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PMC:1435744 / 5165-6300 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T4133 0-3 NN denotes SAM
T4134 4-11 NNS denotes domains
T4136 12-13 -LRB- denotes (
T4137 13-17 RB denotes also
T4138 18-23 VBN denotes known
T4139 24-26 IN denotes as
T4140 27-34 JJ denotes Pointed
T4142 34-36 , denotes ,
T4143 36-39 NN denotes HLH
T4144 39-41 , denotes ,
T4145 41-43 CC denotes or
T4146 44-47 NN denotes SPM
T4141 48-55 NNS denotes domains
T4147 55-56 -RRB- denotes )
T4135 57-60 VBP denotes are
T4148 61-62 SYM denotes ~
T4149 62-64 CD denotes 70
T4150 65-73 NNS denotes residues
T4151 74-78 JJ denotes long
T4152 79-82 CC denotes and
T4153 83-87 VBP denotes have
T4155 88-92 VBN denotes been
T4154 93-101 VBN denotes reported
T4156 102-104 IN denotes as
T4157 105-111 JJ denotes common
T4159 112-119 NN denotes protein
T4161 119-120 HYPH denotes -
T4160 120-127 NN denotes protein
T4162 128-139 NN denotes interaction
T4158 140-147 NNS denotes modules
T4163 148-149 -LRB- denotes [
T4164 149-151 CD denotes 15
T4165 151-152 SYM denotes -
T4166 152-154 CD denotes 17
T4167 154-155 -RRB- denotes ]
T4168 155-156 . denotes .
T4169 156-518 sentence denotes This domain is found in a large number of proteins, including Polycomb group (PcG) proteins [18], serine threonine kinases [19], Eph family receptor tyrosine kinases [20], the p73 tumor suppressor [21], the RNA-binding protein Smaug [22], diacylglycerol kinases [23,24], yeast mating type signaling proteins [19,25] and ETS family transcription factors [26,27].
T4170 157-161 DT denotes This
T4171 162-168 NN denotes domain
T4173 169-171 VBZ denotes is
T4172 172-177 VBN denotes found
T4174 178-180 IN denotes in
T4175 181-182 DT denotes a
T4177 183-188 JJ denotes large
T4176 189-195 NN denotes number
T4178 196-198 IN denotes of
T4179 199-207 NN denotes proteins
T4180 207-209 , denotes ,
T4181 209-218 VBG denotes including
T4182 219-227 NN denotes Polycomb
T4183 228-233 NN denotes group
T4185 234-235 -LRB- denotes (
T4186 235-238 NN denotes PcG
T4187 238-239 -RRB- denotes )
T4184 240-248 NN denotes proteins
T4188 249-250 -LRB- denotes [
T4189 250-252 CD denotes 18
T4190 252-253 -RRB- denotes ]
T4191 253-255 , denotes ,
T4192 255-261 NN denotes serine
T4194 262-271 NN denotes threonine
T4193 272-279 NNS denotes kinases
T4195 280-281 -LRB- denotes [
T4196 281-283 CD denotes 19
T4197 283-284 -RRB- denotes ]
T4198 284-286 , denotes ,
T4199 286-289 NN denotes Eph
T4200 290-296 NN denotes family
T4202 297-305 NN denotes receptor
T4203 306-314 NN denotes tyrosine
T4201 315-322 NNS denotes kinases
T4204 323-324 -LRB- denotes [
T4205 324-326 CD denotes 20
T4206 326-327 -RRB- denotes ]
T4207 327-329 , denotes ,
T4208 329-332 DT denotes the
T4210 333-336 NN denotes p73
T4211 337-342 NN denotes tumor
T4209 343-353 NN denotes suppressor
T4212 354-355 -LRB- denotes [
T4213 355-357 CD denotes 21
T4214 357-358 -RRB- denotes ]
T4215 358-360 , denotes ,
T4216 360-363 DT denotes the
T4218 364-367 NN denotes RNA
T4220 367-368 HYPH denotes -
T4219 368-375 VBG denotes binding
T4217 376-383 NN denotes protein
T4221 384-389 NN denotes Smaug
T4222 390-391 -LRB- denotes [
T4223 391-393 CD denotes 22
T4224 393-394 -RRB- denotes ]
T4225 394-396 , denotes ,
T4226 396-410 NN denotes diacylglycerol
T4227 411-418 NNS denotes kinases
T4228 419-420 -LRB- denotes [
T4230 420-422 CD denotes 23
T4231 422-423 , denotes ,
T4229 423-425 CD denotes 24
T4232 425-426 -RRB- denotes ]
T4233 426-428 , denotes ,
T4234 428-433 NN denotes yeast
T4236 434-440 NN denotes mating
T4235 441-445 NN denotes type
T4238 446-455 NN denotes signaling
T4237 456-464 NN denotes proteins
T4239 465-466 -LRB- denotes [
T4241 466-468 CD denotes 19
T4242 468-469 , denotes ,
T4240 469-471 CD denotes 25
T4243 471-472 -RRB- denotes ]
T4244 473-476 CC denotes and
T4245 477-480 NN denotes ETS
T4246 481-487 NN denotes family
T4248 488-501 NN denotes transcription
T4247 502-509 NNS denotes factors
T4249 510-511 -LRB- denotes [
T4251 511-513 CD denotes 26
T4252 513-514 , denotes ,
T4250 514-516 CD denotes 27
T4253 516-517 -RRB- denotes ]
T4254 517-518 . denotes .
T4255 518-623 sentence denotes The PcG proteins are transcriptional repressors that maintain gene silencing during development [28-30].
T4256 519-522 DT denotes The
T4258 523-526 NN denotes PcG
T4257 527-535 NN denotes proteins
T4259 536-539 VBP denotes are
T4260 540-555 JJ denotes transcriptional
T4261 556-566 NNS denotes repressors
T4262 567-571 WDT denotes that
T4263 572-580 VBP denotes maintain
T4264 581-585 NN denotes gene
T4265 586-595 NN denotes silencing
T4266 596-602 IN denotes during
T4267 603-614 NN denotes development
T4268 615-616 -LRB- denotes [
T4269 616-618 CD denotes 28
T4270 618-619 SYM denotes -
T4271 619-621 CD denotes 30
T4272 621-622 -RRB- denotes ]
T4273 622-623 . denotes .
T4274 623-692 sentence denotes In mammals, PcG proteins are also implicated in Hox gene regulation.
T4275 624-626 IN denotes In
T4277 627-634 NNS denotes mammals
T4278 634-636 , denotes ,
T4279 636-639 NN denotes PcG
T4280 640-648 NN denotes proteins
T4281 649-652 VBP denotes are
T4282 653-657 RB denotes also
T4276 658-668 VBN denotes implicated
T4283 669-671 IN denotes in
T4284 672-675 NN denotes Hox
T4285 676-680 NN denotes gene
T4286 681-691 NN denotes regulation
T4287 691-692 . denotes .
T4288 692-802 sentence denotes Their biological activity lies in stable silencing of specific sets of genes through chromatin modifications.
T4289 693-698 PRP$ denotes Their
T4291 699-709 JJ denotes biological
T4290 710-718 NN denotes activity
T4292 719-723 VBZ denotes lies
T4293 724-726 IN denotes in
T4294 727-733 JJ denotes stable
T4295 734-743 NN denotes silencing
T4296 744-746 IN denotes of
T4297 747-755 JJ denotes specific
T4298 756-760 NNS denotes sets
T4299 761-763 IN denotes of
T4300 764-769 NNS denotes genes
T4301 770-777 IN denotes through
T4302 778-787 NN denotes chromatin
T4303 788-801 NNS denotes modifications
T4304 801-802 . denotes .
T4305 802-991 sentence denotes A member of polycomb repressive complex 1 (PRC1), ph, contains a SAM domain at the C-terminal, and PRC1 complex is known to form helical, head-to-tail polymers through its SAM domain [31].
T4306 803-804 DT denotes A
T4307 805-811 NN denotes member
T4309 812-814 IN denotes of
T4310 815-823 NN denotes polycomb
T4312 824-834 JJ denotes repressive
T4311 835-842 NN denotes complex
T4313 843-844 CD denotes 1
T4314 845-846 -LRB- denotes (
T4315 846-850 NN denotes PRC1
T4316 850-851 -RRB- denotes )
T4317 851-853 , denotes ,
T4318 853-855 NN denotes ph
T4319 855-857 , denotes ,
T4308 857-865 VBZ denotes contains
T4320 866-867 DT denotes a
T4322 868-871 NN denotes SAM
T4321 872-878 NN denotes domain
T4323 879-881 IN denotes at
T4324 882-885 DT denotes the
T4326 886-887 NN denotes C
T4327 887-888 HYPH denotes -
T4325 888-896 NN denotes terminal
T4328 896-898 , denotes ,
T4329 898-901 CC denotes and
T4330 902-906 NN denotes PRC1
T4331 907-914 NN denotes complex
T4333 915-917 VBZ denotes is
T4332 918-923 VBN denotes known
T4334 924-926 TO denotes to
T4335 927-931 VB denotes form
T4336 932-939 JJ denotes helical
T4338 939-941 , denotes ,
T4339 941-945 NN denotes head
T4340 945-946 HYPH denotes -
T4341 946-948 IN denotes to
T4342 948-949 HYPH denotes -
T4343 949-953 NN denotes tail
T4337 954-962 NNS denotes polymers
T4344 963-970 IN denotes through
T4345 971-974 PRP$ denotes its
T4347 975-978 NN denotes SAM
T4346 979-985 NN denotes domain
T4348 986-987 -LRB- denotes [
T4349 987-989 CD denotes 31
T4350 989-990 -RRB- denotes ]
T4351 990-991 . denotes .
T4352 991-1135 sentence denotes These polymeric structures mediate the formation of a higher order chromatin structure and possibly stabilize the repressed state of Hox genes.
T4353 992-997 DT denotes These
T4355 998-1007 JJ denotes polymeric
T4354 1008-1018 NNS denotes structures
T4356 1019-1026 VBP denotes mediate
T4357 1027-1030 DT denotes the
T4358 1031-1040 NN denotes formation
T4359 1041-1043 IN denotes of
T4360 1044-1045 DT denotes a
T4362 1046-1052 JJR denotes higher
T4363 1053-1058 NN denotes order
T4364 1059-1068 NN denotes chromatin
T4361 1069-1078 NN denotes structure
T4365 1079-1082 CC denotes and
T4366 1083-1091 RB denotes possibly
T4367 1092-1101 VBP denotes stabilize
T4368 1102-1105 DT denotes the
T4370 1106-1115 VBN denotes repressed
T4369 1116-1121 NN denotes state
T4371 1122-1124 IN denotes of
T4372 1125-1128 NN denotes Hox
T4373 1129-1134 NNS denotes genes
T4374 1134-1135 . denotes .
R1000 T4279 T4280 compound PcG,proteins
R1002 T4280 T4276 nsubjpass proteins,implicated
R1003 T4281 T4276 auxpass are,implicated
R1004 T4282 T4276 advmod also,implicated
R1006 T4283 T4276 prep in,implicated
R1007 T4284 T4285 compound Hox,gene
R1009 T4285 T4286 compound gene,regulation
R1010 T4286 T4283 pobj regulation,in
R1011 T4287 T4276 punct .,implicated
R1013 T4289 T4290 poss Their,activity
R1014 T4290 T4292 nsubj activity,lies
R1016 T4291 T4290 amod biological,activity
R1018 T4293 T4292 prep in,lies
R1019 T4294 T4295 amod stable,silencing
R1020 T4295 T4293 pobj silencing,in
R1021 T4296 T4295 prep of,silencing
R1022 T4297 T4298 amod specific,sets
R1023 T4298 T4296 pobj sets,of
R1025 T4299 T4298 prep of,sets
R1026 T4300 T4299 pobj genes,of
R1027 T4301 T4295 prep through,silencing
R1029 T4302 T4303 compound chromatin,modifications
R1030 T4303 T4301 pobj modifications,through
R1031 T4304 T4292 punct .,lies
R1033 T4306 T4307 det A,member
R1035 T4307 T4308 nsubj member,contains
R1036 T4309 T4307 prep of,member
R1038 T4310 T4311 nmod polycomb,complex
R1039 T4311 T4309 pobj complex,of
R1040 T4312 T4311 amod repressive,complex
R1042 T4313 T4311 nummod 1,complex
R1043 T4314 T4311 punct (,complex
R1045 T4315 T4311 appos PRC1,complex
R1046 T4316 T4307 punct ),member
R1047 T4317 T4307 punct ", ",member
R1049 T4318 T4307 appos ph,member
R1050 T4319 T4308 punct ", ",contains
R1051 T4320 T4321 det a,domain
R1053 T4321 T4308 dobj domain,contains
R1054 T4322 T4321 compound SAM,domain
R1056 T4323 T4308 prep at,contains
R1057 T4324 T4325 det the,terminal
R1058 T4325 T4323 pobj terminal,at
R1059 T4133 T4134 compound SAM,domains
R1060 T4326 T4325 compound C,terminal
R1061 T4327 T4325 punct -,terminal
R1062 T4134 T4135 nsubj domains,are
R1063 T4328 T4308 punct ", ",contains
R1064 T4136 T4134 punct (,domains
R1065 T4329 T4308 cc and,contains
R1066 T4330 T4331 compound PRC1,complex
R1067 T4331 T4332 nsubjpass complex,known
R1068 T4332 T4308 conj known,contains
R1069 T4137 T4138 advmod also,known
R1070 T4333 T4332 auxpass is,known
R1071 T4334 T4335 aux to,form
R1072 T4138 T4134 acl known,domains
R1073 T4335 T4332 xcomp form,known
R1074 T4336 T4337 amod helical,polymers
R1075 T4337 T4335 dobj polymers,form
R1076 T4338 T4337 punct ", ",polymers
R1077 T4339 T4337 nmod head,polymers
R1078 T4139 T4138 prep as,known
R1079 T4340 T4339 punct -,head
R1080 T4341 T4339 prep to,head
R1081 T4140 T4141 amod Pointed,domains
R1082 T4342 T4341 punct -,to
R1083 T4343 T4341 pobj tail,to
R1084 T4344 T4335 prep through,form
R1085 T4345 T4346 poss its,domain
R1086 T4141 T4139 pobj domains,as
R1087 T4346 T4344 pobj domain,through
R1088 T4347 T4346 compound SAM,domain
R1089 T4142 T4140 punct ", ",Pointed
R1090 T4348 T4349 punct [,31
R1091 T4349 T4335 parataxis 31,form
R1092 T4350 T4349 punct ],31
R1093 T4143 T4140 conj HLH,Pointed
R1094 T4351 T4332 punct .,known
R1095 T4353 T4354 det These,structures
R1096 T4144 T4143 punct ", ",HLH
R1097 T4354 T4356 nsubj structures,mediate
R1098 T4355 T4354 amod polymeric,structures
R1099 T4145 T4143 cc or,HLH
R1100 T4357 T4358 det the,formation
R1101 T4358 T4356 dobj formation,mediate
R1102 T4359 T4358 prep of,formation
R1103 T4146 T4143 conj SPM,HLH
R1104 T4360 T4361 det a,structure
R1105 T4361 T4359 pobj structure,of
R1106 T4147 T4134 punct ),domains
R1107 T4362 T4363 amod higher,order
R1108 T4363 T4361 compound order,structure
R1109 T4364 T4361 compound chromatin,structure
R1110 T4148 T4149 punct ~,70
R1111 T4365 T4356 cc and,mediate
R1112 T4366 T4367 advmod possibly,stabilize
R1113 T4149 T4150 nummod 70,residues
R1114 T4367 T4356 conj stabilize,mediate
R1115 T4150 T4151 npadvmod residues,long
R1116 T4151 T4135 acomp long,are
R1117 T4368 T4369 det the,state
R1118 T4369 T4367 dobj state,stabilize
R1119 T4152 T4135 cc and,are
R1120 T4370 T4369 amod repressed,state
R1121 T4371 T4369 prep of,state
R1122 T4153 T4154 aux have,reported
R1123 T4372 T4373 compound Hox,genes
R1124 T4373 T4371 pobj genes,of
R1125 T4374 T4356 punct .,mediate
R1127 T4154 T4135 conj reported,are
R1131 T4155 T4154 auxpass been,reported
R1135 T4156 T4154 prep as,reported
R1139 T4157 T4158 amod common,modules
R1143 T4158 T4156 pobj modules,as
R842 T4159 T4160 compound protein,protein
R843 T4160 T4162 compound protein,interaction
R845 T4161 T4160 punct -,protein
R846 T4162 T4158 compound interaction,modules
R848 T4163 T4164 punct [,15
R849 T4164 T4154 parataxis 15,reported
R851 T4165 T4166 punct -,17
R852 T4166 T4164 prep 17,15
R853 T4167 T4164 punct ],15
R855 T4168 T4135 punct .,are
R857 T4170 T4171 det This,domain
R858 T4171 T4172 nsubjpass domain,found
R860 T4173 T4172 auxpass is,found
R861 T4174 T4172 prep in,found
R862 T4175 T4176 det a,number
R863 T4176 T4174 pobj number,in
R864 T4177 T4176 amod large,number
R865 T4178 T4176 prep of,number
R867 T4179 T4178 pobj proteins,of
R868 T4180 T4176 punct ", ",number
R869 T4181 T4176 prep including,number
R870 T4182 T4183 nmod Polycomb,group
R872 T4183 T4184 nmod group,proteins
R873 T4184 T4181 pobj proteins,including
R874 T4185 T4183 punct (,group
R876 T4186 T4183 appos PcG,group
R877 T4187 T4184 punct ),proteins
R879 T4188 T4189 punct [,18
R880 T4189 T4184 parataxis 18,proteins
R881 T4190 T4189 punct ],18
R882 T4191 T4184 punct ", ",proteins
R884 T4192 T4193 compound serine,kinases
R885 T4193 T4184 conj kinases,proteins
R887 T4194 T4193 compound threonine,kinases
R888 T4195 T4196 punct [,19
R889 T4196 T4193 parataxis 19,kinases
R891 T4197 T4196 punct ],19
R892 T4198 T4193 punct ", ",kinases
R893 T4199 T4200 compound Eph,family
R895 T4200 T4201 compound family,kinases
R896 T4201 T4193 conj kinases,kinases
R897 T4202 T4201 compound receptor,kinases
R899 T4203 T4201 compound tyrosine,kinases
R900 T4204 T4205 punct [,20
R902 T4205 T4201 parataxis 20,kinases
R903 T4206 T4205 punct ],20
R904 T4207 T4201 punct ", ",kinases
R906 T4208 T4209 det the,suppressor
R908 T4209 T4201 conj suppressor,kinases
R909 T4210 T4209 compound p73,suppressor
R910 T4211 T4209 compound tumor,suppressor
R911 T4212 T4213 punct [,21
R913 T4213 T4209 parataxis 21,suppressor
R914 T4214 T4213 punct ],21
R915 T4215 T4209 punct ", ",suppressor
R916 T4216 T4217 det the,protein
R917 T4217 T4209 conj protein,suppressor
R918 T4218 T4219 npadvmod RNA,binding
R920 T4219 T4217 amod binding,protein
R921 T4220 T4219 punct -,binding
R922 T4221 T4217 appos Smaug,protein
R924 T4222 T4223 punct [,22
R925 T4223 T4217 parataxis 22,protein
R926 T4224 T4223 punct ],22
R928 T4225 T4217 punct ", ",protein
R929 T4226 T4227 compound diacylglycerol,kinases
R930 T4227 T4217 conj kinases,protein
R932 T4228 T4229 punct [,24
R933 T4229 T4227 parataxis 24,kinases
R934 T4230 T4229 nummod 23,24
R936 T4231 T4229 punct ",",24
R937 T4232 T4229 punct ],24
R939 T4233 T4227 punct ", ",kinases
R940 T4234 T4235 compound yeast,type
R941 T4235 T4237 compound type,proteins
R942 T4236 T4235 compound mating,type
R944 T4237 T4227 conj proteins,kinases
R945 T4238 T4237 compound signaling,proteins
R947 T4239 T4240 punct [,25
R948 T4240 T4237 parataxis 25,proteins
R950 T4241 T4240 nummod 19,25
R951 T4242 T4240 punct ",",25
R952 T4243 T4240 punct ],25
R954 T4244 T4237 cc and,proteins
R955 T4245 T4246 compound ETS,family
R956 T4246 T4247 compound family,factors
R958 T4247 T4237 conj factors,proteins
R960 T4248 T4247 compound transcription,factors
R961 T4249 T4250 punct [,27
R962 T4250 T4247 parataxis 27,factors
R963 T4251 T4250 nummod 26,27
R965 T4252 T4250 punct ",",27
R966 T4253 T4250 punct ],27
R967 T4254 T4172 punct .,found
R968 T4256 T4257 det The,proteins
R969 T4257 T4259 nsubj proteins,are
R971 T4258 T4257 compound PcG,proteins
R972 T4260 T4261 amod transcriptional,repressors
R973 T4261 T4259 attr repressors,are
R975 T4262 T4263 dep that,maintain
R980 T4263 T4261 relcl maintain,repressors
R981 T4264 T4265 compound gene,silencing
R983 T4265 T4263 dobj silencing,maintain
R984 T4266 T4263 prep during,maintain
R986 T4267 T4266 pobj development,during
R987 T4268 T4269 punct [,28
R989 T4269 T4259 parataxis 28,are
R990 T4270 T4271 punct -,30
R991 T4271 T4269 prep 30,28
R993 T4272 T4269 punct ],28
R994 T4273 T4259 punct .,are
R996 T4275 T4276 prep In,implicated
R997 T4277 T4275 pobj mammals,In
R999 T4278 T4276 punct ", ",implicated