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PMC:1435744 / 14988-16028 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T30251 10-13 DT denotes The
T30252 14-27 NN denotes transcription
T30254 28-30 IN denotes of
T30255 31-33 NN denotes mr
T30257 33-34 HYPH denotes -
T30256 34-35 NN denotes s
T30258 36-38 VBZ denotes is
T30253 39-48 VBN denotes regulated
T30259 49-51 IN denotes by
T30260 52-55 NN denotes Crx
T30261 55-56 . denotes .
T30262 56-179 sentence denotes (A, B) In situ hybridization using a probe for mouse mr-s was performed on the wild-type (A) and Crx KO retinas (B) at P5.
T30263 57-58 -LRB- denotes (
T30264 58-59 LS denotes A
T30266 59-61 , denotes ,
T30267 61-62 LS denotes B
T30268 62-63 -RRB- denotes )
T30269 64-66 FW denotes In
T30270 67-71 FW denotes situ
T30271 72-85 NN denotes hybridization
T30272 86-91 VBG denotes using
T30273 92-93 DT denotes a
T30274 94-99 NN denotes probe
T30275 100-103 IN denotes for
T30276 104-109 NN denotes mouse
T30278 110-112 NN denotes mr
T30279 112-113 HYPH denotes -
T30277 113-114 NN denotes s
T30280 115-118 VBD denotes was
T30265 119-128 VBN denotes performed
T30281 129-131 IN denotes on
T30282 132-135 DT denotes the
T30284 136-140 JJ denotes wild
T30286 140-141 HYPH denotes -
T30285 141-145 NN denotes type
T30287 146-147 -LRB- denotes (
T30288 147-148 NN denotes A
T30289 148-149 -RRB- denotes )
T30290 150-153 CC denotes and
T30291 154-157 NN denotes Crx
T30292 158-160 NN denotes KO
T30283 161-168 NNS denotes retinas
T30293 169-170 -LRB- denotes (
T30294 170-171 NN denotes B
T30295 171-172 -RRB- denotes )
T30296 173-175 IN denotes at
T30297 176-178 NN denotes P5
T30298 178-179 . denotes .
T30299 179-245 sentence denotes mr-s expression was drastically reduced in the Crx KO retina (B).
T30300 180-182 NN denotes mr
T30302 182-183 HYPH denotes -
T30301 183-184 NN denotes s
T30303 185-195 NN denotes expression
T30305 196-199 VBD denotes was
T30306 200-211 RB denotes drastically
T30304 212-219 VBN denotes reduced
T30307 220-222 IN denotes in
T30308 223-226 DT denotes the
T30310 227-230 NN denotes Crx
T30311 231-233 NN denotes KO
T30309 234-240 NN denotes retina
T30312 241-242 -LRB- denotes (
T30313 242-243 NN denotes B
T30314 243-244 -RRB- denotes )
T30315 244-245 . denotes .
T30316 245-264 sentence denotes Scale bar, 100 μm.
T30317 246-251 NN denotes Scale
T30318 252-255 NN denotes bar
T30319 255-257 , denotes ,
T30320 257-260 CD denotes 100
T30321 261-263 NN denotes μm
T30322 263-264 . denotes .
T30323 264-365 sentence denotes (C) RT-PCR analysis of total RNAs extracted from the pineal glands of P5 wild-type and Crx KO mouse.
T30324 265-266 -LRB- denotes (
T30325 266-267 LS denotes C
T30327 267-268 -RRB- denotes )
T30328 269-271 NN denotes RT
T30330 271-272 HYPH denotes -
T30329 272-275 NN denotes PCR
T30326 276-284 NN denotes analysis
T30331 285-287 IN denotes of
T30332 288-293 JJ denotes total
T30333 294-298 NNS denotes RNAs
T30334 299-308 VBN denotes extracted
T30335 309-313 IN denotes from
T30336 314-317 DT denotes the
T30338 318-324 JJ denotes pineal
T30337 325-331 NNS denotes glands
T30339 332-334 IN denotes of
T30340 335-337 NN denotes P5
T30342 338-342 JJ denotes wild
T30344 342-343 HYPH denotes -
T30343 343-347 NN denotes type
T30345 348-351 CC denotes and
T30346 352-355 NN denotes Crx
T30347 356-358 NN denotes KO
T30341 359-364 NN denotes mouse
T30348 364-365 . denotes .
T30349 365-488 sentence denotes The upper and lower lanes show PCR products amplified by the primer pairs specific for mr-s and G3PDH cDNAs, respectively.
T30350 366-369 DT denotes The
T30352 370-375 JJ denotes upper
T30353 376-379 CC denotes and
T30354 380-385 JJ denotes lower
T30351 386-391 NNS denotes lanes
T30355 392-396 VBP denotes show
T30356 397-400 NN denotes PCR
T30357 401-409 NNS denotes products
T30358 410-419 VBN denotes amplified
T30359 420-422 IN denotes by
T30360 423-426 DT denotes the
T30362 427-433 NN denotes primer
T30361 434-439 NNS denotes pairs
T30363 440-448 JJ denotes specific
T30364 449-452 IN denotes for
T30365 453-455 NN denotes mr
T30367 455-456 HYPH denotes -
T30366 456-457 NN denotes s
T30368 458-461 CC denotes and
T30369 462-467 NN denotes G3PDH
T30370 468-473 NNS denotes cDNAs
T30371 473-475 , denotes ,
T30372 475-487 RB denotes respectively
T30373 487-488 . denotes .
T30374 488-532 sentence denotes Water was used for control RT-PCR reaction.
T30375 489-494 NN denotes Water
T30377 495-498 VBD denotes was
T30376 499-503 VBN denotes used
T30378 504-507 IN denotes for
T30379 508-515 NN denotes control
T30381 516-518 NN denotes RT
T30383 518-519 HYPH denotes -
T30382 519-522 NN denotes PCR
T30380 523-531 NN denotes reaction
T30384 531-532 . denotes .
T30385 532-577 sentence denotes (D-F) Crx transactivates mr-s transcription.
T30386 533-534 -LRB- denotes (
T30387 534-535 LS denotes D
T30389 535-536 SYM denotes -
T30390 536-537 LS denotes F
T30391 537-538 -RRB- denotes )
T30392 539-542 NN denotes Crx
T30388 543-557 VBZ denotes transactivates
T30393 558-560 NN denotes mr
T30395 560-561 HYPH denotes -
T30394 561-562 NN denotes s
T30396 563-576 NN denotes transcription
T30397 576-577 . denotes .
T30398 577-631 sentence denotes Reporter plasmids for the luciferase assay are shown.
T30399 578-586 NN denotes Reporter
T30400 587-595 NNS denotes plasmids
T30402 596-599 IN denotes for
T30403 600-603 DT denotes the
T30405 604-614 NN denotes luciferase
T30404 615-620 NN denotes assay
T30406 621-624 VBP denotes are
T30401 625-630 VBN denotes shown
T30407 630-631 . denotes .
T30408 631-675 sentence denotes Blue boxes represent Crx binding sites (D).
T30409 632-636 JJ denotes Blue
T30410 637-642 NNS denotes boxes
T30411 643-652 VBP denotes represent
T30412 653-656 NN denotes Crx
T30414 657-664 NN denotes binding
T30413 665-670 NNS denotes sites
T30415 671-672 -LRB- denotes (
T30416 672-673 NN denotes D
T30417 673-674 -RRB- denotes )
T30418 674-675 . denotes .
T30419 675-808 sentence denotes Relative activity of the luciferase is indicated when Pro1.2k was co-transfected with Crx, Otx2, Nrl, and Crx+Nrl, respectively (E).
T30420 676-684 JJ denotes Relative
T30421 685-693 NN denotes activity
T30423 694-696 IN denotes of
T30424 697-700 DT denotes the
T30425 701-711 NN denotes luciferase
T30426 712-714 VBZ denotes is
T30422 715-724 VBN denotes indicated
T30427 725-729 WRB denotes when
T30429 730-737 NN denotes Pro1.2k
T30430 738-741 VBD denotes was
T30428 742-756 VBN denotes co-transfected
T30431 757-761 IN denotes with
T30432 762-765 NN denotes Crx
T30433 765-767 , denotes ,
T30434 767-771 NN denotes Otx2
T30435 771-773 , denotes ,
T30436 773-776 NN denotes Nrl
T30437 776-778 , denotes ,
T30438 778-781 CC denotes and
T30439 782-785 NN denotes Crx
T30441 785-786 SYM denotes +
T30440 786-789 NN denotes Nrl
T30442 789-791 , denotes ,
T30443 791-803 RB denotes respectively
T30444 804-805 -LRB- denotes (
T30445 805-806 NN denotes E
T30446 806-807 -RRB- denotes )
T30447 807-808 . denotes .
T30448 808-995 sentence denotes Fold activation is indicated when Pro1.2k, mut1259, mut198, mut72 and mut all were co-transfected with the Crx expression vector (Crx+) or the empty vector (Crx-) into HEK293T cells (F).
T30449 809-813 NN denotes Fold
T30450 814-824 NN denotes activation
T30452 825-827 VBZ denotes is
T30451 828-837 VBN denotes indicated
T30453 838-842 WRB denotes when
T30455 843-850 NN denotes Pro1.2k
T30456 850-852 , denotes ,
T30457 852-859 NN denotes mut1259
T30458 859-861 , denotes ,
T30459 861-867 NN denotes mut198
T30460 867-869 , denotes ,
T30461 869-874 NN denotes mut72
T30462 875-878 CC denotes and
T30463 879-882 NN denotes mut
T30464 883-886 NN denotes all
T30465 887-891 VBD denotes were
T30454 892-906 VBN denotes co-transfected
T30466 907-911 IN denotes with
T30467 912-915 DT denotes the
T30469 916-919 NN denotes Crx
T30470 920-930 NN denotes expression
T30468 931-937 NN denotes vector
T30471 938-939 -LRB- denotes (
T30472 939-942 NN denotes Crx
T30473 942-943 SYM denotes +
T30474 943-944 -RRB- denotes )
T30475 945-947 CC denotes or
T30476 948-951 DT denotes the
T30478 952-957 JJ denotes empty
T30477 958-964 NN denotes vector
T30479 965-966 -LRB- denotes (
T30480 966-969 NN denotes Crx
T30481 969-970 SYM denotes -
T30482 970-971 -RRB- denotes )
T30483 972-976 IN denotes into
T30484 977-984 NN denotes HEK293T
T30485 985-990 NNS denotes cells
T30486 991-992 -LRB- denotes (
T30487 992-993 NN denotes F
T30488 993-994 -RRB- denotes )
T30489 994-995 . denotes .
T30490 995-1040 sentence denotes Error bars represent standard error of mean.
T30491 996-1001 NN denotes Error
T30492 1002-1006 NNS denotes bars
T30493 1007-1016 VBP denotes represent
T30494 1017-1025 JJ denotes standard
T30495 1026-1031 NN denotes error
T30496 1032-1034 IN denotes of
T30497 1035-1039 NN denotes mean
T30498 1039-1040 . denotes .
R8574 T30251 T30252 det The,transcription
R8575 T30252 T30253 nsubjpass transcription,regulated
R8576 T30254 T30252 prep of,transcription
R8577 T30255 T30256 compound mr,s
R8578 T30256 T30254 pobj s,of
R8579 T30257 T30256 punct -,s
R8580 T30258 T30253 auxpass is,regulated
R8581 T30259 T30253 agent by,regulated
R8582 T30260 T30259 pobj Crx,by
R8583 T30261 T30253 punct .,regulated
R8584 T30263 T30264 punct (,A
R8585 T30264 T30265 meta A,performed
R8586 T30266 T30264 punct ", ",A
R8587 T30267 T30264 dep B,A
R8588 T30268 T30264 punct ),A
R8589 T30269 T30270 advmod In,situ
R8590 T30270 T30271 amod situ,hybridization
R8591 T30271 T30265 nsubjpass hybridization,performed
R8592 T30272 T30271 acl using,hybridization
R8593 T30273 T30274 det a,probe
R8594 T30274 T30272 dobj probe,using
R8595 T30275 T30274 prep for,probe
R8596 T30276 T30277 compound mouse,s
R8597 T30277 T30275 pobj s,for
R8598 T30278 T30277 compound mr,s
R8599 T30279 T30277 punct -,s
R8600 T30280 T30265 auxpass was,performed
R8601 T30281 T30265 prep on,performed
R8602 T30282 T30283 det the,retinas
R8603 T30283 T30281 pobj retinas,on
R8604 T30284 T30285 amod wild,type
R8605 T30285 T30283 nmod type,retinas
R8606 T30286 T30285 punct -,type
R8607 T30287 T30288 punct (,A
R8608 T30288 T30285 parataxis A,type
R8609 T30289 T30288 punct ),A
R8610 T30290 T30285 cc and,type
R8611 T30291 T30292 compound Crx,KO
R8612 T30292 T30285 conj KO,type
R8613 T30293 T30294 punct (,B
R8614 T30294 T30283 parataxis B,retinas
R8615 T30295 T30294 punct ),B
R8616 T30296 T30265 prep at,performed
R8617 T30297 T30296 pobj P5,at
R8618 T30298 T30265 punct .,performed
R8619 T30300 T30301 compound mr,s
R8620 T30301 T30303 compound s,expression
R8621 T30302 T30301 punct -,s
R8622 T30303 T30304 nsubjpass expression,reduced
R8623 T30305 T30304 auxpass was,reduced
R8624 T30306 T30304 advmod drastically,reduced
R8625 T30307 T30304 prep in,reduced
R8626 T30308 T30309 det the,retina
R8627 T30309 T30307 pobj retina,in
R8628 T30310 T30311 compound Crx,KO
R8629 T30311 T30309 compound KO,retina
R8630 T30312 T30313 punct (,B
R8631 T30313 T30309 parataxis B,retina
R8632 T30314 T30313 punct ),B
R8633 T30315 T30304 punct .,reduced
R8634 T30317 T30318 compound Scale,bar
R8635 T30319 T30318 punct ", ",bar
R8636 T30320 T30321 nummod 100,μm
R8637 T30321 T30318 appos μm,bar
R8638 T30322 T30318 punct .,bar
R8639 T30324 T30325 punct (,C
R8640 T30325 T30326 meta C,analysis
R8641 T30327 T30325 punct ),C
R8642 T30328 T30329 compound RT,PCR
R8643 T30329 T30326 compound PCR,analysis
R8644 T30330 T30329 punct -,PCR
R8645 T30331 T30326 prep of,analysis
R8646 T30332 T30333 amod total,RNAs
R8647 T30333 T30331 pobj RNAs,of
R8648 T30334 T30333 acl extracted,RNAs
R8649 T30335 T30334 prep from,extracted
R8650 T30336 T30337 det the,glands
R8651 T30337 T30335 pobj glands,from
R8652 T30338 T30337 amod pineal,glands
R8653 T30339 T30337 prep of,glands
R8654 T30340 T30341 nmod P5,mouse
R8655 T30341 T30339 pobj mouse,of
R8656 T30342 T30343 amod wild,type
R8657 T30343 T30341 nmod type,mouse
R8658 T30344 T30343 punct -,type
R8659 T30345 T30343 cc and,type
R8660 T30346 T30347 compound Crx,KO
R8661 T30347 T30343 conj KO,type
R8662 T30348 T30326 punct .,analysis
R8663 T30350 T30351 det The,lanes
R8664 T30351 T30355 nsubj lanes,show
R8665 T30352 T30351 amod upper,lanes
R8666 T30353 T30352 cc and,upper
R8667 T30354 T30352 conj lower,upper
R8668 T30356 T30357 compound PCR,products
R8669 T30357 T30355 dobj products,show
R8670 T30358 T30357 acl amplified,products
R8671 T30359 T30358 agent by,amplified
R8672 T30360 T30361 det the,pairs
R8673 T30361 T30359 pobj pairs,by
R8674 T30362 T30361 compound primer,pairs
R8675 T30363 T30361 amod specific,pairs
R8676 T30364 T30363 prep for,specific
R8677 T30365 T30366 compound mr,s
R8678 T30366 T30364 pobj s,for
R8679 T30367 T30366 punct -,s
R8680 T30368 T30366 cc and,s
R8681 T30369 T30370 compound G3PDH,cDNAs
R8682 T30370 T30366 conj cDNAs,s
R8683 T30371 T30358 punct ", ",amplified
R8684 T30372 T30358 advmod respectively,amplified
R8685 T30373 T30355 punct .,show
R8686 T30375 T30376 nsubjpass Water,used
R8687 T30377 T30376 auxpass was,used
R8688 T30378 T30376 prep for,used
R8689 T30379 T30380 compound control,reaction
R8690 T30380 T30378 pobj reaction,for
R8691 T30381 T30382 compound RT,PCR
R8692 T30382 T30380 compound PCR,reaction
R8693 T30383 T30382 punct -,PCR
R8694 T30384 T30376 punct .,used
R8695 T30386 T30387 punct (,D
R8696 T30387 T30388 meta D,transactivates
R8697 T30389 T30387 punct -,D
R8698 T30390 T30387 dep F,D
R8699 T30391 T30387 punct ),D
R8700 T30392 T30388 nsubj Crx,transactivates
R8701 T30393 T30394 compound mr,s
R8702 T30394 T30396 compound s,transcription
R8703 T30395 T30394 punct -,s
R8704 T30396 T30388 dobj transcription,transactivates
R8705 T30397 T30388 punct .,transactivates
R8706 T30399 T30400 compound Reporter,plasmids
R8707 T30400 T30401 nsubjpass plasmids,shown
R8708 T30402 T30400 prep for,plasmids
R8709 T30403 T30404 det the,assay
R8710 T30404 T30402 pobj assay,for
R8711 T30405 T30404 compound luciferase,assay
R8712 T30406 T30401 auxpass are,shown
R8713 T30407 T30401 punct .,shown
R8714 T30409 T30410 amod Blue,boxes
R8715 T30410 T30411 nsubj boxes,represent
R8716 T30412 T30413 compound Crx,sites
R8717 T30413 T30411 dobj sites,represent
R8718 T30414 T30413 compound binding,sites
R8719 T30415 T30416 punct (,D
R8720 T30416 T30411 parataxis D,represent
R8721 T30417 T30416 punct ),D
R8722 T30418 T30411 punct .,represent
R8723 T30420 T30421 amod Relative,activity
R8724 T30421 T30422 nsubjpass activity,indicated
R8725 T30423 T30421 prep of,activity
R8726 T30424 T30425 det the,luciferase
R8727 T30425 T30423 pobj luciferase,of
R8728 T30426 T30422 auxpass is,indicated
R8729 T30427 T30428 advmod when,co-transfected
R8730 T30428 T30422 advcl co-transfected,indicated
R8731 T30429 T30428 nsubjpass Pro1.2k,co-transfected
R8732 T30430 T30428 auxpass was,co-transfected
R8733 T30431 T30428 prep with,co-transfected
R8734 T30432 T30431 pobj Crx,with
R8735 T30433 T30432 punct ", ",Crx
R8736 T30434 T30432 conj Otx2,Crx
R8737 T30435 T30434 punct ", ",Otx2
R8738 T30436 T30434 conj Nrl,Otx2
R8739 T30437 T30436 punct ", ",Nrl
R8740 T30438 T30436 cc and,Nrl
R8741 T30439 T30440 nmod Crx,Nrl
R8742 T30440 T30436 conj Nrl,Nrl
R8743 T30441 T30440 punct +,Nrl
R8744 T30442 T30428 punct ", ",co-transfected
R8745 T30443 T30428 advmod respectively,co-transfected
R8746 T30444 T30445 punct (,E
R8747 T30445 T30428 parataxis E,co-transfected
R8748 T30446 T30445 punct ),E
R8749 T30447 T30422 punct .,indicated
R8750 T30449 T30450 compound Fold,activation
R8751 T30450 T30451 nsubjpass activation,indicated
R8752 T30452 T30451 auxpass is,indicated
R8753 T30453 T30454 advmod when,co-transfected
R8754 T30454 T30451 advcl co-transfected,indicated
R8755 T30455 T30454 nsubjpass Pro1.2k,co-transfected
R8756 T30456 T30455 punct ", ",Pro1.2k
R8757 T30457 T30455 conj mut1259,Pro1.2k
R8758 T30458 T30457 punct ", ",mut1259
R8759 T30459 T30457 conj mut198,mut1259
R8760 T30460 T30459 punct ", ",mut198
R8761 T30461 T30459 conj mut72,mut198
R8762 T30462 T30461 cc and,mut72
R8763 T30463 T30464 compound mut,all
R8764 T30464 T30461 conj all,mut72
R8765 T30465 T30454 auxpass were,co-transfected
R8766 T30466 T30454 prep with,co-transfected
R8767 T30467 T30468 det the,vector
R8768 T30468 T30466 pobj vector,with
R8769 T30469 T30468 compound Crx,vector
R8770 T30470 T30468 compound expression,vector
R8771 T30471 T30472 punct (,Crx
R8772 T30472 T30468 parataxis Crx,vector
R8773 T30473 T30472 punct +,Crx
R8774 T30474 T30472 punct ),Crx
R8775 T30475 T30468 cc or,vector
R8776 T30476 T30477 det the,vector
R8777 T30477 T30468 conj vector,vector
R8778 T30478 T30477 amod empty,vector
R8779 T30479 T30480 punct (,Crx
R8780 T30480 T30477 parataxis Crx,vector
R8781 T30481 T30480 punct -,Crx
R8782 T30482 T30480 punct ),Crx
R8783 T30483 T30454 prep into,co-transfected
R8784 T30484 T30485 compound HEK293T,cells
R8785 T30485 T30483 pobj cells,into
R8786 T30486 T30487 punct (,F
R8787 T30487 T30451 parataxis F,indicated
R8788 T30488 T30487 punct ),F
R8789 T30489 T30451 punct .,indicated
R8790 T30491 T30492 compound Error,bars
R8791 T30492 T30493 nsubj bars,represent
R8792 T30494 T30495 amod standard,error
R8793 T30495 T30493 dobj error,represent
R8794 T30496 T30495 prep of,error
R8795 T30497 T30496 pobj mean,of
R8796 T30498 T30493 punct .,represent