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PMC:1189073 / 19902-21145 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T10738 0-7 NNS denotes Animals
T10740 8-20 JJ denotes heterozygous
T10741 21-24 IN denotes for
T10742 25-28 DT denotes the
T10744 29-38 NN denotes Aqp2F204V
T10743 39-47 NN denotes mutation
T10745 48-52 VBD denotes were
T10746 53-56 RB denotes not
T10739 57-65 VBN denotes affected
T10747 66-68 IN denotes in
T10748 69-74 PRP$ denotes their
T10750 75-80 NN denotes urine
T10749 81-91 NN denotes production
T10751 92-94 CC denotes or
T10752 95-100 NN denotes urine
T10753 101-111 NN denotes osmolality
T10754 112-113 -LRB- denotes (
T10755 113-116 VB denotes see
T10756 117-123 NN denotes Figure
T10757 124-126 CD denotes 1C
T10758 127-130 CC denotes and
T10759 131-133 CD denotes 1D
T10760 133-134 -RRB- denotes )
T10761 134-135 . denotes .
T10762 135-306 sentence denotes It has also been shown that a recessive NDI allele, AQP2-R187C, does not interact with wild-type protein in oocytes [24], nor does it homo-oligomerize in MDCK cells [22].
T10763 136-138 PRP denotes It
T10765 139-142 VBZ denotes has
T10766 143-147 RB denotes also
T10767 148-152 VBN denotes been
T10764 153-158 VBN denotes shown
T10768 159-163 IN denotes that
T10770 164-165 DT denotes a
T10772 166-175 JJ denotes recessive
T10773 176-179 NN denotes NDI
T10771 180-186 NN denotes allele
T10774 186-188 , denotes ,
T10775 188-192 NN denotes AQP2
T10777 192-193 HYPH denotes -
T10776 193-198 NN denotes R187C
T10778 198-200 , denotes ,
T10779 200-204 VBZ denotes does
T10780 205-208 RB denotes not
T10769 209-217 VB denotes interact
T10781 218-222 IN denotes with
T10782 223-227 JJ denotes wild
T10784 227-228 HYPH denotes -
T10783 228-232 NN denotes type
T10785 233-240 NN denotes protein
T10786 241-243 IN denotes in
T10787 244-251 NNS denotes oocytes
T10788 252-253 -LRB- denotes [
T10789 253-255 CD denotes 24
T10790 255-256 -RRB- denotes ]
T10791 256-258 , denotes ,
T10792 258-261 CC denotes nor
T10793 262-266 VBZ denotes does
T10795 267-269 PRP denotes it
T10794 270-286 VB denotes homo-oligomerize
T10796 287-289 IN denotes in
T10797 290-294 NN denotes MDCK
T10798 295-300 NNS denotes cells
T10799 301-302 -LRB- denotes [
T10800 302-304 CD denotes 22
T10801 304-305 -RRB- denotes ]
T10802 305-306 . denotes .
T10803 306-414 sentence denotes Therefore, kidneys from heterozygous animals were examined for evidence of two populations of AQP2 protein.
T10804 307-316 RB denotes Therefore
T10806 316-318 , denotes ,
T10807 318-325 NNS denotes kidneys
T10808 326-330 IN denotes from
T10809 331-343 JJ denotes heterozygous
T10810 344-351 NNS denotes animals
T10811 352-356 VBD denotes were
T10805 357-365 VBN denotes examined
T10812 366-369 IN denotes for
T10813 370-378 NN denotes evidence
T10814 379-381 IN denotes of
T10815 382-385 CD denotes two
T10816 386-397 NNS denotes populations
T10817 398-400 IN denotes of
T10818 401-405 NN denotes AQP2
T10819 406-413 NN denotes protein
T10820 413-414 . denotes .
T10821 414-570 sentence denotes Surprisingly, immunohistochemical staining of kidney collecting ducts from Aqp2F204V/+ mice revealed a pattern remarkably similar to wild type (Figure 5A).
T10822 415-427 RB denotes Surprisingly
T10824 427-429 , denotes ,
T10825 429-448 JJ denotes immunohistochemical
T10826 449-457 NN denotes staining
T10827 458-460 IN denotes of
T10828 461-467 NN denotes kidney
T10830 468-478 VBG denotes collecting
T10829 479-484 NNS denotes ducts
T10831 485-489 IN denotes from
T10832 490-499 NN denotes Aqp2F204V
T10834 499-500 HYPH denotes /
T10835 500-501 SYM denotes +
T10833 502-506 NNS denotes mice
T10823 507-515 VBD denotes revealed
T10836 516-517 DT denotes a
T10837 518-525 NN denotes pattern
T10838 526-536 RB denotes remarkably
T10839 537-544 JJ denotes similar
T10840 545-547 IN denotes to
T10841 548-552 JJ denotes wild
T10842 553-557 NN denotes type
T10843 558-559 -LRB- denotes (
T10844 559-565 NN denotes Figure
T10845 566-568 CD denotes 5A
T10846 568-569 -RRB- denotes )
T10847 569-570 . denotes .
T10848 570-650 sentence denotes AQP2 translocated completely to the apical cell surface upon dDAVP stimulation.
T10849 571-575 NN denotes AQP2
T10850 576-588 VBD denotes translocated
T10851 589-599 RB denotes completely
T10852 600-602 IN denotes to
T10853 603-606 DT denotes the
T10855 607-613 JJ denotes apical
T10856 614-618 NN denotes cell
T10854 619-626 NN denotes surface
T10857 627-631 IN denotes upon
T10858 632-637 NN denotes dDAVP
T10859 638-649 NN denotes stimulation
T10860 649-650 . denotes .
T10861 650-809 sentence denotes This wild-type staining pattern may simply reflect the fact that decreasing the amount of mutant protein by half makes it undetectable by immunocytochemistry.
T10862 651-655 DT denotes This
T10864 656-660 JJ denotes wild
T10866 660-661 HYPH denotes -
T10865 661-665 NN denotes type
T10867 666-674 NN denotes staining
T10863 675-682 NN denotes pattern
T10869 683-686 MD denotes may
T10870 687-693 RB denotes simply
T10868 694-701 VB denotes reflect
T10871 702-705 DT denotes the
T10872 706-710 NN denotes fact
T10873 711-715 IN denotes that
T10875 716-726 VBG denotes decreasing
T10876 727-730 DT denotes the
T10877 731-737 NN denotes amount
T10878 738-740 IN denotes of
T10879 741-747 NN denotes mutant
T10880 748-755 NN denotes protein
T10881 756-758 IN denotes by
T10882 759-763 NN denotes half
T10874 764-769 VBZ denotes makes
T10883 770-772 PRP denotes it
T10884 773-785 JJ denotes undetectable
T10885 786-788 IN denotes by
T10886 789-808 NN denotes immunocytochemistry
T10887 808-809 . denotes .
T10888 809-908 sentence denotes Alternatively, the presence of wild-type protein may alter the localization of the mutant protein.
T10889 810-823 RB denotes Alternatively
T10891 823-825 , denotes ,
T10892 825-828 DT denotes the
T10893 829-837 NN denotes presence
T10894 838-840 IN denotes of
T10895 841-845 JJ denotes wild
T10897 845-846 HYPH denotes -
T10896 846-850 NN denotes type
T10898 851-858 NN denotes protein
T10899 859-862 MD denotes may
T10890 863-868 VB denotes alter
T10900 869-872 DT denotes the
T10901 873-885 NN denotes localization
T10902 886-888 IN denotes of
T10903 889-892 DT denotes the
T10905 893-899 NN denotes mutant
T10904 900-907 NN denotes protein
T10906 907-908 . denotes .
T10907 908-1078 sentence denotes Indeed, Hendriks et al. proposed a “piggy-back” mechanism to explain the transport of nonglycosylated subunits of AQP2 to the cell surface by glycosylated subunits [22].
T10908 909-915 RB denotes Indeed
T10910 915-917 , denotes ,
T10911 917-925 NNP denotes Hendriks
T10912 926-928 FW denotes et
T10913 929-932 FW denotes al.
T10909 933-941 VBD denotes proposed
T10914 942-943 DT denotes a
T10916 944-945 `` denotes “
T10917 945-950 NN denotes piggy
T10919 950-951 HYPH denotes -
T10918 951-955 NN denotes back
T10920 955-956 '' denotes ”
T10915 957-966 NN denotes mechanism
T10921 967-969 TO denotes to
T10922 970-977 VB denotes explain
T10923 978-981 DT denotes the
T10924 982-991 NN denotes transport
T10925 992-994 IN denotes of
T10926 995-1010 JJ denotes nonglycosylated
T10927 1011-1019 NNS denotes subunits
T10928 1020-1022 IN denotes of
T10929 1023-1027 NN denotes AQP2
T10930 1028-1030 IN denotes to
T10931 1031-1034 DT denotes the
T10933 1035-1039 NN denotes cell
T10932 1040-1047 NN denotes surface
T10934 1048-1050 IN denotes by
T10935 1051-1063 VBN denotes glycosylated
T10936 1064-1072 NNS denotes subunits
T10937 1073-1074 -LRB- denotes [
T10938 1074-1076 CD denotes 22
T10939 1076-1077 -RRB- denotes ]
T10940 1077-1078 . denotes .
T10941 1078-1243 sentence denotes It has also been shown that wild-type AQP2 protein can rescue a translocation-defective mutant protein, AQP2-P262L, when the two are coexpressed in MDCK cells [25].
T10942 1079-1081 PRP denotes It
T10944 1082-1085 VBZ denotes has
T10945 1086-1090 RB denotes also
T10946 1091-1095 VBN denotes been
T10943 1096-1101 VBN denotes shown
T10947 1102-1106 IN denotes that
T10949 1107-1111 JJ denotes wild
T10951 1111-1112 HYPH denotes -
T10950 1112-1116 NN denotes type
T10953 1117-1121 NN denotes AQP2
T10952 1122-1129 NN denotes protein
T10954 1130-1133 MD denotes can
T10948 1134-1140 VB denotes rescue
T10955 1141-1142 DT denotes a
T10957 1143-1156 NN denotes translocation
T10959 1156-1157 HYPH denotes -
T10958 1157-1166 JJ denotes defective
T10960 1167-1173 NN denotes mutant
T10956 1174-1181 NN denotes protein
T10961 1181-1183 , denotes ,
T10962 1183-1187 NN denotes AQP2
T10964 1187-1188 HYPH denotes -
T10963 1188-1193 NN denotes P262L
T10965 1193-1195 , denotes ,
T10966 1195-1199 WRB denotes when
T10968 1200-1203 DT denotes the
T10969 1204-1207 CD denotes two
T10970 1208-1211 VBP denotes are
T10967 1212-1223 VBN denotes coexpressed
T10971 1224-1226 IN denotes in
T10972 1227-1231 NN denotes MDCK
T10973 1232-1237 NNS denotes cells
T10974 1238-1239 -LRB- denotes [
T10975 1239-1241 CD denotes 25
T10976 1241-1242 -RRB- denotes ]
T10977 1242-1243 . denotes .
R2546 T10738 T10739 nsubjpass Animals,affected
R2548 T10740 T10738 amod heterozygous,Animals
R2549 T10741 T10740 prep for,heterozygous
R2550 T10742 T10743 det the,mutation
R2552 T10743 T10741 pobj mutation,for
R2553 T10744 T10743 compound Aqp2F204V,mutation
R2554 T10745 T10739 auxpass were,affected
R2556 T10746 T10739 neg not,affected
R2557 T10747 T10739 prep in,affected
R2558 T10748 T10749 poss their,production
R2560 T10749 T10747 pobj production,in
R2561 T10750 T10749 compound urine,production
R2562 T10751 T10749 cc or,production
R2564 T10752 T10753 compound urine,osmolality
R2565 T10753 T10749 conj osmolality,production
R2566 T10754 T10755 punct (,see
R2567 T10755 T10739 parataxis see,affected
R2568 T10756 T10757 nmod Figure,1C
R2569 T10757 T10755 dobj 1C,see
R2571 T10758 T10757 cc and,1C
R2572 T10759 T10757 conj 1D,1C
R2573 T10760 T10755 punct ),see
R2575 T10761 T10739 punct .,affected
R2576 T10763 T10764 nsubjpass It,shown
R2578 T10765 T10764 aux has,shown
R2579 T10766 T10764 advmod also,shown
R2581 T10767 T10764 auxpass been,shown
R2582 T10768 T10769 mark that,interact
R2583 T10769 T10764 ccomp interact,shown
R2585 T10770 T10771 det a,allele
R2586 T10771 T10769 nsubj allele,interact
R2587 T10772 T10771 amod recessive,allele
R2589 T10773 T10771 compound NDI,allele
R2590 T10774 T10771 punct ", ",allele
R2591 T10775 T10776 compound AQP2,R187C
R2593 T10776 T10771 appos R187C,allele
R2594 T10777 T10776 punct -,R187C
R2595 T10778 T10769 punct ", ",interact
R2599 T10779 T10769 aux does,interact
R2601 T10780 T10769 neg not,interact
R2602 T10781 T10769 prep with,interact
R2603 T10782 T10783 amod wild,type
R2605 T10783 T10785 compound type,protein
R2606 T10784 T10783 punct -,type
R2608 T10785 T10781 pobj protein,with
R2609 T10786 T10769 prep in,interact
R2610 T10787 T10786 pobj oocytes,in
R2612 T10788 T10789 punct [,24
R2613 T10789 T10769 parataxis 24,interact
R2614 T10790 T10789 punct ],24
R2616 T10791 T10769 punct ", ",interact
R2617 T10792 T10769 cc nor,interact
R2618 T10793 T10794 aux does,homo-oligomerize
R2619 T10794 T10769 conj homo-oligomerize,interact
R2620 T10795 T10794 nsubj it,homo-oligomerize
R2621 T10796 T10794 prep in,homo-oligomerize
R2623 T10797 T10798 compound MDCK,cells
R2624 T10798 T10796 pobj cells,in
R2625 T10799 T10800 punct [,22
R2627 T10800 T10764 parataxis 22,shown
R2628 T10801 T10800 punct ],22
R2629 T10802 T10764 punct .,shown
R2631 T10804 T10805 advmod Therefore,examined
R2634 T10806 T10805 punct ", ",examined
R2636 T10807 T10805 nsubjpass kidneys,examined
R2637 T10808 T10807 prep from,kidneys
R2639 T10809 T10810 amod heterozygous,animals
R2640 T10810 T10808 pobj animals,from
R2641 T10811 T10805 auxpass were,examined
R2642 T10885 T10884 prep by,undetectable
R2643 T10812 T10805 prep for,examined
R2644 T10813 T10812 pobj evidence,for
R2645 T10814 T10813 prep of,evidence
R2646 T10815 T10816 nummod two,populations
R2647 T10886 T10885 pobj immunocytochemistry,by
R2648 T10816 T10814 pobj populations,of
R2649 T10817 T10816 prep of,populations
R2650 T10818 T10819 compound AQP2,protein
R2651 T10887 T10868 punct .,reflect
R2652 T10819 T10817 pobj protein,of
R2653 T10820 T10805 punct .,examined
R2654 T10889 T10890 advmod Alternatively,alter
R2655 T10822 T10823 advmod Surprisingly,revealed
R2656 T10824 T10823 punct ", ",revealed
R2657 T10891 T10890 punct ", ",alter
R2658 T10825 T10826 amod immunohistochemical,staining
R2659 T10826 T10823 nsubj staining,revealed
R2660 T10827 T10826 prep of,staining
R2661 T10828 T10829 nmod kidney,ducts
R2662 T10892 T10893 det the,presence
R2663 T10829 T10827 pobj ducts,of
R2664 T10830 T10829 amod collecting,ducts
R2665 T10831 T10829 prep from,ducts
R2666 T10893 T10890 nsubj presence,alter
R2667 T10832 T10833 nmod Aqp2F204V,mice
R2668 T10833 T10831 pobj mice,from
R2669 T10834 T10832 punct /,Aqp2F204V
R2670 T10835 T10832 punct +,Aqp2F204V
R2671 T10836 T10837 det a,pattern
R2672 T10837 T10823 dobj pattern,revealed
R2673 T10894 T10893 prep of,presence
R2674 T10838 T10839 advmod remarkably,similar
R2675 T10839 T10837 amod similar,pattern
R2676 T10840 T10839 prep to,similar
R2677 T10895 T10896 amod wild,type
R2678 T10841 T10842 amod wild,type
R2679 T10842 T10840 pobj type,to
R2680 T10843 T10844 punct (,Figure
R2681 T10844 T10823 parataxis Figure,revealed
R2682 T10845 T10844 nummod 5A,Figure
R2683 T10846 T10844 punct ),Figure
R2684 T10847 T10823 punct .,revealed
R2685 T10896 T10898 compound type,protein
R2686 T10849 T10850 nsubj AQP2,translocated
R2687 T10897 T10896 punct -,type
R2688 T10851 T10850 advmod completely,translocated
R2689 T10852 T10850 prep to,translocated
R2690 T10898 T10894 pobj protein,of
R2691 T10853 T10854 det the,surface
R2692 T10854 T10852 pobj surface,to
R2693 T10855 T10854 amod apical,surface
R2694 T10856 T10854 compound cell,surface
R2695 T10899 T10890 aux may,alter
R2696 T10857 T10850 prep upon,translocated
R2697 T10858 T10859 compound dDAVP,stimulation
R2698 T10859 T10857 pobj stimulation,upon
R2699 T10900 T10901 det the,localization
R2700 T10860 T10850 punct .,translocated
R2701 T10901 T10890 dobj localization,alter
R2702 T10862 T10863 det This,pattern
R2703 T10863 T10868 nsubj pattern,reflect
R2704 T10864 T10865 amod wild,type
R2705 T10902 T10901 prep of,localization
R2706 T10865 T10863 compound type,pattern
R2707 T10866 T10865 punct -,type
R2708 T10867 T10863 compound staining,pattern
R2709 T10903 T10904 det the,protein
R2710 T10869 T10868 aux may,reflect
R2711 T10904 T10902 pobj protein,of
R2712 T10870 T10868 advmod simply,reflect
R2713 T10871 T10872 det the,fact
R2714 T10872 T10868 dobj fact,reflect
R2715 T10873 T10874 mark that,makes
R2716 T10905 T10904 compound mutant,protein
R2717 T10874 T10872 acl makes,fact
R2718 T10875 T10874 csubj decreasing,makes
R2719 T10876 T10877 det the,amount
R2720 T10906 T10890 punct .,alter
R2721 T10877 T10875 dobj amount,decreasing
R2722 T10878 T10877 prep of,amount
R2723 T10879 T10880 compound mutant,protein
R2724 T10880 T10878 pobj protein,of
R2725 T10881 T10875 prep by,decreasing
R2726 T10882 T10881 pobj half,by
R2727 T10908 T10909 advmod Indeed,proposed
R2728 T10883 T10884 nsubj it,undetectable
R2729 T10884 T10874 ccomp undetectable,makes
R2730 T10910 T10909 punct ", ",proposed
R2731 T10911 T10909 nsubj Hendriks,proposed
R2732 T10912 T10913 advmod et,al.
R2733 T10913 T10911 advmod al.,Hendriks
R2735 T10914 T10915 det a,mechanism
R2737 T10915 T10909 dobj mechanism,proposed
R2740 T10916 T10915 punct “,mechanism
R2744 T10917 T10918 nmod piggy,back
R2747 T10918 T10915 nmod back,mechanism
R2752 T10919 T10918 punct -,back
R2755 T10920 T10915 punct ”,mechanism
R2758 T10921 T10922 aux to,explain
R2760 T10922 T10909 advcl explain,proposed
R2765 T10923 T10924 det the,transport
R2768 T10924 T10922 dobj transport,explain
R2772 T10925 T10924 prep of,transport
R2778 T10926 T10927 amod nonglycosylated,subunits
R2782 T10927 T10925 pobj subunits,of
R2786 T10928 T10927 prep of,subunits
R2791 T10929 T10928 pobj AQP2,of
R2793 T10930 T10924 prep to,transport
R2796 T10931 T10932 det the,surface
R2799 T10932 T10930 pobj surface,to
R2803 T10933 T10932 compound cell,surface
R2807 T10934 T10924 prep by,transport
R2811 T10935 T10936 amod glycosylated,subunits
R2814 T10936 T10934 pobj subunits,by
R2818 T10937 T10938 punct [,22
R2822 T10938 T10922 parataxis 22,explain
R2829 T10939 T10938 punct ],22
R2832 T10940 T10909 punct .,proposed
R2833 T10942 T10943 nsubjpass It,shown
R2835 T10944 T10943 aux has,shown
R2839 T10945 T10943 advmod also,shown
R2842 T10946 T10943 auxpass been,shown
R2846 T10947 T10948 mark that,rescue
R2849 T10948 T10943 ccomp rescue,shown
R2853 T10949 T10950 amod wild,type
R2857 T10950 T10952 compound type,protein
R2860 T10951 T10950 punct -,type
R2864 T10952 T10948 nsubj protein,rescue
R2868 T10953 T10952 compound AQP2,protein
R2871 T10954 T10948 aux can,rescue
R2873 T10955 T10956 det a,protein
R2874 T10956 T10948 dobj protein,rescue
R2875 T10957 T10958 npadvmod translocation,defective
R2881 T10958 T10956 amod defective,protein
R2885 T10959 T10958 punct -,defective
R2889 T10960 T10956 compound mutant,protein
R2892 T10961 T10956 punct ", ",protein
R2896 T10962 T10963 compound AQP2,P262L
R2900 T10963 T10956 appos P262L,protein
R2902 T10964 T10963 punct -,P262L
R2905 T10965 T10948 punct ", ",rescue
R2909 T10966 T10967 advmod when,coexpressed
R2913 T10967 T10948 advcl coexpressed,rescue
R2917 T10968 T10969 det the,two
R2920 T10969 T10967 nsubjpass two,coexpressed
R2925 T10970 T10967 auxpass are,coexpressed
R2932 T10971 T10967 prep in,coexpressed
R2936 T10972 T10973 compound MDCK,cells
R2937 T10973 T10971 pobj cells,in
R2939 T10974 T10975 punct [,25
R2944 T10975 T10943 parataxis 25,shown
R2948 T10976 T10975 punct ],25
R2951 T10977 T10943 punct .,shown