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PMC:1564426 / 12771-13855 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T7910 0-2 PRP denotes We
T7911 3-12 VBD denotes genotyped
T7912 13-14 DT denotes a
T7914 15-20 NN denotes total
T7915 21-23 IN denotes of
T7913 24-27 CD denotes 458
T7916 28-32 NNS denotes pups
T7917 33-34 -LRB- denotes (
T7919 34-35 CD denotes 8
T7921 35-36 SYM denotes –
T7920 36-38 CD denotes 10
T7922 39-40 NNS denotes d
T7918 41-44 JJ denotes old
T7923 44-45 -RRB- denotes )
T7924 46-50 IN denotes from
T7925 51-53 CD denotes 67
T7926 54-61 NNS denotes litters
T7927 62-71 VBG denotes resulting
T7928 72-76 IN denotes from
T7929 77-84 NNS denotes crosses
T7930 85-92 IN denotes between
T7931 93-96 NN denotes K14
T7933 96-97 HYPH denotes -
T7932 97-100 NN denotes cre
T7935 100-101 : denotes ;
T7936 102-108 NN denotes ApcCKO
T7937 108-109 HYPH denotes /
T7938 109-110 SYM denotes +
T7939 111-114 CC denotes and
T7940 115-121 NN denotes ApcCKO
T7942 121-122 HYPH denotes /
T7941 122-125 NN denotes CKO
T7934 126-130 NNS denotes mice
T7943 130-131 . denotes .
T7944 131-348 sentence denotes The mutant mice of the genotype K14-cre; ApcCKO/CKO (hereafter, KA mutant) were born, but the observed frequency of KA mutants was much less than expected (78 of 458 [17.0%]; p < 0.0005 Chi-square analysis, Table 1).
T7945 132-135 DT denotes The
T7947 136-142 JJ denotes mutant
T7946 143-147 NNS denotes mice
T7949 148-150 IN denotes of
T7950 151-154 DT denotes the
T7951 155-163 NN denotes genotype
T7952 164-167 NN denotes K14
T7954 167-168 HYPH denotes -
T7953 168-171 NN denotes cre
T7955 171-172 : denotes ;
T7956 173-179 NN denotes ApcCKO
T7958 179-180 HYPH denotes /
T7957 180-183 NN denotes CKO
T7959 184-185 -LRB- denotes (
T7961 185-194 RB denotes hereafter
T7962 194-196 , denotes ,
T7963 196-198 NN denotes KA
T7960 199-205 NN denotes mutant
T7964 205-206 -RRB- denotes )
T7965 207-211 VBD denotes were
T7948 212-216 VBN denotes born
T7966 216-218 , denotes ,
T7967 218-221 CC denotes but
T7968 222-225 DT denotes the
T7970 226-234 VBN denotes observed
T7969 235-244 NN denotes frequency
T7972 245-247 IN denotes of
T7973 248-250 NN denotes KA
T7974 251-258 NNS denotes mutants
T7971 259-262 VBD denotes was
T7975 263-267 RB denotes much
T7976 268-272 JJR denotes less
T7977 273-277 IN denotes than
T7978 278-286 VBN denotes expected
T7979 287-288 -LRB- denotes (
T7981 288-290 CD denotes 78
T7982 291-293 IN denotes of
T7983 294-297 CD denotes 458
T7984 298-299 -LRB- denotes [
T7986 299-303 CD denotes 17.0
T7985 303-304 NN denotes %
T7987 304-305 -RRB- denotes ]
T7988 305-306 : denotes ;
T7989 307-308 NN denotes p
T7991 309-310 SYM denotes <
T7992 311-317 CD denotes 0.0005
T7993 318-321 NN denotes Chi
T7995 321-322 HYPH denotes -
T7994 322-328 NN denotes square
T7990 329-337 NN denotes analysis
T7996 337-339 , denotes ,
T7980 339-344 NN denotes Table
T7997 345-346 CD denotes 1
T7998 346-347 -RRB- denotes )
T7999 347-348 . denotes .
T8000 348-511 sentence denotes To assess the basis for the neonatal lethality of KA mutants, we monitored three litters from birth to weaning by measuring the body weight of each pup every day.
T8001 349-351 TO denotes To
T8002 352-358 VB denotes assess
T8004 359-362 DT denotes the
T8005 363-368 NN denotes basis
T8006 369-372 IN denotes for
T8007 373-376 DT denotes the
T8009 377-385 JJ denotes neonatal
T8008 386-395 NN denotes lethality
T8010 396-398 IN denotes of
T8011 399-401 NN denotes KA
T8012 402-409 NNS denotes mutants
T8013 409-411 , denotes ,
T8014 411-413 PRP denotes we
T8003 414-423 VBD denotes monitored
T8015 424-429 CD denotes three
T8016 430-437 NNS denotes litters
T8017 438-442 IN denotes from
T8018 443-448 NN denotes birth
T8019 449-451 IN denotes to
T8020 452-459 VBG denotes weaning
T8021 460-462 IN denotes by
T8022 463-472 VBG denotes measuring
T8023 473-476 DT denotes the
T8025 477-481 NN denotes body
T8024 482-488 NN denotes weight
T8026 489-491 IN denotes of
T8027 492-496 DT denotes each
T8028 497-500 NN denotes pup
T8029 501-506 DT denotes every
T8030 507-510 NN denotes day
T8031 510-511 . denotes .
T8032 511-703 sentence denotes A total of 25 pups were born from three litters, of which 7 (28%) were confirmed to be K14-cre; ApcCKO/CKO by genotyping, indicating that KA mutants were born in the expected Mendelian ratio.
T8033 512-513 DT denotes A
T8035 514-519 NN denotes total
T8036 520-522 IN denotes of
T8034 523-525 CD denotes 25
T8037 526-530 NNS denotes pups
T8039 531-535 VBD denotes were
T8038 536-540 VBN denotes born
T8040 541-545 IN denotes from
T8041 546-551 CD denotes three
T8042 552-559 NNS denotes litters
T8043 559-561 , denotes ,
T8044 561-563 IN denotes of
T8046 564-569 WDT denotes which
T8047 570-571 CD denotes 7
T8048 572-573 -LRB- denotes (
T8050 573-575 CD denotes 28
T8049 575-576 NN denotes %
T8051 576-577 -RRB- denotes )
T8052 578-582 VBD denotes were
T8045 583-592 VBN denotes confirmed
T8053 593-595 TO denotes to
T8054 596-598 VB denotes be
T8055 599-602 NN denotes K14
T8057 602-603 HYPH denotes -
T8056 603-606 NN denotes cre
T8058 606-607 : denotes ;
T8059 608-614 NN denotes ApcCKO
T8061 614-615 HYPH denotes /
T8060 615-618 NN denotes CKO
T8062 619-621 IN denotes by
T8063 622-632 NN denotes genotyping
T8064 632-634 , denotes ,
T8065 634-644 VBG denotes indicating
T8066 645-649 IN denotes that
T8068 650-652 NN denotes KA
T8069 653-660 NNS denotes mutants
T8070 661-665 VBD denotes were
T8067 666-670 VBN denotes born
T8071 671-673 IN denotes in
T8072 674-677 DT denotes the
T8074 678-686 VBN denotes expected
T8075 687-696 JJ denotes Mendelian
T8073 697-702 NN denotes ratio
T8076 702-703 . denotes .
T8077 703-858 sentence denotes The KA mutant pups were nursed normally, and there was milk in their stomachs during the first 2 or 3 d after birth, but they failed to thrive (Figure 2).
T8078 704-707 DT denotes The
T8080 708-710 NN denotes KA
T8081 711-717 JJ denotes mutant
T8079 718-722 NNS denotes pups
T8083 723-727 VBD denotes were
T8082 728-734 VBN denotes nursed
T8084 735-743 RB denotes normally
T8085 743-745 , denotes ,
T8086 745-748 CC denotes and
T8087 749-754 EX denotes there
T8088 755-758 VBD denotes was
T8089 759-763 NN denotes milk
T8090 764-766 IN denotes in
T8091 767-772 PRP$ denotes their
T8092 773-781 NNS denotes stomachs
T8093 782-788 IN denotes during
T8094 789-792 DT denotes the
T8096 793-798 JJ denotes first
T8097 799-800 CD denotes 2
T8098 801-803 CC denotes or
T8099 804-805 CD denotes 3
T8095 806-807 NNS denotes d
T8100 808-813 IN denotes after
T8101 814-819 NN denotes birth
T8102 819-821 , denotes ,
T8103 821-824 CC denotes but
T8104 825-829 PRP denotes they
T8105 830-836 VBD denotes failed
T8106 837-839 TO denotes to
T8107 840-846 VB denotes thrive
T8108 847-848 -LRB- denotes (
T8109 848-854 NN denotes Figure
T8110 855-856 CD denotes 2
T8111 856-857 -RRB- denotes )
T8112 857-858 . denotes .
T8113 858-1040 sentence denotes By postnatal day (P) 8–10, at the time of genotyping, many KA mutant pups were considerably smaller than their littermates (Figure 2B–2F) and some have died at or prior to this age.
T8114 859-861 IN denotes By
T8116 862-871 JJ denotes postnatal
T8117 872-875 NN denotes day
T8118 876-877 -LRB- denotes (
T8119 877-878 NN denotes P
T8120 878-879 -RRB- denotes )
T8121 880-881 CD denotes 8
T8122 881-882 SYM denotes –
T8123 882-884 CD denotes 10
T8124 884-886 , denotes ,
T8125 886-888 IN denotes at
T8126 889-892 DT denotes the
T8127 893-897 NN denotes time
T8128 898-900 IN denotes of
T8129 901-911 NN denotes genotyping
T8130 911-913 , denotes ,
T8131 913-917 JJ denotes many
T8133 918-920 NN denotes KA
T8134 921-927 JJ denotes mutant
T8132 928-932 NNS denotes pups
T8115 933-937 VBD denotes were
T8135 938-950 RB denotes considerably
T8136 951-958 JJR denotes smaller
T8137 959-963 IN denotes than
T8138 964-969 PRP$ denotes their
T8139 970-981 NNS denotes littermates
T8140 982-983 -LRB- denotes (
T8142 983-989 NN denotes Figure
T8141 990-992 NN denotes 2B
T8143 992-993 SYM denotes –
T8144 993-995 NN denotes 2F
T8145 995-996 -RRB- denotes )
T8146 997-1000 CC denotes and
T8147 1001-1005 DT denotes some
T8149 1006-1010 VBP denotes have
T8148 1011-1015 VBN denotes died
T8150 1016-1018 IN denotes at
T8151 1019-1021 CC denotes or
T8152 1022-1027 JJ denotes prior
T8153 1028-1030 IN denotes to
T8154 1031-1035 DT denotes this
T8155 1036-1039 NN denotes age
T8156 1039-1040 . denotes .
T8157 1040-1084 sentence denotes None of KA mutants survived to weaning age.
T8158 1041-1045 NN denotes None
T8160 1046-1048 IN denotes of
T8161 1049-1051 NN denotes KA
T8162 1052-1059 NNS denotes mutants
T8159 1060-1068 VBD denotes survived
T8163 1069-1071 IN denotes to
T8164 1072-1079 VBG denotes weaning
T8165 1080-1083 NN denotes age
T8166 1083-1084 . denotes .
R1737 T7929 T7928 pobj crosses,from
R1739 T7930 T7929 prep between,crosses
R1746 T7931 T7932 nmod K14,cre
R1750 T7932 T7934 nmod cre,mice
R1754 T7933 T7932 punct -,cre
R1758 T7934 T7930 pobj mice,between
R1765 T7935 T7932 punct ;,cre
R1769 T7936 T7932 appos ApcCKO,cre
R1772 T7937 T7936 punct /,ApcCKO
R1773 T7938 T7936 punct +,ApcCKO
R1775 T7939 T7932 cc and,cre
R1780 T7940 T7941 compound ApcCKO,CKO
R1783 T7941 T7932 conj CKO,cre
R1786 T7942 T7941 punct /,CKO
R1790 T7943 T7911 punct .,genotyped
R1794 T7945 T7946 det The,mice
R1802 T7946 T7948 nsubjpass mice,born
R1807 T7947 T7946 amod mutant,mice
R1810 T7949 T7946 prep of,mice
R1815 T7950 T7951 det the,genotype
R1819 T7951 T7949 pobj genotype,of
R1823 T7952 T7953 compound K14,cre
R1826 T7953 T7951 appos cre,genotype
R1830 T7954 T7953 punct -,cre
R1835 T7955 T7953 punct ;,cre
R1839 T7956 T7957 compound ApcCKO,CKO
R1843 T7957 T7953 appos CKO,cre
R1844 T7910 T7911 nsubj We,genotyped
R1845 T7958 T7957 punct /,CKO
R1846 T7912 T7913 quantmod a,458
R1847 T7913 T7916 nummod 458,pups
R1848 T7914 T7913 quantmod total,458
R1849 T7915 T7913 quantmod of,458
R1850 T7916 T7911 dobj pups,genotyped
R1851 T7959 T7960 punct (,mutant
R1852 T7917 T7918 punct (,old
R1853 T7918 T7916 parataxis old,pups
R1854 T7919 T7920 quantmod 8,10
R1855 T7920 T7922 nummod 10,d
R1856 T7960 T7946 parataxis mutant,mice
R1857 T7921 T7920 punct –,10
R1858 T7922 T7918 npadvmod d,old
R1859 T7923 T7918 punct ),old
R1860 T7961 T7960 advmod hereafter,mutant
R1861 T7924 T7916 prep from,pups
R1862 T7925 T7926 nummod 67,litters
R1863 T7926 T7924 pobj litters,from
R1864 T7962 T7960 punct ", ",mutant
R1865 T7927 T7926 acl resulting,litters
R1866 T7928 T7927 prep from,resulting
R1867 T7963 T7960 compound KA,mutant
R1868 T7964 T7960 punct ),mutant
R1869 T7965 T7948 auxpass were,born
R1870 T7966 T7948 punct ", ",born
R1871 T7967 T7948 cc but,born
R1872 T7968 T7969 det the,frequency
R1873 T8034 T8037 nummod 25,pups
R1874 T7969 T7971 nsubj frequency,was
R1875 T8035 T8034 quantmod total,25
R1876 T8036 T8034 quantmod of,25
R1877 T7970 T7969 amod observed,frequency
R1878 T8037 T8038 nsubjpass pups,born
R1879 T8039 T8038 auxpass were,born
R1880 T7971 T7948 conj was,born
R1881 T8040 T8038 prep from,born
R1882 T8041 T8042 nummod three,litters
R1883 T7972 T7969 prep of,frequency
R1884 T8042 T8040 pobj litters,from
R1885 T8043 T8042 punct ", ",litters
R1886 T8044 T8045 prep of,confirmed
R1887 T7973 T7974 compound KA,mutants
R1888 T8045 T8042 relcl confirmed,litters
R1889 T8046 T8044 pobj which,of
R1890 T8047 T8045 nsubjpass 7,confirmed
R1891 T7974 T7972 pobj mutants,of
R1892 T8048 T8049 punct (,%
R1893 T8049 T8047 parataxis %,7
R1894 T7975 T7976 advmod much,less
R1895 T8050 T8049 nummod 28,%
R1896 T8051 T8049 punct ),%
R1897 T8052 T8045 auxpass were,confirmed
R1898 T8053 T8054 aux to,be
R1899 T8054 T8045 xcomp be,confirmed
R1900 T8055 T8056 compound K14,cre
R1901 T8056 T8054 attr cre,be
R1902 T7976 T7971 acomp less,was
R1903 T8057 T8056 punct -,cre
R1904 T8058 T8056 punct ;,cre
R1905 T8059 T8060 compound ApcCKO,CKO
R1906 T7977 T7978 mark than,expected
R1907 T8060 T8056 appos CKO,cre
R1908 T8061 T8060 punct /,CKO
R1909 T8062 T8045 prep by,confirmed
R1910 T7978 T7976 advcl expected,less
R1911 T8063 T8062 pobj genotyping,by
R1912 T8064 T8045 punct ", ",confirmed
R1913 T7979 T7980 punct (,Table
R1914 T8065 T8045 advcl indicating,confirmed
R1915 T8066 T8067 mark that,born
R1916 T8067 T8065 ccomp born,indicating
R1917 T7980 T7976 parataxis Table,less
R1918 T8068 T8069 compound KA,mutants
R1919 T8069 T8067 nsubjpass mutants,born
R1920 T8070 T8067 auxpass were,born
R1921 T7981 T7980 dep 78,Table
R1922 T8071 T8067 prep in,born
R1923 T8072 T8073 det the,ratio
R1924 T8073 T8071 pobj ratio,in
R1925 T7982 T7981 prep of,78
R1926 T8074 T8073 amod expected,ratio
R1927 T8075 T8073 amod Mendelian,ratio
R1928 T7983 T7982 pobj 458,of
R1929 T8076 T8038 punct .,born
R1930 T8078 T8079 det The,pups
R1931 T7984 T7985 punct [,%
R1932 T8079 T8082 nsubjpass pups,nursed
R1933 T8080 T8079 nmod KA,pups
R1934 T8081 T8079 amod mutant,pups
R1935 T7985 T7981 parataxis %,78
R1936 T8083 T8082 auxpass were,nursed
R1937 T7986 T7985 nummod 17.0,%
R1938 T8084 T8082 advmod normally,nursed
R1939 T8085 T8082 punct ", ",nursed
R1940 T8086 T8082 cc and,nursed
R1941 T7987 T7985 punct ],%
R1942 T8087 T8088 expl there,was
R1943 T8088 T8082 conj was,nursed
R1944 T8089 T8088 attr milk,was
R1945 T7988 T7980 punct ;,Table
R1946 T8090 T8088 prep in,was
R1947 T8091 T8092 poss their,stomachs
R1948 T7989 T7990 nsubj p,analysis
R1949 T8092 T8090 pobj stomachs,in
R1950 T8093 T8088 prep during,was
R1951 T8094 T8095 det the,d
R1952 T8095 T8093 pobj d,during
R1953 T8096 T8095 amod first,d
R1954 T8097 T8095 nummod 2,d
R1955 T8098 T8097 cc or,2
R1956 T7990 T7980 ccomp analysis,Table
R1957 T8099 T8097 conj 3,2
R1958 T8100 T8095 prep after,d
R1959 T8101 T8100 pobj birth,after
R1960 T7991 T7990 punct <,analysis
R1961 T8102 T8082 punct ", ",nursed
R1962 T8103 T8082 cc but,nursed
R1963 T8104 T8105 nsubj they,failed
R1964 T7992 T7990 nummod 0.0005,analysis
R1965 T8105 T8082 conj failed,nursed
R1966 T7993 T7994 compound Chi,square
R1967 T8106 T8107 aux to,thrive
R1968 T8107 T8105 xcomp thrive,failed
R1969 T7994 T7990 compound square,analysis
R1970 T8108 T8109 punct (,Figure
R1971 T8109 T8107 parataxis Figure,thrive
R1972 T8110 T8109 nummod 2,Figure
R1973 T7995 T7994 punct -,square
R1974 T8111 T8109 punct ),Figure
R1975 T8112 T8105 punct .,failed
R1976 T7996 T7980 punct ", ",Table
R1977 T8114 T8115 prep By,were
R1978 T7997 T7980 nummod 1,Table
R1979 T8116 T8117 amod postnatal,day
R1980 T8117 T8114 pobj day,By
R1981 T7998 T7980 punct ),Table
R1982 T8118 T8117 punct (,day
R1983 T8119 T8117 appos P,day
R1984 T7999 T7971 punct .,was
R1985 T8120 T8117 punct ),day
R1986 T8121 T8117 appos 8,day
R1987 T8122 T8123 punct –,10
R1988 T8001 T8002 aux To,assess
R1989 T8123 T8121 prep 10,8
R1990 T8124 T8115 punct ", ",were
R1991 T8125 T8115 prep at,were
R1992 T8002 T8003 advcl assess,monitored
R1993 T8126 T8127 det the,time
R1994 T8127 T8125 pobj time,at
R1995 T8128 T8127 prep of,time
R1996 T8129 T8128 pobj genotyping,of
R1997 T8004 T8005 det the,basis
R1998 T8130 T8115 punct ", ",were
R1999 T8131 T8132 amod many,pups
R2000 T8005 T8002 dobj basis,assess
R2001 T8132 T8115 nsubj pups,were
R2002 T8133 T8132 nmod KA,pups
R2003 T8134 T8132 amod mutant,pups
R2004 T8135 T8136 advmod considerably,smaller
R2005 T8006 T8005 prep for,basis
R2006 T8136 T8115 acomp smaller,were
R2007 T8137 T8136 prep than,smaller
R2008 T8138 T8139 poss their,littermates
R2009 T8007 T8008 det the,lethality
R2010 T8139 T8137 pobj littermates,than
R2011 T8008 T8006 pobj lethality,for
R2012 T8009 T8008 amod neonatal,lethality
R2013 T8010 T8008 prep of,lethality
R2014 T8140 T8141 punct (,2B
R2015 T8141 T8115 parataxis 2B,were
R2016 T8011 T8012 compound KA,mutants
R2017 T8142 T8141 compound Figure,2B
R2018 T8143 T8144 punct –,2F
R2019 T8144 T8141 prep 2F,2B
R2020 T8012 T8010 pobj mutants,of
R2021 T8145 T8141 punct ),2B
R2022 T8146 T8115 cc and,were
R2023 T8013 T8003 punct ", ",monitored
R2024 T8147 T8148 nsubj some,died
R2025 T8148 T8115 conj died,were
R2026 T8149 T8148 aux have,died
R2027 T8014 T8003 nsubj we,monitored
R2028 T8150 T8148 prep at,died
R2029 T8151 T8150 cc or,at
R2030 T8015 T8016 nummod three,litters
R2031 T8152 T8153 amod prior,to
R2032 T8153 T8150 conj to,at
R2033 T8154 T8155 det this,age
R2034 T8016 T8003 dobj litters,monitored
R2035 T8155 T8153 pobj age,to
R2036 T8156 T8115 punct .,were
R2037 T8017 T8003 prep from,monitored
R2038 T8158 T8159 nsubj None,survived
R2039 T8018 T8017 pobj birth,from
R2040 T8160 T8158 prep of,None
R2041 T8161 T8162 compound KA,mutants
R2042 T8162 T8160 pobj mutants,of
R2043 T8019 T8003 prep to,monitored
R2044 T8163 T8159 prep to,survived
R2045 T8164 T8165 amod weaning,age
R2046 T8165 T8163 pobj age,to
R2047 T8020 T8019 pobj weaning,to
R2048 T8166 T8159 punct .,survived
R2049 T8021 T8003 prep by,monitored
R2052 T8022 T8021 pcomp measuring,by
R2059 T8023 T8024 det the,weight
R2063 T8024 T8022 dobj weight,measuring
R2068 T8025 T8024 compound body,weight
R2073 T8026 T8024 prep of,weight
R2077 T8027 T8028 det each,pup
R2079 T8028 T8026 pobj pup,of
R2081 T8029 T8030 det every,day
R2085 T8030 T8022 npadvmod day,measuring
R2088 T8031 T8003 punct .,monitored
R2091 T8033 T8034 quantmod A,25