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PMC:1435744 / 37321-38296 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T21891 0-3 CD denotes Two
T21893 4-12 JJ denotes distinct
T21894 13-25 NN denotes multiprotein
T21895 26-29 NN denotes PcG
T21892 30-39 NNS denotes complexes
T21897 39-41 , denotes ,
T21898 41-45 NN denotes PRC1
T21899 46-49 CC denotes and
T21900 50-54 NN denotes PRC2
T21901 54-56 , denotes ,
T21902 56-60 VBP denotes have
T21903 61-65 VBN denotes been
T21896 66-76 VBN denotes identified
T21904 76-77 . denotes .
T21905 77-276 sentence denotes PRC2 is involved in the initiation of silencing and contains histone deacetylases (HDACs) and histone methyltransferases, which can methylate histone H3 lysine 9 and 27, marks of silenced chromatin.
T21906 78-82 NN denotes PRC2
T21908 83-85 VBZ denotes is
T21907 86-94 VBN denotes involved
T21909 95-97 IN denotes in
T21910 98-101 DT denotes the
T21911 102-112 NN denotes initiation
T21912 113-115 IN denotes of
T21913 116-125 NN denotes silencing
T21914 126-129 CC denotes and
T21915 130-138 VBZ denotes contains
T21916 139-146 NN denotes histone
T21917 147-159 NNS denotes deacetylases
T21918 160-161 -LRB- denotes (
T21919 161-166 NNS denotes HDACs
T21920 166-167 -RRB- denotes )
T21921 168-171 CC denotes and
T21922 172-179 NN denotes histone
T21923 180-198 NNS denotes methyltransferases
T21924 198-200 , denotes ,
T21925 200-205 WDT denotes which
T21927 206-209 MD denotes can
T21926 210-219 VB denotes methylate
T21928 220-227 NN denotes histone
T21930 228-230 NN denotes H3
T21931 231-237 NN denotes lysine
T21929 238-239 CD denotes 9
T21932 240-243 CC denotes and
T21933 244-246 CD denotes 27
T21934 246-248 , denotes ,
T21935 248-253 NNS denotes marks
T21936 254-256 IN denotes of
T21937 257-265 VBN denotes silenced
T21938 266-275 NN denotes chromatin
T21939 275-276 . denotes .
T21940 276-495 sentence denotes PRC1, including ph, recognizes the histone H3 lysine 27 mark set by PRC2 and maintains a stable state of gene repression in which PRC1 blocks chromatin remodeling by the trithorax group-related SWI-SNF complex [46,47].
T21941 277-281 NN denotes PRC1
T21943 281-283 , denotes ,
T21944 283-292 VBG denotes including
T21945 293-295 NN denotes ph
T21946 295-297 , denotes ,
T21942 297-307 VBZ denotes recognizes
T21947 308-311 DT denotes the
T21949 312-319 NN denotes histone
T21950 320-322 NN denotes H3
T21951 323-329 NN denotes lysine
T21952 330-332 CD denotes 27
T21948 333-337 NN denotes mark
T21953 338-341 VBN denotes set
T21954 342-344 IN denotes by
T21955 345-349 NN denotes PRC2
T21956 350-353 CC denotes and
T21957 354-363 VBZ denotes maintains
T21958 364-365 DT denotes a
T21960 366-372 JJ denotes stable
T21959 373-378 NN denotes state
T21961 379-381 IN denotes of
T21962 382-386 NN denotes gene
T21963 387-397 NN denotes repression
T21964 398-400 IN denotes in
T21966 401-406 WDT denotes which
T21967 407-411 NN denotes PRC1
T21965 412-418 VBZ denotes blocks
T21968 419-428 NN denotes chromatin
T21969 429-439 NN denotes remodeling
T21970 440-442 IN denotes by
T21971 443-446 DT denotes the
T21973 447-456 NN denotes trithorax
T21974 457-462 NN denotes group
T21976 462-463 HYPH denotes -
T21975 463-470 VBN denotes related
T21977 471-474 NN denotes SWI
T21979 474-475 HYPH denotes -
T21978 475-478 NN denotes SNF
T21972 479-486 NN denotes complex
T21980 487-488 -LRB- denotes [
T21982 488-490 CD denotes 46
T21983 490-491 , denotes ,
T21981 491-493 CD denotes 47
T21984 493-494 -RRB- denotes ]
T21985 494-495 . denotes .
T21986 495-648 sentence denotes Therefore, the mechanism of repression by PRC2 is thought to be HDAC-dependent while the mechanism of repression by PRC1 appears to be HDAC-independent.
T21987 496-505 RB denotes Therefore
T21989 505-507 , denotes ,
T21990 507-510 DT denotes the
T21991 511-520 NN denotes mechanism
T21992 521-523 IN denotes of
T21993 524-534 NN denotes repression
T21994 535-537 IN denotes by
T21995 538-542 NN denotes PRC2
T21996 543-545 VBZ denotes is
T21988 546-553 VBN denotes thought
T21997 554-556 TO denotes to
T21998 557-559 VB denotes be
T21999 560-564 NN denotes HDAC
T22001 564-565 HYPH denotes -
T22000 565-574 JJ denotes dependent
T22002 575-580 IN denotes while
T22004 581-584 DT denotes the
T22005 585-594 NN denotes mechanism
T22006 595-597 IN denotes of
T22007 598-608 NN denotes repression
T22008 609-611 IN denotes by
T22009 612-616 NN denotes PRC1
T22003 617-624 VBZ denotes appears
T22010 625-627 TO denotes to
T22011 628-630 VB denotes be
T22012 631-635 NN denotes HDAC
T22014 635-636 HYPH denotes -
T22013 636-647 JJ denotes independent
T22015 647-648 . denotes .
T22016 648-844 sentence denotes Our luciferase assay also showed that transcriptional repression of DBD-mrs was not affected by the addition of various concentrations of trichostatin A, a potent HDAC inhibitor (data not shown).
T22017 649-652 PRP$ denotes Our
T22019 653-663 NN denotes luciferase
T22018 664-669 NN denotes assay
T22021 670-674 RB denotes also
T22020 675-681 VBD denotes showed
T22022 682-686 IN denotes that
T22024 687-702 JJ denotes transcriptional
T22025 703-713 NN denotes repression
T22026 714-716 IN denotes of
T22027 717-720 NN denotes DBD
T22029 720-721 HYPH denotes -
T22028 721-724 NN denotes mrs
T22030 725-728 VBD denotes was
T22031 729-732 RB denotes not
T22023 733-741 VBN denotes affected
T22032 742-744 IN denotes by
T22033 745-748 DT denotes the
T22034 749-757 NN denotes addition
T22035 758-760 IN denotes of
T22036 761-768 JJ denotes various
T22037 769-783 NNS denotes concentrations
T22038 784-786 IN denotes of
T22039 787-799 NN denotes trichostatin
T22040 800-801 NN denotes A
T22041 801-803 , denotes ,
T22042 803-804 DT denotes a
T22044 805-811 JJ denotes potent
T22045 812-816 NN denotes HDAC
T22043 817-826 NN denotes inhibitor
T22046 827-828 -LRB- denotes (
T22048 828-832 NNS denotes data
T22049 833-836 RB denotes not
T22047 837-842 VBN denotes shown
T22050 842-843 -RRB- denotes )
T22051 843-844 . denotes .
T22052 844-975 sentence denotes Therefore, we speculate that the mechanism of repression of mr-s may be HDAC-independent and more similar to that of PRC1 complex.
T22053 845-854 RB denotes Therefore
T22055 854-856 , denotes ,
T22056 856-858 PRP denotes we
T22054 859-868 VBP denotes speculate
T22057 869-873 IN denotes that
T22059 874-877 DT denotes the
T22060 878-887 NN denotes mechanism
T22061 888-890 IN denotes of
T22062 891-901 NN denotes repression
T22063 902-904 IN denotes of
T22064 905-907 NN denotes mr
T22066 907-908 HYPH denotes -
T22065 908-909 NN denotes s
T22067 910-913 MD denotes may
T22058 914-916 VB denotes be
T22068 917-921 NN denotes HDAC
T22070 921-922 HYPH denotes -
T22069 922-933 JJ denotes independent
T22071 934-937 CC denotes and
T22072 938-942 RBR denotes more
T22073 943-950 JJ denotes similar
T22074 951-953 IN denotes to
T22075 954-958 DT denotes that
T22076 959-961 IN denotes of
T22077 962-966 NN denotes PRC1
T22078 967-974 NN denotes complex
T22079 974-975 . denotes .
R5969 T21891 T21892 nummod Two,complexes
R5971 T21892 T21896 nsubjpass complexes,identified
R5972 T21893 T21892 amod distinct,complexes
R5974 T21894 T21892 compound multiprotein,complexes
R5975 T21895 T21892 compound PcG,complexes
R5977 T21897 T21892 punct ", ",complexes
R5978 T21898 T21892 appos PRC1,complexes
R5980 T21899 T21898 cc and,PRC1
R5981 T21900 T21898 conj PRC2,PRC1
R5982 T21901 T21896 punct ", ",identified
R5984 T21902 T21896 aux have,identified
R5985 T21903 T21896 auxpass been,identified
R5987 T21904 T21896 punct .,identified
R5988 T21906 T21907 nsubjpass PRC2,involved
R5990 T21908 T21907 auxpass is,involved
R5991 T21909 T21907 prep in,involved
R5993 T21910 T21911 det the,initiation
R5997 T21911 T21909 pobj initiation,in
R5998 T21912 T21911 prep of,initiation
R5999 T21913 T21912 pobj silencing,of
R6001 T21914 T21907 cc and,involved
R6002 T21915 T21907 conj contains,involved
R6004 T21916 T21917 compound histone,deacetylases
R6005 T21917 T21915 dobj deacetylases,contains
R6006 T21918 T21917 punct (,deacetylases
R6008 T21919 T21917 appos HDACs,deacetylases
R6010 T21920 T21917 punct ),deacetylases
R6011 T21921 T21917 cc and,deacetylases
R6012 T21922 T21923 compound histone,methyltransferases
R6013 T21923 T21917 conj methyltransferases,deacetylases
R6015 T21924 T21917 punct ", ",deacetylases
R6016 T21925 T21926 dep which,methylate
R6017 T21926 T21917 relcl methylate,deacetylases
R6018 T21927 T21926 aux can,methylate
R6019 T21928 T21929 nmod histone,9
R6020 T21929 T21926 dobj 9,methylate
R6022 T21930 T21929 nmod H3,9
R6023 T21931 T21929 nmod lysine,9
R6024 T21932 T21929 cc and,9
R6026 T21933 T21929 conj 27,9
R6027 T21934 T21929 punct ", ",9
R6028 T21935 T21929 appos marks,9
R6030 T21936 T21935 prep of,marks
R6031 T21937 T21938 amod silenced,chromatin
R6032 T21938 T21936 pobj chromatin,of
R6034 T21939 T21907 punct .,involved
R6035 T21941 T21942 nsubj PRC1,recognizes
R6037 T21943 T21941 punct ", ",PRC1
R6039 T21944 T21941 prep including,PRC1
R6040 T21945 T21944 pobj ph,including
R6041 T21946 T21942 punct ", ",recognizes
R6042 T22017 T22018 poss Our,assay
R6043 T21947 T21948 det the,mark
R6044 T21948 T21942 dobj mark,recognizes
R6045 T21949 T21948 nmod histone,mark
R6046 T21950 T21948 nmod H3,mark
R6047 T22018 T22020 nsubj assay,showed
R6048 T21951 T21948 nmod lysine,mark
R6049 T21952 T21951 nummod 27,lysine
R6050 T21953 T21948 acl set,mark
R6051 T22019 T22018 compound luciferase,assay
R6052 T21954 T21953 agent by,set
R6053 T21955 T21954 pobj PRC2,by
R6054 T22021 T22020 advmod also,showed
R6055 T21956 T21942 cc and,recognizes
R6056 T21957 T21942 conj maintains,recognizes
R6057 T21958 T21959 det a,state
R6058 T21959 T21957 dobj state,maintains
R6059 T22022 T22023 mark that,affected
R6060 T21960 T21959 amod stable,state
R6061 T22023 T22020 ccomp affected,showed
R6062 T21961 T21959 prep of,state
R6063 T21962 T21963 compound gene,repression
R6064 T21963 T21961 pobj repression,of
R6065 T21964 T21965 prep in,blocks
R6066 T22024 T22025 amod transcriptional,repression
R6067 T21965 T21959 relcl blocks,state
R6068 T21966 T21964 pobj which,in
R6069 T21967 T21965 nsubj PRC1,blocks
R6070 T21968 T21969 compound chromatin,remodeling
R6071 T21969 T21965 dobj remodeling,blocks
R6072 T21970 T21969 prep by,remodeling
R6073 T22025 T22023 nsubjpass repression,affected
R6074 T21971 T21972 det the,complex
R6075 T22026 T22025 prep of,repression
R6076 T21972 T21970 pobj complex,by
R6077 T22027 T22028 compound DBD,mrs
R6078 T21973 T21972 nmod trithorax,complex
R6079 T21974 T21975 npadvmod group,related
R6080 T22028 T22026 pobj mrs,of
R6081 T21975 T21972 amod related,complex
R6082 T21976 T21975 punct -,related
R6083 T21977 T21978 compound SWI,SNF
R6084 T22029 T22028 punct -,mrs
R6085 T21978 T21972 compound SNF,complex
R6086 T21979 T21978 punct -,SNF
R6087 T22030 T22023 auxpass was,affected
R6088 T21980 T21981 punct [,47
R6089 T21981 T21965 parataxis 47,blocks
R6090 T22031 T22023 neg not,affected
R6091 T21982 T21981 nummod 46,47
R6092 T21983 T21981 punct ",",47
R6093 T21984 T21981 punct ],47
R6094 T22032 T22023 agent by,affected
R6095 T21985 T21942 punct .,recognizes
R6096 T22033 T22034 det the,addition
R6097 T21987 T21988 advmod Therefore,thought
R6098 T21989 T21988 punct ", ",thought
R6099 T22034 T22032 pobj addition,by
R6100 T21990 T21991 det the,mechanism
R6101 T21991 T21988 nsubjpass mechanism,thought
R6102 T21992 T21991 prep of,mechanism
R6103 T22035 T22034 prep of,addition
R6104 T21993 T21992 pobj repression,of
R6105 T21994 T21993 prep by,repression
R6106 T21995 T21994 pobj PRC2,by
R6107 T22036 T22037 amod various,concentrations
R6108 T21996 T21988 auxpass is,thought
R6109 T21997 T21998 aux to,be
R6110 T22037 T22035 pobj concentrations,of
R6111 T21998 T21988 xcomp be,thought
R6112 T21999 T22000 npadvmod HDAC,dependent
R6113 T22000 T21998 acomp dependent,be
R6114 T22038 T22037 prep of,concentrations
R6115 T22001 T22000 punct -,dependent
R6116 T22039 T22040 compound trichostatin,A
R6117 T22002 T22003 mark while,appears
R6118 T22003 T21988 advcl appears,thought
R6119 T22004 T22005 det the,mechanism
R6120 T22005 T22003 nsubj mechanism,appears
R6121 T22006 T22005 prep of,mechanism
R6122 T22007 T22006 pobj repression,of
R6123 T22008 T22007 prep by,repression
R6124 T22040 T22038 pobj A,of
R6125 T22009 T22008 pobj PRC1,by
R6126 T22010 T22011 aux to,be
R6127 T22011 T22003 xcomp be,appears
R6128 T22041 T22040 punct ", ",A
R6129 T22012 T22013 npadvmod HDAC,independent
R6130 T22013 T22011 acomp independent,be
R6131 T22014 T22013 punct -,independent
R6132 T22042 T22043 det a,inhibitor
R6133 T22015 T21988 punct .,thought
R6134 T22043 T22040 appos inhibitor,A
R6135 T22044 T22043 amod potent,inhibitor
R6136 T22045 T22043 compound HDAC,inhibitor
R6137 T22046 T22047 punct (,shown
R6140 T22047 T22020 parataxis shown,showed
R6144 T22048 T22047 nsubj data,shown
R6147 T22049 T22047 neg not,shown
R6151 T22050 T22047 punct ),shown
R6155 T22051 T22020 punct .,showed
R6159 T22053 T22054 advmod Therefore,speculate
R6163 T22055 T22054 punct ", ",speculate
R6165 T22056 T22054 nsubj we,speculate
R6168 T22057 T22058 mark that,be
R6174 T22058 T22054 ccomp be,speculate
R6177 T22059 T22060 det the,mechanism
R6180 T22060 T22058 nsubj mechanism,be
R6183 T22061 T22060 prep of,mechanism
R6187 T22062 T22061 pobj repression,of
R6190 T22063 T22062 prep of,repression
R6193 T22064 T22065 compound mr,s
R6196 T22065 T22063 pobj s,of
R6200 T22066 T22065 punct -,s
R6204 T22067 T22058 aux may,be
R6208 T22068 T22069 npadvmod HDAC,independent
R6211 T22069 T22058 acomp independent,be
R6215 T22070 T22069 punct -,independent
R6219 T22071 T22069 cc and,independent
R6221 T22072 T22073 advmod more,similar
R6228 T22073 T22069 conj similar,independent
R6232 T22074 T22073 prep to,similar
R6236 T22075 T22074 pobj that,to
R6238 T22076 T22075 prep of,that
R6241 T22077 T22078 compound PRC1,complex
R6243 T22078 T22076 pobj complex,of
R6244 T22079 T22054 punct .,speculate