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PMC:1283364 / 55969-58350 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T11964 0-3 DT denotes The
T11965 4-15 NN denotes persistence
T11967 16-19 CC denotes and
T11968 20-29 NN denotes stability
T11969 30-32 IN denotes of
T11970 33-40 NN denotes amyloid
T11971 41-49 NNS denotes deposits
T11972 50-52 IN denotes in
T11973 53-56 PRP$ denotes our
T11974 57-63 NN denotes system
T11966 64-66 VBZ denotes is
T11975 67-77 JJ denotes unexpected
T11976 78-83 VBN denotes given
T11977 84-87 DT denotes the
T11978 88-93 NN denotes speed
T11979 94-98 IN denotes with
T11981 99-104 WDT denotes which
T11982 105-107 NN denotes Aβ
T11983 108-118 NNS denotes aggregates
T11984 119-122 VBP denotes are
T11980 123-130 VBN denotes cleared
T11985 131-133 IN denotes in
T11986 134-139 JJ denotes other
T11988 140-145 NN denotes mouse
T11987 146-152 NNS denotes models
T11989 153-155 IN denotes of
T11990 156-167 JJ denotes therapeutic
T11991 168-180 NN denotes intervention
T11992 180-181 . denotes .
T11993 181-325 sentence denotes Anti-Aβ antibodies injected directly into the brain have been shown to eliminate amyloid deposits in as little as 1 wk after treatment [49–51].
T11994 182-189 JJ denotes Anti-Aβ
T11995 190-200 NNS denotes antibodies
T11997 201-209 VBN denotes injected
T11998 210-218 RB denotes directly
T11999 219-223 IN denotes into
T12000 224-227 DT denotes the
T12001 228-233 NN denotes brain
T12002 234-238 VBP denotes have
T12003 239-243 VBN denotes been
T11996 244-249 VBN denotes shown
T12004 250-252 TO denotes to
T12005 253-262 VB denotes eliminate
T12006 263-270 NN denotes amyloid
T12007 271-279 NNS denotes deposits
T12008 280-282 IN denotes in
T12009 283-285 RB denotes as
T12011 286-292 JJ denotes little
T12012 293-295 IN denotes as
T12010 296-297 CD denotes 1
T12013 298-300 NN denotes wk
T12014 301-306 IN denotes after
T12015 307-316 NN denotes treatment
T12016 317-318 -LRB- denotes [
T12017 318-320 CD denotes 49
T12018 320-321 SYM denotes –
T12019 321-323 CD denotes 51
T12020 323-324 -RRB- denotes ]
T12021 324-325 . denotes .
T12022 325-542 sentence denotes Peripheral antibody injection decreases amyloid load more broadly, and although it does not appear to act as quickly as local injection, can significantly reduce amyloid load within 2 mo of initial treatment [52,53].
T12023 326-336 JJ denotes Peripheral
T12025 337-345 NN denotes antibody
T12024 346-355 NN denotes injection
T12026 356-365 VBZ denotes decreases
T12027 366-373 NN denotes amyloid
T12028 374-378 NN denotes load
T12029 379-383 RBR denotes more
T12030 384-391 RB denotes broadly
T12031 391-393 , denotes ,
T12032 393-396 CC denotes and
T12033 397-405 IN denotes although
T12035 406-408 PRP denotes it
T12036 409-413 VBZ denotes does
T12037 414-417 RB denotes not
T12034 418-424 VB denotes appear
T12039 425-427 TO denotes to
T12040 428-431 VB denotes act
T12041 432-434 RB denotes as
T12042 435-442 RB denotes quickly
T12043 443-445 IN denotes as
T12044 446-451 JJ denotes local
T12045 452-461 NN denotes injection
T12046 461-463 , denotes ,
T12047 463-466 MD denotes can
T12048 467-480 RB denotes significantly
T12038 481-487 VB denotes reduce
T12049 488-495 NN denotes amyloid
T12050 496-500 NN denotes load
T12051 501-507 IN denotes within
T12052 508-509 CD denotes 2
T12053 510-512 NN denotes mo
T12054 513-515 IN denotes of
T12055 516-523 JJ denotes initial
T12056 524-533 NN denotes treatment
T12057 534-535 -LRB- denotes [
T12059 535-537 CD denotes 52
T12060 537-538 , denotes ,
T12058 538-540 CD denotes 53
T12061 540-541 -RRB- denotes ]
T12062 541-542 . denotes .
T12063 542-711 sentence denotes More recently, an alternative approach has shown that lentiviral transfer of neprilysin can also reduce the number of aggregates in the area of the injection site [54].
T12064 543-547 RBR denotes More
T12065 548-556 RB denotes recently
T12067 556-558 , denotes ,
T12068 558-560 DT denotes an
T12070 561-572 JJ denotes alternative
T12069 573-581 NN denotes approach
T12071 582-585 VBZ denotes has
T12066 586-591 VBN denotes shown
T12072 592-596 IN denotes that
T12074 597-607 JJ denotes lentiviral
T12075 608-616 NN denotes transfer
T12076 617-619 IN denotes of
T12077 620-630 NN denotes neprilysin
T12078 631-634 MD denotes can
T12079 635-639 RB denotes also
T12073 640-646 VB denotes reduce
T12080 647-650 DT denotes the
T12081 651-657 NN denotes number
T12082 658-660 IN denotes of
T12083 661-671 NNS denotes aggregates
T12084 672-674 IN denotes in
T12085 675-678 DT denotes the
T12086 679-683 NN denotes area
T12087 684-686 IN denotes of
T12088 687-690 DT denotes the
T12090 691-700 NN denotes injection
T12089 701-705 NN denotes site
T12091 706-707 -LRB- denotes [
T12092 707-709 CD denotes 54
T12093 709-710 -RRB- denotes ]
T12094 710-711 . denotes .
T12095 711-921 sentence denotes Careful study of the mechanism behind several of the antibody-mediated therapies has suggested that activated microglia play an important role in the removal of fibrillar plaques after immunization [50,52,55].
T12096 712-719 JJ denotes Careful
T12097 720-725 NN denotes study
T12099 726-728 IN denotes of
T12100 729-732 DT denotes the
T12101 733-742 NN denotes mechanism
T12102 743-749 IN denotes behind
T12103 750-757 JJ denotes several
T12104 758-760 IN denotes of
T12105 761-764 DT denotes the
T12107 765-773 NN denotes antibody
T12109 773-774 HYPH denotes -
T12108 774-782 VBN denotes mediated
T12106 783-792 NNS denotes therapies
T12110 793-796 VBZ denotes has
T12098 797-806 VBN denotes suggested
T12111 807-811 IN denotes that
T12113 812-821 VBN denotes activated
T12114 822-831 NNS denotes microglia
T12112 832-836 VBP denotes play
T12115 837-839 DT denotes an
T12117 840-849 JJ denotes important
T12116 850-854 NN denotes role
T12118 855-857 IN denotes in
T12119 858-861 DT denotes the
T12120 862-869 NN denotes removal
T12121 870-872 IN denotes of
T12122 873-882 JJ denotes fibrillar
T12123 883-890 NNS denotes plaques
T12124 891-896 IN denotes after
T12125 897-909 NN denotes immunization
T12126 910-911 -LRB- denotes [
T12128 911-913 CD denotes 50
T12129 913-914 , denotes ,
T12130 914-916 CD denotes 52
T12131 916-917 , denotes ,
T12127 917-919 CD denotes 55
T12132 919-920 -RRB- denotes ]
T12133 920-921 . denotes .
T12134 921-1166 sentence denotes However, it has been noted that deletion of the Fc receptor (the primary receptor for microglial opsinization of antibody–antigen complexes) in APP transgenic mouse models has no impact on the effectiveness of antibody-mediated therapy [56,57].
T12135 922-929 RB denotes However
T12137 929-931 , denotes ,
T12138 931-933 PRP denotes it
T12139 934-937 VBZ denotes has
T12140 938-942 VBN denotes been
T12136 943-948 VBN denotes noted
T12141 949-953 IN denotes that
T12143 954-962 NN denotes deletion
T12144 963-965 IN denotes of
T12145 966-969 DT denotes the
T12147 970-972 NN denotes Fc
T12146 973-981 NN denotes receptor
T12148 982-983 -LRB- denotes (
T12149 983-986 DT denotes the
T12151 987-994 JJ denotes primary
T12150 995-1003 NN denotes receptor
T12152 1004-1007 IN denotes for
T12153 1008-1018 JJ denotes microglial
T12154 1019-1031 NN denotes opsinization
T12155 1032-1034 IN denotes of
T12156 1035-1043 NN denotes antibody
T12158 1043-1044 HYPH denotes –
T12157 1044-1051 NN denotes antigen
T12159 1052-1061 NNS denotes complexes
T12160 1061-1062 -RRB- denotes )
T12161 1063-1065 IN denotes in
T12162 1066-1069 NN denotes APP
T12163 1070-1080 JJ denotes transgenic
T12165 1081-1086 NN denotes mouse
T12164 1087-1093 NNS denotes models
T12142 1094-1097 VBZ denotes has
T12166 1098-1100 DT denotes no
T12167 1101-1107 NN denotes impact
T12168 1108-1110 IN denotes on
T12169 1111-1114 DT denotes the
T12170 1115-1128 NN denotes effectiveness
T12171 1129-1131 IN denotes of
T12172 1132-1140 NN denotes antibody
T12174 1140-1141 HYPH denotes -
T12173 1141-1149 VBN denotes mediated
T12175 1150-1157 NN denotes therapy
T12176 1158-1159 -LRB- denotes [
T12178 1159-1161 CD denotes 56
T12179 1161-1162 , denotes ,
T12177 1162-1164 CD denotes 57
T12180 1164-1165 -RRB- denotes ]
T12181 1165-1166 . denotes .
T12182 1166-1437 sentence denotes It is, nevertheless, possible that lack of microglia activation is the major difference between the slow clearance described here, where no perturbation of the immune system is expected, and the rapid clearance described in studies involving antibody or viral injection.
T12183 1167-1169 PRP denotes It
T12184 1170-1172 VBZ denotes is
T12185 1172-1174 , denotes ,
T12186 1174-1186 RB denotes nevertheless
T12187 1186-1188 , denotes ,
T12188 1188-1196 JJ denotes possible
T12189 1197-1201 IN denotes that
T12191 1202-1206 NN denotes lack
T12192 1207-1209 IN denotes of
T12193 1210-1219 NNS denotes microglia
T12194 1220-1230 NN denotes activation
T12190 1231-1233 VBZ denotes is
T12195 1234-1237 DT denotes the
T12197 1238-1243 JJ denotes major
T12196 1244-1254 NN denotes difference
T12198 1255-1262 IN denotes between
T12199 1263-1266 DT denotes the
T12201 1267-1271 JJ denotes slow
T12200 1272-1281 NN denotes clearance
T12202 1282-1291 VBN denotes described
T12203 1292-1296 RB denotes here
T12204 1296-1298 , denotes ,
T12205 1298-1303 WRB denotes where
T12207 1304-1306 DT denotes no
T12208 1307-1319 NN denotes perturbation
T12209 1320-1322 IN denotes of
T12210 1323-1326 DT denotes the
T12212 1327-1333 JJ denotes immune
T12211 1334-1340 NN denotes system
T12213 1341-1343 VBZ denotes is
T12206 1344-1352 VBN denotes expected
T12214 1352-1354 , denotes ,
T12215 1354-1357 CC denotes and
T12216 1358-1361 DT denotes the
T12218 1362-1367 JJ denotes rapid
T12217 1368-1377 NN denotes clearance
T12219 1378-1387 VBN denotes described
T12220 1388-1390 IN denotes in
T12221 1391-1398 NNS denotes studies
T12222 1399-1408 VBG denotes involving
T12223 1409-1417 NN denotes antibody
T12225 1418-1420 CC denotes or
T12226 1421-1426 JJ denotes viral
T12224 1427-1436 NN denotes injection
T12227 1436-1437 . denotes .
T12228 1437-1718 sentence denotes In isolation, mild activation of microglia by injection damage or opsinization may not be adequate to induce substantial phagocytosis, but when combined with an Aβ-lowering agent, such as neprilysin or Aβ-targeted antibodies, the two may work in concert to clear peptide deposits.
T12229 1438-1440 IN denotes In
T12231 1441-1450 NN denotes isolation
T12232 1450-1452 , denotes ,
T12233 1452-1456 JJ denotes mild
T12234 1457-1467 NN denotes activation
T12235 1468-1470 IN denotes of
T12236 1471-1480 NNS denotes microglia
T12237 1481-1483 IN denotes by
T12238 1484-1493 NN denotes injection
T12239 1494-1500 NN denotes damage
T12240 1501-1503 CC denotes or
T12241 1504-1516 NN denotes opsinization
T12242 1517-1520 MD denotes may
T12243 1521-1524 RB denotes not
T12230 1525-1527 VB denotes be
T12244 1528-1536 JJ denotes adequate
T12245 1537-1539 TO denotes to
T12246 1540-1546 VB denotes induce
T12247 1547-1558 JJ denotes substantial
T12248 1559-1571 NN denotes phagocytosis
T12249 1571-1573 , denotes ,
T12250 1573-1576 CC denotes but
T12251 1577-1581 WRB denotes when
T12252 1582-1590 VBN denotes combined
T12254 1591-1595 IN denotes with
T12255 1596-1598 DT denotes an
T12257 1599-1601 NN denotes Aβ
T12259 1601-1602 HYPH denotes -
T12258 1602-1610 VBG denotes lowering
T12256 1611-1616 NN denotes agent
T12260 1616-1618 , denotes ,
T12261 1618-1622 JJ denotes such
T12262 1623-1625 IN denotes as
T12263 1626-1636 NN denotes neprilysin
T12265 1637-1639 CC denotes or
T12266 1640-1642 NN denotes Aβ
T12267 1642-1643 HYPH denotes -
T12264 1643-1651 VBN denotes targeted
T12268 1652-1662 NNS denotes antibodies
T12269 1662-1664 , denotes ,
T12270 1664-1667 DT denotes the
T12271 1668-1671 CD denotes two
T12272 1672-1675 MD denotes may
T12253 1676-1680 VB denotes work
T12273 1681-1683 IN denotes in
T12274 1684-1691 NN denotes concert
T12275 1692-1694 TO denotes to
T12276 1695-1700 VB denotes clear
T12277 1701-1708 NN denotes peptide
T12278 1709-1717 NNS denotes deposits
T12279 1717-1718 . denotes .
T12280 1718-1949 sentence denotes Consistent with this hypothesis, strong activation of microglia through transgenic expression of TGFβ [58] or central injection of lipopolysaccharide [59,60] can by itself substantially reduce plaque burden in APP transgenic mice.
T12281 1719-1729 JJ denotes Consistent
T12283 1730-1734 IN denotes with
T12284 1735-1739 DT denotes this
T12285 1740-1750 NN denotes hypothesis
T12286 1750-1752 , denotes ,
T12287 1752-1758 JJ denotes strong
T12288 1759-1769 NN denotes activation
T12289 1770-1772 IN denotes of
T12290 1773-1782 NNS denotes microglia
T12291 1783-1790 IN denotes through
T12292 1791-1801 JJ denotes transgenic
T12293 1802-1812 NN denotes expression
T12294 1813-1815 IN denotes of
T12295 1816-1820 NN denotes TGFβ
T12296 1821-1822 -LRB- denotes [
T12297 1822-1824 CD denotes 58
T12298 1824-1825 -RRB- denotes ]
T12299 1826-1828 CC denotes or
T12300 1829-1836 JJ denotes central
T12301 1837-1846 NN denotes injection
T12302 1847-1849 IN denotes of
T12303 1850-1868 NN denotes lipopolysaccharide
T12304 1869-1870 -LRB- denotes [
T12306 1870-1872 CD denotes 59
T12307 1872-1873 , denotes ,
T12305 1873-1875 CD denotes 60
T12308 1875-1876 -RRB- denotes ]
T12309 1877-1880 MD denotes can
T12310 1881-1883 IN denotes by
T12311 1884-1890 PRP denotes itself
T12312 1891-1904 RB denotes substantially
T12282 1905-1911 VB denotes reduce
T12313 1912-1918 NN denotes plaque
T12314 1919-1925 NN denotes burden
T12315 1926-1928 IN denotes in
T12316 1929-1932 NN denotes APP
T12317 1933-1943 JJ denotes transgenic
T12318 1944-1948 NNS denotes mice
T12319 1948-1949 . denotes .
T12320 1949-2203 sentence denotes But in the case of acute antibody- and/or injury-mediated activation, once the inflammation has passed, and the antibody and bound peptide have been cleared and degraded, the remaining Aβ quickly reaggregates and amyloid pathology is reestablished [49].
T12321 1950-1953 CC denotes But
T12323 1954-1956 IN denotes in
T12324 1957-1960 DT denotes the
T12325 1961-1965 NN denotes case
T12326 1966-1968 IN denotes of
T12327 1969-1974 JJ denotes acute
T12329 1975-1983 NN denotes antibody
T12331 1983-1984 HYPH denotes -
T12332 1985-1988 CC denotes and
T12333 1988-1989 HYPH denotes /
T12334 1989-1991 CC denotes or
T12335 1992-1998 NN denotes injury
T12336 1998-1999 HYPH denotes -
T12330 1999-2007 VBN denotes mediated
T12328 2008-2018 NN denotes activation
T12337 2018-2020 , denotes ,
T12338 2020-2024 IN denotes once
T12340 2025-2028 DT denotes the
T12341 2029-2041 NN denotes inflammation
T12342 2042-2045 VBZ denotes has
T12339 2046-2052 VBN denotes passed
T12343 2052-2054 , denotes ,
T12344 2054-2057 CC denotes and
T12345 2058-2061 DT denotes the
T12346 2062-2070 NN denotes antibody
T12348 2071-2074 CC denotes and
T12349 2075-2080 VBN denotes bound
T12350 2081-2088 NN denotes peptide
T12351 2089-2093 VBP denotes have
T12352 2094-2098 VBN denotes been
T12347 2099-2106 VBN denotes cleared
T12353 2107-2110 CC denotes and
T12354 2111-2119 VBN denotes degraded
T12355 2119-2121 , denotes ,
T12356 2121-2124 DT denotes the
T12358 2125-2134 VBG denotes remaining
T12357 2135-2137 NN denotes Aβ
T12359 2138-2145 RB denotes quickly
T12322 2146-2158 VBZ denotes reaggregates
T12360 2159-2162 CC denotes and
T12361 2163-2170 NN denotes amyloid
T12362 2171-2180 NN denotes pathology
T12364 2181-2183 VBZ denotes is
T12363 2184-2197 VBN denotes reestablished
T12365 2198-2199 -LRB- denotes [
T12366 2199-2201 CD denotes 49
T12367 2201-2202 -RRB- denotes ]
T12368 2202-2203 . denotes .
T12369 2203-2381 sentence denotes This finding reinforces the notion that without continued stimulation, microglia in mouse models do not maintain the same level of sustained activation that may occur in humans.
T12370 2204-2208 DT denotes This
T12371 2209-2216 NN denotes finding
T12372 2217-2227 VBZ denotes reinforces
T12373 2228-2231 DT denotes the
T12374 2232-2238 NN denotes notion
T12375 2239-2243 IN denotes that
T12377 2244-2251 IN denotes without
T12378 2252-2261 VBN denotes continued
T12379 2262-2273 NN denotes stimulation
T12380 2273-2275 , denotes ,
T12381 2275-2284 NNS denotes microglia
T12382 2285-2287 IN denotes in
T12383 2288-2293 NN denotes mouse
T12384 2294-2300 NNS denotes models
T12385 2301-2303 VBP denotes do
T12386 2304-2307 RB denotes not
T12376 2308-2316 VB denotes maintain
T12387 2317-2320 DT denotes the
T12389 2321-2325 JJ denotes same
T12388 2326-2331 NN denotes level
T12390 2332-2334 IN denotes of
T12391 2335-2344 VBN denotes sustained
T12392 2345-2355 NN denotes activation
T12393 2356-2360 WDT denotes that
T12395 2361-2364 MD denotes may
T12394 2365-2370 VB denotes occur
T12396 2371-2373 IN denotes in
T12397 2374-2380 NNS denotes humans
T12398 2380-2381 . denotes .
R8323 T11964 T11965 det The,persistence
R8324 T11965 T11966 nsubj persistence,is
R8325 T11967 T11965 cc and,persistence
R8326 T11968 T11965 conj stability,persistence
R8327 T11969 T11965 prep of,persistence
R8328 T11970 T11971 compound amyloid,deposits
R8329 T11971 T11969 pobj deposits,of
R8330 T11972 T11965 prep in,persistence
R8331 T11973 T11974 poss our,system
R8332 T11974 T11972 pobj system,in
R8333 T11975 T11966 acomp unexpected,is
R8334 T11976 T11966 prep given,is
R8335 T11977 T11978 det the,speed
R8336 T11978 T11976 pobj speed,given
R8337 T11979 T11980 prep with,cleared
R8338 T11980 T11978 relcl cleared,speed
R8339 T11981 T11979 pobj which,with
R8340 T11982 T11983 compound Aβ,aggregates
R8341 T11983 T11980 nsubjpass aggregates,cleared
R8342 T11984 T11980 auxpass are,cleared
R8343 T11985 T11980 prep in,cleared
R8344 T11986 T11987 amod other,models
R8345 T11987 T11985 pobj models,in
R8346 T11988 T11987 compound mouse,models
R8347 T11989 T11987 prep of,models
R8348 T11990 T11991 amod therapeutic,intervention
R8349 T11991 T11989 pobj intervention,of
R8350 T11992 T11966 punct .,is
R8351 T11994 T11995 amod Anti-Aβ,antibodies
R8352 T11995 T11996 nsubjpass antibodies,shown
R8353 T11997 T11995 acl injected,antibodies
R8354 T11998 T11997 advmod directly,injected
R8355 T11999 T11997 prep into,injected
R8356 T12000 T12001 det the,brain
R8357 T12001 T11999 pobj brain,into
R8358 T12002 T11996 aux have,shown
R8359 T12003 T11996 auxpass been,shown
R8360 T12004 T12005 aux to,eliminate
R8361 T12005 T11996 xcomp eliminate,shown
R8362 T12006 T12007 compound amyloid,deposits
R8363 T12007 T12005 dobj deposits,eliminate
R8364 T12008 T12005 prep in,eliminate
R8365 T12009 T12010 advmod as,1
R8366 T12010 T12013 nummod 1,wk
R8367 T12011 T12010 amod little,1
R8368 T12012 T12010 quantmod as,1
R8369 T12013 T12008 pobj wk,in
R8370 T12014 T12013 prep after,wk
R8371 T12015 T12014 pobj treatment,after
R8372 T12016 T12017 punct [,49
R8373 T12017 T12005 parataxis 49,eliminate
R8374 T12018 T12019 punct –,51
R8375 T12019 T12017 prep 51,49
R8376 T12020 T12017 punct ],49
R8377 T12021 T11996 punct .,shown
R8378 T12023 T12024 amod Peripheral,injection
R8379 T12024 T12026 nsubj injection,decreases
R8380 T12025 T12024 compound antibody,injection
R8381 T12027 T12028 compound amyloid,load
R8382 T12028 T12026 dobj load,decreases
R8383 T12029 T12030 advmod more,broadly
R8384 T12030 T12026 advmod broadly,decreases
R8385 T12031 T12026 punct ", ",decreases
R8386 T12032 T12026 cc and,decreases
R8387 T12033 T12034 mark although,appear
R8388 T12034 T12038 advcl appear,reduce
R8389 T12035 T12034 nsubj it,appear
R8390 T12036 T12034 aux does,appear
R8391 T12037 T12034 neg not,appear
R8392 T12038 T12026 conj reduce,decreases
R8393 T12039 T12040 aux to,act
R8394 T12040 T12034 xcomp act,appear
R8395 T12041 T12042 advmod as,quickly
R8396 T12042 T12040 advmod quickly,act
R8397 T12043 T12042 prep as,quickly
R8398 T12044 T12045 amod local,injection
R8399 T12045 T12043 pobj injection,as
R8400 T12046 T12038 punct ", ",reduce
R8401 T12047 T12038 aux can,reduce
R8402 T12048 T12038 advmod significantly,reduce
R8403 T12086 T12084 pobj area,in
R8404 T12049 T12050 compound amyloid,load
R8405 T12087 T12086 prep of,area
R8406 T12050 T12038 dobj load,reduce
R8407 T12088 T12089 det the,site
R8408 T12051 T12038 prep within,reduce
R8409 T12052 T12053 nummod 2,mo
R8410 T12089 T12087 pobj site,of
R8411 T12090 T12089 compound injection,site
R8412 T12053 T12051 pobj mo,within
R8413 T12091 T12092 punct [,54
R8414 T12092 T12073 parataxis 54,reduce
R8415 T12054 T12053 prep of,mo
R8416 T12093 T12092 punct ],54
R8417 T12094 T12066 punct .,shown
R8418 T12055 T12056 amod initial,treatment
R8419 T12096 T12097 amod Careful,study
R8420 T12097 T12098 nsubj study,suggested
R8421 T12056 T12054 pobj treatment,of
R8422 T12099 T12097 prep of,study
R8423 T12057 T12058 punct [,53
R8424 T12100 T12101 det the,mechanism
R8425 T12101 T12099 pobj mechanism,of
R8426 T12058 T12038 parataxis 53,reduce
R8427 T12102 T12101 prep behind,mechanism
R8428 T12103 T12102 pobj several,behind
R8429 T12104 T12103 prep of,several
R8430 T12059 T12058 nummod 52,53
R8431 T12105 T12106 det the,therapies
R8432 T12106 T12104 pobj therapies,of
R8433 T12107 T12108 npadvmod antibody,mediated
R8434 T12108 T12106 amod mediated,therapies
R8435 T12109 T12108 punct -,mediated
R8436 T12060 T12058 punct ",",53
R8437 T12110 T12098 aux has,suggested
R8438 T12111 T12112 mark that,play
R8439 T12112 T12098 ccomp play,suggested
R8440 T12061 T12058 punct ],53
R8441 T12113 T12114 amod activated,microglia
R8442 T12114 T12112 nsubj microglia,play
R8443 T12115 T12116 det an,role
R8444 T12062 T12026 punct .,decreases
R8445 T12116 T12112 dobj role,play
R8446 T12117 T12116 amod important,role
R8447 T12064 T12065 advmod More,recently
R8448 T12118 T12112 prep in,play
R8449 T12119 T12120 det the,removal
R8450 T12120 T12118 pobj removal,in
R8451 T12121 T12120 prep of,removal
R8452 T12065 T12066 advmod recently,shown
R8453 T12122 T12123 amod fibrillar,plaques
R8454 T12123 T12121 pobj plaques,of
R8455 T12124 T12112 prep after,play
R8456 T12067 T12066 punct ", ",shown
R8457 T12125 T12124 pobj immunization,after
R8458 T12126 T12127 punct [,55
R8459 T12127 T12098 parataxis 55,suggested
R8460 T12128 T12127 nummod 50,55
R8461 T12068 T12069 det an,approach
R8462 T12129 T12127 punct ",",55
R8463 T12130 T12127 nummod 52,55
R8464 T12131 T12127 punct ",",55
R8465 T12069 T12066 nsubj approach,shown
R8466 T12132 T12127 punct ],55
R8467 T12133 T12098 punct .,suggested
R8468 T12070 T12069 amod alternative,approach
R8469 T12135 T12136 advmod However,noted
R8470 T12071 T12066 aux has,shown
R8471 T12137 T12136 punct ", ",noted
R8472 T12138 T12136 nsubjpass it,noted
R8473 T12139 T12136 aux has,noted
R8474 T12072 T12073 mark that,reduce
R8475 T12140 T12136 auxpass been,noted
R8476 T12141 T12142 mark that,has
R8477 T12073 T12066 ccomp reduce,shown
R8478 T12142 T12136 ccomp has,noted
R8479 T12143 T12142 nsubj deletion,has
R8480 T12144 T12143 prep of,deletion
R8481 T12074 T12075 amod lentiviral,transfer
R8482 T12145 T12146 det the,receptor
R8483 T12146 T12144 pobj receptor,of
R8484 T12147 T12146 compound Fc,receptor
R8485 T12148 T12146 punct (,receptor
R8486 T12149 T12150 det the,receptor
R8487 T12075 T12073 nsubj transfer,reduce
R8488 T12150 T12146 appos receptor,receptor
R8489 T12151 T12150 amod primary,receptor
R8490 T12152 T12150 prep for,receptor
R8491 T12076 T12075 prep of,transfer
R8492 T12153 T12154 amod microglial,opsinization
R8493 T12154 T12152 pobj opsinization,for
R8494 T12155 T12154 prep of,opsinization
R8495 T12077 T12076 pobj neprilysin,of
R8496 T12156 T12157 compound antibody,antigen
R8497 T12157 T12159 compound antigen,complexes
R8498 T12158 T12157 punct –,antigen
R8499 T12078 T12073 aux can,reduce
R8500 T12159 T12155 pobj complexes,of
R8501 T12160 T12143 punct ),deletion
R8502 T12079 T12073 advmod also,reduce
R8503 T12161 T12143 prep in,deletion
R8504 T12162 T12163 npadvmod APP,transgenic
R8505 T12163 T12164 amod transgenic,models
R8506 T12080 T12081 det the,number
R8507 T12164 T12161 pobj models,in
R8508 T12165 T12164 compound mouse,models
R8509 T12166 T12167 det no,impact
R8510 T12081 T12073 dobj number,reduce
R8511 T12167 T12142 dobj impact,has
R8512 T12168 T12167 prep on,impact
R8513 T12082 T12081 prep of,number
R8514 T12169 T12170 det the,effectiveness
R8515 T12170 T12168 pobj effectiveness,on
R8516 T12171 T12170 prep of,effectiveness
R8517 T12083 T12082 pobj aggregates,of
R8518 T12172 T12173 npadvmod antibody,mediated
R8519 T12084 T12073 prep in,reduce
R8520 T12085 T12086 det the,area
R8521 T12173 T12175 amod mediated,therapy
R8522 T12192 T12191 prep of,lack
R8523 T12174 T12173 punct -,mediated
R8524 T12175 T12171 pobj therapy,of
R8525 T12176 T12177 punct [,57
R8526 T12177 T12142 parataxis 57,has
R8527 T12193 T12194 compound microglia,activation
R8528 T12178 T12177 nummod 56,57
R8529 T12179 T12177 punct ",",57
R8530 T12180 T12177 punct ],57
R8531 T12194 T12192 pobj activation,of
R8532 T12181 T12136 punct .,noted
R8533 T12195 T12196 det the,difference
R8534 T12183 T12184 nsubj It,is
R8535 T12196 T12190 attr difference,is
R8536 T12185 T12184 punct ", ",is
R8537 T12186 T12184 advmod nevertheless,is
R8538 T12187 T12184 punct ", ",is
R8539 T12188 T12184 acomp possible,is
R8540 T12189 T12190 mark that,is
R8541 T12190 T12184 ccomp is,is
R8542 T12197 T12196 amod major,difference
R8543 T12191 T12190 nsubj lack,is
R8544 T12198 T12196 prep between,difference
R8545 T12199 T12200 det the,clearance
R8546 T12200 T12198 pobj clearance,between
R8547 T12201 T12200 amod slow,clearance
R8548 T12202 T12200 acl described,clearance
R8549 T12203 T12202 advmod here,described
R8550 T12298 T12297 punct ],58
R8551 T12299 T12293 cc or,expression
R8552 T12204 T12200 punct ", ",clearance
R8553 T12300 T12301 amod central,injection
R8554 T12301 T12293 conj injection,expression
R8555 T12302 T12301 prep of,injection
R8556 T12205 T12206 advmod where,expected
R8557 T12303 T12302 pobj lipopolysaccharide,of
R8558 T12304 T12305 punct [,60
R8559 T12305 T12303 parataxis 60,lipopolysaccharide
R8560 T12206 T12200 relcl expected,clearance
R8561 T12306 T12305 nummod 59,60
R8562 T12307 T12305 punct ",",60
R8563 T12207 T12208 det no,perturbation
R8564 T12308 T12305 punct ],60
R8565 T12309 T12282 aux can,reduce
R8566 T12310 T12282 prep by,reduce
R8567 T12208 T12206 nsubjpass perturbation,expected
R8568 T12311 T12310 pobj itself,by
R8569 T12312 T12282 advmod substantially,reduce
R8570 T12209 T12208 prep of,perturbation
R8571 T12313 T12314 compound plaque,burden
R8572 T12314 T12282 dobj burden,reduce
R8573 T12315 T12282 prep in,reduce
R8574 T12210 T12211 det the,system
R8575 T12316 T12317 npadvmod APP,transgenic
R8576 T12317 T12318 amod transgenic,mice
R8577 T12211 T12209 pobj system,of
R8578 T12318 T12315 pobj mice,in
R8579 T12319 T12282 punct .,reduce
R8580 T12212 T12211 amod immune,system
R8581 T12321 T12322 cc But,reaggregates
R8582 T12213 T12206 auxpass is,expected
R8583 T12323 T12322 prep in,reaggregates
R8584 T12324 T12325 det the,case
R8585 T12325 T12323 pobj case,in
R8586 T12214 T12200 punct ", ",clearance
R8587 T12326 T12325 prep of,case
R8588 T12327 T12328 amod acute,activation
R8589 T12328 T12326 pobj activation,of
R8590 T12329 T12330 npadvmod antibody,mediated
R8591 T12330 T12328 amod mediated,activation
R8592 T12215 T12200 cc and,clearance
R8593 T12331 T12329 punct -,antibody
R8594 T12332 T12329 cc and,antibody
R8595 T12333 T12332 punct /,and
R8596 T12216 T12217 det the,clearance
R8597 T12334 T12332 cc or,and
R8598 T12335 T12329 conj injury,antibody
R8599 T12336 T12330 punct -,mediated
R8600 T12217 T12200 conj clearance,clearance
R8601 T12337 T12322 punct ", ",reaggregates
R8602 T12338 T12339 mark once,passed
R8603 T12339 T12322 advcl passed,reaggregates
R8604 T12218 T12217 amod rapid,clearance
R8605 T12340 T12341 det the,inflammation
R8606 T12341 T12339 nsubj inflammation,passed
R8607 T12219 T12217 acl described,clearance
R8608 T12342 T12339 aux has,passed
R8609 T12220 T12219 prep in,described
R8610 T12343 T12339 punct ", ",passed
R8611 T12221 T12220 pobj studies,in
R8612 T12344 T12339 cc and,passed
R8613 T12345 T12346 det the,antibody
R8614 T12346 T12347 nsubjpass antibody,cleared
R8615 T12222 T12221 acl involving,studies
R8616 T12347 T12339 conj cleared,passed
R8617 T12223 T12224 nmod antibody,injection
R8618 T12348 T12346 cc and,antibody
R8619 T12349 T12350 amod bound,peptide
R8620 T12350 T12346 conj peptide,antibody
R8621 T12224 T12222 dobj injection,involving
R8622 T12351 T12347 aux have,cleared
R8623 T12352 T12347 auxpass been,cleared
R8624 T12353 T12347 cc and,cleared
R8625 T12225 T12223 cc or,antibody
R8626 T12354 T12347 conj degraded,cleared
R8627 T12355 T12322 punct ", ",reaggregates
R8628 T12356 T12357 det the,Aβ
R8629 T12226 T12223 conj viral,antibody
R8630 T12357 T12322 nsubj Aβ,reaggregates
R8631 T12358 T12357 amod remaining,Aβ
R8632 T12227 T12184 punct .,is
R8633 T12359 T12322 advmod quickly,reaggregates
R8634 T12360 T12322 cc and,reaggregates
R8635 T12361 T12362 compound amyloid,pathology
R8636 T12229 T12230 prep In,be
R8637 T12362 T12363 nsubjpass pathology,reestablished
R8638 T12363 T12322 conj reestablished,reaggregates
R8639 T12364 T12363 auxpass is,reestablished
R8640 T12365 T12366 punct [,49
R8641 T12366 T12363 parataxis 49,reestablished
R8642 T12367 T12366 punct ],49
R8643 T12368 T12322 punct .,reaggregates
R8644 T12231 T12229 pobj isolation,In
R8645 T12370 T12371 det This,finding
R8646 T12371 T12372 nsubj finding,reinforces
R8647 T12232 T12230 punct ", ",be
R8648 T12373 T12374 det the,notion
R8649 T12374 T12372 dobj notion,reinforces
R8650 T12375 T12376 mark that,maintain
R8651 T12233 T12234 amod mild,activation
R8652 T12376 T12374 acl maintain,notion
R8653 T12377 T12376 prep without,maintain
R8654 T12234 T12230 nsubj activation,be
R8655 T12378 T12379 amod continued,stimulation
R8656 T12379 T12377 pobj stimulation,without
R8657 T12380 T12376 punct ", ",maintain
R8658 T12235 T12234 prep of,activation
R8659 T12381 T12376 nsubj microglia,maintain
R8660 T12382 T12381 prep in,microglia
R8661 T12236 T12235 pobj microglia,of
R8662 T12383 T12384 compound mouse,models
R8663 T12384 T12382 pobj models,in
R8664 T12385 T12376 aux do,maintain
R8665 T12237 T12234 prep by,activation
R8666 T12386 T12376 neg not,maintain
R8667 T12387 T12388 det the,level
R8668 T12388 T12376 dobj level,maintain
R8669 T12238 T12239 compound injection,damage
R8670 T12389 T12388 amod same,level
R8671 T12390 T12388 prep of,level
R8672 T12239 T12237 pobj damage,by
R8673 T12391 T12392 amod sustained,activation
R8674 T12392 T12390 pobj activation,of
R8675 T12393 T12394 dep that,occur
R8676 T12240 T12239 cc or,damage
R8677 T12394 T12388 relcl occur,level
R8678 T12395 T12394 aux may,occur
R8679 T12241 T12239 conj opsinization,damage
R8680 T12396 T12394 prep in,occur
R8681 T12397 T12396 pobj humans,in
R8682 T12398 T12372 punct .,reinforces
R8683 T12242 T12230 aux may,be
R8685 T12243 T12230 neg not,be
R8688 T12244 T12230 acomp adequate,be
R8689 T12245 T12246 aux to,induce
R8690 T12246 T12230 advcl induce,be
R8692 T12247 T12248 amod substantial,phagocytosis
R8699 T12248 T12246 dobj phagocytosis,induce
R8702 T12249 T12230 punct ", ",be
R8706 T12250 T12230 cc but,be
R8709 T12251 T12252 advmod when,combined
R8713 T12252 T12253 advcl combined,work
R8716 T12253 T12230 conj work,be
R8718 T12254 T12252 prep with,combined
R8721 T12255 T12256 det an,agent
R8722 T12256 T12254 pobj agent,with
R8725 T12257 T12258 npadvmod Aβ,lowering
R8728 T12258 T12256 amod lowering,agent
R8732 T12259 T12258 punct -,lowering
R8736 T12260 T12256 punct ", ",agent
R8739 T12261 T12262 amod such,as
R8742 T12262 T12256 prep as,agent
R8748 T12263 T12264 npadvmod neprilysin,targeted
R8753 T12264 T12268 amod targeted,antibodies
R8757 T12265 T12263 cc or,neprilysin
R8760 T12266 T12263 conj Aβ,neprilysin
R8762 T12267 T12264 punct -,targeted
R8766 T12268 T12262 pobj antibodies,as
R8769 T12269 T12253 punct ", ",work
R8773 T12270 T12271 det the,two
R8776 T12271 T12253 nsubj two,work
R8780 T12272 T12253 aux may,work
R8783 T12273 T12253 prep in,work
R8787 T12274 T12273 pobj concert,in
R8791 T12275 T12276 aux to,clear
R8794 T12276 T12253 advcl clear,work
R8801 T12277 T12278 compound peptide,deposits
R8805 T12278 T12276 dobj deposits,clear
R8809 T12279 T12253 punct .,work
R8812 T12281 T12282 advcl Consistent,reduce
R8815 T12283 T12281 prep with,Consistent
R8820 T12284 T12285 det this,hypothesis
R8824 T12285 T12283 pobj hypothesis,with
R8828 T12286 T12282 punct ", ",reduce
R8829 T12287 T12288 amod strong,activation
R8830 T12288 T12282 nsubj activation,reduce
R8831 T12289 T12288 prep of,activation
R8833 T12290 T12289 pobj microglia,of
R8837 T12291 T12288 prep through,activation
R8838 T12292 T12293 amod transgenic,expression
R8840 T12293 T12291 pobj expression,through
R8844 T12294 T12293 prep of,expression
R8847 T12295 T12294 pobj TGFβ,of
R8852 T12296 T12297 punct [,58
R8855 T12297 T12295 parataxis 58,TGFβ