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PMC:1382200 / 93-853 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T681 0-1 NN denotes μ
T683 1-2 HYPH denotes -
T682 2-9 NN denotes calpain
T685 10-13 CC denotes and
T686 14-15 NN denotes m
T688 15-16 HYPH denotes -
T687 16-23 NN denotes calpain
T684 24-27 VBP denotes are
T689 28-40 RB denotes ubiquitously
T690 41-50 VBN denotes expressed
T691 51-60 NNS denotes proteases
T692 61-71 VBN denotes implicated
T693 72-74 IN denotes in
T694 75-83 JJ denotes cellular
T695 84-93 NN denotes migration
T696 93-95 , denotes ,
T697 95-99 NN denotes cell
T698 100-105 NN denotes cycle
T699 106-117 NN denotes progression
T700 117-119 , denotes ,
T701 119-131 JJ denotes degenerative
T702 132-141 NNS denotes processes
T703 142-145 CC denotes and
T704 146-150 NN denotes cell
T705 151-156 NN denotes death
T706 156-157 . denotes .
T707 157-331 sentence denotes These heterodimeric enzymes are composed of distinct catalytic subunits, encoded by Capn1 (μ-calpain) or Capn2 (m-calpain), and a common regulatory subunit encoded by Capn4.
T708 158-163 DT denotes These
T710 164-177 JJ denotes heterodimeric
T709 178-185 NNS denotes enzymes
T712 186-189 VBP denotes are
T711 190-198 VBN denotes composed
T713 199-201 IN denotes of
T714 202-210 JJ denotes distinct
T716 211-220 JJ denotes catalytic
T715 221-229 NNS denotes subunits
T717 229-231 , denotes ,
T718 231-238 VBN denotes encoded
T719 239-241 IN denotes by
T720 242-247 NN denotes Capn1
T721 248-249 -LRB- denotes (
T722 249-250 NN denotes μ
T724 250-251 HYPH denotes -
T723 251-258 NN denotes calpain
T725 258-259 -RRB- denotes )
T726 260-262 CC denotes or
T727 263-268 NN denotes Capn2
T728 269-270 -LRB- denotes (
T729 270-271 NN denotes m
T731 271-272 HYPH denotes -
T730 272-279 NN denotes calpain
T732 279-280 -RRB- denotes )
T733 280-282 , denotes ,
T734 282-285 CC denotes and
T735 286-287 DT denotes a
T737 288-294 JJ denotes common
T738 295-305 JJ denotes regulatory
T736 306-313 NN denotes subunit
T739 314-321 VBN denotes encoded
T740 322-324 IN denotes by
T741 325-330 NN denotes Capn4
T742 330-331 . denotes .
T743 331-552 sentence denotes Disruption of the mouse Capn4 gene abolished both μ-calpain and m-calpain activity, and resulted in embryonic lethality, thereby suggesting essential roles for one or both of these enzymes during mammalian embryogenesis.
T744 332-342 NN denotes Disruption
T746 343-345 IN denotes of
T747 346-349 DT denotes the
T749 350-355 NN denotes mouse
T750 356-361 NN denotes Capn4
T748 362-366 NN denotes gene
T745 367-376 VBD denotes abolished
T751 377-381 CC denotes both
T753 382-383 NN denotes μ
T754 383-384 HYPH denotes -
T752 384-391 NN denotes calpain
T756 392-395 CC denotes and
T757 396-397 NN denotes m
T759 397-398 HYPH denotes -
T758 398-405 NN denotes calpain
T755 406-414 NN denotes activity
T760 414-416 , denotes ,
T761 416-419 CC denotes and
T762 420-428 VBD denotes resulted
T763 429-431 IN denotes in
T764 432-441 JJ denotes embryonic
T765 442-451 NN denotes lethality
T766 451-453 , denotes ,
T767 453-460 RB denotes thereby
T768 461-471 VBG denotes suggesting
T769 472-481 JJ denotes essential
T770 482-487 NNS denotes roles
T771 488-491 IN denotes for
T772 492-495 CD denotes one
T773 496-498 CC denotes or
T774 499-503 DT denotes both
T775 504-506 IN denotes of
T776 507-512 DT denotes these
T777 513-520 NNS denotes enzymes
T778 521-527 IN denotes during
T779 528-537 JJ denotes mammalian
T780 538-551 NN denotes embryogenesis
T781 551-552 . denotes .
T782 552-760 sentence denotes Disruption of the Capn1 gene produced viable, fertile mice implying that either m-calpain could compensate for the loss of μ-calpain, or that the loss of m-calpain was responsible for death of Capn4-/- mice.
T783 553-563 NN denotes Disruption
T785 564-566 IN denotes of
T786 567-570 DT denotes the
T788 571-576 NN denotes Capn1
T787 577-581 NN denotes gene
T784 582-590 VBD denotes produced
T789 591-597 JJ denotes viable
T791 597-599 , denotes ,
T792 599-606 JJ denotes fertile
T790 607-611 NNS denotes mice
T793 612-620 VBG denotes implying
T794 621-625 IN denotes that
T796 626-632 DT denotes either
T797 633-634 NN denotes m
T799 634-635 HYPH denotes -
T798 635-642 NN denotes calpain
T800 643-648 MD denotes could
T795 649-659 VB denotes compensate
T801 660-663 IN denotes for
T802 664-667 DT denotes the
T803 668-672 NN denotes loss
T804 673-675 IN denotes of
T805 676-677 NN denotes μ
T807 677-678 HYPH denotes -
T806 678-685 NN denotes calpain
T808 685-687 , denotes ,
T809 687-689 CC denotes or
T810 690-694 IN denotes that
T812 695-698 DT denotes the
T813 699-703 NN denotes loss
T814 704-706 IN denotes of
T815 707-708 NN denotes m
T817 708-709 HYPH denotes -
T816 709-716 NN denotes calpain
T811 717-720 VBD denotes was
T818 721-732 JJ denotes responsible
T819 733-736 IN denotes for
T820 737-742 NN denotes death
T821 743-745 IN denotes of
T822 746-751 NN denotes Capn4
T824 751-752 SYM denotes -
T825 752-753 HYPH denotes /
T826 753-754 SYM denotes -
T823 755-759 NNS denotes mice
T827 759-760 . denotes .
R100 T774 T772 conj both,one
R101 T775 T772 prep of,one
R102 T776 T777 det these,enzymes
R103 T777 T775 pobj enzymes,of
R104 T778 T770 prep during,roles
R105 T779 T780 amod mammalian,embryogenesis
R106 T780 T778 pobj embryogenesis,during
R107 T781 T745 punct .,abolished
R108 T783 T784 nsubj Disruption,produced
R109 T785 T783 prep of,Disruption
R110 T786 T787 det the,gene
R111 T787 T785 pobj gene,of
R112 T788 T787 compound Capn1,gene
R113 T789 T790 amod viable,mice
R114 T790 T784 dobj mice,produced
R115 T791 T790 punct ", ",mice
R116 T792 T790 amod fertile,mice
R117 T793 T784 advcl implying,produced
R118 T794 T795 mark that,compensate
R119 T795 T793 advcl compensate,implying
R12 T681 T682 compound μ,calpain
R120 T796 T795 mark either,compensate
R121 T797 T798 compound m,calpain
R122 T798 T795 nsubj calpain,compensate
R123 T799 T798 punct -,calpain
R124 T800 T795 aux could,compensate
R125 T801 T795 prep for,compensate
R126 T802 T803 det the,loss
R127 T803 T801 pobj loss,for
R128 T804 T803 prep of,loss
R129 T805 T806 compound μ,calpain
R13 T682 T684 nsubj calpain,are
R130 T806 T804 pobj calpain,of
R131 T807 T806 punct -,calpain
R132 T808 T795 punct ", ",compensate
R133 T809 T795 cc or,compensate
R134 T810 T811 mark that,was
R135 T811 T795 conj was,compensate
R136 T812 T813 det the,loss
R137 T813 T811 nsubj loss,was
R138 T814 T813 prep of,loss
R139 T815 T816 compound m,calpain
R14 T683 T682 punct -,calpain
R140 T816 T814 pobj calpain,of
R141 T817 T816 punct -,calpain
R142 T818 T811 acomp responsible,was
R143 T819 T818 prep for,responsible
R144 T820 T819 pobj death,for
R145 T821 T820 prep of,death
R146 T822 T823 nmod Capn4,mice
R147 T823 T821 pobj mice,of
R148 T824 T822 punct -,Capn4
R149 T825 T822 punct /,Capn4
R15 T685 T682 cc and,calpain
R150 T826 T822 punct -,Capn4
R151 T827 T784 punct .,produced
R16 T686 T687 compound m,calpain
R17 T687 T682 conj calpain,calpain
R18 T688 T687 punct -,calpain
R19 T689 T690 advmod ubiquitously,expressed
R20 T690 T691 amod expressed,proteases
R21 T691 T684 attr proteases,are
R22 T692 T691 acl implicated,proteases
R23 T693 T692 prep in,implicated
R24 T694 T695 amod cellular,migration
R25 T695 T693 pobj migration,in
R26 T696 T695 punct ", ",migration
R27 T697 T698 compound cell,cycle
R28 T698 T699 compound cycle,progression
R29 T699 T695 conj progression,migration
R30 T700 T699 punct ", ",progression
R31 T701 T702 amod degenerative,processes
R32 T702 T699 conj processes,progression
R33 T703 T702 cc and,processes
R34 T704 T705 compound cell,death
R35 T705 T702 conj death,processes
R36 T706 T684 punct .,are
R37 T708 T709 det These,enzymes
R38 T709 T711 nsubjpass enzymes,composed
R39 T710 T709 amod heterodimeric,enzymes
R40 T712 T711 auxpass are,composed
R41 T713 T711 prep of,composed
R42 T714 T715 amod distinct,subunits
R43 T715 T713 pobj subunits,of
R44 T716 T715 amod catalytic,subunits
R45 T717 T715 punct ", ",subunits
R46 T718 T715 acl encoded,subunits
R47 T719 T718 agent by,encoded
R48 T720 T719 pobj Capn1,by
R49 T721 T720 punct (,Capn1
R50 T722 T723 compound μ,calpain
R51 T723 T720 appos calpain,Capn1
R52 T724 T723 punct -,calpain
R53 T725 T720 punct ),Capn1
R54 T726 T720 cc or,Capn1
R55 T727 T720 conj Capn2,Capn1
R56 T728 T727 punct (,Capn2
R57 T729 T730 compound m,calpain
R58 T730 T727 appos calpain,Capn2
R59 T731 T730 punct -,calpain
R60 T732 T715 punct ),subunits
R61 T733 T715 punct ", ",subunits
R62 T734 T715 cc and,subunits
R63 T735 T736 det a,subunit
R64 T736 T715 conj subunit,subunits
R65 T737 T736 amod common,subunit
R66 T738 T736 amod regulatory,subunit
R67 T739 T736 acl encoded,subunit
R68 T740 T739 agent by,encoded
R69 T741 T740 pobj Capn4,by
R70 T742 T711 punct .,composed
R71 T744 T745 nsubj Disruption,abolished
R72 T746 T744 prep of,Disruption
R73 T747 T748 det the,gene
R74 T748 T746 pobj gene,of
R75 T749 T748 compound mouse,gene
R76 T750 T748 compound Capn4,gene
R77 T751 T752 preconj both,calpain
R78 T752 T755 nmod calpain,activity
R79 T753 T752 nmod μ,calpain
R80 T754 T752 punct -,calpain
R81 T755 T745 dobj activity,abolished
R82 T756 T752 cc and,calpain
R83 T757 T758 compound m,calpain
R84 T758 T752 conj calpain,calpain
R85 T759 T758 punct -,calpain
R86 T760 T745 punct ", ",abolished
R87 T761 T745 cc and,abolished
R88 T762 T745 conj resulted,abolished
R89 T763 T762 prep in,resulted
R90 T764 T765 amod embryonic,lethality
R91 T765 T763 pobj lethality,in
R92 T766 T762 punct ", ",resulted
R93 T767 T768 advmod thereby,suggesting
R94 T768 T762 advcl suggesting,resulted
R95 T769 T770 amod essential,roles
R96 T770 T768 dobj roles,suggesting
R97 T771 T770 prep for,roles
R98 T772 T771 pobj one,for
R99 T773 T772 cc or,one