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PMC:1166548 / 2176-5554 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T786 11-17 JJ denotes Cystic
T787 18-26 NN denotes fibrosis
T789 27-28 -LRB- denotes (
T790 28-30 NN denotes CF
T791 30-31 -RRB- denotes )
T792 32-34 VBZ denotes is
T788 35-41 VBN denotes caused
T793 42-44 IN denotes by
T794 45-54 NNS denotes mutations
T795 55-57 IN denotes in
T796 58-61 DT denotes the
T798 62-68 JJ denotes cystic
T799 69-77 NN denotes fibrosis
T801 78-91 JJ denotes transmembrane
T802 92-103 NN denotes conductance
T800 104-113 NN denotes regulator
T803 114-115 -LRB- denotes (
T804 115-119 NN denotes CFTR
T805 119-120 -RRB- denotes )
T797 121-125 NN denotes gene
T806 126-127 -LRB- denotes [
T807 127-128 CD denotes 1
T808 128-129 -RRB- denotes ]
T809 129-130 . denotes .
T810 130-279 sentence denotes Different mutations have a range of effects on the levels of CFTR protein and its proper functioning in epithelial transport of Cl- and HCO3- [2,3].
T811 131-140 JJ denotes Different
T812 141-150 NNS denotes mutations
T813 151-155 VBP denotes have
T814 156-157 DT denotes a
T815 158-163 NN denotes range
T816 164-166 IN denotes of
T817 167-174 NNS denotes effects
T818 175-177 IN denotes on
T819 178-181 DT denotes the
T820 182-188 NNS denotes levels
T821 189-191 IN denotes of
T822 192-196 NN denotes CFTR
T823 197-204 NN denotes protein
T824 205-208 CC denotes and
T825 209-212 PRP$ denotes its
T827 213-219 JJ denotes proper
T826 220-231 NN denotes functioning
T828 232-234 IN denotes in
T829 235-245 JJ denotes epithelial
T830 246-255 NN denotes transport
T831 256-258 IN denotes of
T832 259-261 NN denotes Cl
T833 261-262 SYM denotes -
T834 263-266 CC denotes and
T835 267-271 NN denotes HCO3
T836 271-272 SYM denotes -
T837 273-274 -LRB- denotes [
T839 274-275 CD denotes 2
T840 275-276 , denotes ,
T838 276-277 CD denotes 3
T841 277-278 -RRB- denotes ]
T842 278-279 . denotes .
T843 279-423 sentence denotes The severity of the pancreatic phenotype in human CF is well correlated with the extent of impaired CFTR function caused by specific mutations.
T844 280-283 DT denotes The
T845 284-292 NN denotes severity
T847 293-295 IN denotes of
T848 296-299 DT denotes the
T850 300-310 JJ denotes pancreatic
T849 311-320 NN denotes phenotype
T851 321-323 IN denotes in
T852 324-329 JJ denotes human
T853 330-332 NN denotes CF
T846 333-335 VBZ denotes is
T854 336-340 RB denotes well
T855 341-351 JJ denotes correlated
T856 352-356 IN denotes with
T857 357-360 DT denotes the
T858 361-367 NN denotes extent
T859 368-370 IN denotes of
T860 371-379 JJ denotes impaired
T862 380-384 NN denotes CFTR
T861 385-393 NN denotes function
T863 394-400 VBN denotes caused
T864 401-403 IN denotes by
T865 404-412 JJ denotes specific
T866 413-422 NNS denotes mutations
T867 422-423 . denotes .
T868 423-530 sentence denotes Loss of CFTR function results in destruction of the exocrine tissue and eventual pancreatic insufficiency.
T869 424-428 NN denotes Loss
T871 429-431 IN denotes of
T872 432-436 NN denotes CFTR
T873 437-445 NN denotes function
T870 446-453 VBZ denotes results
T874 454-456 IN denotes in
T875 457-468 NN denotes destruction
T876 469-471 IN denotes of
T877 472-475 DT denotes the
T879 476-484 NN denotes exocrine
T878 485-491 NN denotes tissue
T880 492-495 CC denotes and
T881 496-504 JJ denotes eventual
T883 505-515 JJ denotes pancreatic
T882 516-529 NN denotes insufficiency
T884 529-530 . denotes .
T885 530-717 sentence denotes On the other hand, the effects of CF on organs including the airways and intestines is less well correlated with specific CFTR mutations and their effects on CFTR protein function [4-8].
T886 531-533 IN denotes On
T888 534-537 DT denotes the
T890 538-543 JJ denotes other
T889 544-548 NN denotes hand
T891 548-550 , denotes ,
T892 550-553 DT denotes the
T893 554-561 NNS denotes effects
T894 562-564 IN denotes of
T895 565-567 NN denotes CF
T896 568-570 IN denotes on
T897 571-577 NNS denotes organs
T898 578-587 VBG denotes including
T899 588-591 DT denotes the
T900 592-599 NNS denotes airways
T901 600-603 CC denotes and
T902 604-614 NNS denotes intestines
T887 615-617 VBZ denotes is
T903 618-622 RBR denotes less
T905 623-627 RB denotes well
T904 628-638 JJ denotes correlated
T906 639-643 IN denotes with
T907 644-652 JJ denotes specific
T909 653-657 NN denotes CFTR
T908 658-667 NNS denotes mutations
T910 668-671 CC denotes and
T911 672-677 PRP$ denotes their
T912 678-685 NNS denotes effects
T913 686-688 IN denotes on
T914 689-693 NN denotes CFTR
T916 694-701 NN denotes protein
T915 702-710 NN denotes function
T917 711-712 -LRB- denotes [
T918 712-713 CD denotes 4
T919 713-714 SYM denotes -
T920 714-715 CD denotes 8
T921 715-716 -RRB- denotes ]
T922 716-717 . denotes .
T923 717-810 sentence denotes This indicates that other genes are likely to be important as modifiers of the CF phenotype.
T924 718-722 DT denotes This
T925 723-732 VBZ denotes indicates
T926 733-737 IN denotes that
T928 738-743 JJ denotes other
T929 744-749 NNS denotes genes
T927 750-753 VBP denotes are
T930 754-760 JJ denotes likely
T931 761-763 TO denotes to
T932 764-766 VB denotes be
T933 767-776 JJ denotes important
T934 777-779 IN denotes as
T935 780-789 NNS denotes modifiers
T936 790-792 IN denotes of
T937 793-796 DT denotes the
T939 797-799 NN denotes CF
T938 800-809 NN denotes phenotype
T940 809-810 . denotes .
T941 810-961 sentence denotes With the exception of pancreatic insufficiency resulting in impaired digestion, other aspects of CF are less readily related to loss of CFTR function.
T942 811-815 IN denotes With
T944 816-819 DT denotes the
T945 820-829 NN denotes exception
T946 830-832 IN denotes of
T947 833-843 JJ denotes pancreatic
T948 844-857 NN denotes insufficiency
T949 858-867 VBG denotes resulting
T950 868-870 IN denotes in
T951 871-879 VBN denotes impaired
T952 880-889 NN denotes digestion
T953 889-891 , denotes ,
T954 891-896 JJ denotes other
T955 897-904 NNS denotes aspects
T956 905-907 IN denotes of
T957 908-910 NN denotes CF
T943 911-914 VBP denotes are
T958 915-919 RBR denotes less
T959 920-927 RB denotes readily
T960 928-935 JJ denotes related
T961 936-938 IN denotes to
T962 939-943 NN denotes loss
T963 944-946 IN denotes of
T964 947-951 NN denotes CFTR
T965 952-960 NN denotes function
T966 960-961 . denotes .
T967 961-1187 sentence denotes Nutritional problems can persist even with adequate oral enzyme supplementation [9] and neutralization of gastric acid to improve lipase function [10], and may involve both impaired digestion and absorption of nutrients [11].
T968 962-973 JJ denotes Nutritional
T969 974-982 NNS denotes problems
T971 983-986 MD denotes can
T970 987-994 VB denotes persist
T972 995-999 RB denotes even
T973 1000-1004 IN denotes with
T974 1005-1013 JJ denotes adequate
T976 1014-1018 JJ denotes oral
T977 1019-1025 NN denotes enzyme
T975 1026-1041 NN denotes supplementation
T978 1042-1043 -LRB- denotes [
T979 1043-1044 CD denotes 9
T980 1044-1045 -RRB- denotes ]
T981 1046-1049 CC denotes and
T982 1050-1064 NN denotes neutralization
T983 1065-1067 IN denotes of
T984 1068-1075 JJ denotes gastric
T985 1076-1080 NN denotes acid
T986 1081-1083 TO denotes to
T987 1084-1091 VB denotes improve
T988 1092-1098 NN denotes lipase
T989 1099-1107 NN denotes function
T990 1108-1109 -LRB- denotes [
T991 1109-1111 CD denotes 10
T992 1111-1112 -RRB- denotes ]
T993 1112-1114 , denotes ,
T994 1114-1117 CC denotes and
T995 1118-1121 MD denotes may
T996 1122-1129 VB denotes involve
T997 1130-1134 CC denotes both
T999 1135-1143 JJ denotes impaired
T998 1144-1153 NN denotes digestion
T1000 1154-1157 CC denotes and
T1001 1158-1168 NN denotes absorption
T1002 1169-1171 IN denotes of
T1003 1172-1181 NNS denotes nutrients
T1004 1182-1183 -LRB- denotes [
T1005 1183-1185 CD denotes 11
T1006 1185-1186 -RRB- denotes ]
T1007 1186-1187 . denotes .
T1008 1187-1371 sentence denotes Inadequate absorption or assimilation of nutrients appears to be of greater importance because even with adequate oral enzyme supplementation nutrition is rarely fully corrected [11].
T1009 1188-1198 JJ denotes Inadequate
T1010 1199-1209 NN denotes absorption
T1012 1210-1212 CC denotes or
T1013 1213-1225 NN denotes assimilation
T1014 1226-1228 IN denotes of
T1015 1229-1238 NNS denotes nutrients
T1011 1239-1246 VBZ denotes appears
T1016 1247-1249 TO denotes to
T1017 1250-1252 VB denotes be
T1018 1253-1255 IN denotes of
T1019 1256-1263 JJR denotes greater
T1020 1264-1274 NN denotes importance
T1021 1275-1282 IN denotes because
T1023 1283-1287 RB denotes even
T1024 1288-1292 IN denotes with
T1025 1293-1301 JJ denotes adequate
T1027 1302-1306 JJ denotes oral
T1028 1307-1313 NN denotes enzyme
T1026 1314-1329 NN denotes supplementation
T1029 1330-1339 NN denotes nutrition
T1030 1340-1342 VBZ denotes is
T1031 1343-1349 RB denotes rarely
T1032 1350-1355 RB denotes fully
T1022 1356-1365 VBN denotes corrected
T1033 1366-1367 -LRB- denotes [
T1034 1367-1369 CD denotes 11
T1035 1369-1370 -RRB- denotes ]
T1036 1370-1371 . denotes .
T1037 1371-1482 sentence denotes There is also excessive mucus accumulation in the CF intestine, and inappropriate inflammation is common [12].
T1038 1372-1377 EX denotes There
T1039 1378-1380 VBZ denotes is
T1040 1381-1385 RB denotes also
T1041 1386-1395 JJ denotes excessive
T1043 1396-1401 NN denotes mucus
T1042 1402-1414 NN denotes accumulation
T1044 1415-1417 IN denotes in
T1045 1418-1421 DT denotes the
T1047 1422-1424 NN denotes CF
T1046 1425-1434 NN denotes intestine
T1048 1434-1436 , denotes ,
T1049 1436-1439 CC denotes and
T1050 1440-1453 JJ denotes inappropriate
T1051 1454-1466 NN denotes inflammation
T1052 1467-1469 VBZ denotes is
T1053 1470-1476 JJ denotes common
T1054 1477-1478 -LRB- denotes [
T1055 1478-1480 CD denotes 12
T1056 1480-1481 -RRB- denotes ]
T1057 1481-1482 . denotes .
T1058 1482-1666 sentence denotes Mucus is involved in obstruction of the gut which occurs frequently in CF infants (called meconium ileus, MI) and adults (called distal intestinal obstruction syndrome, DIOS) [11,13].
T1059 1483-1488 NN denotes Mucus
T1061 1489-1491 VBZ denotes is
T1060 1492-1500 VBN denotes involved
T1062 1501-1503 IN denotes in
T1063 1504-1515 NN denotes obstruction
T1064 1516-1518 IN denotes of
T1065 1519-1522 DT denotes the
T1066 1523-1526 NN denotes gut
T1067 1527-1532 WDT denotes which
T1068 1533-1539 VBZ denotes occurs
T1069 1540-1550 RB denotes frequently
T1070 1551-1553 IN denotes in
T1071 1554-1556 NN denotes CF
T1072 1557-1564 NNS denotes infants
T1073 1565-1566 -LRB- denotes (
T1074 1566-1572 VBN denotes called
T1075 1573-1581 NN denotes meconium
T1076 1582-1587 NN denotes ileus
T1077 1587-1589 , denotes ,
T1078 1589-1591 NN denotes MI
T1079 1591-1592 -RRB- denotes )
T1080 1593-1596 CC denotes and
T1081 1597-1603 NNS denotes adults
T1082 1604-1605 -LRB- denotes (
T1083 1605-1611 VBN denotes called
T1084 1612-1618 JJ denotes distal
T1086 1619-1629 JJ denotes intestinal
T1087 1630-1641 NN denotes obstruction
T1085 1642-1650 NN denotes syndrome
T1088 1650-1652 , denotes ,
T1089 1652-1656 NN denotes DIOS
T1090 1656-1657 -RRB- denotes )
T1091 1658-1659 -LRB- denotes [
T1093 1659-1661 CD denotes 11
T1094 1661-1662 , denotes ,
T1092 1662-1664 CD denotes 13
T1095 1664-1665 -RRB- denotes ]
T1096 1665-1666 . denotes .
T1097 1666-1754 sentence denotes And, similar to CF airways, there is also an inflammation of the CF intestines [14,15].
T1098 1667-1670 CC denotes And
T1100 1670-1672 , denotes ,
T1101 1672-1679 JJ denotes similar
T1102 1680-1682 IN denotes to
T1103 1683-1685 NN denotes CF
T1104 1686-1693 NNS denotes airways
T1105 1693-1695 , denotes ,
T1106 1695-1700 EX denotes there
T1099 1701-1703 VBZ denotes is
T1107 1704-1708 RB denotes also
T1108 1709-1711 DT denotes an
T1109 1712-1724 NN denotes inflammation
T1110 1725-1727 IN denotes of
T1111 1728-1731 DT denotes the
T1113 1732-1734 NN denotes CF
T1112 1735-1745 NNS denotes intestines
T1114 1746-1747 -LRB- denotes [
T1116 1747-1749 CD denotes 14
T1117 1749-1750 , denotes ,
T1115 1750-1752 CD denotes 15
T1118 1752-1753 -RRB- denotes ]
T1119 1753-1754 . denotes .
T1120 1754-1907 sentence denotes These changes are less directly related to specific mutations in the CFTR gene and are likely related to other differences in individual genetic makeup.
T1121 1755-1760 DT denotes These
T1122 1761-1768 NNS denotes changes
T1123 1769-1772 VBP denotes are
T1124 1773-1777 RBR denotes less
T1125 1778-1786 RB denotes directly
T1126 1787-1794 JJ denotes related
T1127 1795-1797 IN denotes to
T1128 1798-1806 JJ denotes specific
T1129 1807-1816 NNS denotes mutations
T1130 1817-1819 IN denotes in
T1131 1820-1823 DT denotes the
T1133 1824-1828 NN denotes CFTR
T1132 1829-1833 NN denotes gene
T1134 1834-1837 CC denotes and
T1135 1838-1841 VBP denotes are
T1136 1842-1848 RB denotes likely
T1137 1849-1856 JJ denotes related
T1138 1857-1859 IN denotes to
T1139 1860-1865 JJ denotes other
T1140 1866-1877 NNS denotes differences
T1141 1878-1880 IN denotes in
T1142 1881-1891 JJ denotes individual
T1144 1892-1899 JJ denotes genetic
T1143 1900-1906 NN denotes makeup
T1145 1906-1907 . denotes .
T1146 1907-2069 sentence denotes Previous work using human patients and genetically altered mice has identified some modifier genes and have advanced our understanding of CF pathophysiology [4].
T1147 1908-1916 JJ denotes Previous
T1148 1917-1921 NN denotes work
T1150 1922-1927 VBG denotes using
T1151 1928-1933 JJ denotes human
T1152 1934-1942 NNS denotes patients
T1153 1943-1946 CC denotes and
T1154 1947-1958 RB denotes genetically
T1155 1959-1966 VBN denotes altered
T1156 1967-1971 NNS denotes mice
T1157 1972-1975 VBZ denotes has
T1149 1976-1986 VBN denotes identified
T1158 1987-1991 DT denotes some
T1160 1992-2000 NN denotes modifier
T1159 2001-2006 NNS denotes genes
T1161 2007-2010 CC denotes and
T1162 2011-2015 VBP denotes have
T1163 2016-2024 VBN denotes advanced
T1164 2025-2028 PRP$ denotes our
T1165 2029-2042 NN denotes understanding
T1166 2043-2045 IN denotes of
T1167 2046-2048 NN denotes CF
T1168 2049-2064 NN denotes pathophysiology
T1169 2065-2066 -LRB- denotes [
T1170 2066-2067 CD denotes 4
T1171 2067-2068 -RRB- denotes ]
T1172 2068-2069 . denotes .
T1173 2069-2323 sentence denotes In one study using CF mice on different genetic backgrounds, a region on mouse chromosome 7 was shown to ameliorate intestinal blockage and the effect was in part due to a calcium-regulated Cl-channel which compensated for loss of CFTR function [16,17].
T1174 2070-2072 IN denotes In
T1176 2073-2076 CD denotes one
T1177 2077-2082 NN denotes study
T1178 2083-2088 VBG denotes using
T1179 2089-2091 NN denotes CF
T1180 2092-2096 NNS denotes mice
T1181 2097-2099 IN denotes on
T1182 2100-2109 JJ denotes different
T1184 2110-2117 JJ denotes genetic
T1183 2118-2129 NNS denotes backgrounds
T1185 2129-2131 , denotes ,
T1186 2131-2132 DT denotes a
T1187 2133-2139 NN denotes region
T1188 2140-2142 IN denotes on
T1189 2143-2148 NN denotes mouse
T1190 2149-2159 NN denotes chromosome
T1191 2160-2161 CD denotes 7
T1192 2162-2165 VBD denotes was
T1175 2166-2171 VBN denotes shown
T1193 2172-2174 TO denotes to
T1194 2175-2185 VB denotes ameliorate
T1195 2186-2196 JJ denotes intestinal
T1196 2197-2205 NN denotes blockage
T1197 2206-2209 CC denotes and
T1198 2210-2213 DT denotes the
T1199 2214-2220 NN denotes effect
T1200 2221-2224 VBD denotes was
T1201 2225-2227 IN denotes in
T1202 2228-2232 JJ denotes part
T1203 2233-2236 IN denotes due
T1204 2237-2239 IN denotes to
T1205 2240-2241 DT denotes a
T1207 2242-2249 NN denotes calcium
T1209 2249-2250 HYPH denotes -
T1208 2250-2259 VBN denotes regulated
T1210 2260-2262 NN denotes Cl
T1211 2262-2263 SYM denotes -
T1206 2263-2270 NN denotes channel
T1212 2271-2276 WDT denotes which
T1213 2277-2288 VBD denotes compensated
T1214 2289-2292 IN denotes for
T1215 2293-2297 NN denotes loss
T1216 2298-2300 IN denotes of
T1217 2301-2305 NN denotes CFTR
T1218 2306-2314 NN denotes function
T1219 2315-2316 -LRB- denotes [
T1221 2316-2318 CD denotes 16
T1222 2318-2319 , denotes ,
T1220 2319-2321 CD denotes 17
T1223 2321-2322 -RRB- denotes ]
T1224 2322-2323 . denotes .
T1225 2323-2464 sentence denotes Marker haplotypes of the syntenic region of human chromosome 19q13 were also shown to be associated with the risk of MI in CF patients [18].
T1226 2324-2330 NN denotes Marker
T1227 2331-2341 NNS denotes haplotypes
T1229 2342-2344 IN denotes of
T1230 2345-2348 DT denotes the
T1232 2349-2357 JJ denotes syntenic
T1231 2358-2364 NN denotes region
T1233 2365-2367 IN denotes of
T1234 2368-2373 JJ denotes human
T1235 2374-2384 NN denotes chromosome
T1236 2385-2390 CD denotes 19q13
T1237 2391-2395 VBD denotes were
T1238 2396-2400 RB denotes also
T1228 2401-2406 VBN denotes shown
T1239 2407-2409 TO denotes to
T1241 2410-2412 VB denotes be
T1240 2413-2423 VBN denotes associated
T1242 2424-2428 IN denotes with
T1243 2429-2432 DT denotes the
T1244 2433-2437 NN denotes risk
T1245 2438-2440 IN denotes of
T1246 2441-2443 NN denotes MI
T1247 2444-2446 IN denotes in
T1248 2447-2449 NN denotes CF
T1249 2450-2458 NNS denotes patients
T1250 2459-2460 -LRB- denotes [
T1251 2460-2462 CD denotes 18
T1252 2462-2463 -RRB- denotes ]
T1253 2463-2464 . denotes .
T1254 2464-2730 sentence denotes In other work, a region on mouse chr. 6 was strongly associated with lung inflammation, consisting of mononuclear cell interstitial infiltration and fibrosis in CF mouse airways; and other loci on chr. 1, 2, 10, and 17 were also linked to the airway phenotype [19].
T1255 2465-2467 IN denotes In
T1257 2468-2473 JJ denotes other
T1258 2474-2478 NN denotes work
T1259 2478-2480 , denotes ,
T1260 2480-2481 DT denotes a
T1261 2482-2488 NN denotes region
T1262 2489-2491 IN denotes on
T1263 2492-2497 NN denotes mouse
T1264 2498-2502 NN denotes chr.
T1265 2503-2504 CD denotes 6
T1266 2505-2508 VBD denotes was
T1267 2509-2517 RB denotes strongly
T1256 2518-2528 VBN denotes associated
T1268 2529-2533 IN denotes with
T1269 2534-2538 NN denotes lung
T1270 2539-2551 NN denotes inflammation
T1271 2551-2553 , denotes ,
T1272 2553-2563 VBG denotes consisting
T1273 2564-2566 IN denotes of
T1274 2567-2578 JJ denotes mononuclear
T1275 2579-2583 NN denotes cell
T1277 2584-2596 JJ denotes interstitial
T1276 2597-2609 NN denotes infiltration
T1278 2610-2613 CC denotes and
T1279 2614-2622 NN denotes fibrosis
T1280 2623-2625 IN denotes in
T1281 2626-2628 NN denotes CF
T1283 2629-2634 NN denotes mouse
T1282 2635-2642 NNS denotes airways
T1284 2642-2643 : denotes ;
T1285 2644-2647 CC denotes and
T1286 2648-2653 JJ denotes other
T1287 2654-2658 NNS denotes loci
T1289 2659-2661 IN denotes on
T1290 2662-2666 NN denotes chr.
T1291 2667-2668 CD denotes 1
T1292 2668-2670 , denotes ,
T1293 2670-2671 CD denotes 2
T1294 2671-2673 , denotes ,
T1295 2673-2675 CD denotes 10
T1296 2675-2677 , denotes ,
T1297 2677-2680 CC denotes and
T1298 2681-2683 CD denotes 17
T1299 2684-2688 VBD denotes were
T1300 2689-2693 RB denotes also
T1288 2694-2700 VBN denotes linked
T1301 2701-2703 IN denotes to
T1302 2704-2707 DT denotes the
T1304 2708-2714 NN denotes airway
T1303 2715-2724 NN denotes phenotype
T1305 2725-2726 -LRB- denotes [
T1306 2726-2728 CD denotes 19
T1307 2728-2729 -RRB- denotes ]
T1308 2729-2730 . denotes .
T1309 2730-2883 sentence denotes In this work, CF mice on a mixed strain background were found to have a less severe CF phenotype compared to CF mice congenic on the C57Bl/6 background.
T1310 2731-2733 IN denotes In
T1312 2734-2738 DT denotes this
T1313 2739-2743 NN denotes work
T1314 2743-2745 , denotes ,
T1315 2745-2747 NN denotes CF
T1316 2748-2752 NNS denotes mice
T1317 2753-2755 IN denotes on
T1318 2756-2757 DT denotes a
T1320 2758-2763 JJ denotes mixed
T1321 2764-2770 NN denotes strain
T1319 2771-2781 NN denotes background
T1322 2782-2786 VBD denotes were
T1311 2787-2792 VBN denotes found
T1323 2793-2795 TO denotes to
T1324 2796-2800 VB denotes have
T1325 2801-2802 DT denotes a
T1327 2803-2807 RBR denotes less
T1328 2808-2814 JJ denotes severe
T1329 2815-2817 NN denotes CF
T1326 2818-2827 NN denotes phenotype
T1330 2828-2836 VBN denotes compared
T1331 2837-2839 IN denotes to
T1332 2840-2842 NN denotes CF
T1333 2843-2847 NNS denotes mice
T1334 2848-2856 JJ denotes congenic
T1335 2857-2859 IN denotes on
T1336 2860-2863 DT denotes the
T1338 2864-2869 NN denotes C57Bl
T1339 2869-2870 HYPH denotes /
T1340 2870-2871 CD denotes 6
T1337 2872-2882 NN denotes background
T1341 2882-2883 . denotes .
T1342 2883-2990 sentence denotes There were no differences in the pancreatic phenotype comparing CF mice on the different backgrounds [20].
T1343 2884-2889 EX denotes There
T1344 2890-2894 VBD denotes were
T1345 2895-2897 DT denotes no
T1346 2898-2909 NNS denotes differences
T1347 2910-2912 IN denotes in
T1348 2913-2916 DT denotes the
T1350 2917-2927 JJ denotes pancreatic
T1349 2928-2937 NN denotes phenotype
T1351 2938-2947 VBG denotes comparing
T1352 2948-2950 NN denotes CF
T1353 2951-2955 NNS denotes mice
T1354 2956-2958 IN denotes on
T1355 2959-2962 DT denotes the
T1357 2963-2972 JJ denotes different
T1356 2973-2984 NNS denotes backgrounds
T1358 2985-2986 -LRB- denotes [
T1359 2986-2988 CD denotes 20
T1360 2988-2989 -RRB- denotes ]
T1361 2989-2990 . denotes .
T1362 2990-3139 sentence denotes However, mice on the mixed background seemed more robust than CF mice on the B6 background which prompted us to characterize them in greater detail.
T1363 2991-2998 RB denotes However
T1365 2998-3000 , denotes ,
T1366 3000-3004 NNS denotes mice
T1367 3005-3007 IN denotes on
T1368 3008-3011 DT denotes the
T1370 3012-3017 JJ denotes mixed
T1369 3018-3028 NN denotes background
T1364 3029-3035 VBD denotes seemed
T1371 3036-3040 RBR denotes more
T1372 3041-3047 JJ denotes robust
T1373 3048-3052 IN denotes than
T1374 3053-3055 NN denotes CF
T1375 3056-3060 NNS denotes mice
T1376 3061-3063 IN denotes on
T1377 3064-3067 DT denotes the
T1379 3068-3070 NN denotes B6
T1378 3071-3081 NN denotes background
T1380 3082-3087 WDT denotes which
T1381 3088-3096 VBD denotes prompted
T1382 3097-3099 PRP denotes us
T1383 3100-3102 TO denotes to
T1384 3103-3115 VB denotes characterize
T1385 3116-3120 PRP denotes them
T1386 3121-3123 IN denotes in
T1387 3124-3131 JJR denotes greater
T1388 3132-3138 NN denotes detail
T1389 3138-3139 . denotes .
T1390 3139-3265 sentence denotes Genome wide allele scanning was used to begin identification of regions associated with the less severe intestinal phenotype.
T1391 3140-3146 NN denotes Genome
T1392 3147-3151 JJ denotes wide
T1394 3152-3158 NN denotes allele
T1393 3159-3167 NN denotes scanning
T1396 3168-3171 VBD denotes was
T1395 3172-3176 VBN denotes used
T1397 3177-3179 TO denotes to
T1398 3180-3185 VB denotes begin
T1399 3186-3200 NN denotes identification
T1400 3201-3203 IN denotes of
T1401 3204-3211 NNS denotes regions
T1402 3212-3222 VBN denotes associated
T1403 3223-3227 IN denotes with
T1404 3228-3231 DT denotes the
T1406 3232-3236 RBR denotes less
T1407 3237-3243 JJ denotes severe
T1408 3244-3254 JJ denotes intestinal
T1405 3255-3264 NN denotes phenotype
T1409 3264-3265 . denotes .
T1410 3265-3378 sentence denotes Future identification of specific genes should further our understanding of the complex intestinal CF phenotype.
T1411 3266-3272 JJ denotes Future
T1412 3273-3287 NN denotes identification
T1414 3288-3290 IN denotes of
T1415 3291-3299 JJ denotes specific
T1416 3300-3305 NNS denotes genes
T1417 3306-3312 MD denotes should
T1413 3313-3320 VB denotes further
T1418 3321-3324 PRP$ denotes our
T1419 3325-3338 NN denotes understanding
T1420 3339-3341 IN denotes of
T1421 3342-3345 DT denotes the
T1423 3346-3353 JJ denotes complex
T1424 3354-3364 JJ denotes intestinal
T1425 3365-3367 NN denotes CF
T1422 3368-3377 NN denotes phenotype
T1426 3377-3378 . denotes .
R379 T786 T787 amod Cystic,fibrosis
R380 T787 T788 nsubjpass fibrosis,caused
R381 T789 T787 punct (,fibrosis
R382 T790 T787 appos CF,fibrosis
R383 T791 T788 punct ),caused
R384 T792 T788 auxpass is,caused
R385 T793 T788 agent by,caused
R386 T794 T793 pobj mutations,by
R387 T795 T794 prep in,mutations
R388 T796 T797 det the,gene
R389 T797 T795 pobj gene,in
R390 T798 T799 amod cystic,fibrosis
R391 T799 T800 nmod fibrosis,regulator
R392 T800 T797 nmod regulator,gene
R393 T801 T802 amod transmembrane,conductance
R394 T802 T800 nmod conductance,regulator
R395 T803 T800 punct (,regulator
R396 T804 T800 appos CFTR,regulator
R397 T805 T797 punct ),gene
R398 T806 T807 punct [,1
R399 T807 T788 parataxis 1,caused
R400 T808 T807 punct ],1
R401 T809 T788 punct .,caused
R402 T811 T812 amod Different,mutations
R403 T812 T813 nsubj mutations,have
R404 T814 T815 det a,range
R405 T815 T813 dobj range,have
R406 T816 T815 prep of,range
R407 T817 T816 pobj effects,of
R408 T818 T817 prep on,effects
R409 T819 T820 det the,levels
R410 T820 T818 pobj levels,on
R411 T821 T820 prep of,levels
R412 T822 T823 compound CFTR,protein
R413 T823 T821 pobj protein,of
R414 T824 T820 cc and,levels
R415 T825 T826 poss its,functioning
R416 T826 T820 conj functioning,levels
R417 T827 T826 amod proper,functioning
R418 T828 T826 prep in,functioning
R419 T829 T830 amod epithelial,transport
R420 T830 T828 pobj transport,in
R421 T831 T830 prep of,transport
R422 T832 T831 pobj Cl,of
R423 T833 T832 punct -,Cl
R424 T834 T832 cc and,Cl
R425 T835 T832 conj HCO3,Cl
R426 T836 T835 punct -,HCO3
R427 T837 T838 punct [,3
R428 T838 T813 parataxis 3,have
R429 T839 T838 nummod 2,3
R430 T840 T838 punct ",",3
R431 T841 T838 punct ],3
R432 T842 T813 punct .,have
R433 T844 T845 det The,severity
R434 T845 T846 nsubj severity,is
R435 T847 T845 prep of,severity
R436 T848 T849 det the,phenotype
R437 T849 T847 pobj phenotype,of
R438 T850 T849 amod pancreatic,phenotype
R439 T851 T845 prep in,severity
R440 T852 T853 amod human,CF
R441 T853 T851 pobj CF,in
R442 T854 T855 advmod well,correlated
R443 T855 T846 acomp correlated,is
R444 T856 T855 prep with,correlated
R445 T857 T858 det the,extent
R446 T858 T856 pobj extent,with
R447 T859 T858 prep of,extent
R448 T860 T861 amod impaired,function
R449 T861 T859 pobj function,of
R450 T862 T861 compound CFTR,function
R451 T863 T861 acl caused,function
R452 T864 T863 prep by,caused
R453 T865 T866 amod specific,mutations
R454 T866 T864 pobj mutations,by
R455 T867 T846 punct .,is
R456 T869 T870 nsubj Loss,results
R457 T871 T869 prep of,Loss
R458 T872 T873 compound CFTR,function
R459 T873 T871 pobj function,of
R460 T874 T870 prep in,results
R461 T875 T874 pobj destruction,in
R462 T876 T875 prep of,destruction
R463 T877 T878 det the,tissue
R464 T878 T876 pobj tissue,of
R465 T879 T878 compound exocrine,tissue
R466 T880 T878 cc and,tissue
R467 T881 T882 amod eventual,insufficiency
R468 T882 T878 conj insufficiency,tissue
R469 T883 T882 amod pancreatic,insufficiency
R470 T884 T870 punct .,results
R471 T886 T887 prep On,is
R472 T888 T889 det the,hand
R473 T889 T886 pobj hand,On
R474 T890 T889 amod other,hand
R475 T891 T887 punct ", ",is
R476 T892 T893 det the,effects
R477 T893 T887 nsubj effects,is
R478 T894 T893 prep of,effects
R479 T895 T894 pobj CF,of
R480 T896 T893 prep on,effects
R481 T897 T896 pobj organs,on
R482 T898 T897 prep including,organs
R483 T899 T900 det the,airways
R484 T900 T898 pobj airways,including
R485 T901 T900 cc and,airways
R486 T902 T900 conj intestines,airways
R487 T903 T904 advmod less,correlated
R488 T904 T887 acomp correlated,is
R489 T905 T904 advmod well,correlated
R490 T906 T904 prep with,correlated
R491 T907 T908 amod specific,mutations
R492 T908 T906 pobj mutations,with
R493 T909 T908 compound CFTR,mutations
R494 T910 T908 cc and,mutations
R495 T911 T912 poss their,effects
R496 T912 T908 conj effects,mutations
R497 T913 T912 prep on,effects
R498 T914 T915 compound CFTR,function
R499 T915 T913 pobj function,on
R500 T916 T915 compound protein,function
R501 T917 T918 punct [,4
R502 T918 T887 parataxis 4,is
R503 T919 T920 punct -,8
R504 T920 T918 prep 8,4
R505 T921 T918 punct ],4
R506 T922 T887 punct .,is
R507 T924 T925 nsubj This,indicates
R508 T926 T927 mark that,are
R509 T927 T925 ccomp are,indicates
R510 T928 T929 amod other,genes
R511 T929 T927 nsubj genes,are
R512 T930 T927 acomp likely,are
R513 T931 T932 aux to,be
R514 T932 T930 xcomp be,likely
R515 T933 T932 acomp important,be
R516 T934 T932 prep as,be
R517 T935 T934 pobj modifiers,as
R518 T936 T935 prep of,modifiers
R519 T937 T938 det the,phenotype
R520 T938 T936 pobj phenotype,of
R521 T939 T938 compound CF,phenotype
R522 T940 T925 punct .,indicates
R523 T942 T943 prep With,are
R524 T944 T945 det the,exception
R525 T945 T942 pobj exception,With
R526 T946 T945 prep of,exception
R527 T947 T948 amod pancreatic,insufficiency
R528 T948 T949 nsubj insufficiency,resulting
R529 T949 T946 pcomp resulting,of
R530 T950 T949 prep in,resulting
R531 T951 T952 amod impaired,digestion
R532 T952 T950 pobj digestion,in
R533 T953 T943 punct ", ",are
R534 T954 T955 amod other,aspects
R535 T955 T943 nsubj aspects,are
R536 T956 T955 prep of,aspects
R537 T957 T956 pobj CF,of
R538 T958 T959 advmod less,readily
R539 T959 T960 advmod readily,related
R540 T960 T943 acomp related,are
R541 T961 T960 prep to,related
R542 T962 T961 pobj loss,to
R543 T963 T962 prep of,loss
R544 T964 T965 compound CFTR,function
R545 T965 T963 pobj function,of
R546 T966 T943 punct .,are
R547 T968 T969 amod Nutritional,problems
R548 T969 T970 nsubj problems,persist
R549 T971 T970 aux can,persist
R550 T972 T973 advmod even,with
R551 T973 T970 prep with,persist
R552 T974 T975 amod adequate,supplementation
R553 T975 T973 pobj supplementation,with
R554 T976 T977 amod oral,enzyme
R555 T977 T975 compound enzyme,supplementation
R556 T978 T979 punct [,9
R557 T979 T975 parataxis 9,supplementation
R558 T980 T979 punct ],9
R559 T981 T975 cc and,supplementation
R560 T982 T975 conj neutralization,supplementation
R561 T983 T982 prep of,neutralization
R562 T984 T985 amod gastric,acid
R563 T985 T983 pobj acid,of
R564 T986 T987 aux to,improve
R565 T987 T982 advcl improve,neutralization
R566 T988 T987 dep lipase,improve
R567 T989 T987 dep function,improve
R568 T990 T991 punct [,10
R569 T991 T982 parataxis 10,neutralization
R570 T992 T991 punct ],10
R571 T993 T970 punct ", ",persist
R572 T994 T970 cc and,persist
R573 T995 T996 aux may,involve
R574 T996 T970 conj involve,persist
R575 T997 T998 preconj both,digestion
R576 T998 T996 dobj digestion,involve
R577 T999 T998 amod impaired,digestion
R578 T1000 T998 cc and,digestion
R579 T1001 T998 conj absorption,digestion
R580 T1002 T998 prep of,digestion
R581 T1003 T1002 pobj nutrients,of
R582 T1004 T1005 punct [,11
R583 T1005 T996 parataxis 11,involve
R584 T1006 T1005 punct ],11
R585 T1007 T970 punct .,persist
R586 T1009 T1010 amod Inadequate,absorption
R587 T1010 T1011 nsubj absorption,appears
R588 T1012 T1010 cc or,absorption
R589 T1013 T1010 conj assimilation,absorption
R590 T1014 T1010 prep of,absorption
R591 T1015 T1014 pobj nutrients,of
R592 T1016 T1017 aux to,be
R593 T1017 T1011 xcomp be,appears
R594 T1018 T1017 prep of,be
R595 T1019 T1020 amod greater,importance
R596 T1020 T1018 pobj importance,of
R597 T1021 T1022 mark because,corrected
R598 T1022 T1011 advcl corrected,appears
R599 T1023 T1024 advmod even,with
R600 T1024 T1022 prep with,corrected
R601 T1025 T1026 amod adequate,supplementation
R602 T1026 T1024 pobj supplementation,with
R603 T1027 T1028 amod oral,enzyme
R604 T1028 T1026 compound enzyme,supplementation
R605 T1029 T1022 nsubjpass nutrition,corrected
R606 T1030 T1022 auxpass is,corrected
R607 T1031 T1022 advmod rarely,corrected
R608 T1032 T1022 advmod fully,corrected
R609 T1033 T1034 punct [,11
R610 T1034 T1011 parataxis 11,appears
R611 T1035 T1034 punct ],11
R612 T1036 T1011 punct .,appears
R613 T1038 T1039 expl There,is
R614 T1040 T1039 advmod also,is
R615 T1041 T1042 amod excessive,accumulation
R616 T1042 T1039 attr accumulation,is
R617 T1043 T1042 compound mucus,accumulation
R618 T1044 T1039 prep in,is
R619 T1045 T1046 det the,intestine
R620 T1046 T1044 pobj intestine,in
R621 T1047 T1046 compound CF,intestine
R622 T1048 T1039 punct ", ",is
R623 T1049 T1039 cc and,is
R624 T1050 T1051 amod inappropriate,inflammation
R625 T1051 T1052 nsubj inflammation,is
R626 T1052 T1039 conj is,is
R627 T1053 T1052 acomp common,is
R628 T1054 T1055 punct [,12
R629 T1055 T1052 parataxis 12,is
R630 T1056 T1055 punct ],12
R631 T1057 T1052 punct .,is
R632 T1059 T1060 nsubjpass Mucus,involved
R633 T1061 T1060 auxpass is,involved
R634 T1062 T1060 prep in,involved
R635 T1063 T1062 pobj obstruction,in
R636 T1064 T1063 prep of,obstruction
R637 T1065 T1066 det the,gut
R638 T1066 T1064 pobj gut,of
R639 T1067 T1068 dep which,occurs
R640 T1068 T1063 relcl occurs,obstruction
R641 T1069 T1068 advmod frequently,occurs
R642 T1070 T1068 prep in,occurs
R643 T1071 T1072 compound CF,infants
R644 T1072 T1070 pobj infants,in
R645 T1073 T1072 punct (,infants
R646 T1074 T1072 acl called,infants
R647 T1075 T1076 compound meconium,ileus
R648 T1076 T1074 oprd ileus,called
R649 T1077 T1076 punct ", ",ileus
R650 T1078 T1076 appos MI,ileus
R651 T1079 T1072 punct ),infants
R652 T1080 T1072 cc and,infants
R653 T1081 T1072 conj adults,infants
R654 T1082 T1081 punct (,adults
R655 T1083 T1081 acl called,adults
R656 T1084 T1085 amod distal,syndrome
R657 T1085 T1083 oprd syndrome,called
R658 T1086 T1085 amod intestinal,syndrome
R659 T1087 T1085 compound obstruction,syndrome
R660 T1088 T1085 punct ", ",syndrome
R661 T1089 T1085 appos DIOS,syndrome
R662 T1090 T1060 punct ),involved
R663 T1091 T1092 punct [,13
R664 T1092 T1060 parataxis 13,involved
R665 T1093 T1092 nummod 11,13
R666 T1094 T1092 punct ",",13
R667 T1095 T1092 punct ],13
R668 T1096 T1060 punct .,involved
R669 T1098 T1099 cc And,is
R670 T1100 T1099 punct ", ",is
R671 T1101 T1099 advcl similar,is
R672 T1102 T1101 prep to,similar
R673 T1103 T1104 compound CF,airways
R674 T1104 T1102 pobj airways,to
R675 T1105 T1099 punct ", ",is
R676 T1106 T1099 expl there,is
R677 T1107 T1099 advmod also,is
R678 T1108 T1109 det an,inflammation
R679 T1109 T1099 attr inflammation,is
R680 T1110 T1109 prep of,inflammation
R681 T1111 T1112 det the,intestines
R682 T1112 T1110 pobj intestines,of
R683 T1113 T1112 compound CF,intestines
R684 T1114 T1115 punct [,15
R685 T1115 T1099 parataxis 15,is
R686 T1116 T1115 nummod 14,15
R687 T1117 T1115 punct ",",15
R688 T1118 T1115 punct ],15
R689 T1119 T1099 punct .,is
R690 T1121 T1122 det These,changes
R691 T1122 T1123 nsubj changes,are
R692 T1124 T1125 advmod less,directly
R693 T1125 T1126 advmod directly,related
R694 T1126 T1123 acomp related,are
R695 T1127 T1126 prep to,related
R696 T1128 T1129 amod specific,mutations
R697 T1129 T1127 pobj mutations,to
R698 T1130 T1129 prep in,mutations
R699 T1131 T1132 det the,gene
R700 T1132 T1130 pobj gene,in
R701 T1133 T1132 compound CFTR,gene
R702 T1134 T1123 cc and,are
R703 T1135 T1123 conj are,are
R704 T1136 T1135 advmod likely,are
R705 T1137 T1135 acomp related,are
R706 T1138 T1137 prep to,related
R707 T1139 T1140 amod other,differences
R708 T1140 T1138 pobj differences,to
R709 T1141 T1140 prep in,differences
R710 T1142 T1143 amod individual,makeup
R711 T1143 T1141 pobj makeup,in
R712 T1144 T1143 amod genetic,makeup
R713 T1145 T1123 punct .,are
R714 T1147 T1148 amod Previous,work
R715 T1148 T1149 nsubj work,identified
R716 T1150 T1148 acl using,work
R717 T1151 T1152 amod human,patients
R718 T1152 T1150 dobj patients,using
R719 T1153 T1152 cc and,patients
R720 T1154 T1155 advmod genetically,altered
R721 T1155 T1156 amod altered,mice
R722 T1156 T1152 conj mice,patients
R723 T1157 T1149 aux has,identified
R724 T1158 T1159 det some,genes
R725 T1159 T1149 dobj genes,identified
R726 T1160 T1159 compound modifier,genes
R727 T1161 T1149 cc and,identified
R728 T1162 T1163 aux have,advanced
R729 T1163 T1149 conj advanced,identified
R730 T1164 T1165 poss our,understanding
R731 T1165 T1163 dobj understanding,advanced
R732 T1166 T1165 prep of,understanding
R733 T1167 T1168 compound CF,pathophysiology
R734 T1168 T1166 pobj pathophysiology,of
R735 T1169 T1170 punct [,4
R736 T1170 T1163 parataxis 4,advanced
R737 T1171 T1170 punct ],4
R738 T1172 T1149 punct .,identified
R739 T1174 T1175 prep In,shown
R740 T1176 T1177 nummod one,study
R741 T1177 T1174 pobj study,In
R742 T1178 T1177 acl using,study
R743 T1179 T1180 compound CF,mice
R744 T1180 T1178 dobj mice,using
R745 T1181 T1180 prep on,mice
R746 T1182 T1183 amod different,backgrounds
R747 T1183 T1181 pobj backgrounds,on
R748 T1184 T1183 amod genetic,backgrounds
R749 T1185 T1175 punct ", ",shown
R750 T1186 T1187 det a,region
R751 T1187 T1175 nsubjpass region,shown
R752 T1188 T1187 prep on,region
R753 T1189 T1190 compound mouse,chromosome
R754 T1190 T1188 pobj chromosome,on
R755 T1191 T1190 nummod 7,chromosome
R756 T1192 T1175 auxpass was,shown
R757 T1193 T1194 aux to,ameliorate
R758 T1194 T1175 xcomp ameliorate,shown
R759 T1195 T1196 amod intestinal,blockage
R760 T1196 T1194 dobj blockage,ameliorate
R761 T1197 T1175 cc and,shown
R762 T1198 T1199 det the,effect
R763 T1199 T1200 nsubj effect,was
R764 T1200 T1175 conj was,shown
R765 T1201 T1200 prep in,was
R766 T1202 T1201 amod part,in
R767 T1203 T1200 prep due,was
R768 T1204 T1203 pcomp to,due
R769 T1205 T1206 det a,channel
R770 T1206 T1203 pobj channel,due
R771 T1207 T1208 npadvmod calcium,regulated
R772 T1208 T1206 amod regulated,channel
R773 T1209 T1208 punct -,regulated
R774 T1210 T1206 nmod Cl,channel
R775 T1211 T1206 punct -,channel
R776 T1212 T1213 dep which,compensated
R777 T1213 T1206 relcl compensated,channel
R778 T1214 T1213 prep for,compensated
R779 T1215 T1214 pobj loss,for
R780 T1216 T1215 prep of,loss
R781 T1217 T1218 compound CFTR,function
R782 T1218 T1216 pobj function,of
R783 T1219 T1220 punct [,17
R784 T1220 T1200 parataxis 17,was
R785 T1221 T1220 nummod 16,17
R786 T1222 T1220 punct ",",17
R787 T1223 T1220 punct ],17
R788 T1224 T1200 punct .,was
R789 T1226 T1227 compound Marker,haplotypes
R790 T1227 T1228 nsubjpass haplotypes,shown
R791 T1229 T1227 prep of,haplotypes
R792 T1230 T1231 det the,region
R793 T1231 T1229 pobj region,of
R794 T1232 T1231 amod syntenic,region
R795 T1233 T1231 prep of,region
R796 T1234 T1235 amod human,chromosome
R797 T1235 T1233 pobj chromosome,of
R798 T1236 T1235 nummod 19q13,chromosome
R799 T1237 T1228 auxpass were,shown
R800 T1238 T1228 advmod also,shown
R801 T1239 T1240 aux to,associated
R802 T1240 T1228 xcomp associated,shown
R803 T1241 T1240 auxpass be,associated
R804 T1242 T1240 prep with,associated
R805 T1243 T1244 det the,risk
R806 T1244 T1242 pobj risk,with
R807 T1245 T1244 prep of,risk
R808 T1246 T1245 pobj MI,of
R809 T1247 T1240 prep in,associated
R810 T1248 T1249 compound CF,patients
R811 T1249 T1247 pobj patients,in
R812 T1250 T1251 punct [,18
R813 T1251 T1228 parataxis 18,shown
R814 T1252 T1251 punct ],18
R815 T1253 T1228 punct .,shown
R816 T1255 T1256 prep In,associated
R817 T1257 T1258 amod other,work
R818 T1258 T1255 pobj work,In
R819 T1259 T1256 punct ", ",associated
R820 T1260 T1261 det a,region
R821 T1261 T1256 nsubjpass region,associated
R822 T1262 T1261 prep on,region
R823 T1263 T1264 compound mouse,chr.
R824 T1264 T1262 pobj chr.,on
R825 T1265 T1264 nummod 6,chr.
R826 T1266 T1256 auxpass was,associated
R827 T1267 T1256 advmod strongly,associated
R828 T1268 T1256 prep with,associated
R829 T1269 T1270 compound lung,inflammation
R830 T1270 T1268 pobj inflammation,with
R831 T1271 T1270 punct ", ",inflammation
R832 T1272 T1270 acl consisting,inflammation
R833 T1273 T1272 prep of,consisting
R834 T1274 T1275 amod mononuclear,cell
R835 T1275 T1276 nmod cell,infiltration
R836 T1276 T1273 pobj infiltration,of
R837 T1277 T1276 amod interstitial,infiltration
R838 T1278 T1276 cc and,infiltration
R839 T1279 T1276 conj fibrosis,infiltration
R840 T1280 T1272 prep in,consisting
R841 T1281 T1282 compound CF,airways
R842 T1282 T1280 pobj airways,in
R843 T1283 T1282 compound mouse,airways
R844 T1284 T1256 punct ;,associated
R845 T1285 T1256 cc and,associated
R846 T1286 T1287 amod other,loci
R847 T1287 T1288 nsubjpass loci,linked
R848 T1288 T1256 conj linked,associated
R849 T1289 T1287 prep on,loci
R850 T1290 T1291 nmod chr.,1
R851 T1291 T1289 pobj 1,on
R852 T1292 T1291 punct ", ",1
R853 T1293 T1291 conj 2,1
R854 T1294 T1293 punct ", ",2
R855 T1295 T1293 conj 10,2
R856 T1296 T1295 punct ", ",10
R857 T1297 T1295 cc and,10
R858 T1298 T1295 conj 17,10
R859 T1299 T1288 auxpass were,linked
R860 T1300 T1288 advmod also,linked
R861 T1301 T1288 prep to,linked
R862 T1302 T1303 det the,phenotype
R863 T1303 T1301 pobj phenotype,to
R864 T1304 T1303 compound airway,phenotype
R865 T1305 T1306 punct [,19
R866 T1306 T1288 parataxis 19,linked
R867 T1307 T1306 punct ],19
R868 T1308 T1256 punct .,associated
R869 T1310 T1311 prep In,found
R870 T1312 T1313 det this,work
R871 T1313 T1310 pobj work,In
R872 T1314 T1311 punct ", ",found
R873 T1315 T1316 compound CF,mice
R874 T1316 T1311 nsubjpass mice,found
R875 T1317 T1316 prep on,mice
R876 T1318 T1319 det a,background
R877 T1319 T1317 pobj background,on
R878 T1320 T1321 amod mixed,strain
R879 T1321 T1319 compound strain,background
R880 T1322 T1311 auxpass were,found
R881 T1323 T1324 aux to,have
R882 T1324 T1311 xcomp have,found
R883 T1325 T1326 det a,phenotype
R884 T1326 T1324 dobj phenotype,have
R885 T1327 T1328 advmod less,severe
R886 T1328 T1326 amod severe,phenotype
R887 T1329 T1326 compound CF,phenotype
R888 T1330 T1324 prep compared,have
R889 T1331 T1330 prep to,compared
R890 T1332 T1333 compound CF,mice
R891 T1333 T1331 pobj mice,to
R892 T1334 T1333 amod congenic,mice
R893 T1335 T1334 prep on,congenic
R894 T1336 T1337 det the,background
R895 T1337 T1335 pobj background,on
R896 T1338 T1337 nmod C57Bl,background
R897 T1339 T1338 punct /,C57Bl
R898 T1340 T1338 nummod 6,C57Bl
R899 T1341 T1311 punct .,found
R900 T1343 T1344 expl There,were
R901 T1345 T1346 det no,differences
R902 T1346 T1344 attr differences,were
R903 T1347 T1346 prep in,differences
R904 T1348 T1349 det the,phenotype
R905 T1349 T1347 pobj phenotype,in
R906 T1350 T1349 amod pancreatic,phenotype
R907 T1351 T1344 advcl comparing,were
R908 T1352 T1353 compound CF,mice
R909 T1353 T1351 dobj mice,comparing
R910 T1354 T1351 prep on,comparing
R911 T1355 T1356 det the,backgrounds
R912 T1356 T1354 pobj backgrounds,on
R913 T1357 T1356 amod different,backgrounds
R914 T1358 T1359 punct [,20
R915 T1359 T1344 parataxis 20,were
R916 T1360 T1359 punct ],20
R917 T1361 T1344 punct .,were
R918 T1363 T1364 advmod However,seemed
R919 T1365 T1364 punct ", ",seemed
R920 T1366 T1364 nsubj mice,seemed
R921 T1367 T1366 prep on,mice
R922 T1368 T1369 det the,background
R923 T1369 T1367 pobj background,on
R924 T1370 T1369 amod mixed,background
R925 T1371 T1372 advmod more,robust
R926 T1372 T1364 oprd robust,seemed
R927 T1373 T1372 prep than,robust
R928 T1374 T1375 compound CF,mice
R929 T1375 T1373 pobj mice,than
R930 T1376 T1375 prep on,mice
R931 T1377 T1378 det the,background
R932 T1378 T1376 pobj background,on
R933 T1379 T1378 compound B6,background
R934 T1380 T1381 dep which,prompted
R935 T1381 T1364 advcl prompted,seemed
R936 T1382 T1381 dobj us,prompted
R937 T1383 T1384 aux to,characterize
R938 T1384 T1381 xcomp characterize,prompted
R939 T1385 T1384 dobj them,characterize
R940 T1386 T1384 prep in,characterize
R941 T1387 T1388 amod greater,detail
R942 T1388 T1386 pobj detail,in
R943 T1389 T1364 punct .,seemed
R944 T1391 T1392 npadvmod Genome,wide
R945 T1392 T1393 amod wide,scanning
R946 T1393 T1395 nsubjpass scanning,used
R947 T1394 T1393 compound allele,scanning
R948 T1396 T1395 auxpass was,used
R949 T1397 T1398 aux to,begin
R950 T1398 T1395 xcomp begin,used
R951 T1399 T1398 dobj identification,begin
R952 T1400 T1399 prep of,identification
R953 T1401 T1400 pobj regions,of
R954 T1402 T1401 acl associated,regions
R955 T1403 T1402 prep with,associated
R956 T1404 T1405 det the,phenotype
R957 T1405 T1403 pobj phenotype,with
R958 T1406 T1407 advmod less,severe
R959 T1407 T1405 amod severe,phenotype
R960 T1408 T1405 amod intestinal,phenotype
R961 T1409 T1395 punct .,used
R962 T1411 T1412 amod Future,identification
R963 T1412 T1413 nsubj identification,further
R964 T1414 T1412 prep of,identification
R965 T1415 T1416 amod specific,genes
R966 T1416 T1414 pobj genes,of
R967 T1417 T1413 aux should,further
R968 T1418 T1419 poss our,understanding
R969 T1419 T1413 dobj understanding,further
R970 T1420 T1419 prep of,understanding
R971 T1421 T1422 det the,phenotype
R972 T1422 T1420 pobj phenotype,of
R973 T1423 T1422 amod complex,phenotype
R974 T1424 T1422 amod intestinal,phenotype
R975 T1425 T1422 compound CF,phenotype
R976 T1426 T1413 punct .,further