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PMC:1064854 / 5463-6226 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T4189 0-3 DT denotes The
T4191 4-8 NN denotes gain
T4192 8-9 HYPH denotes -
T4193 9-11 IN denotes of
T4194 11-12 HYPH denotes -
T4195 12-20 NN denotes function
T4190 21-28 NNS denotes studies
T4197 29-38 VBN denotes described
T4198 39-41 IN denotes to
T4199 42-46 NN denotes date
T4196 47-54 VBP denotes provide
T4200 55-65 JJ denotes compelling
T4201 66-74 NN denotes evidence
T4202 75-79 IN denotes that
T4204 80-83 NN denotes PGC
T4206 83-84 HYPH denotes -
T4205 84-86 NN denotes 1α
T4203 87-89 VBZ denotes is
T4207 90-97 JJ denotes capable
T4208 98-100 IN denotes of
T4209 101-111 VBG denotes regulating
T4210 112-121 JJ denotes postnatal
T4212 122-128 NN denotes energy
T4211 129-139 NN denotes metabolism
T4213 139-140 . denotes .
T4214 140-314 sentence denotes However, the necessity of PGC-1α for energy metabolic homeostasis, mitochondrial biogenesis, development, and growth can only be addressed using loss-of-function strategies.
T4215 141-148 RB denotes However
T4217 148-150 , denotes ,
T4218 150-153 DT denotes the
T4219 154-163 NN denotes necessity
T4220 164-166 IN denotes of
T4221 167-170 NN denotes PGC
T4223 170-171 HYPH denotes -
T4222 171-173 NN denotes 1α
T4224 174-177 IN denotes for
T4225 178-184 NN denotes energy
T4227 185-194 JJ denotes metabolic
T4226 195-206 NN denotes homeostasis
T4228 206-208 , denotes ,
T4229 208-221 JJ denotes mitochondrial
T4230 222-232 NN denotes biogenesis
T4231 232-234 , denotes ,
T4232 234-245 NN denotes development
T4233 245-247 , denotes ,
T4234 247-250 CC denotes and
T4235 251-257 NN denotes growth
T4236 258-261 MD denotes can
T4237 262-266 RB denotes only
T4238 267-269 VB denotes be
T4216 270-279 VBN denotes addressed
T4239 280-285 VBG denotes using
T4240 286-290 NN denotes loss
T4242 290-291 HYPH denotes -
T4243 291-293 IN denotes of
T4244 293-294 HYPH denotes -
T4245 294-302 NN denotes function
T4241 303-313 NNS denotes strategies
T4246 313-314 . denotes .
T4247 314-413 sentence denotes To this end, we have established and characterized mice with targeted deletion of the PGC-1α gene.
T4248 315-317 IN denotes To
T4250 318-322 DT denotes this
T4251 323-326 NN denotes end
T4252 326-328 , denotes ,
T4253 328-330 PRP denotes we
T4254 331-335 VBP denotes have
T4249 336-347 VBN denotes established
T4255 348-351 CC denotes and
T4256 352-365 VBN denotes characterized
T4257 366-370 NNS denotes mice
T4258 371-375 IN denotes with
T4259 376-384 VBN denotes targeted
T4260 385-393 NN denotes deletion
T4261 394-396 IN denotes of
T4262 397-400 DT denotes the
T4264 401-404 NN denotes PGC
T4266 404-405 HYPH denotes -
T4265 405-407 NN denotes 1α
T4263 408-412 NN denotes gene
T4267 412-413 . denotes .
T4268 413-553 sentence denotes Our studies of PGC-1α−/− mice demonstrate that PGC-1α is not absolutely required for prenatal viability including mitochondrial biogenesis.
T4269 414-417 PRP$ denotes Our
T4270 418-425 NNS denotes studies
T4272 426-428 IN denotes of
T4273 429-432 NN denotes PGC
T4275 432-433 HYPH denotes -
T4274 433-435 NN denotes 1α
T4277 435-436 SYM denotes −
T4278 436-437 HYPH denotes /
T4279 437-438 SYM denotes −
T4276 439-443 NNS denotes mice
T4271 444-455 VBP denotes demonstrate
T4280 456-460 IN denotes that
T4282 461-464 NN denotes PGC
T4284 464-465 HYPH denotes -
T4283 465-467 NN denotes 1α
T4285 468-470 VBZ denotes is
T4286 471-474 RB denotes not
T4287 475-485 RB denotes absolutely
T4281 486-494 VBN denotes required
T4288 495-498 IN denotes for
T4289 499-507 JJ denotes prenatal
T4290 508-517 NN denotes viability
T4291 518-527 VBG denotes including
T4292 528-541 JJ denotes mitochondrial
T4293 542-552 NN denotes biogenesis
T4294 552-553 . denotes .
T4295 553-763 sentence denotes However, our findings indicate that the coactivator PGC-1α serves a critical role in the normal metabolic function of multiple organs and for appropriate adaptation to physiologic stress during postnatal life.
T4296 554-561 RB denotes However
T4298 561-563 , denotes ,
T4299 563-566 PRP$ denotes our
T4300 567-575 NNS denotes findings
T4297 576-584 VBP denotes indicate
T4301 585-589 IN denotes that
T4303 590-593 DT denotes the
T4304 594-605 NN denotes coactivator
T4305 606-609 NN denotes PGC
T4307 609-610 HYPH denotes -
T4306 610-612 NN denotes 1α
T4302 613-619 VBZ denotes serves
T4308 620-621 DT denotes a
T4310 622-630 JJ denotes critical
T4309 631-635 NN denotes role
T4311 636-638 IN denotes in
T4312 639-642 DT denotes the
T4314 643-649 JJ denotes normal
T4315 650-659 JJ denotes metabolic
T4313 660-668 NN denotes function
T4316 669-671 IN denotes of
T4317 672-680 JJ denotes multiple
T4318 681-687 NNS denotes organs
T4319 688-691 CC denotes and
T4320 692-695 IN denotes for
T4321 696-707 JJ denotes appropriate
T4322 708-718 NN denotes adaptation
T4323 719-721 IN denotes to
T4324 722-733 JJ denotes physiologic
T4325 734-740 NN denotes stress
T4326 741-747 IN denotes during
T4327 748-757 JJ denotes postnatal
T4328 758-762 NN denotes life
T4329 762-763 . denotes .
R1000 T4246 T4216 punct .,addressed
R1001 T4248 T4249 prep To,established
R1003 T4250 T4251 det this,end
R1004 T4251 T4248 pobj end,To
R1006 T4252 T4249 punct ", ",established
R1007 T4253 T4249 nsubj we,established
R1008 T4254 T4249 aux have,established
R1010 T4255 T4249 cc and,established
R1011 T4256 T4249 conj characterized,established
R1012 T4257 T4256 dobj mice,characterized
R1013 T4258 T4257 prep with,mice
R1015 T4259 T4260 amod targeted,deletion
R1016 T4260 T4258 pobj deletion,with
R1018 T4261 T4260 prep of,deletion
R1019 T4262 T4263 det the,gene
R1020 T4263 T4261 pobj gene,of
R1022 T4264 T4265 compound PGC,1α
R1023 T4265 T4263 compound 1α,gene
R1024 T4266 T4265 punct -,1α
R1026 T4267 T4249 punct .,established
R1030 T4269 T4270 poss Our,studies
R1031 T4270 T4271 nsubj studies,demonstrate
R1032 T4272 T4270 prep of,studies
R1033 T4273 T4274 nmod PGC,1α
R1035 T4274 T4276 nmod 1α,mice
R1038 T4275 T4274 punct -,1α
R1040 T4276 T4272 pobj mice,of
R1041 T4277 T4274 punct −,1α
R1042 T4278 T4274 punct /,1α
R1044 T4279 T4274 punct −,1α
R1045 T4280 T4281 mark that,required
R1047 T4281 T4271 ccomp required,demonstrate
R1048 T4282 T4283 compound PGC,1α
R1049 T4283 T4281 nsubjpass 1α,required
R1051 T4284 T4283 punct -,1α
R1052 T4285 T4281 auxpass is,required
R1053 T4286 T4281 neg not,required
R1055 T4287 T4281 advmod absolutely,required
R1056 T4288 T4281 prep for,required
R1057 T4289 T4290 amod prenatal,viability
R1059 T4290 T4288 pobj viability,for
R1060 T4291 T4290 prep including,viability
R1061 T4292 T4293 amod mitochondrial,biogenesis
R1063 T4293 T4291 pobj biogenesis,including
R1064 T4294 T4271 punct .,demonstrate
R1066 T4296 T4297 advmod However,indicate
R1067 T4298 T4297 punct ", ",indicate
R1069 T4299 T4300 poss our,findings
R1070 T4300 T4297 nsubj findings,indicate
R1071 T4301 T4302 mark that,serves
R1075 T4302 T4297 ccomp serves,indicate
R1076 T4303 T4304 det the,coactivator
R1078 T4304 T4302 nsubj coactivator,serves
R1079 T4305 T4306 compound PGC,1α
R1080 T4306 T4304 appos 1α,coactivator
R1082 T4307 T4306 punct -,1α
R1083 T4308 T4309 det a,role
R1084 T4309 T4302 dobj role,serves
R1085 T4310 T4309 amod critical,role
R1086 T4311 T4309 prep in,role
R1088 T4312 T4313 det the,function
R1089 T4313 T4311 pobj function,in
R1090 T4314 T4313 amod normal,function
R1092 T4315 T4313 amod metabolic,function
R1093 T4316 T4313 prep of,function
R1094 T4317 T4318 amod multiple,organs
R1096 T4318 T4316 pobj organs,of
R1097 T4319 T4311 cc and,in
R1098 T4320 T4311 conj for,in
R1100 T4321 T4322 amod appropriate,adaptation
R1101 T4322 T4320 pobj adaptation,for
R1102 T4323 T4322 prep to,adaptation
R1103 T4324 T4325 amod physiologic,stress
R1104 T4325 T4323 pobj stress,to
R1105 T4326 T4309 prep during,role
R1106 T4327 T4328 amod postnatal,life
R1107 T4328 T4326 pobj life,during
R1108 T4329 T4297 punct .,indicate
R927 T4189 T4190 det The,studies
R928 T4190 T4196 nsubj studies,provide
R929 T4191 T4190 nmod gain,studies
R931 T4192 T4191 punct -,gain
R932 T4193 T4191 prep of,gain
R933 T4194 T4193 punct -,of
R935 T4195 T4193 pobj function,of
R936 T4197 T4190 acl described,studies
R937 T4198 T4197 prep to,described
R939 T4199 T4198 pobj date,to
R940 T4200 T4201 amod compelling,evidence
R941 T4201 T4196 dobj evidence,provide
R943 T4202 T4203 mark that,is
R944 T4203 T4201 acl is,evidence
R945 T4204 T4205 compound PGC,1α
R947 T4205 T4203 nsubj 1α,is
R948 T4206 T4205 punct -,1α
R949 T4207 T4203 acomp capable,is
R951 T4208 T4207 prep of,capable
R952 T4209 T4208 pcomp regulating,of
R953 T4210 T4211 amod postnatal,metabolism
R955 T4211 T4209 dobj metabolism,regulating
R956 T4212 T4211 compound energy,metabolism
R957 T4213 T4196 punct .,provide
R959 T4215 T4216 advmod However,addressed
R962 T4217 T4216 punct ", ",addressed
R963 T4218 T4219 det the,necessity
R965 T4219 T4216 nsubjpass necessity,addressed
R966 T4220 T4219 prep of,necessity
R967 T4221 T4222 compound PGC,1α
R969 T4222 T4220 pobj 1α,of
R970 T4223 T4222 punct -,1α
R971 T4224 T4219 prep for,necessity
R973 T4225 T4226 nmod energy,homeostasis
R974 T4226 T4224 pobj homeostasis,for
R976 T4227 T4226 amod metabolic,homeostasis
R977 T4228 T4226 punct ", ",homeostasis
R978 T4229 T4230 amod mitochondrial,biogenesis
R979 T4230 T4226 conj biogenesis,homeostasis
R980 T4231 T4230 punct ", ",biogenesis
R981 T4232 T4230 conj development,biogenesis
R983 T4233 T4232 punct ", ",development
R984 T4234 T4232 cc and,development
R985 T4235 T4232 conj growth,development
R987 T4236 T4216 aux can,addressed
R988 T4237 T4216 advmod only,addressed
R989 T4238 T4216 auxpass be,addressed
R991 T4239 T4216 advcl using,addressed
R992 T4240 T4241 nmod loss,strategies
R993 T4241 T4239 dobj strategies,using
R995 T4242 T4240 punct -,loss
R996 T4243 T4240 prep of,loss
R997 T4244 T4243 punct -,of
R998 T4245 T4243 pobj function,of