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PMC:1382200 / 15786-16444 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T7704 0-9 VBN denotes Attempted
T7705 10-20 NN denotes generation
T7706 21-23 IN denotes of
T7707 24-29 NN denotes Capn2
T7709 29-30 SYM denotes -
T7710 30-31 HYPH denotes /
T7711 31-32 SYM denotes -
T7712 33-35 NN denotes ES
T7708 36-41 NNS denotes cells
T7713 41-194 sentence denotes Capn2+/- ES cells were subjected to clonal selection in the presence of 2 mg/mL G418 in attempts to generate homozygous mutant cells by gene conversion.
T7714 42-47 NN denotes Capn2
T7716 47-48 SYM denotes +
T7717 48-49 HYPH denotes /
T7718 49-50 SYM denotes -
T7719 51-53 NN denotes ES
T7715 54-59 NNS denotes cells
T7721 60-64 VBD denotes were
T7720 65-74 VBN denotes subjected
T7722 75-77 IN denotes to
T7723 78-84 JJ denotes clonal
T7724 85-94 NN denotes selection
T7725 95-97 IN denotes in
T7726 98-101 DT denotes the
T7727 102-110 NN denotes presence
T7728 111-113 IN denotes of
T7729 114-115 CD denotes 2
T7730 116-118 NN denotes mg
T7732 118-119 SYM denotes /
T7733 119-121 NN denotes mL
T7731 122-126 NN denotes G418
T7734 127-129 IN denotes in
T7735 130-138 NNS denotes attempts
T7736 139-141 TO denotes to
T7737 142-150 VB denotes generate
T7738 151-161 JJ denotes homozygous
T7740 162-168 NN denotes mutant
T7739 169-174 NNS denotes cells
T7741 175-177 IN denotes by
T7742 178-182 NN denotes gene
T7743 183-193 NN denotes conversion
T7744 193-194 . denotes .
T7745 194-323 sentence denotes This procedure has been extensively applied to targeted ES cells and was readily achieved in the case of Capn4+/- ES cells [31].
T7746 195-199 DT denotes This
T7747 200-209 NN denotes procedure
T7749 210-213 VBZ denotes has
T7750 214-218 VBN denotes been
T7751 219-230 RB denotes extensively
T7748 231-238 VBN denotes applied
T7752 239-241 IN denotes to
T7753 242-250 VBN denotes targeted
T7755 251-253 NN denotes ES
T7754 254-259 NNS denotes cells
T7756 260-263 CC denotes and
T7757 264-267 VBD denotes was
T7759 268-275 RB denotes readily
T7758 276-284 VBN denotes achieved
T7760 285-287 IN denotes in
T7761 288-291 DT denotes the
T7762 292-296 NN denotes case
T7763 297-299 IN denotes of
T7764 300-305 NN denotes Capn4
T7766 305-306 SYM denotes +
T7767 306-307 HYPH denotes /
T7768 307-308 SYM denotes -
T7769 309-311 NN denotes ES
T7765 312-317 NNS denotes cells
T7770 318-319 -LRB- denotes [
T7771 319-321 CD denotes 31
T7772 321-322 -RRB- denotes ]
T7773 322-323 . denotes .
T7774 323-422 sentence denotes In this case, however, no Capn2-/- ES cells were isolated in screens of 126 drug-resistant clones.
T7775 324-326 IN denotes In
T7777 327-331 DT denotes this
T7778 332-336 NN denotes case
T7779 336-338 , denotes ,
T7780 338-345 RB denotes however
T7781 345-347 , denotes ,
T7782 347-349 DT denotes no
T7784 350-355 NN denotes Capn2
T7785 355-356 SYM denotes -
T7786 356-357 HYPH denotes /
T7787 357-358 SYM denotes -
T7788 359-361 NN denotes ES
T7783 362-367 NNS denotes cells
T7789 368-372 VBD denotes were
T7776 373-381 VBN denotes isolated
T7790 382-384 IN denotes in
T7791 385-392 NNS denotes screens
T7792 393-395 IN denotes of
T7793 396-399 CD denotes 126
T7795 400-404 NN denotes drug
T7797 404-405 HYPH denotes -
T7796 405-414 JJ denotes resistant
T7794 415-421 NNS denotes clones
T7798 421-422 . denotes .
T7799 422-658 sentence denotes The inability to isolate Capn2-/- ES cells, in concert with the absence of Capn2-/- embryos beyond the 8-cell stage, suggested that m-calpain activity might be essential for cell viability or the establishment of viable ES cell clones.
T7800 423-426 DT denotes The
T7801 427-436 NN denotes inability
T7803 437-439 TO denotes to
T7804 440-447 VB denotes isolate
T7805 448-453 NN denotes Capn2
T7807 453-454 SYM denotes -
T7808 454-455 HYPH denotes /
T7809 455-456 SYM denotes -
T7810 457-459 NN denotes ES
T7806 460-465 NNS denotes cells
T7811 465-467 , denotes ,
T7812 467-469 IN denotes in
T7813 470-477 NN denotes concert
T7814 478-482 IN denotes with
T7815 483-486 DT denotes the
T7816 487-494 NN denotes absence
T7817 495-497 IN denotes of
T7818 498-503 NN denotes Capn2
T7820 503-504 SYM denotes -
T7821 504-505 HYPH denotes /
T7822 505-506 SYM denotes -
T7819 507-514 NNS denotes embryos
T7823 515-521 IN denotes beyond
T7824 522-525 DT denotes the
T7826 526-527 CD denotes 8
T7828 527-528 HYPH denotes -
T7827 528-532 NN denotes cell
T7825 533-538 NN denotes stage
T7829 538-540 , denotes ,
T7802 540-549 VBD denotes suggested
T7830 550-554 IN denotes that
T7832 555-556 NN denotes m
T7834 556-557 HYPH denotes -
T7833 557-564 NN denotes calpain
T7835 565-573 NN denotes activity
T7836 574-579 MD denotes might
T7831 580-582 VB denotes be
T7837 583-592 JJ denotes essential
T7838 593-596 IN denotes for
T7839 597-601 NN denotes cell
T7840 602-611 NN denotes viability
T7841 612-614 CC denotes or
T7842 615-618 DT denotes the
T7843 619-632 NN denotes establishment
T7844 633-635 IN denotes of
T7845 636-642 JJ denotes viable
T7847 643-645 NN denotes ES
T7848 646-650 NN denotes cell
T7846 651-657 NNS denotes clones
T7849 657-658 . denotes .
R2221 T7704 T7705 amod Attempted,generation
R2222 T7706 T7705 prep of,generation
R2223 T7707 T7708 nmod Capn2,cells
R2224 T7708 T7706 pobj cells,of
R2225 T7709 T7707 punct -,Capn2
R2226 T7710 T7707 punct /,Capn2
R2227 T7711 T7707 punct -,Capn2
R2228 T7712 T7708 compound ES,cells
R2229 T7714 T7715 nmod Capn2,cells
R2230 T7715 T7720 nsubjpass cells,subjected
R2231 T7716 T7714 punct +,Capn2
R2232 T7717 T7714 punct /,Capn2
R2233 T7718 T7714 punct -,Capn2
R2234 T7719 T7715 compound ES,cells
R2235 T7721 T7720 auxpass were,subjected
R2236 T7722 T7720 prep to,subjected
R2237 T7723 T7724 amod clonal,selection
R2238 T7724 T7722 pobj selection,to
R2239 T7725 T7720 prep in,subjected
R2240 T7726 T7727 det the,presence
R2241 T7727 T7725 pobj presence,in
R2242 T7728 T7727 prep of,presence
R2243 T7729 T7730 nummod 2,mg
R2244 T7730 T7731 nmod mg,G418
R2245 T7731 T7728 pobj G418,of
R2246 T7732 T7733 punct /,mL
R2247 T7733 T7730 prep mL,mg
R2248 T7734 T7727 prep in,presence
R2249 T7735 T7734 pobj attempts,in
R2250 T7736 T7737 aux to,generate
R2251 T7737 T7735 acl generate,attempts
R2252 T7738 T7739 amod homozygous,cells
R2253 T7739 T7737 dobj cells,generate
R2254 T7740 T7739 compound mutant,cells
R2255 T7741 T7737 prep by,generate
R2256 T7742 T7743 compound gene,conversion
R2257 T7743 T7741 pobj conversion,by
R2258 T7744 T7720 punct .,subjected
R2259 T7746 T7747 det This,procedure
R2260 T7747 T7748 nsubjpass procedure,applied
R2261 T7749 T7748 aux has,applied
R2262 T7750 T7748 auxpass been,applied
R2263 T7751 T7748 advmod extensively,applied
R2264 T7752 T7748 prep to,applied
R2265 T7753 T7754 amod targeted,cells
R2266 T7754 T7752 pobj cells,to
R2267 T7755 T7754 compound ES,cells
R2268 T7756 T7748 cc and,applied
R2269 T7757 T7758 auxpass was,achieved
R2270 T7758 T7748 conj achieved,applied
R2271 T7759 T7758 advmod readily,achieved
R2272 T7760 T7758 prep in,achieved
R2273 T7761 T7762 det the,case
R2274 T7762 T7760 pobj case,in
R2275 T7763 T7762 prep of,case
R2276 T7764 T7765 nmod Capn4,cells
R2277 T7765 T7763 pobj cells,of
R2278 T7766 T7764 punct +,Capn4
R2279 T7767 T7764 punct /,Capn4
R2280 T7768 T7764 punct -,Capn4
R2281 T7769 T7765 compound ES,cells
R2282 T7770 T7771 punct [,31
R2283 T7771 T7758 parataxis 31,achieved
R2284 T7772 T7771 punct ],31
R2285 T7773 T7748 punct .,applied
R2286 T7775 T7776 prep In,isolated
R2287 T7777 T7778 det this,case
R2288 T7778 T7775 pobj case,In
R2289 T7779 T7776 punct ", ",isolated
R2290 T7780 T7776 advmod however,isolated
R2291 T7781 T7776 punct ", ",isolated
R2292 T7782 T7783 det no,cells
R2293 T7783 T7776 nsubjpass cells,isolated
R2294 T7784 T7783 nmod Capn2,cells
R2295 T7785 T7784 punct -,Capn2
R2296 T7786 T7784 punct /,Capn2
R2297 T7787 T7784 punct -,Capn2
R2298 T7788 T7783 compound ES,cells
R2299 T7789 T7776 auxpass were,isolated
R2300 T7790 T7776 prep in,isolated
R2301 T7791 T7790 pobj screens,in
R2302 T7792 T7791 prep of,screens
R2303 T7793 T7794 nummod 126,clones
R2304 T7794 T7792 pobj clones,of
R2305 T7795 T7796 npadvmod drug,resistant
R2306 T7796 T7794 amod resistant,clones
R2307 T7797 T7796 punct -,resistant
R2308 T7798 T7776 punct .,isolated
R2309 T7800 T7801 det The,inability
R2310 T7801 T7802 nsubj inability,suggested
R2311 T7803 T7804 aux to,isolate
R2312 T7804 T7801 acl isolate,inability
R2313 T7805 T7806 nmod Capn2,cells
R2314 T7806 T7804 dobj cells,isolate
R2315 T7807 T7805 punct -,Capn2
R2316 T7808 T7805 punct /,Capn2
R2317 T7809 T7805 punct -,Capn2
R2318 T7810 T7806 compound ES,cells
R2319 T7811 T7804 punct ", ",isolate
R2320 T7812 T7804 prep in,isolate
R2321 T7813 T7812 pobj concert,in
R2322 T7814 T7813 prep with,concert
R2323 T7815 T7816 det the,absence
R2324 T7816 T7814 pobj absence,with
R2325 T7817 T7816 prep of,absence
R2326 T7818 T7819 nmod Capn2,embryos
R2327 T7819 T7817 pobj embryos,of
R2328 T7820 T7818 punct -,Capn2
R2329 T7821 T7818 punct /,Capn2
R2330 T7822 T7818 punct -,Capn2
R2331 T7823 T7816 prep beyond,absence
R2332 T7824 T7825 det the,stage
R2333 T7825 T7823 pobj stage,beyond
R2334 T7826 T7827 nummod 8,cell
R2335 T7827 T7825 compound cell,stage
R2336 T7828 T7827 punct -,cell
R2337 T7829 T7802 punct ", ",suggested
R2338 T7830 T7831 mark that,be
R2339 T7831 T7802 ccomp be,suggested
R2340 T7832 T7833 compound m,calpain
R2341 T7833 T7835 compound calpain,activity
R2342 T7834 T7833 punct -,calpain
R2343 T7835 T7831 nsubj activity,be
R2344 T7836 T7831 aux might,be
R2345 T7837 T7831 acomp essential,be
R2346 T7838 T7837 prep for,essential
R2347 T7839 T7840 compound cell,viability
R2348 T7840 T7838 pobj viability,for
R2349 T7841 T7840 cc or,viability
R2350 T7842 T7843 det the,establishment
R2351 T7843 T7840 conj establishment,viability
R2352 T7844 T7843 prep of,establishment
R2353 T7845 T7846 amod viable,clones
R2354 T7846 T7844 pobj clones,of
R2355 T7847 T7846 compound ES,clones
R2356 T7848 T7846 compound cell,clones
R2357 T7849 T7802 punct .,suggested