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PMC:138691 / 1382-3109 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T437 0-9 VBG denotes Following
T439 10-13 DT denotes the
T441 14-22 NN denotes landmark
T440 23-32 NN denotes discovery
T442 33-35 IN denotes by
T443 36-42 NNP denotes Scully
T444 43-45 FW denotes et
T445 46-48 FW denotes al
T446 49-53 IN denotes that
T448 54-57 DT denotes the
T450 58-68 JJ denotes homologous
T451 69-80 NN denotes recombinase
T449 81-86 NN denotes RAD51
T447 87-98 VBZ denotes colocalizes
T452 99-101 IN denotes at
T453 102-112 JJ denotes subnuclear
T454 113-118 NNS denotes sites
T455 119-123 IN denotes with
T456 124-129 NN denotes BRCA1
T457 130-131 -LRB- denotes [
T458 131-132 CD denotes 9
T459 132-133 -RRB- denotes ]
T460 133-135 , denotes ,
T461 135-136 DT denotes a
T462 137-143 NN denotes number
T463 144-146 IN denotes of
T464 147-157 JJ denotes additional
T465 158-165 NNS denotes results
T466 166-170 VBP denotes have
T438 171-179 VBN denotes provided
T467 180-188 NN denotes evidence
T468 189-193 IN denotes that
T470 194-198 CC denotes both
T471 199-204 NN denotes BRCA1
T472 205-208 CC denotes and
T473 209-214 NN denotes BRCA2
T474 215-218 VBP denotes are
T469 219-227 VBN denotes involved
T475 228-230 IN denotes in
T476 231-246 JJ denotes recombinational
T477 247-253 NN denotes repair
T478 254-256 IN denotes of
T479 257-260 NN denotes DNA
T480 261-267 NN denotes damage
T481 267-268 . denotes .
T482 268-383 sentence denotes BRCA1 and BRCA2 form discrete nuclear foci during the S phase and after exposure to DNA damaging agents [9,10,11].
T483 269-274 NN denotes BRCA1
T485 275-278 CC denotes and
T486 279-284 NN denotes BRCA2
T484 285-289 VBP denotes form
T487 290-298 JJ denotes discrete
T489 299-306 JJ denotes nuclear
T488 307-311 NNS denotes foci
T490 312-318 IN denotes during
T491 319-322 DT denotes the
T493 323-324 NN denotes S
T492 325-330 NN denotes phase
T494 331-334 CC denotes and
T495 335-340 IN denotes after
T496 341-349 NN denotes exposure
T497 350-352 IN denotes to
T498 353-356 NN denotes DNA
T499 357-365 VBG denotes damaging
T500 366-372 NNS denotes agents
T501 373-374 -LRB- denotes [
T503 374-375 CD denotes 9
T504 375-376 , denotes ,
T505 376-378 CD denotes 10
T506 378-379 , denotes ,
T502 379-381 CD denotes 11
T507 381-382 -RRB- denotes ]
T508 382-383 . denotes .
T509 383-473 sentence denotes These foci are probably sites of repair of spontaneous and induced DNA damage [12,13,14].
T510 384-389 DT denotes These
T511 390-394 NNS denotes foci
T512 395-398 VBP denotes are
T513 399-407 RB denotes probably
T514 408-413 NNS denotes sites
T515 414-416 IN denotes of
T516 417-423 NN denotes repair
T517 424-426 IN denotes of
T518 427-438 JJ denotes spontaneous
T520 439-442 CC denotes and
T521 443-450 JJ denotes induced
T522 451-454 NN denotes DNA
T519 455-461 NN denotes damage
T523 462-463 -LRB- denotes [
T525 463-465 CD denotes 12
T526 465-466 , denotes ,
T527 466-468 CD denotes 13
T528 468-469 , denotes ,
T524 469-471 CD denotes 14
T529 471-472 -RRB- denotes ]
T530 472-473 . denotes .
T531 473-671 sentence denotes Cell lines defective in either BRCA1 or BRCA2 are sensitive to damaging agents that form double-strand breaks (DSBs), as are other cell lines defective in recombinational repair (reviewed in [15]).
T532 474-478 NN denotes Cell
T533 479-484 NNS denotes lines
T535 485-494 JJ denotes defective
T536 495-497 IN denotes in
T537 498-504 CC denotes either
T538 505-510 NN denotes BRCA1
T539 511-513 CC denotes or
T540 514-519 NN denotes BRCA2
T534 520-523 VBP denotes are
T541 524-533 JJ denotes sensitive
T542 534-536 IN denotes to
T543 537-545 VBG denotes damaging
T544 546-552 NNS denotes agents
T545 553-557 WDT denotes that
T546 558-562 VBP denotes form
T547 563-569 JJ denotes double
T549 569-570 HYPH denotes -
T548 570-576 JJ denotes strand
T550 577-583 NNS denotes breaks
T551 584-585 -LRB- denotes (
T552 585-589 NNS denotes DSBs
T553 589-590 -RRB- denotes )
T554 590-592 , denotes ,
T555 592-594 IN denotes as
T556 595-598 VBP denotes are
T557 599-604 JJ denotes other
T559 605-609 NN denotes cell
T558 610-615 NNS denotes lines
T560 616-625 JJ denotes defective
T561 626-628 IN denotes in
T562 629-644 JJ denotes recombinational
T563 645-651 NN denotes repair
T564 652-653 -LRB- denotes (
T565 653-661 VBN denotes reviewed
T566 662-664 IN denotes in
T567 665-666 -LRB- denotes [
T568 666-668 CD denotes 15
T569 668-669 -RRB- denotes ]
T570 669-670 -RRB- denotes )
T571 670-671 . denotes .
T572 671-765 sentence denotes BRCA2 interacts with the RAD51 recombinase via direct protein-protein contacts [16,17,18,19].
T573 672-677 NN denotes BRCA2
T574 678-687 VBZ denotes interacts
T575 688-692 IN denotes with
T576 693-696 DT denotes the
T578 697-702 NN denotes RAD51
T577 703-714 NN denotes recombinase
T579 715-718 IN denotes via
T580 719-725 JJ denotes direct
T582 726-733 NN denotes protein
T584 733-734 HYPH denotes -
T583 734-741 NN denotes protein
T581 742-750 NNS denotes contacts
T585 751-752 -LRB- denotes [
T587 752-754 CD denotes 16
T588 754-755 , denotes ,
T589 755-757 CD denotes 17
T590 757-758 , denotes ,
T591 758-760 CD denotes 18
T592 760-761 , denotes ,
T586 761-763 CD denotes 19
T593 763-764 -RRB- denotes ]
T594 764-765 . denotes .
T595 765-900 sentence denotes Biochemical analysis also showed interaction between BRCA1 and RAD51, although these detected interactions may have been indirect [9].
T596 766-777 JJ denotes Biochemical
T597 778-786 NN denotes analysis
T599 787-791 RB denotes also
T598 792-798 VBD denotes showed
T600 799-810 NN denotes interaction
T601 811-818 IN denotes between
T602 819-824 NN denotes BRCA1
T603 825-828 CC denotes and
T604 829-834 NN denotes RAD51
T605 834-836 , denotes ,
T606 836-844 IN denotes although
T608 845-850 DT denotes these
T610 851-859 VBN denotes detected
T609 860-872 NNS denotes interactions
T611 873-876 MD denotes may
T612 877-881 VB denotes have
T607 882-886 VBN denotes been
T613 887-895 JJ denotes indirect
T614 896-897 -LRB- denotes [
T615 897-898 CD denotes 9
T616 898-899 -RRB- denotes ]
T617 899-900 . denotes .
T618 900-971 sentence denotes The BRC repeats of BRCA2 are responsible for direct RAD51 interaction.
T619 901-904 DT denotes The
T621 905-908 NN denotes BRC
T620 909-916 NNS denotes repeats
T623 917-919 IN denotes of
T624 920-925 NN denotes BRCA2
T622 926-929 VBP denotes are
T625 930-941 JJ denotes responsible
T626 942-945 IN denotes for
T627 946-952 JJ denotes direct
T629 953-958 NN denotes RAD51
T628 959-970 NN denotes interaction
T630 970-971 . denotes .
T631 971-1190 sentence denotes Cells lacking BRCA1/2 fail to form damage-induced subnuclear RAD51 foci with normal efficiency, suggesting that these proteins are required for the formation of recombinase complexes at the sites of DNA damage [20,21].
T632 972-977 NNS denotes Cells
T634 978-985 VBG denotes lacking
T635 986-991 NN denotes BRCA1
T637 991-992 HYPH denotes /
T636 992-993 NN denotes 2
T633 994-998 VBP denotes fail
T638 999-1001 TO denotes to
T639 1002-1006 VB denotes form
T640 1007-1013 NN denotes damage
T642 1013-1014 HYPH denotes -
T641 1014-1021 VBN denotes induced
T644 1022-1032 JJ denotes subnuclear
T643 1033-1038 NN denotes RAD51
T645 1039-1043 NNS denotes foci
T646 1044-1048 IN denotes with
T647 1049-1055 JJ denotes normal
T648 1056-1066 NN denotes efficiency
T649 1066-1068 , denotes ,
T650 1068-1078 VBG denotes suggesting
T651 1079-1083 IN denotes that
T653 1084-1089 DT denotes these
T654 1090-1098 NN denotes proteins
T655 1099-1102 VBP denotes are
T652 1103-1111 VBN denotes required
T656 1112-1115 IN denotes for
T657 1116-1119 DT denotes the
T658 1120-1129 NN denotes formation
T659 1130-1132 IN denotes of
T660 1133-1144 NN denotes recombinase
T661 1145-1154 NNS denotes complexes
T662 1155-1157 IN denotes at
T663 1158-1161 DT denotes the
T664 1162-1167 NNS denotes sites
T665 1168-1170 IN denotes of
T666 1171-1174 NN denotes DNA
T667 1175-1181 NN denotes damage
T668 1182-1183 -LRB- denotes [
T670 1183-1185 CD denotes 20
T671 1185-1186 , denotes ,
T669 1186-1188 CD denotes 21
T672 1188-1189 -RRB- denotes ]
T673 1189-1190 . denotes .
T674 1190-1351 sentence denotes Finally, genetic measurements of recombination frequency have shown that Brca1-/- embryonic stem (ES) cells are deficient in recombinational DSB repair [22,23].
T675 1191-1198 RB denotes Finally
T677 1198-1200 , denotes ,
T678 1200-1207 JJ denotes genetic
T679 1208-1220 NNS denotes measurements
T680 1221-1223 IN denotes of
T681 1224-1237 NN denotes recombination
T682 1238-1247 NN denotes frequency
T683 1248-1252 VBP denotes have
T676 1253-1258 VBN denotes shown
T684 1259-1263 IN denotes that
T686 1264-1269 NN denotes Brca1
T688 1269-1270 SYM denotes -
T689 1270-1271 HYPH denotes /
T690 1271-1272 SYM denotes -
T691 1273-1282 JJ denotes embryonic
T692 1283-1287 NN denotes stem
T693 1288-1289 -LRB- denotes (
T694 1289-1291 NN denotes ES
T695 1291-1292 -RRB- denotes )
T687 1293-1298 NNS denotes cells
T685 1299-1302 VBP denotes are
T696 1303-1312 JJ denotes deficient
T697 1313-1315 IN denotes in
T698 1316-1331 JJ denotes recombinational
T700 1332-1335 NN denotes DSB
T699 1336-1342 NN denotes repair
T701 1343-1344 -LRB- denotes [
T703 1344-1346 CD denotes 22
T704 1346-1347 , denotes ,
T702 1347-1349 CD denotes 23
T705 1349-1350 -RRB- denotes ]
T706 1350-1351 . denotes .
T707 1351-1646 sentence denotes The similarity between phenotypes associated with BRCA1 and BRCA2 deficiency, together with data showing a similar effect of DNA damage on distribution of BRCA1 and BRCA2 in repair-proficient cells, led to the hypothesis that BRCA2, like BRCA1, is required for efficient recombinational repair.
T708 1352-1355 DT denotes The
T709 1356-1366 NN denotes similarity
T711 1367-1374 IN denotes between
T712 1375-1385 NNS denotes phenotypes
T713 1386-1396 VBN denotes associated
T714 1397-1401 IN denotes with
T715 1402-1407 NN denotes BRCA1
T717 1408-1411 CC denotes and
T718 1412-1417 NN denotes BRCA2
T716 1418-1428 NN denotes deficiency
T719 1428-1430 , denotes ,
T720 1430-1438 RB denotes together
T721 1439-1443 IN denotes with
T722 1444-1448 NNS denotes data
T723 1449-1456 VBG denotes showing
T724 1457-1458 DT denotes a
T726 1459-1466 JJ denotes similar
T725 1467-1473 NN denotes effect
T727 1474-1476 IN denotes of
T728 1477-1480 NN denotes DNA
T729 1481-1487 NN denotes damage
T730 1488-1490 IN denotes on
T731 1491-1503 NN denotes distribution
T732 1504-1506 IN denotes of
T733 1507-1512 NN denotes BRCA1
T734 1513-1516 CC denotes and
T735 1517-1522 NN denotes BRCA2
T736 1523-1525 IN denotes in
T737 1526-1532 NN denotes repair
T739 1532-1533 HYPH denotes -
T738 1533-1543 JJ denotes proficient
T740 1544-1549 NNS denotes cells
T741 1549-1551 , denotes ,
T710 1551-1554 VBD denotes led
T742 1555-1557 IN denotes to
T743 1558-1561 DT denotes the
T744 1562-1572 NN denotes hypothesis
T745 1573-1577 IN denotes that
T747 1578-1583 NN denotes BRCA2
T748 1583-1585 , denotes ,
T749 1585-1589 IN denotes like
T750 1590-1595 NN denotes BRCA1
T751 1595-1597 , denotes ,
T752 1597-1599 VBZ denotes is
T746 1600-1608 VBN denotes required
T753 1609-1612 IN denotes for
T754 1613-1622 JJ denotes efficient
T756 1623-1638 JJ denotes recombinational
T755 1639-1645 NN denotes repair
T757 1645-1646 . denotes .
T758 1646-1727 sentence denotes The paper by Moynahan et al [24] provides important support for this hypothesis.
T759 1647-1650 DT denotes The
T760 1651-1656 NN denotes paper
T762 1657-1659 IN denotes by
T763 1660-1668 NNP denotes Moynahan
T764 1669-1671 FW denotes et
T765 1672-1674 FW denotes al
T766 1675-1676 -LRB- denotes [
T767 1676-1678 CD denotes 24
T768 1678-1679 -RRB- denotes ]
T761 1680-1688 VBZ denotes provides
T769 1689-1698 JJ denotes important
T770 1699-1706 NN denotes support
T771 1707-1710 IN denotes for
T772 1711-1715 DT denotes this
T773 1716-1726 NN denotes hypothesis
T774 1726-1727 . denotes .
R241 T437 T438 prep Following,provided
R242 T439 T440 det the,discovery
R243 T440 T437 pobj discovery,Following
R244 T441 T440 compound landmark,discovery
R245 T442 T440 prep by,discovery
R246 T443 T442 pobj Scully,by
R247 T444 T445 advmod et,al
R248 T445 T443 advmod al,Scully
R249 T446 T447 mark that,colocalizes
R250 T447 T440 acl colocalizes,discovery
R251 T448 T449 det the,RAD51
R252 T449 T447 nsubj RAD51,colocalizes
R253 T450 T449 amod homologous,RAD51
R254 T451 T449 compound recombinase,RAD51
R255 T452 T447 prep at,colocalizes
R256 T453 T454 amod subnuclear,sites
R257 T454 T452 pobj sites,at
R258 T455 T447 prep with,colocalizes
R259 T456 T455 pobj BRCA1,with
R260 T457 T458 punct [,9
R261 T458 T447 parataxis 9,colocalizes
R262 T459 T458 punct ],9
R263 T460 T438 punct ", ",provided
R264 T461 T462 det a,number
R265 T462 T438 nsubj number,provided
R266 T463 T462 prep of,number
R267 T464 T465 amod additional,results
R268 T465 T463 pobj results,of
R269 T466 T438 aux have,provided
R270 T467 T438 dobj evidence,provided
R271 T468 T469 mark that,involved
R272 T469 T467 acl involved,evidence
R273 T470 T471 preconj both,BRCA1
R274 T471 T469 nsubjpass BRCA1,involved
R275 T472 T471 cc and,BRCA1
R276 T473 T471 conj BRCA2,BRCA1
R277 T474 T469 auxpass are,involved
R278 T475 T469 prep in,involved
R279 T476 T477 amod recombinational,repair
R280 T477 T475 pobj repair,in
R281 T478 T477 prep of,repair
R282 T479 T480 compound DNA,damage
R283 T480 T478 pobj damage,of
R284 T481 T438 punct .,provided
R285 T483 T484 nsubj BRCA1,form
R286 T485 T483 cc and,BRCA1
R287 T486 T483 conj BRCA2,BRCA1
R288 T487 T488 amod discrete,foci
R289 T488 T484 dobj foci,form
R290 T489 T488 amod nuclear,foci
R291 T490 T484 prep during,form
R292 T491 T492 det the,phase
R293 T492 T490 pobj phase,during
R294 T493 T492 compound S,phase
R295 T494 T490 cc and,during
R296 T495 T490 conj after,during
R297 T496 T495 pobj exposure,after
R298 T497 T496 prep to,exposure
R299 T498 T499 npadvmod DNA,damaging
R300 T499 T500 amod damaging,agents
R301 T500 T497 pobj agents,to
R302 T501 T502 punct [,11
R303 T502 T484 parataxis 11,form
R304 T503 T502 nummod 9,11
R305 T504 T502 punct ",",11
R306 T505 T502 nummod 10,11
R307 T506 T502 punct ",",11
R308 T507 T502 punct ],11
R309 T508 T484 punct .,form
R310 T510 T511 det These,foci
R311 T511 T512 nsubj foci,are
R312 T513 T512 advmod probably,are
R313 T514 T512 attr sites,are
R314 T515 T514 prep of,sites
R315 T516 T515 pobj repair,of
R316 T517 T516 prep of,repair
R317 T518 T519 amod spontaneous,damage
R318 T519 T517 pobj damage,of
R319 T520 T518 cc and,spontaneous
R320 T521 T518 conj induced,spontaneous
R321 T522 T519 compound DNA,damage
R322 T523 T524 punct [,14
R323 T524 T512 parataxis 14,are
R324 T525 T524 nummod 12,14
R325 T526 T524 punct ",",14
R326 T527 T524 nummod 13,14
R327 T528 T524 punct ",",14
R328 T529 T524 punct ],14
R329 T530 T512 punct .,are
R330 T532 T533 compound Cell,lines
R331 T533 T534 nsubj lines,are
R332 T535 T533 amod defective,lines
R333 T536 T535 prep in,defective
R334 T537 T538 preconj either,BRCA1
R335 T538 T536 pobj BRCA1,in
R336 T539 T538 cc or,BRCA1
R337 T540 T538 conj BRCA2,BRCA1
R338 T541 T534 acomp sensitive,are
R339 T542 T541 prep to,sensitive
R340 T543 T544 amod damaging,agents
R341 T544 T542 pobj agents,to
R342 T545 T546 dep that,form
R343 T546 T544 relcl form,agents
R344 T547 T548 amod double,strand
R345 T548 T550 amod strand,breaks
R346 T549 T548 punct -,strand
R347 T550 T546 dobj breaks,form
R348 T551 T550 punct (,breaks
R349 T552 T550 appos DSBs,breaks
R350 T553 T534 punct ),are
R351 T554 T534 punct ", ",are
R352 T555 T556 mark as,are
R353 T556 T534 advcl are,are
R354 T557 T558 amod other,lines
R355 T558 T556 nsubj lines,are
R356 T559 T558 compound cell,lines
R357 T560 T558 amod defective,lines
R358 T561 T560 prep in,defective
R359 T562 T563 amod recombinational,repair
R360 T563 T561 pobj repair,in
R361 T564 T565 punct (,reviewed
R362 T565 T534 parataxis reviewed,are
R363 T566 T565 prep in,reviewed
R364 T567 T566 punct [,in
R365 T568 T566 pobj 15,in
R366 T569 T566 punct ],in
R367 T570 T565 punct ),reviewed
R368 T571 T534 punct .,are
R369 T573 T574 nsubj BRCA2,interacts
R370 T575 T574 prep with,interacts
R371 T576 T577 det the,recombinase
R372 T577 T575 pobj recombinase,with
R373 T578 T577 compound RAD51,recombinase
R374 T579 T574 prep via,interacts
R375 T580 T581 amod direct,contacts
R376 T581 T579 pobj contacts,via
R377 T582 T583 compound protein,protein
R378 T583 T581 compound protein,contacts
R379 T584 T583 punct -,protein
R380 T585 T586 punct [,19
R381 T586 T574 parataxis 19,interacts
R382 T587 T586 nummod 16,19
R383 T588 T586 punct ",",19
R384 T589 T586 nummod 17,19
R385 T590 T586 punct ",",19
R386 T591 T586 nummod 18,19
R387 T592 T586 punct ",",19
R388 T593 T586 punct ],19
R389 T594 T574 punct .,interacts
R390 T596 T597 amod Biochemical,analysis
R391 T597 T598 nsubj analysis,showed
R392 T599 T598 advmod also,showed
R393 T600 T598 dobj interaction,showed
R394 T601 T600 prep between,interaction
R395 T602 T601 pobj BRCA1,between
R396 T603 T602 cc and,BRCA1
R397 T604 T602 conj RAD51,BRCA1
R398 T605 T598 punct ", ",showed
R399 T606 T607 mark although,been
R400 T607 T598 advcl been,showed
R401 T608 T609 det these,interactions
R402 T609 T607 nsubj interactions,been
R403 T610 T609 amod detected,interactions
R404 T611 T607 aux may,been
R405 T612 T607 aux have,been
R406 T613 T607 acomp indirect,been
R407 T614 T615 punct [,9
R408 T615 T598 parataxis 9,showed
R409 T616 T615 punct ],9
R410 T617 T598 punct .,showed
R411 T619 T620 det The,repeats
R412 T620 T622 nsubj repeats,are
R413 T621 T620 compound BRC,repeats
R414 T623 T620 prep of,repeats
R415 T624 T623 pobj BRCA2,of
R416 T625 T622 acomp responsible,are
R417 T626 T625 prep for,responsible
R418 T627 T628 amod direct,interaction
R419 T628 T626 pobj interaction,for
R420 T629 T628 compound RAD51,interaction
R421 T630 T622 punct .,are
R422 T632 T633 nsubj Cells,fail
R423 T634 T632 acl lacking,Cells
R424 T635 T636 compound BRCA1,2
R425 T636 T634 dobj 2,lacking
R426 T637 T636 punct /,2
R427 T638 T639 aux to,form
R428 T639 T633 xcomp form,fail
R429 T640 T641 npadvmod damage,induced
R430 T641 T643 amod induced,RAD51
R431 T642 T641 punct -,induced
R432 T643 T645 compound RAD51,foci
R433 T644 T643 amod subnuclear,RAD51
R434 T645 T639 dobj foci,form
R435 T646 T639 prep with,form
R436 T647 T648 amod normal,efficiency
R437 T648 T646 pobj efficiency,with
R438 T649 T633 punct ", ",fail
R439 T650 T633 advcl suggesting,fail
R440 T651 T652 mark that,required
R441 T652 T650 ccomp required,suggesting
R442 T653 T654 det these,proteins
R443 T654 T652 nsubjpass proteins,required
R444 T655 T652 auxpass are,required
R445 T656 T652 prep for,required
R446 T657 T658 det the,formation
R447 T658 T656 pobj formation,for
R448 T659 T658 prep of,formation
R449 T660 T661 compound recombinase,complexes
R450 T661 T659 pobj complexes,of
R451 T662 T658 prep at,formation
R452 T663 T664 det the,sites
R453 T664 T662 pobj sites,at
R454 T665 T664 prep of,sites
R455 T666 T667 compound DNA,damage
R456 T667 T665 pobj damage,of
R457 T668 T669 punct [,21
R458 T669 T633 parataxis 21,fail
R459 T670 T669 nummod 20,21
R460 T671 T669 punct ",",21
R461 T672 T669 punct ],21
R462 T673 T633 punct .,fail
R463 T675 T676 advmod Finally,shown
R464 T677 T676 punct ", ",shown
R465 T678 T679 amod genetic,measurements
R466 T679 T676 nsubj measurements,shown
R467 T680 T679 prep of,measurements
R468 T681 T682 compound recombination,frequency
R469 T682 T680 pobj frequency,of
R470 T683 T676 aux have,shown
R471 T684 T685 mark that,are
R472 T685 T676 ccomp are,shown
R473 T686 T687 nmod Brca1,cells
R474 T687 T685 nsubj cells,are
R475 T688 T686 punct -,Brca1
R476 T689 T686 punct /,Brca1
R477 T690 T686 punct -,Brca1
R478 T691 T692 amod embryonic,stem
R479 T692 T687 nmod stem,cells
R480 T693 T692 punct (,stem
R481 T694 T692 appos ES,stem
R482 T695 T687 punct ),cells
R483 T696 T685 acomp deficient,are
R484 T697 T696 prep in,deficient
R485 T698 T699 amod recombinational,repair
R486 T699 T697 pobj repair,in
R487 T700 T699 compound DSB,repair
R488 T701 T702 punct [,23
R489 T702 T676 parataxis 23,shown
R490 T703 T702 nummod 22,23
R491 T704 T702 punct ",",23
R492 T705 T702 punct ],23
R493 T706 T676 punct .,shown
R494 T708 T709 det The,similarity
R495 T709 T710 nsubj similarity,led
R496 T711 T709 prep between,similarity
R497 T712 T711 pobj phenotypes,between
R498 T713 T712 acl associated,phenotypes
R499 T714 T713 prep with,associated
R500 T715 T716 nmod BRCA1,deficiency
R501 T716 T714 pobj deficiency,with
R502 T717 T715 cc and,BRCA1
R503 T718 T715 conj BRCA2,BRCA1
R504 T719 T709 punct ", ",similarity
R505 T720 T721 advmod together,with
R506 T721 T709 prep with,similarity
R507 T722 T721 pobj data,with
R508 T723 T722 acl showing,data
R509 T724 T725 det a,effect
R510 T725 T723 dobj effect,showing
R511 T726 T725 amod similar,effect
R512 T727 T725 prep of,effect
R513 T728 T729 compound DNA,damage
R514 T729 T727 pobj damage,of
R515 T730 T729 prep on,damage
R516 T731 T730 pobj distribution,on
R517 T732 T731 prep of,distribution
R518 T733 T732 pobj BRCA1,of
R519 T734 T733 cc and,BRCA1
R520 T735 T733 conj BRCA2,BRCA1
R521 T736 T731 prep in,distribution
R522 T737 T738 npadvmod repair,proficient
R523 T738 T740 amod proficient,cells
R524 T739 T738 punct -,proficient
R525 T740 T736 pobj cells,in
R526 T741 T710 punct ", ",led
R527 T742 T710 prep to,led
R528 T743 T744 det the,hypothesis
R529 T744 T742 pobj hypothesis,to
R530 T745 T746 mark that,required
R531 T746 T744 acl required,hypothesis
R532 T747 T746 nsubjpass BRCA2,required
R533 T748 T747 punct ", ",BRCA2
R534 T749 T747 prep like,BRCA2
R535 T750 T749 pobj BRCA1,like
R536 T751 T746 punct ", ",required
R537 T752 T746 auxpass is,required
R538 T753 T746 prep for,required
R539 T754 T755 amod efficient,repair
R540 T755 T753 pobj repair,for
R541 T756 T755 amod recombinational,repair
R542 T757 T710 punct .,led
R543 T759 T760 det The,paper
R544 T760 T761 nsubj paper,provides
R545 T762 T760 prep by,paper
R546 T763 T762 pobj Moynahan,by
R547 T764 T765 advmod et,al
R548 T765 T763 advmod al,Moynahan
R549 T766 T767 punct [,24
R550 T767 T760 parataxis 24,paper
R551 T768 T767 punct ],24
R552 T769 T770 amod important,support
R553 T770 T761 dobj support,provides
R554 T771 T761 dative for,provides
R555 T772 T773 det this,hypothesis
R556 T773 T771 pobj hypothesis,for
R557 T774 T761 punct .,provides