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PMC:1420314 / 1337-4540 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2208 11-14 DT denotes The
T2210 15-19 NN denotes ADAM
T2211 20-21 -LRB- denotes (
T2212 21-22 DT denotes A
T2213 23-34 NN denotes Disintegrin
T2214 35-38 CC denotes And
T2215 39-54 NN denotes Metalloprotease
T2216 54-55 -RRB- denotes )
T2209 56-62 NN denotes family
T2217 63-72 VBZ denotes comprises
T2218 73-81 NN denotes membrane
T2220 81-82 HYPH denotes -
T2219 82-90 VBG denotes spanning
T2222 91-103 JJ denotes multi-domain
T2221 104-112 NN denotes proteins
T2223 113-123 VBG denotes containing
T2224 124-125 DT denotes a
T2226 126-143 NN denotes metalloproteinase
T2228 143-144 HYPH denotes -
T2227 144-148 JJ denotes like
T2225 149-155 NN denotes domain
T2229 156-159 CC denotes and
T2230 160-161 DT denotes a
T2232 162-173 NN denotes disintegrin
T2234 173-174 HYPH denotes -
T2233 174-178 JJ denotes like
T2231 179-185 NN denotes domain
T2235 185-186 . denotes .
T2236 186-371 sentence denotes Approximately half of the ADAMs are catalytically active metalloproteases that shed a broad range of substrates, such as cytokines, growth factors, receptors, adhesion molecules [1,2].
T2237 187-200 RB denotes Approximately
T2238 201-205 NN denotes half
T2240 206-208 IN denotes of
T2241 209-212 DT denotes the
T2242 213-218 NNS denotes ADAMs
T2239 219-222 VBP denotes are
T2243 223-236 RB denotes catalytically
T2244 237-243 JJ denotes active
T2245 244-260 NNS denotes metalloproteases
T2246 261-265 WDT denotes that
T2247 266-270 VBD denotes shed
T2248 271-272 DT denotes a
T2250 273-278 JJ denotes broad
T2249 279-284 NN denotes range
T2251 285-287 IN denotes of
T2252 288-298 NNS denotes substrates
T2253 298-300 , denotes ,
T2254 300-304 JJ denotes such
T2255 305-307 IN denotes as
T2256 308-317 NNS denotes cytokines
T2257 317-319 , denotes ,
T2258 319-325 NN denotes growth
T2259 326-333 NNS denotes factors
T2260 333-335 , denotes ,
T2261 335-344 NNS denotes receptors
T2262 344-346 , denotes ,
T2263 346-354 NN denotes adhesion
T2264 355-364 NNS denotes molecules
T2265 365-366 -LRB- denotes [
T2267 366-367 CD denotes 1
T2268 367-368 , denotes ,
T2266 368-369 CD denotes 2
T2269 369-370 -RRB- denotes ]
T2270 370-371 . denotes .
T2271 371-460 sentence denotes Recent gene-disruption studies in mice have disclosed a physiological role of each ADAM.
T2272 372-378 JJ denotes Recent
T2274 379-383 NN denotes gene
T2276 383-384 HYPH denotes -
T2275 384-394 NN denotes disruption
T2273 395-402 NNS denotes studies
T2278 403-405 IN denotes in
T2279 406-410 NNS denotes mice
T2280 411-415 VBP denotes have
T2277 416-425 VBN denotes disclosed
T2281 426-427 DT denotes a
T2283 428-441 JJ denotes physiological
T2282 442-446 NN denotes role
T2284 447-449 IN denotes of
T2285 450-454 DT denotes each
T2286 455-459 NN denotes ADAM
T2287 459-460 . denotes .
T2288 460-602 sentence denotes For example, ADAM10, ADAM17 and ADAM19 are critical for normal development by providing growth signals at the correct times and places [3-6].
T2289 461-464 IN denotes For
T2291 465-472 NN denotes example
T2292 472-474 , denotes ,
T2293 474-480 NN denotes ADAM10
T2294 480-482 , denotes ,
T2295 482-488 NN denotes ADAM17
T2296 489-492 CC denotes and
T2297 493-499 NN denotes ADAM19
T2290 500-503 VBP denotes are
T2298 504-512 JJ denotes critical
T2299 513-516 IN denotes for
T2300 517-523 JJ denotes normal
T2301 524-535 NN denotes development
T2302 536-538 IN denotes by
T2303 539-548 VBG denotes providing
T2304 549-555 NN denotes growth
T2305 556-563 NNS denotes signals
T2306 564-566 IN denotes at
T2307 567-570 DT denotes the
T2309 571-578 JJ denotes correct
T2308 579-584 NNS denotes times
T2310 585-588 CC denotes and
T2311 589-595 NNS denotes places
T2312 596-597 -LRB- denotes [
T2313 597-598 CD denotes 3
T2314 598-599 SYM denotes -
T2315 599-600 CD denotes 6
T2316 600-601 -RRB- denotes ]
T2317 601-602 . denotes .
T2318 602-773 sentence denotes In contrast, the functions of ADAM8, ADAM9, ADAM12 and ADAM15 are not essential for embryogenesis, suggesting a possible functional redundancy with other protease [7-10].
T2319 603-605 IN denotes In
T2321 606-614 NN denotes contrast
T2322 614-616 , denotes ,
T2323 616-619 DT denotes the
T2324 620-629 NNS denotes functions
T2325 630-632 IN denotes of
T2326 633-638 NN denotes ADAM8
T2327 638-640 , denotes ,
T2328 640-645 NN denotes ADAM9
T2329 645-647 , denotes ,
T2330 647-653 NN denotes ADAM12
T2331 654-657 CC denotes and
T2332 658-664 NN denotes ADAM15
T2320 665-668 VBP denotes are
T2333 669-672 RB denotes not
T2334 673-682 JJ denotes essential
T2335 683-686 IN denotes for
T2336 687-700 NN denotes embryogenesis
T2337 700-702 , denotes ,
T2338 702-712 VBG denotes suggesting
T2339 713-714 DT denotes a
T2341 715-723 JJ denotes possible
T2342 724-734 JJ denotes functional
T2340 735-745 NN denotes redundancy
T2343 746-750 IN denotes with
T2344 751-756 JJ denotes other
T2345 757-765 NN denotes protease
T2346 766-767 -LRB- denotes [
T2347 767-768 CD denotes 7
T2348 768-769 SYM denotes -
T2349 769-771 CD denotes 10
T2350 771-772 -RRB- denotes ]
T2351 772-773 . denotes .
T2352 773-861 sentence denotes The remaining half, which are non-protease-ADAMs, are thought to be adhesion molecules.
T2353 774-777 DT denotes The
T2355 778-787 VBG denotes remaining
T2354 788-792 NN denotes half
T2357 792-794 , denotes ,
T2358 794-799 WDT denotes which
T2359 800-803 VBP denotes are
T2360 804-816 JJ denotes non-protease
T2362 816-817 HYPH denotes -
T2361 817-822 NNS denotes ADAMs
T2363 822-824 , denotes ,
T2364 824-827 VBP denotes are
T2356 828-835 VBN denotes thought
T2365 836-838 TO denotes to
T2366 839-841 VB denotes be
T2367 842-850 NN denotes adhesion
T2368 851-860 NNS denotes molecules
T2369 860-861 . denotes .
T2370 861-955 sentence denotes More than ten ADAMs have been shown to support integrin-mediated cell adhesion in vitro [11].
T2371 862-866 JJR denotes More
T2373 867-871 IN denotes than
T2372 872-875 CD denotes ten
T2374 876-881 NNS denotes ADAMs
T2376 882-886 VBP denotes have
T2377 887-891 VBN denotes been
T2375 892-897 VBN denotes shown
T2378 898-900 TO denotes to
T2379 901-908 VB denotes support
T2380 909-917 NN denotes integrin
T2382 917-918 HYPH denotes -
T2381 918-926 VBN denotes mediated
T2384 927-931 NN denotes cell
T2383 932-940 NN denotes adhesion
T2385 941-943 FW denotes in
T2386 944-949 FW denotes vitro
T2387 950-951 -LRB- denotes [
T2388 951-953 CD denotes 11
T2389 953-954 -RRB- denotes ]
T2390 954-955 . denotes .
T2391 955-1104 sentence denotes More recently, the finding has been reported that integrin-mediated cell migration of tissue culture cells can be controlled by distinct ADAMs [12].
T2392 956-960 RBR denotes More
T2393 961-969 RB denotes recently
T2395 969-971 , denotes ,
T2396 971-974 DT denotes the
T2397 975-982 NN denotes finding
T2398 983-986 VBZ denotes has
T2399 987-991 VBN denotes been
T2394 992-1000 VBN denotes reported
T2400 1001-1005 IN denotes that
T2402 1006-1014 NN denotes integrin
T2404 1014-1015 HYPH denotes -
T2403 1015-1023 VBN denotes mediated
T2406 1024-1028 NN denotes cell
T2405 1029-1038 NN denotes migration
T2407 1039-1041 IN denotes of
T2408 1042-1048 NN denotes tissue
T2409 1049-1056 NN denotes culture
T2410 1057-1062 NNS denotes cells
T2411 1063-1066 MD denotes can
T2412 1067-1069 VB denotes be
T2401 1070-1080 VBN denotes controlled
T2413 1081-1083 IN denotes by
T2414 1084-1092 JJ denotes distinct
T2415 1093-1098 NNS denotes ADAMs
T2416 1099-1100 -LRB- denotes [
T2417 1100-1102 CD denotes 12
T2418 1102-1103 -RRB- denotes ]
T2419 1103-1104 . denotes .
T2420 1104-1236 sentence denotes In C. elegans, unc-71 gene coding a non-protease-ADAM protein have been shown to be involved in cell migration events in vivo [13].
T2421 1105-1107 IN denotes In
T2423 1108-1110 NNP denotes C.
T2424 1111-1118 NNP denotes elegans
T2425 1118-1120 , denotes ,
T2426 1120-1123 NN denotes unc
T2428 1123-1124 HYPH denotes -
T2429 1124-1126 CD denotes 71
T2427 1127-1131 NN denotes gene
T2430 1132-1138 VBG denotes coding
T2431 1139-1140 DT denotes a
T2433 1141-1153 JJ denotes non-protease
T2434 1153-1154 HYPH denotes -
T2435 1154-1158 NN denotes ADAM
T2432 1159-1166 NN denotes protein
T2436 1167-1171 VBP denotes have
T2437 1172-1176 VBN denotes been
T2422 1177-1182 VBN denotes shown
T2438 1183-1185 TO denotes to
T2440 1186-1188 VB denotes be
T2439 1189-1197 VBN denotes involved
T2441 1198-1200 IN denotes in
T2442 1201-1205 NN denotes cell
T2443 1206-1215 NN denotes migration
T2444 1216-1222 NNS denotes events
T2445 1223-1225 FW denotes in
T2446 1226-1230 FW denotes vivo
T2447 1231-1232 -LRB- denotes [
T2448 1232-1234 CD denotes 13
T2449 1234-1235 -RRB- denotes ]
T2450 1235-1236 . denotes .
T2451 1236-1332 sentence denotes However, the physiological roles of mammalian non-protease-ADAMs are poorly understood in vivo.
T2452 1237-1244 RB denotes However
T2454 1244-1246 , denotes ,
T2455 1246-1249 DT denotes the
T2457 1250-1263 JJ denotes physiological
T2456 1264-1269 NNS denotes roles
T2458 1270-1272 IN denotes of
T2459 1273-1282 JJ denotes mammalian
T2461 1283-1295 JJ denotes non-protease
T2462 1295-1296 HYPH denotes -
T2460 1296-1301 NNS denotes ADAMs
T2453 1302-1305 VBP denotes are
T2463 1306-1312 RB denotes poorly
T2464 1313-1323 VBN denotes understood
T2465 1324-1326 FW denotes in
T2466 1327-1331 FW denotes vivo
T2467 1331-1332 . denotes .
T2468 1332-1497 sentence denotes Genetic deletion studies in mice have shown that both Adam2-null and Adam3-null male mutants are infertile and their spermatozoa lack egg-binding abilities [14-16].
T2469 1333-1340 JJ denotes Genetic
T2470 1341-1349 NN denotes deletion
T2471 1350-1357 NNS denotes studies
T2473 1358-1360 IN denotes in
T2474 1361-1365 NNS denotes mice
T2475 1366-1370 VBP denotes have
T2472 1371-1376 VBN denotes shown
T2476 1377-1381 IN denotes that
T2478 1382-1386 CC denotes both
T2480 1387-1392 NN denotes Adam2
T2482 1392-1393 HYPH denotes -
T2481 1393-1397 JJ denotes null
T2483 1398-1401 CC denotes and
T2484 1402-1407 NN denotes Adam3
T2486 1407-1408 HYPH denotes -
T2485 1408-1412 JJ denotes null
T2487 1413-1417 JJ denotes male
T2479 1418-1425 NNS denotes mutants
T2477 1426-1429 VBP denotes are
T2488 1430-1439 JJ denotes infertile
T2489 1440-1443 CC denotes and
T2490 1444-1449 PRP$ denotes their
T2491 1450-1461 NNS denotes spermatozoa
T2492 1462-1466 VBP denotes lack
T2493 1467-1470 NN denotes egg
T2495 1470-1471 HYPH denotes -
T2496 1471-1478 VBG denotes binding
T2494 1479-1488 NNS denotes abilities
T2497 1489-1490 -LRB- denotes [
T2498 1490-1492 CD denotes 14
T2499 1492-1493 SYM denotes -
T2500 1493-1495 CD denotes 16
T2501 1495-1496 -RRB- denotes ]
T2502 1496-1497 . denotes .
T2503 1497-1548 sentence denotes The precise mechanism is under investigation [17].
T2504 1498-1501 DT denotes The
T2506 1502-1509 JJ denotes precise
T2505 1510-1519 NN denotes mechanism
T2507 1520-1522 VBZ denotes is
T2508 1523-1528 IN denotes under
T2509 1529-1542 NN denotes investigation
T2510 1543-1544 -LRB- denotes [
T2511 1544-1546 CD denotes 17
T2512 1546-1547 -RRB- denotes ]
T2513 1547-1548 . denotes .
T2514 1548-1694 sentence denotes We have reported the findings of ADAM11, ADAM22 and ADAM23 genes and their restricted expression in the human and murine nervous systems [18,19].
T2515 1549-1551 PRP denotes We
T2517 1552-1556 VBP denotes have
T2516 1557-1565 VBN denotes reported
T2518 1566-1569 DT denotes the
T2519 1570-1578 NNS denotes findings
T2520 1579-1581 IN denotes of
T2521 1582-1588 NN denotes ADAM11
T2523 1588-1590 , denotes ,
T2524 1590-1596 NN denotes ADAM22
T2525 1597-1600 CC denotes and
T2526 1601-1607 NN denotes ADAM23
T2522 1608-1613 NNS denotes genes
T2527 1614-1617 CC denotes and
T2528 1618-1623 PRP$ denotes their
T2530 1624-1634 VBN denotes restricted
T2529 1635-1645 NN denotes expression
T2531 1646-1648 IN denotes in
T2532 1649-1652 DT denotes the
T2534 1653-1658 JJ denotes human
T2535 1659-1662 CC denotes and
T2536 1663-1669 JJ denotes murine
T2537 1670-1677 JJ denotes nervous
T2533 1678-1685 NNS denotes systems
T2538 1686-1687 -LRB- denotes [
T2540 1687-1689 CD denotes 18
T2541 1689-1690 , denotes ,
T2539 1690-1692 CD denotes 19
T2542 1692-1693 -RRB- denotes ]
T2543 1693-1694 . denotes .
T2544 1694-1814 sentence denotes These ADAMs lack a catalytic motif critical for the metalloproteinase activity, suggesting that they are not proteases.
T2545 1695-1700 DT denotes These
T2546 1701-1706 NNS denotes ADAMs
T2547 1707-1711 VBP denotes lack
T2548 1712-1713 DT denotes a
T2550 1714-1723 JJ denotes catalytic
T2549 1724-1729 NN denotes motif
T2551 1730-1738 JJ denotes critical
T2552 1739-1742 IN denotes for
T2553 1743-1746 DT denotes the
T2555 1747-1764 NN denotes metalloproteinase
T2554 1765-1773 NN denotes activity
T2556 1773-1775 , denotes ,
T2557 1775-1785 VBG denotes suggesting
T2558 1786-1790 IN denotes that
T2560 1791-1795 PRP denotes they
T2559 1796-1799 VBP denotes are
T2561 1800-1803 RB denotes not
T2562 1804-1813 NNS denotes proteases
T2563 1813-1814 . denotes .
T2564 1814-2023 sentence denotes We assume that these ADAMs might contribute to cell migration, differentiation and survival or synaptic regulation by binding to integrins, cell-surface proteins or intracellular signalling molecules [20,21].
T2565 1815-1817 PRP denotes We
T2566 1818-1824 VBP denotes assume
T2567 1825-1829 IN denotes that
T2569 1830-1835 DT denotes these
T2570 1836-1841 NNS denotes ADAMs
T2571 1842-1847 MD denotes might
T2568 1848-1858 VB denotes contribute
T2572 1859-1861 IN denotes to
T2573 1862-1866 NN denotes cell
T2574 1867-1876 NN denotes migration
T2575 1876-1878 , denotes ,
T2576 1878-1893 NN denotes differentiation
T2577 1894-1897 CC denotes and
T2578 1898-1906 NN denotes survival
T2579 1907-1909 CC denotes or
T2580 1910-1918 JJ denotes synaptic
T2581 1919-1929 NN denotes regulation
T2582 1930-1932 IN denotes by
T2583 1933-1940 VBG denotes binding
T2584 1941-1943 IN denotes to
T2585 1944-1953 NNS denotes integrins
T2586 1953-1955 , denotes ,
T2587 1955-1959 NN denotes cell
T2589 1959-1960 HYPH denotes -
T2588 1960-1967 NN denotes surface
T2590 1968-1976 NN denotes proteins
T2591 1977-1979 CC denotes or
T2592 1980-1993 JJ denotes intracellular
T2594 1994-2004 NN denotes signalling
T2593 2005-2014 NNS denotes molecules
T2595 2015-2016 -LRB- denotes [
T2597 2016-2018 CD denotes 20
T2598 2018-2019 , denotes ,
T2596 2019-2021 CD denotes 21
T2599 2021-2022 -RRB- denotes ]
T2600 2022-2023 . denotes .
T2601 2023-2190 sentence denotes We have reported severe ataxia, seizures, and death before weaning, accompanied with hypomyelination of the peripheral nervous system in Adam22-null mutant mice [22].
T2602 2024-2026 PRP denotes We
T2604 2027-2031 VBP denotes have
T2603 2032-2040 VBN denotes reported
T2605 2041-2047 JJ denotes severe
T2606 2048-2054 NN denotes ataxia
T2607 2054-2056 , denotes ,
T2608 2056-2064 NNS denotes seizures
T2609 2064-2066 , denotes ,
T2610 2066-2069 CC denotes and
T2611 2070-2075 NN denotes death
T2612 2076-2082 IN denotes before
T2613 2083-2090 NN denotes weaning
T2614 2090-2092 , denotes ,
T2615 2092-2103 VBN denotes accompanied
T2616 2104-2108 IN denotes with
T2617 2109-2124 NN denotes hypomyelination
T2618 2125-2127 IN denotes of
T2619 2128-2131 DT denotes the
T2621 2132-2142 JJ denotes peripheral
T2622 2143-2150 JJ denotes nervous
T2620 2151-2157 NN denotes system
T2623 2158-2160 IN denotes in
T2624 2161-2167 NN denotes Adam22
T2626 2167-2168 HYPH denotes -
T2625 2168-2172 JJ denotes null
T2628 2173-2179 NN denotes mutant
T2627 2180-2184 NNS denotes mice
T2629 2185-2186 -LRB- denotes [
T2630 2186-2188 CD denotes 22
T2631 2188-2189 -RRB- denotes ]
T2632 2189-2190 . denotes .
T2633 2190-2326 sentence denotes It has been reported that the disruption of Adam23 gene in the mouse results in premature death associated with ataxia and tremor [23].
T2634 2191-2193 PRP denotes It
T2636 2194-2197 VBZ denotes has
T2637 2198-2202 VBN denotes been
T2635 2203-2211 VBN denotes reported
T2638 2212-2216 IN denotes that
T2640 2217-2220 DT denotes the
T2641 2221-2231 NN denotes disruption
T2642 2232-2234 IN denotes of
T2643 2235-2241 NN denotes Adam23
T2644 2242-2246 NN denotes gene
T2645 2247-2249 IN denotes in
T2646 2250-2253 DT denotes the
T2647 2254-2259 NN denotes mouse
T2639 2260-2267 VBZ denotes results
T2648 2268-2270 IN denotes in
T2649 2271-2280 JJ denotes premature
T2650 2281-2286 NN denotes death
T2651 2287-2297 VBN denotes associated
T2652 2298-2302 IN denotes with
T2653 2303-2309 NN denotes ataxia
T2654 2310-2313 CC denotes and
T2655 2314-2320 NN denotes tremor
T2656 2321-2322 -LRB- denotes [
T2657 2322-2324 CD denotes 23
T2658 2324-2325 -RRB- denotes ]
T2659 2325-2326 . denotes .
T2660 2326-2462 sentence denotes Is spite of such extreme phenotypes, no histological defects in the brain has been observed in either Adam22-null nor Adam23-null mice.
T2661 2327-2329 IN denotes Is
T2663 2330-2335 NN denotes spite
T2664 2336-2338 IN denotes of
T2665 2339-2343 JJ denotes such
T2667 2344-2351 JJ denotes extreme
T2666 2352-2362 NNS denotes phenotypes
T2668 2362-2364 , denotes ,
T2669 2364-2366 DT denotes no
T2671 2367-2379 JJ denotes histological
T2670 2380-2387 NNS denotes defects
T2672 2388-2390 IN denotes in
T2673 2391-2394 DT denotes the
T2674 2395-2400 NN denotes brain
T2675 2401-2404 VBZ denotes has
T2676 2405-2409 VBN denotes been
T2662 2410-2418 VBN denotes observed
T2677 2419-2421 IN denotes in
T2678 2422-2428 CC denotes either
T2680 2429-2435 NN denotes Adam22
T2682 2435-2436 HYPH denotes -
T2681 2436-2440 JJ denotes null
T2683 2441-2444 CC denotes nor
T2684 2445-2451 NN denotes Adam23
T2686 2451-2452 HYPH denotes -
T2685 2452-2456 JJ denotes null
T2679 2457-2461 NNS denotes mice
T2687 2461-2462 . denotes .
T2688 2462-2590 sentence denotes ADAM11 is the closest paralog of ADAM22 and ADAM23, and its orthologs have been found in vertebrates, but not in invertebrates.
T2689 2463-2469 NN denotes ADAM11
T2690 2470-2472 VBZ denotes is
T2691 2473-2476 DT denotes the
T2693 2477-2484 JJS denotes closest
T2692 2485-2492 NN denotes paralog
T2694 2493-2495 IN denotes of
T2695 2496-2502 NN denotes ADAM22
T2696 2503-2506 CC denotes and
T2697 2507-2513 NN denotes ADAM23
T2698 2513-2515 , denotes ,
T2699 2515-2518 CC denotes and
T2700 2519-2522 PRP$ denotes its
T2701 2523-2532 NNS denotes orthologs
T2703 2533-2537 VBP denotes have
T2704 2538-2542 VBN denotes been
T2702 2543-2548 VBN denotes found
T2705 2549-2551 IN denotes in
T2706 2552-2563 NNS denotes vertebrates
T2707 2563-2565 , denotes ,
T2708 2565-2568 CC denotes but
T2709 2569-2572 RB denotes not
T2710 2573-2575 IN denotes in
T2711 2576-2589 NNS denotes invertebrates
T2712 2589-2590 . denotes .
T2713 2590-2950 sentence denotes It has been reported that the Xenopus ADAM11 ortholog, xMDC11a, has an expression pattern associated with neural development, with a proposed role in cell migration [24]; and it has been reported in analyses using Northern blot and in situ hybridisation methods that the murine Adam11 gene is expressed in both the developing and adult nervous system [19,25].
T2714 2591-2593 PRP denotes It
T2716 2594-2597 VBZ denotes has
T2717 2598-2602 VBN denotes been
T2715 2603-2611 VBN denotes reported
T2718 2612-2616 IN denotes that
T2720 2617-2620 DT denotes the
T2722 2621-2628 NNP denotes Xenopus
T2723 2629-2635 NN denotes ADAM11
T2721 2636-2644 NN denotes ortholog
T2724 2644-2646 , denotes ,
T2725 2646-2653 NN denotes xMDC11a
T2726 2653-2655 , denotes ,
T2719 2655-2658 VBZ denotes has
T2727 2659-2661 DT denotes an
T2729 2662-2672 NN denotes expression
T2728 2673-2680 NN denotes pattern
T2730 2681-2691 VBN denotes associated
T2731 2692-2696 IN denotes with
T2732 2697-2703 JJ denotes neural
T2733 2704-2715 NN denotes development
T2734 2715-2717 , denotes ,
T2735 2717-2721 IN denotes with
T2736 2722-2723 DT denotes a
T2738 2724-2732 VBN denotes proposed
T2737 2733-2737 NN denotes role
T2739 2738-2740 IN denotes in
T2740 2741-2745 NN denotes cell
T2741 2746-2755 NN denotes migration
T2742 2756-2757 -LRB- denotes [
T2743 2757-2759 CD denotes 24
T2744 2759-2760 -RRB- denotes ]
T2745 2760-2761 : denotes ;
T2746 2762-2765 CC denotes and
T2747 2766-2768 PRP denotes it
T2749 2769-2772 VBZ denotes has
T2750 2773-2777 VBN denotes been
T2748 2778-2786 VBN denotes reported
T2751 2787-2789 IN denotes in
T2752 2790-2798 NNS denotes analyses
T2753 2799-2804 VBG denotes using
T2754 2805-2813 NNP denotes Northern
T2755 2814-2818 NN denotes blot
T2757 2819-2822 CC denotes and
T2758 2823-2825 FW denotes in
T2759 2826-2830 FW denotes situ
T2760 2831-2844 NN denotes hybridisation
T2756 2845-2852 NNS denotes methods
T2761 2853-2857 IN denotes that
T2763 2858-2861 DT denotes the
T2765 2862-2868 JJ denotes murine
T2766 2869-2875 NN denotes Adam11
T2764 2876-2880 NN denotes gene
T2767 2881-2883 VBZ denotes is
T2762 2884-2893 VBN denotes expressed
T2768 2894-2896 IN denotes in
T2769 2897-2901 CC denotes both
T2771 2902-2905 DT denotes the
T2772 2906-2916 VBG denotes developing
T2773 2917-2920 CC denotes and
T2774 2921-2926 JJ denotes adult
T2775 2927-2934 JJ denotes nervous
T2770 2935-2941 NN denotes system
T2776 2942-2943 -LRB- denotes [
T2778 2943-2945 CD denotes 19
T2779 2945-2946 , denotes ,
T2777 2946-2948 CD denotes 25
T2780 2948-2949 -RRB- denotes ]
T2781 2949-2950 . denotes .
T2782 2950-3098 sentence denotes These findings led us to hypothesise that ADAM11 is an integrin binder that plays an important role in the nervous system, as do ADAM22 and ADAM23.
T2783 2951-2956 DT denotes These
T2784 2957-2965 NNS denotes findings
T2785 2966-2969 VBD denotes led
T2786 2970-2972 PRP denotes us
T2787 2973-2975 TO denotes to
T2788 2976-2987 VB denotes hypothesise
T2789 2988-2992 IN denotes that
T2791 2993-2999 NN denotes ADAM11
T2790 3000-3002 VBZ denotes is
T2792 3003-3005 DT denotes an
T2794 3006-3014 NN denotes integrin
T2793 3015-3021 NN denotes binder
T2795 3022-3026 WDT denotes that
T2796 3027-3032 VBZ denotes plays
T2797 3033-3035 DT denotes an
T2799 3036-3045 JJ denotes important
T2798 3046-3050 NN denotes role
T2800 3051-3053 IN denotes in
T2801 3054-3057 DT denotes the
T2803 3058-3065 JJ denotes nervous
T2802 3066-3072 NN denotes system
T2804 3072-3074 , denotes ,
T2805 3074-3076 IN denotes as
T2806 3077-3079 VBP denotes do
T2807 3080-3086 NN denotes ADAM22
T2808 3087-3090 CC denotes and
T2809 3091-3097 NN denotes ADAM23
T2810 3097-3098 . denotes .
T2811 3098-3203 sentence denotes To determine the physiological functions of ADAM11, we generated and analysed Adam11 gene-targeted mice.
T2812 3099-3101 TO denotes To
T2813 3102-3111 VB denotes determine
T2815 3112-3115 DT denotes the
T2817 3116-3129 JJ denotes physiological
T2816 3130-3139 NNS denotes functions
T2818 3140-3142 IN denotes of
T2819 3143-3149 NN denotes ADAM11
T2820 3149-3151 , denotes ,
T2821 3151-3153 PRP denotes we
T2814 3154-3163 VBD denotes generated
T2822 3164-3167 CC denotes and
T2823 3168-3176 VBD denotes analysed
T2824 3177-3183 NN denotes Adam11
T2826 3184-3188 NN denotes gene
T2828 3188-3189 HYPH denotes -
T2827 3189-3197 VBN denotes targeted
T2825 3198-3202 NNS denotes mice
T2829 3202-3203 . denotes .
R222 T2208 T2209 det The,family
R223 T2209 T2217 nsubj family,comprises
R224 T2210 T2209 nmod ADAM,family
R225 T2211 T2210 punct (,ADAM
R226 T2212 T2213 det A,Disintegrin
R227 T2213 T2210 appos Disintegrin,ADAM
R228 T2214 T2213 cc And,Disintegrin
R229 T2215 T2213 conj Metalloprotease,Disintegrin
R230 T2216 T2209 punct ),family
R231 T2218 T2219 npadvmod membrane,spanning
R232 T2219 T2221 amod spanning,proteins
R233 T2220 T2219 punct -,spanning
R234 T2221 T2217 dobj proteins,comprises
R235 T2222 T2221 amod multi-domain,proteins
R236 T2223 T2221 acl containing,proteins
R237 T2224 T2225 det a,domain
R238 T2225 T2223 dobj domain,containing
R239 T2226 T2227 npadvmod metalloproteinase,like
R240 T2227 T2225 amod like,domain
R241 T2228 T2227 punct -,like
R242 T2229 T2225 cc and,domain
R243 T2230 T2231 det a,domain
R244 T2231 T2225 conj domain,domain
R245 T2232 T2233 npadvmod disintegrin,like
R246 T2233 T2231 amod like,domain
R247 T2234 T2233 punct -,like
R248 T2235 T2217 punct .,comprises
R249 T2237 T2238 advmod Approximately,half
R250 T2238 T2239 nsubj half,are
R251 T2240 T2238 prep of,half
R252 T2241 T2242 det the,ADAMs
R253 T2242 T2240 pobj ADAMs,of
R254 T2243 T2244 advmod catalytically,active
R255 T2244 T2245 amod active,metalloproteases
R256 T2245 T2239 attr metalloproteases,are
R257 T2246 T2247 dep that,shed
R258 T2247 T2245 relcl shed,metalloproteases
R259 T2248 T2249 det a,range
R260 T2249 T2247 dobj range,shed
R261 T2250 T2249 amod broad,range
R262 T2251 T2249 prep of,range
R263 T2252 T2251 pobj substrates,of
R264 T2253 T2252 punct ", ",substrates
R265 T2254 T2255 amod such,as
R266 T2255 T2252 prep as,substrates
R267 T2256 T2255 pobj cytokines,as
R268 T2257 T2256 punct ", ",cytokines
R269 T2258 T2259 compound growth,factors
R270 T2259 T2256 appos factors,cytokines
R271 T2260 T2256 punct ", ",cytokines
R272 T2261 T2256 appos receptors,cytokines
R273 T2262 T2256 punct ", ",cytokines
R274 T2263 T2264 compound adhesion,molecules
R275 T2264 T2256 appos molecules,cytokines
R276 T2265 T2266 punct [,2
R277 T2266 T2247 parataxis 2,shed
R278 T2267 T2266 nummod 1,2
R279 T2268 T2266 punct ",",2
R280 T2269 T2266 punct ],2
R281 T2270 T2239 punct .,are
R282 T2272 T2273 amod Recent,studies
R283 T2273 T2277 nsubj studies,disclosed
R284 T2274 T2275 compound gene,disruption
R285 T2275 T2273 compound disruption,studies
R286 T2276 T2275 punct -,disruption
R287 T2278 T2273 prep in,studies
R288 T2279 T2278 pobj mice,in
R289 T2280 T2277 aux have,disclosed
R290 T2281 T2282 det a,role
R291 T2282 T2277 dobj role,disclosed
R292 T2283 T2282 amod physiological,role
R293 T2284 T2282 prep of,role
R294 T2285 T2286 det each,ADAM
R295 T2286 T2284 pobj ADAM,of
R296 T2287 T2277 punct .,disclosed
R297 T2289 T2290 prep For,are
R298 T2291 T2289 pobj example,For
R299 T2292 T2290 punct ", ",are
R300 T2293 T2290 nsubj ADAM10,are
R301 T2294 T2293 punct ", ",ADAM10
R302 T2295 T2293 conj ADAM17,ADAM10
R303 T2296 T2295 cc and,ADAM17
R304 T2297 T2295 conj ADAM19,ADAM17
R305 T2298 T2290 acomp critical,are
R306 T2299 T2298 prep for,critical
R307 T2300 T2301 amod normal,development
R308 T2301 T2299 pobj development,for
R309 T2302 T2290 prep by,are
R310 T2303 T2302 pcomp providing,by
R311 T2304 T2305 compound growth,signals
R312 T2305 T2303 dobj signals,providing
R313 T2306 T2303 prep at,providing
R314 T2307 T2308 det the,times
R315 T2308 T2306 pobj times,at
R316 T2309 T2308 amod correct,times
R317 T2310 T2308 cc and,times
R318 T2311 T2308 conj places,times
R319 T2312 T2313 punct [,3
R320 T2313 T2303 parataxis 3,providing
R321 T2314 T2315 punct -,6
R322 T2315 T2313 prep 6,3
R323 T2316 T2313 punct ],3
R324 T2317 T2290 punct .,are
R325 T2319 T2320 prep In,are
R326 T2321 T2319 pobj contrast,In
R327 T2322 T2320 punct ", ",are
R328 T2323 T2324 det the,functions
R329 T2324 T2320 nsubj functions,are
R330 T2325 T2324 prep of,functions
R331 T2326 T2325 pobj ADAM8,of
R332 T2327 T2326 punct ", ",ADAM8
R333 T2328 T2326 conj ADAM9,ADAM8
R334 T2329 T2328 punct ", ",ADAM9
R335 T2330 T2328 conj ADAM12,ADAM9
R336 T2331 T2330 cc and,ADAM12
R337 T2332 T2330 conj ADAM15,ADAM12
R338 T2333 T2320 neg not,are
R339 T2334 T2320 acomp essential,are
R340 T2335 T2334 prep for,essential
R341 T2336 T2335 pobj embryogenesis,for
R342 T2337 T2320 punct ", ",are
R343 T2338 T2320 advcl suggesting,are
R344 T2339 T2340 det a,redundancy
R345 T2340 T2338 dobj redundancy,suggesting
R346 T2341 T2340 amod possible,redundancy
R347 T2342 T2340 amod functional,redundancy
R348 T2343 T2340 prep with,redundancy
R349 T2344 T2345 amod other,protease
R350 T2345 T2343 pobj protease,with
R351 T2346 T2347 punct [,7
R352 T2347 T2338 parataxis 7,suggesting
R353 T2348 T2349 punct -,10
R354 T2349 T2347 prep 10,7
R355 T2350 T2347 punct ],7
R356 T2351 T2320 punct .,are
R357 T2353 T2354 det The,half
R358 T2354 T2356 nsubjpass half,thought
R359 T2355 T2354 amod remaining,half
R360 T2357 T2354 punct ", ",half
R361 T2358 T2359 dep which,are
R362 T2359 T2354 relcl are,half
R363 T2360 T2361 amod non-protease,ADAMs
R364 T2361 T2359 attr ADAMs,are
R365 T2362 T2361 punct -,ADAMs
R366 T2363 T2356 punct ", ",thought
R367 T2364 T2356 auxpass are,thought
R368 T2365 T2366 aux to,be
R369 T2366 T2356 xcomp be,thought
R370 T2367 T2368 compound adhesion,molecules
R371 T2368 T2366 attr molecules,be
R372 T2369 T2356 punct .,thought
R373 T2371 T2372 amod More,ten
R374 T2372 T2374 nummod ten,ADAMs
R375 T2373 T2372 quantmod than,ten
R376 T2374 T2375 nsubjpass ADAMs,shown
R377 T2376 T2375 aux have,shown
R378 T2377 T2375 auxpass been,shown
R379 T2378 T2379 aux to,support
R380 T2379 T2375 xcomp support,shown
R381 T2380 T2381 npadvmod integrin,mediated
R382 T2381 T2383 amod mediated,adhesion
R383 T2382 T2381 punct -,mediated
R384 T2383 T2379 dobj adhesion,support
R385 T2384 T2383 compound cell,adhesion
R386 T2385 T2386 advmod in,vitro
R387 T2386 T2379 advmod vitro,support
R388 T2387 T2388 punct [,11
R389 T2388 T2375 parataxis 11,shown
R390 T2389 T2388 punct ],11
R391 T2390 T2375 punct .,shown
R392 T2392 T2393 advmod More,recently
R393 T2393 T2394 advmod recently,reported
R394 T2395 T2394 punct ", ",reported
R395 T2396 T2397 det the,finding
R396 T2397 T2394 nsubjpass finding,reported
R397 T2398 T2394 aux has,reported
R398 T2399 T2394 auxpass been,reported
R399 T2400 T2401 mark that,controlled
R400 T2401 T2394 ccomp controlled,reported
R401 T2402 T2403 npadvmod integrin,mediated
R402 T2403 T2405 amod mediated,migration
R403 T2404 T2403 punct -,mediated
R404 T2405 T2401 nsubjpass migration,controlled
R405 T2406 T2405 compound cell,migration
R406 T2407 T2405 prep of,migration
R407 T2408 T2409 compound tissue,culture
R408 T2409 T2410 compound culture,cells
R409 T2410 T2407 pobj cells,of
R410 T2411 T2401 aux can,controlled
R411 T2412 T2401 auxpass be,controlled
R412 T2413 T2401 agent by,controlled
R413 T2414 T2415 amod distinct,ADAMs
R414 T2415 T2413 pobj ADAMs,by
R415 T2416 T2417 punct [,12
R416 T2417 T2401 parataxis 12,controlled
R417 T2418 T2417 punct ],12
R418 T2419 T2394 punct .,reported
R419 T2421 T2422 prep In,shown
R420 T2423 T2424 compound C.,elegans
R421 T2424 T2421 pobj elegans,In
R422 T2425 T2422 punct ", ",shown
R423 T2426 T2427 nmod unc,gene
R424 T2427 T2422 nsubjpass gene,shown
R425 T2428 T2426 punct -,unc
R426 T2429 T2426 nummod 71,unc
R427 T2430 T2427 acl coding,gene
R428 T2431 T2432 det a,protein
R429 T2432 T2430 dobj protein,coding
R430 T2433 T2432 amod non-protease,protein
R431 T2434 T2432 punct -,protein
R432 T2435 T2432 compound ADAM,protein
R433 T2436 T2422 aux have,shown
R434 T2437 T2422 auxpass been,shown
R435 T2438 T2439 aux to,involved
R436 T2439 T2422 xcomp involved,shown
R437 T2440 T2439 auxpass be,involved
R438 T2441 T2439 prep in,involved
R439 T2442 T2443 compound cell,migration
R440 T2443 T2444 compound migration,events
R441 T2444 T2441 pobj events,in
R442 T2445 T2446 advmod in,vivo
R443 T2446 T2439 advmod vivo,involved
R444 T2447 T2448 punct [,13
R445 T2448 T2422 parataxis 13,shown
R446 T2449 T2448 punct ],13
R447 T2450 T2422 punct .,shown
R448 T2452 T2453 advmod However,are
R449 T2454 T2453 punct ", ",are
R450 T2455 T2456 det the,roles
R451 T2456 T2453 nsubj roles,are
R452 T2457 T2456 amod physiological,roles
R453 T2458 T2456 prep of,roles
R454 T2459 T2460 amod mammalian,ADAMs
R455 T2460 T2458 pobj ADAMs,of
R456 T2461 T2460 amod non-protease,ADAMs
R457 T2462 T2460 punct -,ADAMs
R458 T2463 T2464 advmod poorly,understood
R459 T2464 T2453 acomp understood,are
R460 T2465 T2466 advmod in,vivo
R461 T2466 T2453 advmod vivo,are
R462 T2467 T2453 punct .,are
R463 T2469 T2470 amod Genetic,deletion
R464 T2470 T2471 compound deletion,studies
R465 T2471 T2472 nsubj studies,shown
R466 T2473 T2471 prep in,studies
R467 T2474 T2473 pobj mice,in
R468 T2475 T2472 aux have,shown
R469 T2476 T2477 mark that,are
R470 T2477 T2472 ccomp are,shown
R471 T2478 T2479 preconj both,mutants
R472 T2479 T2477 nsubj mutants,are
R473 T2480 T2481 npadvmod Adam2,null
R474 T2481 T2479 amod null,mutants
R475 T2482 T2481 punct -,null
R476 T2483 T2481 cc and,null
R477 T2484 T2485 npadvmod Adam3,null
R478 T2485 T2481 conj null,null
R479 T2486 T2485 punct -,null
R480 T2487 T2479 amod male,mutants
R481 T2488 T2477 acomp infertile,are
R482 T2489 T2477 cc and,are
R483 T2490 T2491 poss their,spermatozoa
R484 T2491 T2492 nsubj spermatozoa,lack
R485 T2492 T2477 conj lack,are
R486 T2493 T2494 nmod egg,abilities
R487 T2494 T2492 dobj abilities,lack
R488 T2495 T2493 punct -,egg
R489 T2496 T2493 amod binding,egg
R490 T2497 T2498 punct [,14
R491 T2498 T2492 parataxis 14,lack
R492 T2499 T2500 punct -,16
R493 T2500 T2498 prep 16,14
R494 T2501 T2498 punct ],14
R495 T2502 T2472 punct .,shown
R496 T2504 T2505 det The,mechanism
R497 T2505 T2507 nsubj mechanism,is
R498 T2506 T2505 amod precise,mechanism
R499 T2508 T2507 prep under,is
R500 T2509 T2508 pobj investigation,under
R501 T2510 T2511 punct [,17
R502 T2511 T2507 parataxis 17,is
R503 T2512 T2511 punct ],17
R504 T2513 T2507 punct .,is
R505 T2515 T2516 nsubj We,reported
R506 T2517 T2516 aux have,reported
R507 T2518 T2519 det the,findings
R508 T2519 T2516 dobj findings,reported
R509 T2520 T2519 prep of,findings
R510 T2521 T2522 nmod ADAM11,genes
R511 T2522 T2520 pobj genes,of
R512 T2523 T2521 punct ", ",ADAM11
R513 T2524 T2521 conj ADAM22,ADAM11
R514 T2525 T2524 cc and,ADAM22
R515 T2526 T2524 conj ADAM23,ADAM22
R516 T2527 T2522 cc and,genes
R517 T2528 T2529 poss their,expression
R518 T2529 T2522 conj expression,genes
R519 T2636 T2635 aux has,reported
R520 T2530 T2529 amod restricted,expression
R521 T2637 T2635 auxpass been,reported
R522 T2531 T2529 prep in,expression
R523 T2638 T2639 mark that,results
R524 T2532 T2533 det the,systems
R525 T2639 T2635 ccomp results,reported
R526 T2533 T2531 pobj systems,in
R527 T2640 T2641 det the,disruption
R528 T2534 T2533 amod human,systems
R529 T2535 T2534 cc and,human
R530 T2641 T2639 nsubj disruption,results
R531 T2536 T2534 conj murine,human
R532 T2537 T2533 amod nervous,systems
R533 T2538 T2539 punct [,19
R534 T2539 T2516 parataxis 19,reported
R535 T2540 T2539 nummod 18,19
R536 T2541 T2539 punct ",",19
R537 T2642 T2641 prep of,disruption
R538 T2542 T2539 punct ],19
R539 T2543 T2516 punct .,reported
R540 T2643 T2644 compound Adam23,gene
R541 T2545 T2546 det These,ADAMs
R542 T2644 T2642 pobj gene,of
R543 T2645 T2641 prep in,disruption
R544 T2546 T2547 nsubj ADAMs,lack
R545 T2646 T2647 det the,mouse
R546 T2548 T2549 det a,motif
R547 T2549 T2547 dobj motif,lack
R548 T2647 T2645 pobj mouse,in
R549 T2550 T2549 amod catalytic,motif
R550 T2551 T2549 amod critical,motif
R551 T2648 T2639 prep in,results
R552 T2552 T2551 prep for,critical
R553 T2553 T2554 det the,activity
R554 T2554 T2552 pobj activity,for
R555 T2649 T2650 amod premature,death
R556 T2555 T2554 compound metalloproteinase,activity
R557 T2556 T2547 punct ", ",lack
R558 T2557 T2547 advcl suggesting,lack
R559 T2650 T2648 pobj death,in
R560 T2558 T2559 mark that,are
R561 T2559 T2557 ccomp are,suggesting
R562 T2560 T2559 nsubj they,are
R563 T2651 T2650 acl associated,death
R564 T2561 T2559 neg not,are
R565 T2652 T2651 prep with,associated
R566 T2562 T2559 attr proteases,are
R567 T2563 T2547 punct .,lack
R568 T2565 T2566 nsubj We,assume
R569 T2653 T2652 pobj ataxia,with
R570 T2567 T2568 mark that,contribute
R571 T2654 T2653 cc and,ataxia
R572 T2568 T2566 ccomp contribute,assume
R573 T2569 T2570 det these,ADAMs
R574 T2570 T2568 nsubj ADAMs,contribute
R575 T2655 T2653 conj tremor,ataxia
R576 T2571 T2568 aux might,contribute
R577 T2572 T2568 prep to,contribute
R578 T2573 T2574 compound cell,migration
R579 T2574 T2572 pobj migration,to
R580 T2656 T2657 punct [,23
R581 T2575 T2574 punct ", ",migration
R582 T2576 T2574 conj differentiation,migration
R583 T2657 T2635 parataxis 23,reported
R584 T2577 T2576 cc and,differentiation
R585 T2578 T2576 conj survival,differentiation
R586 T2579 T2574 cc or,migration
R587 T2580 T2581 amod synaptic,regulation
R588 T2581 T2574 conj regulation,migration
R589 T2582 T2568 prep by,contribute
R590 T2583 T2582 pcomp binding,by
R591 T2658 T2657 punct ],23
R592 T2584 T2583 prep to,binding
R593 T2585 T2584 pobj integrins,to
R594 T2586 T2585 punct ", ",integrins
R595 T2659 T2635 punct .,reported
R596 T2587 T2588 compound cell,surface
R597 T2588 T2590 compound surface,proteins
R598 T2589 T2588 punct -,surface
R599 T2661 T2662 prep Is,observed
R600 T2590 T2585 conj proteins,integrins
R601 T2591 T2590 cc or,proteins
R602 T2592 T2593 amod intracellular,molecules
R603 T2593 T2590 conj molecules,proteins
R604 T2663 T2661 pobj spite,Is
R605 T2594 T2593 compound signalling,molecules
R606 T2595 T2596 punct [,21
R607 T2596 T2568 parataxis 21,contribute
R608 T2597 T2596 nummod 20,21
R609 T2598 T2596 punct ",",21
R610 T2664 T2663 prep of,spite
R611 T2599 T2596 punct ],21
R612 T2600 T2566 punct .,assume
R613 T2665 T2666 amod such,phenotypes
R614 T2602 T2603 nsubj We,reported
R615 T2666 T2664 pobj phenotypes,of
R616 T2604 T2603 aux have,reported
R617 T2667 T2666 amod extreme,phenotypes
R618 T2605 T2606 amod severe,ataxia
R619 T2606 T2603 dobj ataxia,reported
R620 T2607 T2606 punct ", ",ataxia
R621 T2668 T2662 punct ", ",observed
R622 T2608 T2606 conj seizures,ataxia
R623 T2609 T2608 punct ", ",seizures
R624 T2610 T2608 cc and,seizures
R625 T2669 T2670 det no,defects
R626 T2611 T2608 conj death,seizures
R627 T2612 T2611 prep before,death
R628 T2613 T2612 pobj weaning,before
R629 T2670 T2662 nsubjpass defects,observed
R630 T2614 T2606 punct ", ",ataxia
R631 T2615 T2606 acl accompanied,ataxia
R632 T2671 T2670 amod histological,defects
R633 T2616 T2615 prep with,accompanied
R634 T2617 T2616 pobj hypomyelination,with
R635 T2618 T2617 prep of,hypomyelination
R636 T2672 T2670 prep in,defects
R637 T2619 T2620 det the,system
R638 T2673 T2674 det the,brain
R639 T2620 T2618 pobj system,of
R640 T2621 T2620 amod peripheral,system
R641 T2622 T2620 amod nervous,system
R642 T2623 T2603 prep in,reported
R643 T2624 T2625 npadvmod Adam22,null
R644 T2674 T2672 pobj brain,in
R645 T2625 T2627 amod null,mice
R646 T2626 T2625 punct -,null
R647 T2627 T2623 pobj mice,in
R648 T2675 T2662 aux has,observed
R649 T2628 T2627 compound mutant,mice
R650 T2629 T2630 punct [,22
R651 T2630 T2603 parataxis 22,reported
R652 T2676 T2662 auxpass been,observed
R653 T2631 T2630 punct ],22
R654 T2632 T2603 punct .,reported
R655 T2677 T2662 prep in,observed
R656 T2634 T2635 nsubjpass It,reported
R657 T2678 T2679 preconj either,mice
R658 T2679 T2677 pobj mice,in
R659 T2680 T2681 npadvmod Adam22,null
R660 T2681 T2679 amod null,mice
R661 T2682 T2681 punct -,null
R662 T2683 T2681 cc nor,null
R663 T2742 T2743 punct [,24
R664 T2743 T2715 parataxis 24,reported
R665 T2684 T2685 npadvmod Adam23,null
R666 T2744 T2743 punct ],24
R667 T2745 T2715 punct ;,reported
R668 T2685 T2681 conj null,null
R669 T2746 T2715 cc and,reported
R670 T2747 T2748 nsubjpass it,reported
R671 T2748 T2715 conj reported,reported
R672 T2749 T2748 aux has,reported
R673 T2686 T2685 punct -,null
R674 T2750 T2748 auxpass been,reported
R675 T2751 T2748 prep in,reported
R676 T2687 T2662 punct .,observed
R677 T2752 T2751 pobj analyses,in
R678 T2753 T2752 acl using,analyses
R679 T2689 T2690 nsubj ADAM11,is
R680 T2754 T2755 nmod Northern,blot
R681 T2755 T2756 nmod blot,methods
R682 T2756 T2753 dobj methods,using
R683 T2757 T2755 cc and,blot
R684 T2691 T2692 det the,paralog
R685 T2758 T2759 advmod in,situ
R686 T2759 T2755 conj situ,blot
R687 T2760 T2756 compound hybridisation,methods
R688 T2761 T2762 mark that,expressed
R689 T2692 T2690 attr paralog,is
R690 T2762 T2748 ccomp expressed,reported
R691 T2763 T2764 det the,gene
R692 T2764 T2762 nsubjpass gene,expressed
R693 T2765 T2764 amod murine,gene
R694 T2766 T2764 compound Adam11,gene
R695 T2767 T2762 auxpass is,expressed
R696 T2693 T2692 amod closest,paralog
R697 T2768 T2762 prep in,expressed
R698 T2769 T2770 preconj both,system
R699 T2770 T2768 pobj system,in
R700 T2694 T2692 prep of,paralog
R701 T2771 T2770 det the,system
R702 T2772 T2770 amod developing,system
R703 T2773 T2772 cc and,developing
R704 T2695 T2694 pobj ADAM22,of
R705 T2774 T2772 conj adult,developing
R706 T2775 T2770 amod nervous,system
R707 T2696 T2695 cc and,ADAM22
R708 T2776 T2777 punct [,25
R709 T2777 T2748 parataxis 25,reported
R710 T2778 T2777 nummod 19,25
R711 T2697 T2695 conj ADAM23,ADAM22
R712 T2779 T2777 punct ",",25
R713 T2780 T2777 punct ],25
R714 T2781 T2748 punct .,reported
R715 T2698 T2690 punct ", ",is
R716 T2783 T2784 det These,findings
R717 T2784 T2785 nsubj findings,led
R718 T2699 T2690 cc and,is
R719 T2786 T2785 dobj us,led
R720 T2700 T2701 poss its,orthologs
R721 T2787 T2788 aux to,hypothesise
R722 T2788 T2785 xcomp hypothesise,led
R723 T2789 T2790 mark that,is
R724 T2790 T2788 ccomp is,hypothesise
R725 T2701 T2702 nsubjpass orthologs,found
R726 T2791 T2790 nsubj ADAM11,is
R727 T2792 T2793 det an,binder
R728 T2702 T2690 conj found,is
R729 T2703 T2702 aux have,found
R730 T2704 T2702 auxpass been,found
R731 T2793 T2790 attr binder,is
R732 T2705 T2702 prep in,found
R733 T2794 T2793 compound integrin,binder
R734 T2795 T2796 dep that,plays
R735 T2796 T2793 relcl plays,binder
R736 T2797 T2798 det an,role
R737 T2706 T2705 pobj vertebrates,in
R738 T2798 T2796 dobj role,plays
R739 T2799 T2798 amod important,role
R740 T2800 T2796 prep in,plays
R741 T2707 T2705 punct ", ",in
R742 T2801 T2802 det the,system
R743 T2708 T2705 cc but,in
R744 T2802 T2800 pobj system,in
R745 T2803 T2802 amod nervous,system
R746 T2804 T2796 punct ", ",plays
R747 T2805 T2806 mark as,do
R748 T2806 T2796 advcl do,plays
R749 T2807 T2806 nsubj ADAM22,do
R750 T2709 T2708 neg not,but
R751 T2808 T2807 cc and,ADAM22
R752 T2809 T2807 conj ADAM23,ADAM22
R753 T2810 T2785 punct .,led
R754 T2710 T2705 conj in,in
R755 T2812 T2813 aux To,determine
R756 T2813 T2814 advcl determine,generated
R757 T2711 T2710 pobj invertebrates,in
R758 T2815 T2816 det the,functions
R759 T2816 T2813 dobj functions,determine
R760 T2712 T2702 punct .,found
R761 T2817 T2816 amod physiological,functions
R762 T2818 T2816 prep of,functions
R763 T2714 T2715 nsubjpass It,reported
R764 T2819 T2818 pobj ADAM11,of
R765 T2820 T2814 punct ", ",generated
R766 T2821 T2814 nsubj we,generated
R767 T2822 T2814 cc and,generated
R768 T2823 T2814 conj analysed,generated
R769 T2716 T2715 aux has,reported
R770 T2824 T2825 nmod Adam11,mice
R771 T2825 T2823 dobj mice,analysed
R772 T2826 T2827 npadvmod gene,targeted
R773 T2717 T2715 auxpass been,reported
R774 T2827 T2825 amod targeted,mice
R775 T2828 T2827 punct -,targeted
R776 T2829 T2814 punct .,generated
R777 T2718 T2719 mark that,has
R778 T2719 T2715 ccomp has,reported
R779 T2720 T2721 det the,ortholog
R780 T2721 T2719 nsubj ortholog,has
R781 T2722 T2721 compound Xenopus,ortholog
R782 T2723 T2721 compound ADAM11,ortholog
R783 T2724 T2721 punct ", ",ortholog
R784 T2725 T2721 appos xMDC11a,ortholog
R785 T2726 T2719 punct ", ",has
R786 T2727 T2728 det an,pattern
R787 T2728 T2719 dobj pattern,has
R788 T2729 T2728 compound expression,pattern
R789 T2730 T2728 acl associated,pattern
R790 T2731 T2730 prep with,associated
R791 T2732 T2733 amod neural,development
R792 T2733 T2731 pobj development,with
R793 T2734 T2728 punct ", ",pattern
R794 T2735 T2728 prep with,pattern
R795 T2736 T2737 det a,role
R796 T2737 T2735 pobj role,with
R797 T2738 T2737 amod proposed,role
R798 T2739 T2737 prep in,role
R799 T2740 T2741 compound cell,migration
R800 T2741 T2739 pobj migration,in