PMC:1914394 / 45977-49201 4 Projects
Annnotations
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T24500 | 0-2 | PR_EXT:000013773 | denotes | Rb |
| T24501 | 3-11 | GO:0065007 | denotes | Controls |
| T24502 | 16-31 | GO_RO_EXT:developmental_differentiation_process | denotes | Differentiation |
| T24503 | 40-45 | PR_EXT:000028775 | denotes | E2f3a |
| T24504 | 60-66 | CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag | denotes | marker |
| T24505 | 121-128 | UBERON:0000966 | denotes | retinal |
| T24506 | 129-136 | CL:0000540 | denotes | neurons |
| T24507 | 138-142 | PR_EXT:000006852 | denotes | E2f1 |
| T24508 | 143-151 | SO_EXT:sequence_deletion_entity_or_process | denotes | deletion |
| T24509 | 180-182 | PR_EXT:000013773 | denotes | Rb |
| T24510 | 186-197 | CHEBI:15355 | denotes | cholinergic |
| T24511 | 225-229 | PR_EXT:000006852 | denotes | E2f1 |
| T24512 | 306-314 | CHEBI_PR_EXT:protein | denotes | proteins |
| T24513 | 382-394 | CL:0000099 | denotes | interneurons |
| T24514 | 478-480 | PR_EXT:000013773 | denotes | Rb |
| T24515 | 481-490 | GO:0065007 | denotes | regulates |
| T24516 | 491-503 | GO:0022008 | denotes | neurogenesis |
| T24517 | 520-527 | GO:0007067 | denotes | mitosis |
| T24518 | 529-531 | PR_EXT:000013773 | denotes | Rb |
| T24519 | 532-537 | CHEMINF_GO_EXT:chemical_binding_or_bond_formation | denotes | binds |
| T24520 | 585-593 | CL:0000540 | denotes | neuronal |
| T24521 | 594-599 | CL_GO_EXT:cell | denotes | cells |
| T24522 | 609-624 | UBERON_EXT:skeletal_muscle_organ_or_tissue | denotes | skeletal muscle |
| T24523 | 626-636 | CL:0000136 | denotes | adipocytes |
| T24524 | 642-646 | UBERON_EXT:bone_element_or_tissue | denotes | bone |
| T24525 | 651-656 | CHEMINF_GO_EXT:chemical_binding_or_bond_formation | denotes | binds |
| T24526 | 673-679 | UBERON:0000479 | denotes | tissue |
| T24527 | 689-702 | GO_EXT:transcription | denotes | transcription |
| T24528 | 689-710 | GO_EXT:transcription_factor | denotes | transcription factors |
| T24529 | 724-739 | GO_RO_EXT:developmental_differentiation_process | denotes | differentiation |
| T24530 | 763-765 | PR_EXT:000013773 | denotes | Rb |
| T24531 | 775-781 | UBERON_EXT:muscle_structure_or_tissue | denotes | muscle |
| T24532 | 782-797 | GO_RO_EXT:developmental_differentiation_process | denotes | differentiation |
| T24533 | 814-819 | PR_EXT:000010875 | denotes | Myod1 |
| T24534 | 906-909 | PR_EXT:E2F | denotes | E2f |
| T24535 | 962-964 | PR_EXT:000013773 | denotes | Rb |
| T24536 | 978-993 | GO_RO_EXT:developmental_differentiation_process | denotes | differentiation |
| T24537 | 1002-1006 | PR_EXT:000006854 | denotes | E2f3 |
| T24538 | 1029-1031 | PR_EXT:000013773 | denotes | Rb |
| T38522 | 1029-1031 | PR_EXT:000013773 | denotes | Rb |
| T38523 | 1032-1041 | GO:0065007 | denotes | Regulates |
| T24539 | 1038-1713 | GO:0007067 | denotes | tes Distinct Processes through E2f1 and E2f3a Red text and arrows indicate Rb-dependent events. Black text and arrows indicate events for which there is no direct evidence of Rb involvement. Rb does not appear to temper RPC expansion and is not required for differentiation of RPCs into RTCs, but is essential to couple RTC birth to terminal mitosis, thus locking them out of cycle. Rb performs this function by inhibiting E2f1. Rb is also required for SAC differentiation, and in this case, acts by inhibiting E2f3a. There is no direct evidence that Rb is required for terminal differentiation of other cell types. Colour codes and abbreviations as in Figure 1A. Rb regulati |
| T38524 | 1069-1073 | PR_EXT:000006852 | denotes | E2f1 |
| T38525 | 1078-1083 | PR_EXT:000028775 | denotes | E2f3a |
| T38526 | 1113-1115 | PR_EXT:000013773 | denotes | Rb |
| T38527 | 1213-1215 | PR_EXT:000013773 | denotes | Rb |
| T38528 | 1229-1231 | PR_EXT:000013773 | denotes | Rb |
| T38529 | 1258-1261 | CL:0002672 | denotes | RPC |
| T38530 | 1296-1311 | GO_RO_EXT:developmental_differentiation_process | denotes | differentiation |
| T38531 | 1315-1319 | CL:0002672 | denotes | RPCs |
| T38532 | 1380-1387 | GO:0007067 | denotes | mitosis |
| T38533 | 1421-1423 | PR_EXT:000013773 | denotes | Rb |
| T38534 | 1461-1465 | PR_EXT:000006852 | denotes | E2f1 |
| T38535 | 1467-1469 | PR_EXT:000013773 | denotes | Rb |
| T38536 | 1495-1510 | GO_RO_EXT:developmental_differentiation_process | denotes | differentiation |
| T38537 | 1549-1554 | PR_EXT:000028775 | denotes | E2f3a |
| T38538 | 1589-1591 | PR_EXT:000013773 | denotes | Rb |
| T38539 | 1617-1632 | GO_RO_EXT:developmental_differentiation_process | denotes | differentiation |
| T38540 | 1642-1646 | CL_GO_EXT:cell | denotes | cell |
| T24540 | 1723-1738 | GO_RO_EXT:developmental_differentiation_process | denotes | differentiation |
| T24541 | 1747-1751 | PR_EXT:000006854 | denotes | E2f3 |
| T24542 | 1783-1794 | GO:0065007 | denotes | controlling |
| T24543 | 1807-1812 | GO:0016265 | denotes | death |
| T24544 | 1814-1818 | PR_EXT:000006854 | denotes | E2f3 |
| T24545 | 1819-1827 | SO_EXT:sequence_deletion_entity_or_process | denotes | deletion |
| T24546 | 1828-1835 | SO_EXT:sequence_rescue_process | denotes | rescued |
| T24547 | 1836-1838 | PR_EXT:000013773 | denotes | Rb |
| T24548 | 1884-1897 | GO:0008283 | denotes | proliferation |
| T24549 | 1901-1906 | GO:0016265 | denotes | death |
| T24550 | 1916-1920 | PR_EXT:000006852 | denotes | E2f1 |
| T24551 | 1921-1929 | SO_EXT:sequence_deletion_entity_or_process | denotes | deletion |
| T24552 | 1948-1961 | GO:0008283 | denotes | proliferation |
| T24553 | 1966-1971 | GO:0016265 | denotes | death |
| T24554 | 1984-1990 | SO_EXT:sequence_rescue_process | denotes | rescue |
| T24555 | 1995-2010 | GO_RO_EXT:developmental_differentiation_process | denotes | differentiation |
| T24556 | 2019-2028 | CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process | denotes | labelling |
| T24557 | 2044-2048 | PR_EXT:000006852 | denotes | E2f1 |
| T24558 | 2057-2061 | PR_EXT:000006854 | denotes | E2f3 |
| T24559 | 2062-2070 | SO_EXT:sequence_deletion_entity_or_process | denotes | deletion |
| T24560 | 2080-2082 | PR_EXT:000013773 | denotes | Rb |
| T24561 | 2110-2118 | SO_EXT:sequence_deletion_process | denotes | deleting |
| T24562 | 2119-2123 | PR_EXT:000006852 | denotes | E2f1 |
| T24563 | 2133-2137 | PR_EXT:000006854 | denotes | E2f3 |
| T24564 | 2150-2159 | GO:0065007 | denotes | regulated |
| T24565 | 2160-2170 | GO:0010467 | denotes | expression |
| T24566 | 2174-2178 | CL_GO_EXT:cell | denotes | cell |
| T24567 | 2174-2184 | GO:0007049 | denotes | cell cycle |
| T24568 | 2189-2198 | GO_PATO_EXT:apoptotic_process_or_quality | denotes | apoptotic |
| T24569 | 2199-2204 | SO_EXT:0000704 | denotes | genes |
| T24570 | 2212-2214 | PR_EXT:000013773 | denotes | Rb |
| T24571 | 2218-2224 | UBERON:0000966 | denotes | retina |
| T24572 | 2226-2230 | PR_EXT:000006854 | denotes | E2f3 |
| T24573 | 2234-2243 | GO:0010467 | denotes | expressed |
| T24574 | 2259-2262 | UBERON:0001017 | denotes | CNS |
| T24575 | 2259-2270 | CL:0000117 | denotes | CNS neurons |
| T24576 | 2303-2307 | CL_GO_EXT:cell | denotes | cell |
| T24577 | 2303-2313 | GO:0007049 | denotes | cell-cycle |
| T24578 | 2337-2339 | PR_EXT:000013773 | denotes | Rb |
| T24579 | 2343-2352 | UBERON:0001890 | denotes | forebrain |
| T24580 | 2343-2360 | CL:0012001 | denotes | forebrain neurons |
| T24581 | 2373-2377 | PR_EXT:000006854 | denotes | E2f3 |
| T24582 | 2443-2445 | PR_EXT:000013773 | denotes | Rb |
| T24583 | 2471-2479 | CL:0000540 | denotes | neuronal |
| T24584 | 2480-2495 | GO_RO_EXT:developmental_differentiation_process | denotes | differentiation |
| T24585 | 2543-2545 | PR_EXT:000013773 | denotes | Rb |
| T24586 | 2572-2576 | PR_EXT:000006854 | denotes | E2f3 |
| T24587 | 2577-2584 | SO_EXT:0001060 | denotes | isoform |
| T24588 | 2607-2622 | GO_RO_EXT:developmental_differentiation_process | denotes | differentiation |
| T24589 | 2663-2665 | PR_EXT:000013773 | denotes | Rb |
| T24590 | 2710-2719 | GO:0044838 | denotes | quiescent |
| T24591 | 2720-2725 | CL_GO_EXT:cell | denotes | cells |
| T24592 | 2816-2819 | PR_EXT:E2F | denotes | E2f |
| T24593 | 2820-2827 | CHEBI_PR_EXT:protein | denotes | protein |
| T24594 | 2828-2835 | SO_EXT:0001060 | denotes | isoform |
| T24595 | 2885-2887 | PR_EXT:000013773 | denotes | Rb |
| T24596 | 2888-2897 | GO:0065007 | denotes | regulates |
| T24597 | 2902-2917 | GO_RO_EXT:developmental_differentiation_process | denotes | differentiation |
| T24598 | 2926-2931 | PR_EXT:000028775 | denotes | E2f3a |
| T24599 | 2993-3001 | SO_EXT:sequence_deletion_process | denotes | deleting |
| T24600 | 3019-3025 | SO_EXT:sequence_rescue_process | denotes | rescue |
| T24601 | 3030-3045 | GO_RO_EXT:developmental_differentiation_process | denotes | differentiation |
| T24602 | 3099-3103 | SO_EXT:sequence_nullness | denotes | null |
| T24603 | 3104-3108 | NCBITaxon:10088 | denotes | mice |
| T24604 | 3144-3146 | PR_EXT:000013773 | denotes | Rb |
| T24605 | 3158-3167 | GO:0065007 | denotes | regulates |
| T24606 | 3172-3187 | GO_RO_EXT:developmental_differentiation_process | denotes | differentiation |
| T24607 | 3211-3215 | PR_EXT:000006854 | denotes | E2f3 |
| T24608 | 3216-3223 | SO_EXT:0001060 | denotes | isoform |