R7713	T25934	T25930	ccomp	infiltrate,caused
R7714	T25935	T25933	prep	of,amount
R7715	T25936	T25935	pobj	neutrophils,of
R7716	T25937	T25936	cc	and,neutrophils
R7717	T25938	T25936	conj	macrophages,neutrophils
R7718	T25939	T25934	aux	to,infiltrate
R7719	T25940	T25941	det	the,thymus
R7720	T25941	T25934	dobj	thymus,infiltrate
R7721	T25942	T25907	punct	.,lead
R7722	T25944	T25945	det	These,structures
R7723	T25945	T25948	nsubj	structures,overtaken
R7724	T25946	T25945	amod	aberrant,structures
R7725	T25947	T25945	amod	epithelial,structures
R7726	T25949	T25948	advmod	eventually,overtaken
R7727	T25950	T25948	aux	have,overtaken
R7728	T25951	T25952	det	the,whole
R7729	T25952	T25948	dobj	whole,overtaken
R7730	T25953	T25952	prep	of,whole
R7731	T25954	T25955	det	the,thymus
R7732	T25955	T25953	pobj	thymus,of
R7733	T25956	T25948	cc	and,overtaken
R7734	T25957	T25948	conj	driven,overtaken
R7735	T25958	T25957	prt	out,driven
R7736	T25959	T25960	det	the,thymocytes
R7737	T25960	T25957	dobj	thymocytes,driven
R7738	T25961	T25960	amod	colonized,thymocytes
R7739	T25962	T25948	punct	.,overtaken
R7740	T25964	T25965	npadvmod	K14,driven
R7741	T25965	T25967	amod	driven,loss
R7742	T25966	T25965	punct	-,driven
R7743	T25967	T25968	nsubj	loss,misdirected
R7744	T25969	T25967	prep	of,loss
R7745	T25970	T25969	pobj	Apc,of
R7746	T25971	T25967	cc	and,loss
R7747	T25972	T25973	amod	subsequent,expression
R7748	T25973	T25967	conj	expression,loss
R7749	T25974	T25973	amod	constitutive,expression
R7750	T25975	T25973	prep	of,expression
R7751	T25976	T25977	compound	β,catenin
R7752	T25977	T25975	pobj	catenin,of
R7753	T25978	T25977	punct	-,catenin
R7754	T25979	T25973	prep	in,expression
R7755	T25980	T25979	pobj	TECs,in
R7756	T25981	T25968	aux	have,misdirected
R7757	T25982	T25968	advmod	therefore,misdirected
R7758	T25983	T25968	dobj	them,misdirected
R7759	T25984	T25968	prep	to,misdirected
R7760	T25985	T25986	amod	wrong,fate
R7761	T25986	T25984	pobj	fate,to
R7762	T25987	T25986	amod	epithelial,fate
R7763	T25988	T25986	compound	cell,fate
R7764	T25989	T25968	punct	", ",misdirected
R7765	T25990	T25991	neg	not,allowing
R7766	T25991	T25968	advcl	allowing,misdirected
R7767	T25992	T25993	amod	proper,differentiation
R7768	T25993	T25991	dobj	differentiation,allowing
R7769	T25994	T25993	prep	to,differentiation
R7770	T25995	T25996	preconj	either,cortical
R7771	T25996	T25997	amod	cortical,TECs
R7772	T25997	T25994	pobj	TECs,to
R7773	T25998	T25996	cc	or,cortical
R7774	T25999	T25996	conj	medullary,cortical
R7775	T26000	T25993	punct	", ",differentiation
R7776	T26001	T26002	dep	which,is
R7777	T26002	T25993	relcl	is,differentiation
R7778	T26003	T26002	acomp	essential,is
R7779	T26004	T26003	prep	for,essential
R7780	T26005	T26006	amod	normal,development
R7781	T26006	T26004	pobj	development,for
R7782	T26007	T26006	compound	thymocyte,development
R7783	T26008	T25968	punct	.,misdirected
R7784	T26010	T26011	nsubj	This,is
R7785	T26012	T26011	preconj	not,is
R7786	T26013	T26012	advmod	only,not
R7787	T26014	T26011	conj	evident,is
R7788	T26015	T26014	prep	from,evident
R7789	T26016	T26017	det	the,lack
R7790	T26017	T26015	pobj	lack,from
R7791	T26018	T26017	prep	of,lack
R7792	T26019	T26020	amod	dividing,thymocytes
R7793	T26020	T26018	pobj	thymocytes,of
R7794	T26021	T26017	prep	in,lack
R7795	T26022	T26023	det	the,thymus
R7796	T26023	T26021	pobj	thymus,in
R7797	T26024	T26023	amod	mutant,thymus
R7798	T26025	T26017	prep	by,lack
R7799	T26026	T26025	pobj	P13,by
R7800	T26027	T26015	punct	", ",from
R7801	T26028	T26015	cc	but,from
R7802	T26029	T26028	advmod	also,but
R7803	T26030	T26015	conj	by,from
R7804	T26031	T26032	det	the,pattern
R7805	T26032	T26030	pobj	pattern,by
R7806	T26033	T26032	amod	differential,pattern
R7807	T26034	T26032	compound	expression,pattern
R7808	T26035	T26032	prep	of,pattern
R7809	T26036	T26035	pobj	keratins,of
R7810	T26037	T26036	punct	", ",keratins
R7811	T26038	T26039	dep	which,were
R7812	T26039	T26036	relcl	were,keratins
R7813	T26040	T26041	advmod	more,like
R7814	T26041	T26039	acomp	like,were
R7815	T26042	T26041	npadvmod	skin,like
R7816	T26043	T26041	punct	-,like
R7817	T26044	T26041	prep	than,like
R7818	T26045	T26046	npadvmod	TEC,like
R7819	T26046	T26044	amod	like,than
R7820	T26047	T26046	punct	-,like
R7821	T26048	T26011	punct	.,is
R7822	T26050	T26051	det	The,importance
R7823	T26051	T26052	nsubjpass	importance,demonstrated
R7824	T26053	T26051	prep	of,importance
R7825	T26054	T26055	compound	Apc,function
R7826	T26055	T26053	pobj	function,of
R7827	T26056	T26051	prep	in,importance
R7828	T26057	T26058	amod	thymic,development
R7829	T26058	T26056	pobj	development,in
R7830	T26059	T26052	aux	has,demonstrated
R7831	T26060	T26052	auxpass	been,demonstrated
R7832	T26061	T26052	agent	by,demonstrated
R7833	T26062	T26063	npadvmod	thymocyte,specific
R7834	T26063	T26065	amod	specific,loss
R7835	T26064	T26063	punct	-,specific
R7836	T26065	T26061	pobj	loss,by
R7837	T26066	T26065	prep	of,loss
R7838	T26067	T26066	pobj	Apc,of
R7839	T26068	T26065	prep	by,loss
R7840	T26069	T26068	pcomp	crossing,by
R7841	T26070	T26071	det	a,strain
R7842	T26071	T26069	dobj	strain,crossing
R7843	T26072	T26071	amod	different,strain
R7844	T26073	T26071	prep	of,strain
R7845	T26074	T26075	nmod	Apc,mice
R7846	T26075	T26073	pobj	mice,of
R7847	T26076	T26075	amod	conditional,mice
R7848	T26077	T26075	cc	and,mice
R7849	T26078	T26079	nmod	LckCre,mice
R7850	T26079	T26075	conj	mice,mice
R7851	T26080	T26079	amod	transgenic,mice
R7852	T26081	T26082	punct	[,33
R7853	T26082	T26052	parataxis	33,demonstrated
R7854	T26083	T26082	punct	],33
R7855	T26084	T26052	punct	.,demonstrated
R7856	T26086	T26087	advmod	Here,demonstrated
R7857	T26088	T26087	punct	", ",demonstrated
R7858	T26089	T26087	prep	by,demonstrated
R7859	T26090	T26091	npadvmod	K14,driven
R7860	T26091	T26093	amod	driven,loss
R7861	T26092	T26091	punct	-,driven
R7862	T26093	T26089	pobj	loss,by
R7863	T26094	T26095	npadvmod	TEC,specific
R7864	T26095	T26093	amod	specific,loss
R7865	T26096	T26095	punct	-,specific
R7866	T26097	T26093	prep	of,loss
R7867	T26098	T26097	pobj	Apc,of
R7868	T26099	T26087	punct	", ",demonstrated
R7869	T26100	T26087	nsubj	we,demonstrated
R7870	T26101	T26087	aux	have,demonstrated
R7871	T26102	T26103	poss	its,importance
R7872	T26103	T26087	dobj	importance,demonstrated
R7873	T26104	T26103	prep	in,importance
R7874	T26105	T26106	compound	thymus,development
R7875	T26106	T26104	pobj	development,in
R7876	T26107	T26108	preconj	not,in
R7877	T26108	T26087	prep	in,demonstrated
R7878	T26109	T26107	advmod	only,not
R7879	T26110	T26108	pobj	thymocytes,in
R7880	T26111	T26108	cc	but,in
R7881	T26112	T26111	advmod	also,but
R7882	T26113	T26108	conj	in,in
R7883	T26114	T26113	pobj	TECs,in
R7884	T26115	T26087	punct	.,demonstrated
R7885	T26117	T26118	nsubj	It,is
R7886	T26119	T26118	prep	of,is
R7887	T26120	T26119	pobj	interest,of
R7888	T26121	T26122	mark	that,seen
R7889	T26122	T26118	ccomp	seen,is
R7890	T26123	T26124	amod	dental,abnormalities
R7891	T26124	T26122	nsubjpass	abnormalities,seen
R7892	T26125	T26124	punct	", ",abnormalities
R7893	T26126	T26127	amod	such,as
R7894	T26127	T26124	prep	as,abnormalities
R7895	T26128	T26129	amod	supernumerary,teeth
R7896	T26129	T26127	pobj	teeth,as
R7897	T26130	T26128	cc	and,supernumerary
R7898	T26131	T26128	conj	impacted,supernumerary
R7899	T26132	T26129	amod	similar,teeth
R7900	T26133	T26132	prep	to,similar
R7901	T26134	T26133	pobj	those,to
R7902	T26135	T26134	acl	observed,those
R7903	T26136	T26135	prep	in,observed
R7904	T26137	T26138	poss	our,mice
R7905	T26138	T26136	pobj	mice,in
R7906	T26139	T26138	amod	mutant,mice
R7907	T26140	T26122	punct	", ",seen
R7908	T26141	T26122	auxpass	are,seen
R7909	T26142	T26122	advmod	frequently,seen
R7910	T26143	T26122	prep	in,seen
R7911	T26144	T26143	pobj	patients,in
R7912	T26145	T26144	prep	with,patients
R7913	T26146	T26147	poss	Gardner,syndrome
R7914	T26147	T26145	pobj	syndrome,with
R7915	T26148	T26146	case	's,Gardner
R7916	T26149	T26144	punct	", ",patients
R7917	T26150	T26144	appos	carriers,patients
R7918	T26151	T26150	prep	of,carriers
R7919	T26152	T26153	compound	APC,mutation
R7920	T26153	T26151	pobj	mutation,of
R7921	T26154	T26153	compound	germline,mutation
R7922	T26155	T26156	punct	[,6
R7923	T26156	T26122	parataxis	6,seen
R7924	T26157	T26156	punct	],6
R7925	T26158	T26118	punct	.,is
R7926	T26160	T26161	det	The,importance
R7927	T26161	T26162	nsubjpass	importance,pointed
R7928	T26163	T26161	prep	of,importance
R7929	T26164	T26165	npadvmod	odonto,stomatological
R7930	T26165	T26167	amod	stomatological,examinations
R7931	T26166	T26165	punct	-,stomatological
R7932	T26167	T26163	pobj	examinations,of
R7933	T26168	T26162	aux	should,pointed
R7934	T26169	T26162	advmod	hence,pointed
R7935	T26170	T26162	auxpass	be,pointed
R7936	T26171	T26162	prt	out,pointed
R7937	T26172	T26162	prep	as,pointed
R7938	T26173	T26174	det	a,means
R7939	T26174	T26172	pobj	means,as
R7940	T26175	T26174	prep	of,means
R7941	T26176	T26175	pcomp	reaching,of
R7942	T26177	T26178	det	a,diagnosis
R7943	T26178	T26176	dobj	diagnosis,reaching
R7944	T26179	T26178	amod	presumptive,diagnosis
R7945	T26180	T26178	punct	", ",diagnosis
R7946	T26181	T26182	poss	whose,confirmation
R7947	T26182	T26183	dep	confirmation,is
R7948	T26183	T26178	relcl	is,diagnosis
R7949	T26184	T26183	acomp	vital,is
R7950	T26185	T26184	prep	to,vital
R7951	T26186	T26187	det	the,patient
R7952	T26187	T26185	pobj	patient,to
R7953	T26188	T26162	punct	.,pointed
R7954	T26190	T26191	amod	Further,characterization
R7955	T26191	T26192	nsubj	characterization,provide
R7956	T26193	T26191	prep	of,characterization
R7957	T26194	T26195	det	the,mechanism
R7958	T26195	T26193	pobj	mechanism,of
R7959	T26196	T26195	prep	of,mechanism
R7960	T26197	T26198	amod	such,defects
R7961	T26198	T26196	pobj	defects,of
R7962	T26199	T26198	amod	developmental,defects
R7963	T26200	T26191	acl	using,characterization
R7964	T26201	T26202	poss	our,model
R7965	T26202	T26200	dobj	model,using
R7966	T26203	T26202	compound	mouse,model
R7967	T26204	T26192	aux	should,provide
R7968	T26205	T26206	amod	important,insights
R7969	T26206	T26192	dobj	insights,provide
R7970	T26207	T26192	prep	into,provide
R7971	T26208	T26209	compound	Apc,function
R7972	T26209	T26207	pobj	function,into
R7973	T26210	T26209	prep	in,function
R7974	T26211	T26212	amod	multiple,systems
R7975	T26212	T26210	pobj	systems,in
R7976	T26213	T26212	compound	organ,systems
R7977	T26214	T26192	cc	and,provide
R7978	T26215	T26216	dep	to,give
R7979	T26216	T26192	conj	give,provide
R7980	T26217	T26218	amod	better,insights
R7981	T26218	T26216	dobj	insights,give
R7982	T26219	T26218	prep	into,insights
R7983	T26220	T26221	amod	potential,events
R7984	T26221	T26219	pobj	events,into
R7985	T26222	T26221	amod	adverse,events
R7986	T26223	T26221	prep	in,events
R7987	T26224	T26225	amod	human,subjects
R7988	T26225	T26223	pobj	subjects,in
R7989	T26226	T26192	punct	.,provide
R7990	T26228	T26229	prep	In,shown
R7991	T26230	T26228	pobj	conclusion,In
R7992	T26231	T26229	punct	", ",shown
R7993	T26232	T26229	nsubj	we,shown
R7994	T26233	T26229	aux	have,shown
R7995	T26234	T26235	mark	that,causes
R7996	T26235	T26229	ccomp	causes,shown
R7997	T26236	T26235	nsubj	loss,causes
R7998	T26237	T26236	prep	of,loss
R7999	T26238	T26237	pobj	Apc,of
R8000	T26239	T26236	prep	in,loss
R8001	T26240	T26241	npadvmod	K14,expressing
R8002	T26241	T26243	amod	expressing,cells
R8003	T26242	T26241	punct	-,expressing
R8004	T26243	T26239	pobj	cells,in
R8005	T26244	T26243	amod	embryonic,cells
R8006	T26245	T26246	amod	aberrant,morphogenesis
R8007	T26246	T26235	dobj	morphogenesis,causes
R8008	T26247	T26235	prep	in,causes
R8009	T26248	T26249	amod	various,appendages
R8010	T26249	T26247	pobj	appendages,in
R8011	T26250	T26249	compound	skin,appendages
R8012	T26251	T26249	punct	", ",appendages
R8013	T26252	T26249	prep	including,appendages
R8014	T26253	T26254	compound	hair,follicles
R8015	T26254	T26252	pobj	follicles,including
R8016	T26255	T26254	cc	and,follicles
R8017	T26256	T26254	conj	teeth,follicles
R8018	T26257	T26256	punct	", ",teeth
R8019	T26258	T26256	cc	and,teeth
R8020	T26259	T26260	amod	abnormal,organogensis
R8021	T26260	T26256	conj	organogensis,teeth
R8022	T26261	T26260	compound	thymus,organogensis
R8023	T26262	T26229	punct	.,shown
R8024	T26264	T26265	poss	Our,results
R8025	T26265	T26266	nsubj	results,provide
R8026	T26267	T26268	amod	genetic,evidence
R8027	T26268	T26266	dobj	evidence,provide
R8028	T26269	T26270	mark	that,is
R8029	T26270	T26268	acl	is,evidence
R8030	T26271	T26270	nsubj	expression,is
R8031	T26272	T26271	prep	of,expression
R8032	T26273	T26272	pobj	Apc,of
R8033	T26274	T26270	acomp	essential,is
R8034	T26275	T26274	prep	for,essential
R8035	T26276	T26275	pobj	regulation,for
R8036	T26277	T26276	prep	of,regulation
R8037	T26278	T26279	amod	proper,fates
R8038	T26279	T26277	pobj	fates,of
R8039	T26280	T26279	compound	cell,fates
R8040	T26281	T26276	prep	in,regulation
R8041	T26282	T26283	det	these,organs
R8042	T26283	T26281	pobj	organs,in
R8043	T26284	T26285	dep	that,require
R8044	T26285	T26283	relcl	require,organs
R8045	T26286	T26287	amod	epithelial,mesenchymal
R8046	T26287	T26289	amod	mesenchymal,interactions
R8047	T26288	T26287	punct	–,mesenchymal
R8048	T26289	T26285	dobj	interactions,require
R8049	T26290	T26266	punct	.,provide

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PMC:1564426 / 37352-50938 JSON TXT 4 Projects