bionlp-st-ge-2016-test-ihmc  

PMC:3342329 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T774 11-38 Protein denotes of C-C Chemokine Receptor 5
T818 98-138 Positive_regulation denotes Upregulation of IL-1Ra in Melanoma Model
T779 111-120 Protein denotes of IL-1Ra
T773 224-271 Protein denotes C-C chemokine receptor type 5 (CCR5) expression
T790 228-237 Protein denotes chemokine
T787 247-260 Protein denotes type 5 (CCR5)
T809 255-259 Protein denotes CCR5
T786 326-330 Protein denotes CCR5
T800 350-354 Protein denotes mice
T796 350-383 Protein denotes mice and wild type (CCR5+/+) mice
T794 393-397 Protein denotes mice
T802 483-498 Protein denotes to CCR5+/+ mice
T814 500-579 Positive_regulation denotes We investigated the activation of NF-κB since it is an implicated transcription
T797 531-539 Protein denotes of NF-κB
T817 590-664 Regulation denotes the regulation of genes involving cell growth, apoptosis, and tumor growth
T778 605-664 Protein denotes of genes involving cell growth, apoptosis, and tumor growth
T777 713-721 Protein denotes of NF-κB
T775 744-747 Protein denotes p50
T791 752-755 Protein denotes p65
T780 761-772 Entity denotes the nucleus
T801 867-871 Protein denotes mice
T808 912-916 Protein denotes mice
T810 918-923 Protein denotes NF-κB
T782 941-948 Protein denotes protein
T819 969-1001 Protein_catabolism denotes cleaved caspase-3, cleaved PARP,
T795 969-1001 Protein denotes cleaved caspase-3, cleaved PARP,
T805 996-1000 Protein denotes PARP
T799 1006-1009 Protein denotes Bax
T813 1046-1053 Protein denotes protein
T816 1046-1064 Gene_expression denotes protein expression
T811 1081-1086 Protein denotes Bcl-2
T806 1088-1095 Protein denotes C-IAP1,
T812 1145-1149 Protein denotes mice
T798 1193-1200 Protein denotes IL-1Ra,
T804 1228-1237 Protein denotes cytokine,
T793 1303-1307 Protein denotes mice
T784 1333-1337 Protein denotes CCR5
T792 1341-1345 Protein denotes mice
T776 1373-1394 Entity denotes CD8+ cytotoxic T cell
T783 1399-1425 Entity denotes CD57+ natural killer cells
T785 1501-1505 Protein denotes mice
T789 1526-1530 Protein denotes CCR5
T803 1534-1538 Protein denotes mice
T781 1577-1592 Protein denotes CCR5 deficiency
T788 1655-1660 Protein denotes NF-κB
T815 1665-1687 Positive_regulation denotes upregulation of IL-1Ra
T807 1678-1687 Protein denotes of IL-1Ra
T4332 1703-1713 Protein denotes Chemokines
T4302 1718-1831 Entity denotes small soluble molecules that are best known for their potent ability to induce cancer cell growth by inflammation
T4311 1844-1859 Entity denotes of cancer cells
T4264 1868-1878 Protein denotes chemokines
T4318 1883-1892 Protein denotes chemokine
T4294 1883-1902 Protein denotes chemokine receptors
T4299 1948-1989 Protein denotes the chemokine (C-C motif) ligand 5 (CCL5)
T4228 1984-1988 Protein denotes CCL5
T4263 1994-2024 Protein denotes C-C chemokine receptor (CCR5),
T4252 2018-2022 Protein denotes CCR5
T4238 2066-2084 Entity denotes inflammatory cells
T4353 2172-2211 Gene_expression denotes Intermediate and strong CCR5 expression
T4281 2196-2200 Protein denotes CCR5
T4265 2381-2406 Entity denotes prostate cancer cells [6]
T4340 2408-2436 Gene_expression denotes Local production of the CCL5
T4248 2425-2436 Protein denotes of the CCL5
T4333 2552-2556 Protein denotes CCR5
T4362 2552-2567 Negative_regulation denotes CCR5 disruption
T4285 2694-2701 Protein denotes of CCR5
T4260 2750-2754 Protein denotes CCR5
T4322 2750-2765 Entity denotes CCR5 inhibitors
T4338 2841-2859 Entity denotes hepatoma cells [4]
T4256 2907-2961 Protein denotes the deficiency of inflammatory chemokine receptor CCR5
T4324 2922-2947 Protein denotes of inflammatory chemokine
T4230 2948-2956 Protein denotes receptor
T4282 2978-3000 Protein denotes a suppressive receptor
T4292 3075-3090 Protein denotes CCR5 deficiency
T4259 3136-3208 Protein denotes Interleukin-1 receptor antagonist (IL-1Ra), a member of the IL-1 family,
T4253 3159-3178 Entity denotes antagonist (IL-1Ra)
T4309 3171-3177 Protein denotes IL-1Ra
T4306 3189-3207 Protein denotes of the IL-1 family
T4354 3212-3291 Negative_regulation denotes a naturally occurring cytokine that competitively blocks the IL-1 receptor [13]
T4298 3212-3291 Protein denotes a naturally occurring cytokine that competitively blocks the IL-1 receptor [13]
T4328 3269-3291 Protein denotes the IL-1 receptor [13]
T4312 3273-3277 Protein denotes IL-1
T4327 3301-3307 Protein denotes IL-1Ra
T4255 3482-3491 Protein denotes of IL-1Ra
T4235 3520-3526 Protein denotes IL-1Ra
T4351 3520-3537 Gene_expression denotes IL-1Ra expression
T4345 3520-3601 Negative_regulation denotes IL-1Ra expression was reduced in prostate [14], breast [15], and skin cancer [16]
T4278 3624-3661 Protein denotes that endogenous IL-1Ra deficient mice
T4293 3640-3646 Protein denotes IL-1Ra
T4274 3712-3728 Entity denotes carcinogens [17]
T4232 3755-3814 Entity denotes of the melanoma cells that were transduced with IL-1Ra gene
T4242 3803-3809 Protein denotes IL-1Ra
T4254 3803-3814 Protein denotes IL-1Ra gene
T4319 3868-3882 Protein denotes IL-1R blockade
T4280 3959-3970 Protein denotes that IL-1Ra
T4316 4010-4029 Entity denotes B16 melanoma growth
T4301 4119-4123 Protein denotes IL-1
T4245 4119-4160 Protein denotes IL-1 knockout mice injected with melanoma
T4290 4221-4228 Protein denotes IL-1Ra,
T4244 4243-4255 Entity denotes temozolomide
T4261 4260-4269 Entity denotes docetaxel
T4291 4341-4372 Entity denotes B16 melanoma cells in vivo [25]
T4307 4399-4405 Protein denotes IL-1Ra
T4234 4449-4457 Protein denotes cytokine
T4337 4459-4464 Protein denotes NF-κB
T4284 4640-4672 Protein denotes Constitutive activation of NF-κB
T4295 4811-4831 Protein denotes anti-apoptotic genes
T4287 4894-4899 Protein denotes NF-κB
T4251 4995-5003 Protein denotes on c-Rel
T4275 5037-5042 Protein denotes c-Rel
T4270 5060-5064 Protein denotes IL-2
T4233 5066-5070 Protein denotes IL-3
T4272 5072-5078 Protein denotes GM-CSF
T4279 5084-5088 Protein denotes IFNγ
T4342 5084-5099 Gene_expression denotes IFNγ expression
T4250 5103-5121 Entity denotes T lymphocytes [30]
T4283 5123-5143 Protein denotes C-Rel-deficient mice
T4335 5186-5203 Protein denotes various cytokines
T4268 5226-5233 Entity denotes T cells
T4323 5238-5249 Entity denotes macrophages
T4297 5330-5335 Protein denotes NF-κB
T4331 5418-5488 Entity denotes apoptotic cancer cell death, (2) stimulating tumor killing lymphocytes
T4350 5505-5563 Positive_regulation denotes (3) increasing the production of tumor killing lymphokines
T4239 5505-5563 Entity denotes (3) increasing the production of tumor killing lymphokines
T4360 5520-5563 Gene_expression denotes the production of tumor killing lymphokines
T4243 5535-5563 Protein denotes of tumor killing lymphokines
T4344 5565-5584 Positive_regulation denotes Activation of NF-κB
T4336 5576-5584 Protein denotes of NF-κB
T4339 5677-5744 Negative_regulation denotes that inhibition of NF-κB by dehydroxymethyl-epoxyquinomicin (DHMEQ)
T4320 5693-5701 Protein denotes of NF-κB
T4334 5702-5744 Entity denotes by dehydroxymethyl-epoxyquinomicin (DHMEQ)
T4347 5796-5830 Negative_regulation denotes inhibition of CCR5 expression [32]
T4343 5807-5825 Gene_expression denotes of CCR5 expression
T4288 5810-5814 Protein denotes CCR5
T4357 5832-5851 Positive_regulation denotes Activation of NF-κB
T4313 5843-5851 Protein denotes of NF-κB
T4303 5867-5880 Protein denotes CCL5-mediated
T4361 5958-5977 Negative_regulation denotes inhibition of NF-κB
T4300 5969-5977 Protein denotes of NF-κB
T4346 5996-6030 Regulation denotes in CCR5 mediated tumor development
T4330 5996-6030 Protein denotes in CCR5 mediated tumor development
T4247 6032-6037 Protein denotes NF-κB
T4267 6032-6072 Entity denotes NF-κB transcription factor binding sites
T4314 6088-6142 Entity denotes the promoter region of proinflammatory cytokine genes,
T4304 6108-6142 Protein denotes of proinflammatory cytokine genes,
T4241 6127-6135 Protein denotes cytokine
T4317 6151-6160 Protein denotes IL-1alpha
T4246 6162-6166 Protein denotes IL-6
T4271 6168-6174 Protein denotes GM-CSF
T4273 6180-6182 Protein denotes KC
T4276 6208-6218 Protein denotes the IL-1Ra
T4326 6319-6328 Protein denotes of IL-1Ra
T4258 6372-6376 Protein denotes IL-1
T4352 6406-6446 Regulation denotes the regulation of IL-1Ra gene expression
T4355 6421-6446 Gene_expression denotes of IL-1Ra gene expression
T4289 6424-6430 Protein denotes IL-1Ra
T4321 6493-6533 Protein denotes of three different transcription factors
T4325 6535-6582 Entity denotes NF-κB/PU.1/GA-binding protein binding site [35]
T4356 6584-6671 Positive_regulation denotes Nuclear translocation of NF-κB (p65) was significantly enhanced and prolonged in IL-1Ra
T4349 6584-6671 Regulation denotes Nuclear translocation of NF-κB (p65) was significantly enhanced and prolonged in IL-1Ra
T4315 6606-6620 Protein denotes of NF-κB (p65)
T4305 6616-6619 Protein denotes p65
T4308 6665-6671 Protein denotes IL-1Ra
T4266 6682-6686 Protein denotes mice
T4229 6708-6727 Protein denotes wild type mice [36]
T4237 6729-6760 Protein denotes Intracellular IL-1Ra (icIL-1Ra)
T4329 6751-6759 Protein denotes icIL-1Ra
T4341 6774-6786 Negative_regulation denotes inhibit IL-1
T4231 6782-6786 Protein denotes IL-1
T4358 6790-6804 Negative_regulation denotes blocking NF-κB
T4269 6799-6804 Protein denotes NF-κB
T4286 6874-6878 Protein denotes IL-1
T4359 6911-6935 Positive_regulation denotes of NF-κB activation [38]
T4296 6914-6919 Protein denotes NF-κB
T4348 6958-6982 Gene_expression denotes the expression of IL-1Ra
T4249 6973-6982 Protein denotes of IL-1Ra
T4240 7065-7070 Protein denotes NF-κB
T4257 7143-7148 Protein denotes NF-κB
T4262 7153-7159 Protein denotes IL-1Ra
T4277 7167-7176 Protein denotes chemokine
T4310 7167-7199 Protein denotes chemokine receptor CCR5-mediated
T4236 7167-7199 Protein denotes chemokine receptor CCR5-mediated
T5332 7279-7291 Protein denotes CCR5−/− Mice
T5329 7303-7310 Protein denotes of CCR5
T5343 7375-7379 Protein denotes mice
T5344 7381-7402 Entity denotes B16-F0 melanoma cells
T5347 7459-7463 Protein denotes mice
T5348 7465-7469 Entity denotes n = 
T5330 7530-7546 Protein denotes the CCR5−/− mice
T5340 7584-7600 Protein denotes the CCR5+/+ mice
T5342 7622-7638 Protein denotes the CCR5−/− mice
T5327 7689-7697 Protein denotes the CCR5
T5326 7701-7705 Protein denotes mice
T5341 7854-7858 Protein denotes mice
T5349 7944-7971 Protein denotes mice (75% of starting time)
T5324 7976-7994 Protein denotes CCR5+/+ mice (15%)
T5339 8098-8110 Protein denotes CCR5−/− mice
T5325 8115-8127 Protein denotes CCR5+/+ mice
T5338 8170-8191 Protein denotes CCR5−/− mice survived
T5336 8198-8235 Protein denotes only 15% of the CCR5+/+ mice survived
T5345 8207-8235 Protein denotes of the CCR5+/+ mice survived
T5335 8277-8296 Protein denotes the sacrificed mice
T5333 8401-8428 Entity denotes proliferation antigen PCNA,
T5323 8401-8428 Protein denotes proliferation antigen PCNA,
T5331 8489-8493 Protein denotes mice
T5328 8571-8620 Protein denotes of the CCR5−/− mice, but not those of the CCR5+/+
T5350 8621-8626 Protein denotes mice,
T5337 8662-8666 Protein denotes PCNA
T5334 8662-8681 Entity denotes PCNA reactive cells
T5346 8724-8740 Protein denotes mice (Figure 1E)
T17675 8821-8833 Protein denotes CCR5−/− mice
T17677 8835-8838 Protein denotes A–C
T17672 8876-8914 Entity denotes B16 melanoma cells (5×105 cells/mouse)
T17683 8941-8970 Protein denotes CCR5+/+ mice and CCR5−/− mice
T17685 8949-8953 Protein denotes mice
T17676 8972-8976 Entity denotes n = 
T17684 9082-9098 Protein denotes The CCR5−/− mice
T17678 9166-9181 Protein denotes to CCR5+/+ mice
T17680 9212-9221 Protein denotes mean ± SD
T17679 9263-9284 Protein denotes CCR5+/+ mice (P<0.05)
T17686 9301-9305 Protein denotes mice
T17682 9364-9398 Protein denotes to CCR5+/+ mice (by Log-rank Test)
T17687 9449-9504 Gene_expression denotes expression of proliferating cell nuclear antigen (PCNA)
T17673 9460-9504 Protein denotes of proliferating cell nuclear antigen (PCNA)
T17681 9499-9503 Protein denotes PCNA
T17671 9547-9580 Entity denotes S.D. of four experimental animals
T17674 9622-9643 Protein denotes CCR5+/+ mice (P<0.05)
T18161 9672-9725 Negative_regulation denotes Decrease of NF-κB Activity in Tumor Tissue of CCR5−/−
T5902 9672-9725 Negative_regulation denotes Decrease of NF-κB Activity in Tumor Tissue of CCR5−/−
T18152 9684-9689 Protein denotes NF-κB
T5893 9684-9689 Protein denotes NF-κB
T18147 9726-9730 Protein denotes Mice
T5884 9726-9730 Protein denotes Mice
T5899 9731-9754 Positive_regulation denotes The activation of NF-κB
T5892 9746-9754 Protein denotes of NF-κB
T5896 9780-9801 Entity denotes cancer cell survival,
T5885 9813-9834 Entity denotes melanoma cancer cells
T5887 9842-9846 Protein denotes CCR5
T5900 9842-9857 Gene_expression denotes CCR5 expression
T5903 9917-9954 Negative_regulation denotes the inactivation of NF-κB in melanoma
T5897 9934-9942 Protein denotes of NF-κB
T5890 9981-9989 Protein denotes of NF-κB
T5886 10140-10144 Protein denotes mice
T5901 10181-10321 Negative_regulation denotes the translocation of p50 and p-p65 into the nucleus through the inhibition of phosphorylation of IκB was also prevented in the tumor tissues
T5898 10202-10205 Protein denotes p50
T5889 10210-10215 Protein denotes p-p65
T5891 10221-10232 Entity denotes the nucleus
T5894 10333-10349 Protein denotes mice (Figure 2B)
T5895 10437-10440 Protein denotes p50
T5888 10487-10503 Protein denotes mice (Figure 2C)
T18159 10676-10699 Entity denotes extracts of the CCR5−/−
T18151 10700-10704 Protein denotes mice
T18153 10709-10721 Protein denotes CCR5+/+ mice
T18162 10782-10799 Gene_expression denotes Expression of p50
T18158 10793-10799 Protein denotes of p50
T18149 10804-10807 Protein denotes p65
T18163 10804-10849 Phosphorylation denotes p65 phosphorylation in nuclear extracts (NE),
T18148 10827-10848 Entity denotes nuclear extracts (NE)
T18155 10885-10896 Entity denotes the cytosol
T18160 10966-10972 Protein denotes of p50
T18157 11028-11031 Protein denotes p50
T18156 11079-11083 Protein denotes mice
T18150 11102-11135 Entity denotes S.D. of four experimental animals
T18154 11177-11198 Protein denotes CCR5+/+ mice (p<0.05)
T6415 11266-11330 Negative_regulation denotes Inhibition of the Expression of Anti-apoptotic Proteins in CCR5−
T6408 11303-11330 Protein denotes apoptotic Proteins in CCR5−
T6399 11333-11337 Protein denotes Mice
T6413 11353-11381 Negative_regulation denotes inhibition of NF-κB activity
T6396 11367-11372 Protein denotes NF-κB
T6414 11542-11596 Gene_expression denotes expression of apoptotic cell death regulatory proteins
T6398 11553-11596 Protein denotes of apoptotic cell death regulatory proteins
T6404 11689-11701 Protein denotes CCR5−/− mice
T6403 11728-11742 Entity denotes melanoma cells
T6410 11814-11851 Protein denotes the tumor tissues of the CCR5−/− mice
T6412 11814-11852 Localization denotes the tumor tissues of the CCR5−/− mice
T6395 11865-11893 Protein denotes the CCR5+/+ mice (Figure 3A)
T6397 11973-11982 Protein denotes caspase-3
T6405 11987-11990 Protein denotes Bax
T6411 12033-12037 Protein denotes mice
T6401 12046-12081 Protein denotes the CCR5+/+ mice (Figure 3B and 3C)
T6406 12151-12168 Protein denotes of tumor proteins
T6394 12194-12241 Protein denotes levels of cleaved caspase-3, cleaved caspase-9,
T6400 12231-12240 Protein denotes caspase-9
T6409 12250-12254 Protein denotes PARP
T6407 12259-12262 Protein denotes Bax
T6392 12286-12291 Protein denotes Bcl-2
T6402 12296-12302 Protein denotes C-IAP1
T6393 12343-12347 Protein denotes mice
T18555 12450-12480 Localization denotes tumor tissues of CCR5 −/− mice
T18545 12450-12480 Protein denotes tumor tissues of CCR5 −/− mice
T18546 12464-12471 Protein denotes of CCR5
T18538 12495-12500 Entity denotes cells
T18527 12566-12570 Entity denotes DAPI
T18537 12677-12692 Entity denotes of DAPI-stained
T18544 12694-12724 Entity denotes TUNEL-positive cells that were
T18540 12756-12789 Protein denotes S.D. of four experimental animals
T18539 12846-12858 Protein denotes CCR5+/+ mice
T18535 12896-12941 Protein denotes Apoptotic protein (cleaved caspase-3 and Bax)
T18525 12923-12932 Protein denotes caspase-3
T18543 12937-12940 Protein denotes Bax
T18532 13057-13134 Entity denotes of DAPI-stained, Specific antibody (cleaved caspase-3 and Bax)-positive cells
T18536 13060-13072 Entity denotes DAPI-stained
T18553 13083-13119 Entity denotes antibody (cleaved caspase-3 and Bax)
T18552 13101-13110 Protein denotes caspase-3
T18533 13115-13118 Protein denotes Bax
T18547 13176-13209 Protein denotes S.D. of four experimental animals
T18551 13266-13278 Protein denotes CCR5+/+ mice
T18554 13310-13346 Gene_expression denotes The expression of apoptotic proteins
T18530 13325-13346 Protein denotes of apoptotic proteins
T18549 13386-13405 Entity denotes specific antibodies
T18534 13415-13444 Protein denotes caspase-3, cleaved caspase-9,
T18542 13434-13443 Protein denotes caspase-9
T18529 13453-13457 Protein denotes PARP
T18526 13459-13462 Protein denotes Bax
T18541 13464-13469 Protein denotes Bcl-2
T18548 13474-13480 Protein denotes c-IAP1
T18524 13503-13522 Protein denotes The β-actin protein
T18550 13503-13522 Protein denotes The β-actin protein
T18528 13644-13678 Entity denotes S.D. of three experimental animals
T18531 13720-13741 Protein denotes CCR5+/+ mice (p<0.05)
T19295 13744-13799 Positive_regulation denotes Upregulation of IL-1Ra in the Tumor and Spleen of CCR5−
T7227 13744-13806 Positive_regulation denotes Upregulation of IL-1Ra in the Tumor and Spleen of CCR5−/− Mice
T19293 13757-13766 Protein denotes of IL-1Ra
T7223 13757-13766 Protein denotes of IL-1Ra
T19286 13770-13799 Protein denotes the Tumor and Spleen of CCR5−
T7212 13794-13806 Protein denotes CCR5−/− Mice
T19288 13802-13806 Protein denotes Mice
T7219 13840-13852 Protein denotes the cytokine
T7214 13924-13928 Protein denotes mice
T7218 13943-14006 Protein denotes a cytokine array assay using a Mouse Proteome Array (Figure 4A)
T7208 14024-14056 Protein denotes cytokines, the levels of IL-1Ra,
T7217 14049-14055 Protein denotes IL-1Ra
T7220 14057-14061 Protein denotes MIG,
T7207 14057-14068 Protein denotes MIG, MIP-1α
T7224 14129-14133 Protein denotes mice
T7206 14154-14158 Protein denotes mice
T7211 14182-14200 Protein denotes no other cytokines
T7213 14236-14252 Protein denotes the CCR5−/− mice
T7210 14257-14285 Protein denotes the CCR5+/+ mice (Figure 4B)
T7221 14345-14372 Protein denotes of CCR5−/− mice (Figure 4C)
T7209 14384-14390 Protein denotes IL-1Ra
T7226 14434-14533 Gene_expression denotes the expression of IL-1Ra in tumor and spleen tissues was analyzed by immunofluorescence and western
T7216 14449-14458 Protein denotes of IL-1Ra
T7228 14544-14568 Gene_expression denotes The expression of IL-1Ra
T7225 14544-14627 Positive_regulation denotes The expression of IL-1Ra was upregulated in tumor and spleen tissues of the CCR5−/−
T7215 14559-14568 Protein denotes of IL-1Ra
T7222 14628-14632 Protein denotes mice
T19268 14779-14817 Protein denotes mouse cytokine array panel coordinates
T19292 14819-14833 Entity denotes Nitrocellulose
T19281 14819-14843 Entity denotes Nitrocellulose membranes
T19275 14855-14889 Entity denotes different anti-cytokine antibodies
T19278 14921-14941 Protein denotes cytokine array panel
T19297 14951-15030 Gene_expression denotes the cytokine expression difference in tumor tissues of CCR5+/+ mice and CCR5−/−
T19267 14955-14963 Protein denotes cytokine
T19283 15006-15018 Protein denotes CCR5+/+ mice
T19269 15031-15036 Protein denotes mice,
T19279 15031-15054 Entity denotes mice, especially IL-1Ra
T19271 15200-15212 Entity denotes the membrane
T19276 15214-15238 Protein denotes C, Protein immune-arrays
T19294 15260-15298 Protein denotes Mouse cytokine array in spleen tissues
T19291 15326-15335 Protein denotes cytokines
T19289 15344-15374 Protein denotes CCR5+/+ mice and CCR5−/− mice,
T19282 15352-15356 Protein denotes mice
T19270 15538-15550 Entity denotes the membrane
T19290 15637-15643 Protein denotes IL-1Ra
T19277 15727-15774 Protein denotes of DAPI-stained, IL-1Ra antibody-positive cells
T19274 15730-15742 Entity denotes DAPI-stained
T19280 15751-15759 Protein denotes antibody
T19273 15816-15849 Entity denotes S.D. of four experimental animals
T19287 15906-15918 Protein denotes CCR5+/+ mice
T19296 15956-16037 Gene_expression denotes Expression of IL-1Ra was analyzed by western blotting in tumor and spleen tissues
T19272 15967-15976 Protein denotes of IL-1Ra
T19284 16127-16161 Entity denotes S.D. of three experimental animals
T19285 16203-16224 Protein denotes CCR5+/+ mice (p<0.05)
T8653 16240-16243 Protein denotes CD8
T8612 16240-16251 Entity denotes CD8 T cells
T8633 16256-16263 Entity denotes NK Cell
T8636 16282-16314 Protein denotes Tumor and Spleen of CCR5−/− Mice
T8637 16372-16384 Protein denotes CCR5−/− mice
T8668 16473-16494 Entity denotes CD8+ cytotoxic T cell
T8634 16499-16553 Entity denotes CD57+ Natural Killer cells in tumor and spleen tissues
T8667 16591-16603 Protein denotes CCR5−/− mice
T8666 16653-16663 Entity denotes CD8+ cells
T8669 16680-16753 Binding denotes as well as an increase in the number of infiltrating NK cells (Figure 5A)
T8627 16733-16753 Entity denotes NK cells (Figure 5A)
T8635 16755-16767 Entity denotes CD8+ T cells
T8671 16755-16839 Binding denotes CD8+ T cells and CD57+ NK cells were spread diffusely throughout the entire sections
T8658 16772-16786 Entity denotes CD57+ NK cells
T8646 16895-16910 Entity denotes of CD8+ T cells
T8652 16915-16929 Entity denotes CD57+ NK cells
T8659 16938-16950 Protein denotes CCR5+/+ mice
T8643 16955-16960 Protein denotes CCR5−
T8670 16961-16994 Localization denotes − mice in immunity-related organ,
T8618 16961-16994 Protein denotes − mice in immunity-related organ,
T8611 17012-17019 Protein denotes the CD8
T8632 17024-17028 Protein denotes CD57
T8625 17080-17095 Entity denotes of CD8+ T cells
T8623 17100-17114 Entity denotes CD57+ NK cells
T8631 17156-17160 Protein denotes mice
T8638 17180-17199 Protein denotes of the CCR5+/+ mice
T8639 17270-17273 Protein denotes CD8
T8622 17270-17281 Entity denotes CD8 T cells
T8624 17286-17294 Entity denotes NK cells
T8641 17313-17322 Entity denotes cytotoxic
T8651 17390-17402 Protein denotes CCR5−/− mice
T19901 17481-17493 Entity denotes CD8+ T cells
T19905 17498-17506 Entity denotes NK cells
T19902 17553-17557 Protein denotes mice
T19903 17644-17686 Protein denotes CD8 (CD8+ cytotoxic T-cell surface marker)
T19897 17649-17685 Entity denotes CD8+ cytotoxic T-cell surface marker
T19896 17649-17685 Entity denotes CD8+ cytotoxic T-cell surface marker
T19894 17649-17685 Entity denotes CD8+ cytotoxic T-cell surface marker
T19900 17697-17704 Entity denotes NK cell
T19904 17898-17922 Entity denotes of lymphocyte phenotypes
T19895 18043-18067 Protein denotes FACSAria flow cytometry,
T19899 18047-18051 Protein denotes Aria
T19898 18116-18149 Entity denotes S.D. of four experimental animals
T8616 18162-18198 Entity denotes the cell phenotype change in CCR5−/−
T8649 18199-18203 Protein denotes mice
T8642 18208-18257 Protein denotes CCR5+/+ mice by inoculation of the melanoma cell,
T8629 18236-18256 Entity denotes of the melanoma cell
T8621 18258-18269 Entity denotes lymphocytes
T8644 18326-18329 Protein denotes CD3
T8610 18326-18331 Entity denotes CD3 T
T8606 18333-18336 Protein denotes CD4
T8626 18333-18338 Entity denotes CD4 T
T8608 18343-18346 Entity denotes 8 T
T8665 18351-18358 Entity denotes NK cell
T8647 18378-18382 Protein denotes mice
T8630 18491-18503 Protein denotes 3.1% of CCR5
T8640 18507-18523 Protein denotes mice (Figure 5C)
T8619 18525-18589 Entity denotes The lymphocytes that infiltrated the tumor tissue of the CCR5−/−
T8656 18590-18594 Protein denotes mice
T8655 18621-18636 Protein denotes CD19, CD3, CD4,
T8660 18621-18640 Protein denotes CD19, CD3, CD4, CD8
T8663 18627-18631 Protein denotes CD3,
T8620 18627-18635 Protein denotes CD3, CD4
T8654 18664-18683 Protein denotes to the CCR5+/+ mice
T8657 18692-18695 Protein denotes CD3
T8628 18692-18697 Entity denotes CD3 T
T8661 18699-18702 Protein denotes CD4
T8648 18699-18704 Entity denotes CD4 T
T8617 18711-18712 Entity denotes T
T8615 18717-18747 Entity denotes NK cell portion of the CCR5−/−
T8609 18748-18752 Protein denotes mice
T8664 18854-18890 Protein denotes 3.9% of the CCR5+/+ mice (Figure 5D)
T8607 18859-18890 Protein denotes of the CCR5+/+ mice (Figure 5D)
T8614 18949-18952 Protein denotes CD8
T8650 18949-18960 Entity denotes CD8 T cells
T8645 18965-18973 Entity denotes NK cells
T8613 18992-19001 Entity denotes cytotoxic
T8662 19079-19091 Protein denotes CCR5−/− mice
T11573 19198-19202 Protein denotes mice
T11668 19212-19285 Protein denotes to the CCR5+/+ mice inoculated with B16 melanoma cells (Figure 1A and 1B)
T11616 19243-19285 Entity denotes with B16 melanoma cells (Figure 1A and 1B)
T11605 19330-19334 Protein denotes mice
T11676 19373-19403 Positive_regulation denotes constitutively activated NF-κB
T11622 19373-19403 Protein denotes constitutively activated NF-κB
T11614 19418-19427 Protein denotes of IL-1Ra
T11634 19520-19535 Protein denotes of NF-κB target
T11592 19592-19616 Protein denotes genes (Bcl-2 and C-IAP1)
T11620 19599-19604 Protein denotes Bcl-2
T11503 19609-19615 Protein denotes C-IAP1
T11589 19663-19678 Protein denotes apoptotic genes
T11594 19688-19697 Protein denotes caspase-3
T11505 19709-19712 Protein denotes Bax
T11523 19768-19822 Entity denotes of cytotoxic CD8+ T cells, CD57+ natural killer cells,
T11522 19771-19780 Entity denotes cytotoxic
T11626 19795-19821 Entity denotes CD57+ natural killer cells
T11652 19841-19847 Protein denotes IL-1Ra
T11574 19942-19959 Protein denotes the CCR5−/− mice,
T11584 19983-19992 Protein denotes of IL-1Ra
T11646 20011-20027 Protein denotes decreased NF-κB,
T11537 20083-20095 Protein denotes CCR5−/− mice
T11631 20097-20102 Protein denotes NF-κB
T11669 20097-20218 Regulation denotes NF-κB regulates the expression of over 200 genes that control the immune system, cancer cell growth and inflammation [39]
T11671 20113-20218 Gene_expression denotes the expression of over 200 genes that control the immune system, cancer cell growth and inflammation [39]
T11600 20128-20218 Protein denotes of over 200 genes that control the immune system, cancer cell growth and inflammation [39]
T11607 20330-20334 Entity denotes core
T11525 20386-20391 Protein denotes NF-κB
T11617 20446-20465 Protein denotes cytokine-associated
T11560 20512-20559 Protein denotes the melanoma tumor tissues of the CCR5−/− mice,
T11686 20512-20559 Localization denotes the melanoma tumor tissues of the CCR5−/− mice,
T11688 20560-20583 Gene_expression denotes the expression of NF-κB
T11547 20560-20674 Entity denotes the expression of NF-κB target cell death genes (Bax, caspase-3 and 9) and the DNA binding activity of NF-κB, were
T11550 20575-20583 Protein denotes of NF-κB
T11649 20602-20630 Protein denotes genes (Bax, caspase-3 and 9)
T11625 20609-20612 Protein denotes Bax
T11628 20614-20623 Protein denotes caspase-3
T11632 20660-20668 Protein denotes of NF-κB
T11693 20704-20786 Gene_expression denotes the expression of cell death inhibitory NF-κB target genes, such as Bcl-2 and cIAP
T11554 20719-20786 Protein denotes of cell death inhibitory NF-κB target genes, such as Bcl-2 and cIAP
T11516 20744-20749 Protein denotes NF-κB
T11557 20750-20771 Protein denotes target genes, such as
T11613 20772-20777 Protein denotes Bcl-2
T11604 20896-20903 Protein denotes the p50
T11545 20908-20911 Protein denotes p65
T11577 20931-20942 Entity denotes the nucleus
T11606 21016-21027 Protein denotes NF-κB [40],
T11562 21118-21123 Protein denotes NF-κB
T11675 21137-21167 Gene_expression denotes the expression of target genes
T11635 21152-21167 Protein denotes of target genes
T11667 21226-21230 Protein denotes mice
T11542 21300-21305 Protein denotes NF-κB
T11672 21324-21380 Positive_regulation denotes that NF-κB is activated or inactivated by many cytokines
T11694 21324-21380 Negative_regulation denotes that NF-κB is activated or inactivated by many cytokines
T11603 21329-21334 Protein denotes NF-κB
T11638 21363-21380 Protein denotes by many cytokines
T11586 21411-21419 Protein denotes cytokine
T11684 21443-21459 Regulation denotes regulating NF-κB
T11564 21454-21459 Protein denotes NF-κB
T11610 21474-21515 Protein denotes cytokines, including IL-1, IL-6 and IL-8,
T11658 21495-21499 Protein denotes IL-1
T11659 21501-21505 Protein denotes IL-6
T11541 21510-21514 Protein denotes IL-8
T11624 21525-21559 Protein denotes NF-κB pathways in tumor cells [41]
T11529 21543-21559 Entity denotes tumor cells [41]
T11536 21561-21587 Protein denotes The interleukin 10 (IL-10)
T11500 21581-21586 Protein denotes IL-10
T11650 21637-21675 Entity denotes an anti-inflammatory factor [42], [43]
T11524 21677-21682 Protein denotes IL-10
T11670 21707-21722 Positive_regulation denotes activated NF-κB
T11657 21707-21722 Protein denotes activated NF-κB
T11683 21760-21792 Negative_regulation denotes Inhibition of NF-κB by the IL-10
T11637 21771-21779 Protein denotes of NF-κB
T11598 21780-21792 Protein denotes by the IL-10
T11655 21857-21866 Protein denotes caspase-3
T11546 21884-21909 Protein denotes Colon26-bearing mice [43]
T11551 21968-21977 Protein denotes of IL-1Ra
T11543 22021-22030 Protein denotes IL-1 [46]
T11654 22058-22062 Protein denotes IL-1
T11687 22058-22151 Positive_regulation denotes IL-1 induces the activation of NF-κB in several cancers, and increases cell cycle progression
T11690 22071-22094 Positive_regulation denotes the activation of NF-κB
T11629 22086-22094 Protein denotes of NF-κB
T11587 22312-22321 Protein denotes of IL-1Ra
T11519 22364-22368 Protein denotes IL-1
T11501 22427-22434 Protein denotes of IL-1
T11662 22453-22463 Entity denotes antagonist
T11673 22515-22546 Negative_regulation denotes dysregulation of IL-1 signaling
T11679 22529-22546 Positive_regulation denotes of IL-1 signaling
T11569 22532-22536 Protein denotes IL-1
T11623 22592-22618 Entity denotes of the receptor antagonist
T11661 22599-22607 Protein denotes receptor
T11499 22658-22662 Protein denotes IL-1
T11674 22658-22672 Positive_regulation denotes IL-1 signaling
T11680 22723-22784 Gene_expression denotes The elevated expression of IL-1Ra, without any change of IL-1
T11602 22747-22756 Protein denotes of IL-1Ra
T11644 22777-22784 Protein denotes of IL-1
T11618 22810-22828 Protein denotes the IL-1-signaling
T11553 22856-22865 Protein denotes by IL-1Ra
T11502 22877-22883 Protein denotes IL-1Ra
T11515 22983-23014 Protein denotes Intracellular IL-1Ra (icIL-1Ra)
T11506 23005-23013 Protein denotes icIL-1Ra
T11527 23024-23028 Protein denotes IL-6
T11511 23033-23037 Protein denotes IL-8
T11695 23033-23048 Gene_expression denotes IL-8 production
T11651 23126-23132 Protein denotes IL-1Ra
T11517 23193-23197 Protein denotes mice
T11566 23214-23232 Entity denotes B16 melanoma cells
T11571 23270-23276 Protein denotes IL-1Ra
T11642 23348-23352 Protein denotes mice
T11682 23361-23407 Negative_regulation denotes the inactivation of NF-κB in the present study
T11656 23378-23386 Protein denotes of NF-κB
T11531 23409-23413 Protein denotes CCR5
T11608 23480-23506 Entity denotes of a dendrite cell vaccine
T11593 23480-23506 Entity denotes of a dendrite cell vaccine
T11643 23485-23493 Entity denotes dendrite
T11621 23518-23522 Protein denotes mice
T11615 23545-23554 Protein denotes mice [10]
T11636 23573-23575 Protein denotes RS
T11612 23596-23603 Protein denotes of CCR5
T11507 23714-23718 Protein denotes CCR5
T11504 23817-23820 Entity denotes Tan
T11513 23817-23823 Protein denotes Tan MC
T11685 23846-23936 Negative_regulation denotes disruption of CCR5/CCL5 signaling, either by reducing CCL5 production by tumor cells or by
T11689 23857-23880 Positive_regulation denotes of CCR5/CCL5 signaling,
T11596 23860-23869 Protein denotes CCR5/CCL5
T11570 23860-23869 Protein denotes CCR5/CCL5
T11539 23865-23869 Protein denotes CCL5
T11677 23891-23930 Negative_regulation denotes reducing CCL5 production by tumor cells
T11526 23900-23904 Protein denotes CCL5
T11681 23900-23915 Gene_expression denotes CCL5 production
T11530 23919-23930 Entity denotes tumor cells
T11497 23966-23970 Protein denotes CCR5
T11641 23966-23980 Entity denotes CCR5 inhibitor
T11575 23992-24004 Entity denotes reduced Treg
T11540 24006-24024 Entity denotes regulatory T cells
T11555 24076-24092 Protein denotes control mice [9]
T11565 24170-24182 Protein denotes CCR5−/− mice
T11581 24289-24293 Protein denotes mice
T11640 24354-24374 Entity denotes of cytotoxic T cells
T11521 24376-24379 Protein denotes CD8
T11647 24380-24408 Entity denotes positive T Lymphocytes cells
T11558 24380-24408 Entity denotes positive T Lymphocytes cells
T11563 24414-24434 Entity denotes natural killer cells
T11578 24441-24458 Entity denotes positive NK cells
T11567 24472-24480 Entity denotes dendrite
T11568 24472-24486 Entity denotes dendrite cells
T11583 24532-24546 Entity denotes melanoma cells
T11665 24552-24587 Entity denotes the lymphocytes of the CCR5−/− mice
T11597 24571-24587 Protein denotes the CCR5−/− mice
T11590 24624-24638 Entity denotes melanoma cells
T11576 24689-24705 Protein denotes the CCR5+/+ mice
T11653 24710-24727 Protein denotes the CCR5−/− mice,
T11520 24841-24871 Protein denotes the cytokine array experiment,
T11595 24885-24891 Protein denotes MIP-1α
T11630 24924-24930 Entity denotes T cell
T11666 24957-25026 Protein denotes increased in the CCR5−/− mice compared with those in the CCR5+/+ mice
T11538 25010-25026 Protein denotes the CCR5+/+ mice
T11645 25034-25093 Entity denotes relatively increased tumor associated cytotoxic lymphocytes
T11552 25072-25081 Entity denotes cytotoxic
T11532 25163-25169 Protein denotes − mice
T11691 25171-25190 Positive_regulation denotes Activation of NF-κB
T11664 25182-25190 Protein denotes of NF-κB
T11627 25231-25242 Entity denotes of NK cells
T11692 25266-25294 Negative_regulation denotes Inhibition of NF-κB activity
T11579 25280-25285 Protein denotes NF-κB
T11518 25305-25312 Entity denotes NK cell
T11549 25377-25381 Protein denotes IL-6
T11544 25405-25424 Protein denotes the decreased NF-κB
T11534 25429-25444 Protein denotes elevated IL-1Ra
T11559 25490-25514 Entity denotes of cytotoxic lymphocytes
T11582 25493-25502 Entity denotes cytotoxic
T11639 25578-25619 Protein denotes IL-23, a tumor growth promoting cytokine,
T11512 25610-25618 Protein denotes cytokine
T11509 25630-25635 Protein denotes NF-κB
T11528 25647-25651 Entity denotes cell
T11591 25710-25715 Protein denotes NF-κB
T11601 25737-25749 Protein denotes the cytokine
T11585 25781-25796 Entity denotes of immune cells
T11619 25825-25831 Protein denotes IL-1Ra
T11588 25889-25916 Entity denotes of myeloid suppressor cells
T11663 25994-25999 Protein denotes IL-1α
T11580 25994-26014 Protein denotes IL-1α knockout mice,
T11611 26032-26038 Protein denotes IL-1Ra
T11535 26032-26043 Protein denotes IL-1Ra mice
T11609 26072-26083 Entity denotes of NK cells
T11533 26152-26160 Protein denotes of NF-κB
T11510 26180-26189 Protein denotes of IL-1Ra
T11660 26249-26253 Protein denotes mice
T11648 26308-26315 Protein denotes of CCR5
T11633 26325-26329 Protein denotes CCR5
T11556 26333-26361 Protein denotes a G protein–coupled receptor
T11572 26391-26434 Entity denotes a small molecule for the inhibition of CCR5
T11678 26412-26434 Negative_regulation denotes the inhibition of CCR5
T11508 26427-26434 Protein denotes of CCR5
T11561 26576-26580 Protein denotes CCR5
T11498 26674-26695 Entity denotes melanoma cells growth
T11548 26725-26749 Protein denotes of NF-κB/IL-1Ra pathways
T11514 26734-26740 Protein denotes IL-1Ra
T11599 26761-26765 Protein denotes mice
T13587 27002-27030 Protein denotes The CCR5 wild type (CCR5+/+)
T13582 27035-27039 Protein denotes CCR5
T13588 27059-27063 Protein denotes mice
T13585 27138-27146 Protein denotes The mice
T13576 27289-27310 Protein denotes The mice (n = 4/cage)
T13581 27305-27309 Protein denotes cage
T13580 27513-27529 Protein denotes The CCR5+/+ mice
T13579 27531-27535 Entity denotes n = 
T13589 27543-27555 Protein denotes CCR5−/− mice
T13574 27557-27561 Entity denotes n = 
T13575 27671-27673 Protein denotes F2
T13578 27671-27737 Protein denotes F2 hybrid mice from the C57BL/6J-AW-J and 129P3/J parental strains
T13584 27739-27743 Protein denotes CCR5
T13577 27739-27748 Protein denotes CCR5 mice
T13590 27804-27855 Regulation denotes of the CCR5 gene deleted from the parental strains,
T13583 27804-27855 Protein denotes of the CCR5 gene deleted from the parental strains,
T13586 27811-27815 Protein denotes CCR5
T14051 27943-27961 Entity denotes B16 melanoma cells
T14053 27992-28009 Entity denotes 5×105 tumor cells
T14055 28013-28029 Entity denotes 0.1 ml Phosphate
T14052 28039-28050 Entity denotes saline(PBS)
T14054 28107-28126 Protein denotes of the carrier mice
T14405 28585-28652 Negative_regulation denotes with protein extraction solution (PRO-PREPTM, Intron Biotechnology,
T14386 28590-28597 Protein denotes protein
T14393 28631-28651 Entity denotes Intron Biotechnology
T14403 28672-28683 Protein denotes lysed by 60
T14385 28702-28705 Entity denotes ice
T14377 28784-28803 Protein denotes of proteins (40 µg)
T14389 28822-28851 Entity denotes a SDS/12%-polyacrylamide gel,
T14383 28822-28851 Entity denotes a SDS/12%-polyacrylamide gel,
T14390 28824-28827 Protein denotes SDS
T14404 28876-28910 Entity denotes a polyvinylidene difluoride (PVDF)
T14373 28905-28909 Entity denotes PVDF
T14398 28911-28955 Entity denotes membrane (GE Water and Process technologies,
T14369 28965-28967 Protein denotes PA
T14384 28998-29054 Entity denotes 1 h at room temperature with 5% (w/v) non-fat dried milk
T14397 29027-29054 Entity denotes 5% (w/v) non-fat dried milk
T14399 29095-29105 Entity denotes 10 mM Tris
T14370 29119-29156 Entity denotes 150 mM NaCl solution containing 0.05%
T14387 29126-29130 Entity denotes NaCl
T14381 29199-29212 Entity denotes the membranes
T14388 29251-29298 Entity denotes primary antibodies: mouse monoclonal antibodies
T14372 29251-29298 Entity denotes primary antibodies: mouse monoclonal antibodies
T14395 29271-29298 Protein denotes mouse monoclonal antibodies
T14380 29316-29319 Protein denotes p65
T14396 29324-29327 Protein denotes p50
T14375 29346-29351 Entity denotes Santa
T14378 29396-29447 Entity denotes polyclonal antibodies directed against Bax and PARP
T14371 29435-29438 Protein denotes Bax
T14382 29443-29447 Protein denotes PARP
T14392 29466-29471 Entity denotes Santa
T14402 29505-29514 Protein denotes caspase-3
T14379 29516-29525 Protein denotes caspase-9
T14368 29527-29532 Protein denotes Bcl-2
T14401 29537-29544 Protein denotes c-IAP-1
T14400 29564-29568 Entity denotes Cell
T14394 29600-29602 Protein denotes MA
T14374 29662-29672 Protein denotes peroxidase
T14391 29760-29783 Protein denotes Immunoreactive proteins
T14376 29807-29810 Protein denotes ECL
T15409 29879-29887 Entity denotes formalin
T15391 29904-29912 Entity denotes paraffin
T15401 30016-30033 Entity denotes paraffin-embedded
T15411 30110-30159 Binding denotes then subjected to heat-mediated antigen retrieval
T15398 30142-30149 Entity denotes antigen
T15386 30172-30182 Protein denotes peroxidase
T15378 30222-30254 Entity denotes 3% hydrogen peroxide in methanol
T15381 30246-30254 Entity denotes methanol
T15385 30453-30486 Entity denotes cell nuclear antigen (PCNA, 1∶200
T15406 30458-30480 Protein denotes nuclear antigen (PCNA,
T15382 30475-30479 Protein denotes PCNA
T15408 30487-30495 Entity denotes dilution
T15405 30497-30518 Protein denotes monoclonal antibodies
T15400 30541-30544 Entity denotes 4 h
T15387 30694-30704 Entity denotes antibodies
T15379 30711-30712 Entity denotes h
T15407 30770-30809 Protein denotes of the avidin biotin peroxidase complex
T15404 30770-30809 Entity denotes of the avidin biotin peroxidase complex
T15396 30770-30809 Entity denotes of the avidin biotin peroxidase complex
T15383 30791-30801 Protein denotes peroxidase
T15394 30894-30904 Protein denotes peroxidase
T15403 30960-30969 Entity denotes peroxide,
T15395 31003-31014 Entity denotes hematoxylin
T15380 31028-31032 Entity denotes aqua
T15412 31124-31207 Positive_regulation denotes A negative control was included in all experiments by omitting the primary antibody
T15397 31187-31207 Entity denotes the primary antibody
T15389 31277-31294 Entity denotes paraffin-embedded
T15390 31322-31393 Entity denotes a mixture of the labeling solution (540 µl) and enzyme solution (60 µl)
T15384 31335-31365 Entity denotes the labeling solution (540 µl)
T15399 31370-31376 Protein denotes enzyme
T15410 31370-31393 Entity denotes enzyme solution (60 µl)
T15393 31398-31410 Entity denotes 1 h at 37°C,
T15402 31568-31589 Entity denotes 2-phenylindole (DAPI)
T15392 31584-31588 Entity denotes DAPI
T15388 31711-31714 Entity denotes DAS
T15682 32436-32439 Protein denotes Apo
T16156 32490-32521 Entity denotes Gel Electromobility Shift Assay
T16168 32522-32549 Entity denotes A gel electromobility shift
T16177 32702-32713 Entity denotes of solution
T16174 32717-32737 Entity denotes 10 mM HEPES [pH 7.9]
T16163 32746-32763 Entity denotes MgCl2, 10 mM KCl,
T16165 32753-32762 Entity denotes 10 mM KCl
T16167 32764-32823 Entity denotes 0.5 mM dithiothreitol, 0.2 mM phenylmethylsulfonylfluoride)
T16164 32787-32822 Entity denotes 0.2 mM phenylmethylsulfonylfluoride
T16179 32825-32833 Entity denotes vortexed
T16159 32859-32862 Entity denotes ice
T16181 32921-32940 Entity denotes The pelleted nuclei
T16169 32961-33031 Entity denotes solution C (solution A supplemented with 420 mM NaCl and 20% glycerol)
T16160 33002-33013 Entity denotes 420 mM NaCl
T16162 33018-33030 Entity denotes 20% glycerol
T16182 33047-33060 Entity denotes on ice for 20
T16180 33134-33176 Entity denotes the resulting nuclear extracts supernatant
T16155 33195-33219 Protein denotes a chilled Eppendorf tube
T16172 33221-33247 Entity denotes Consensus oligonucleotides
T16176 33253-33295 Protein denotes end-labeled using T4 polynucleotide kinase
T16173 33271-33273 Entity denotes T4
T16170 33301-33304 Entity denotes P32
T16157 33305-33320 Entity denotes -ATP for 10 min
T16175 33330-33353 Entity denotes The gel shift reactions
T16161 33426-33513 Entity denotes gel loading buffer was added to each reaction and loaded onto a 6% non-denaturating gel
T16154 33488-33513 Entity denotes a 6% non-denaturating gel
T16178 33515-33522 Entity denotes The gel
T16171 33602-33609 Entity denotes the gel
T16166 33611-33618 Entity denotes The gel
T16158 33633-33636 Entity denotes 1 h
T16704 33711-33722 Entity denotes Lymphocytes
T16721 33711-33789 Binding denotes Lymphocytes were obtained from tumor and spleen tissues for phenotype analysis
T16717 33802-33819 Entity denotes tumor lymphocytes
T16709 33891-33895 Protein denotes mice
T16719 33989-34009 Entity denotes 100 µm cell strainer
T16715 34059-34084 Protein denotes ACK lysing buffer, LONZA)
T16700 34063-34069 Protein denotes lysing
T16710 34095-34110 Entity denotes red blood cells
T16699 34112-34135 Entity denotes One million splenocytes
T16706 34171-34200 Protein denotes 1% bovine serum albumin (BSA)
T16716 34196-34199 Protein denotes BSA
T16707 34235-34238 Protein denotes BSA
T16722 34258-34303 Binding denotes one million cells obtained from tumor tissues
T16696 34258-34303 Entity denotes one million cells obtained from tumor tissues
T16720 34345-34386 Binding denotes obtain suspension cell for 1hour at 37°C,
T16711 34352-34367 Entity denotes suspension cell
T16703 34352-34367 Entity denotes suspension cell
T16712 34447-34462 Entity denotes the lymphocytes
T16714 34502-34524 Protein denotes monoclonal antibodies,
T16698 34535-34542 Protein denotes CD4-APC
T16695 34535-34542 Entity denotes CD4-APC
T16701 34544-34552 Entity denotes CD8-FITC
T16697 34544-34552 Protein denotes CD8-FITC
T16713 34683-34725 Protein denotes a FACSAria flow cytometry (BD Biosciences)
T16702 34689-34693 Protein denotes Aria
T16708 34793-34810 Protein denotes Scripps, La Jolla
T16718 34863-34890 Entity denotes used to gate on lymphocytes
T16705 34871-34875 Entity denotes gate
T16954 34893-34914 Entity denotes Protein Immuno-arrays
T16956 34985-34993 Protein denotes protease
T16961 34985-35033 Entity denotes protease inhibitor cocktail (Sigma-Aldrich, USA)
T16960 35014-35019 Protein denotes Sigma
T16959 35038-35075 Entity denotes Triton X-100 (final concentration 1%)
T16958 35218-35231 Protein denotes protein assay
T16957 35283-35332 Protein denotes proteins, collected from three samples per group,
T16955 35347-35367 Protein denotes Mouse cytokine array
T17078 35551-35554 Protein denotes Pad
T17076 35565-35567 Protein denotes La
T17077 35640-35644 Protein denotes mice
T17080 35649-35661 Protein denotes CCR5+/+ mice
T17079 35682-35683 Entity denotes t
T17075 35861-35871 Protein denotes Mantel-Cox
T17074 35881-35895 Protein denotes GraphPad Prism
R12778 T17673 T17687 themeOf of proliferating cell nuclear antigen (PCNA),expression of proliferating cell nuclear antigen (PCNA)
R13081 T18149 T18163 themeOf p65,"p65 phosphorylation in nuclear extracts (NE),"
R13082 T18152 T18161 themeOf NF-κB,Decrease of NF-κB Activity in Tumor Tissue of CCR5−/−
R13083 T18158 T18162 themeOf of p50,Expression of p50
R13302 T18530 T18554 themeOf of apoptotic proteins,The expression of apoptotic proteins
R13303 T18545 T18555 themeOf tumor tissues of CCR5 −/− mice,tumor tissues of CCR5 −/− mice
R13800 T19267 T19297 themeOf cytokine,the cytokine expression difference in tumor tissues of CCR5+/+ mice and CCR5−/−
R13801 T19272 T19296 themeOf of IL-1Ra,Expression of IL-1Ra was analyzed by western blotting in tumor and spleen tissues
R13802 T19293 T19295 themeOf of IL-1Ra,Upregulation of IL-1Ra in the Tumor and Spleen of CCR5−
R3033 T4231 T4341 themeOf IL-1,inhibit IL-1
R3036 T4235 T4351 themeOf IL-1Ra,IL-1Ra expression
R3038 T4239 T4350 causeOf (3) increasing the production of tumor killing lymphokines,(3) increasing the production of tumor killing lymphokines
R3041 T4243 T4360 themeOf of tumor killing lymphokines,the production of tumor killing lymphokines
R3044 T4248 T4340 themeOf of the CCL5,Local production of the CCL5
R3045 T4249 T4348 themeOf of IL-1Ra,the expression of IL-1Ra
R3051 T4279 T4342 themeOf IFNγ,IFNγ expression
R3052 T4269 T4358 themeOf NF-κB,blocking NF-κB
R3053 T4281 T4353 themeOf CCR5,Intermediate and strong CCR5 expression
R3054 T4288 T4343 themeOf CCR5,of CCR5 expression
R3055 T4289 T4355 themeOf IL-1Ra,of IL-1Ra gene expression
R3056 T4296 T4359 themeOf NF-κB,of NF-κB activation [38]
R3057 T4298 T4354 causeOf a naturally occurring cytokine that competitively blocks the IL-1 receptor [13],a naturally occurring cytokine that competitively blocks the IL-1 receptor [13]
R3058 T4300 T4361 themeOf of NF-κB,inhibition of NF-κB
R3059 T4313 T4357 themeOf of NF-κB,Activation of NF-κB
R3060 T4320 T4339 themeOf of NF-κB,that inhibition of NF-κB by dehydroxymethyl-epoxyquinomicin (DHMEQ)
R3061 T4328 T4354 themeOf the IL-1 receptor [13],a naturally occurring cytokine that competitively blocks the IL-1 receptor [13]
R3062 T4330 T4346 themeOf in CCR5 mediated tumor development,in CCR5 mediated tumor development
R3063 T4333 T4362 themeOf CCR5,CCR5 disruption
R3064 T4334 T4339 causeOf by dehydroxymethyl-epoxyquinomicin (DHMEQ),that inhibition of NF-κB by dehydroxymethyl-epoxyquinomicin (DHMEQ)
R3065 T4336 T4344 themeOf of NF-κB,Activation of NF-κB
R3066 T4343 T4347 themeOf of CCR5 expression,inhibition of CCR5 expression [32]
R3067 T4351 T4345 themeOf IL-1Ra expression,"IL-1Ra expression was reduced in prostate [14], breast [15], and skin cancer [16]"
R3068 T4355 T4352 themeOf of IL-1Ra gene expression,the regulation of IL-1Ra gene expression
R3069 T4360 T4350 themeOf the production of tumor killing lymphokines,(3) increasing the production of tumor killing lymphokines
R4050 T5887 T5900 themeOf CCR5,CCR5 expression
R4051 T5892 T5899 themeOf of NF-κB,The activation of NF-κB
R4052 T5893 T5902 themeOf NF-κB,Decrease of NF-κB Activity in Tumor Tissue of CCR5−/−
R4053 T5897 T5903 themeOf of NF-κB,the inactivation of NF-κB in melanoma
R419 T778 T817 themeOf "of genes involving cell growth, apoptosis, and tumor growth","the regulation of genes involving cell growth, apoptosis, and tumor growth"
R420 T779 T818 themeOf of IL-1Ra,Upregulation of IL-1Ra in Melanoma Model
R421 T795 T819 themeOf "cleaved caspase-3, cleaved PARP,","cleaved caspase-3, cleaved PARP,"
R422 T797 T814 themeOf of NF-κB,We investigated the activation of NF-κB since it is an implicated transcription
R423 T807 T815 themeOf of IL-1Ra,upregulation of IL-1Ra
R424 T813 T816 themeOf protein,protein expression
R4353 T6398 T6414 themeOf of apoptotic cell death regulatory proteins,expression of apoptotic cell death regulatory proteins
R4354 T6410 T6412 themeOf the tumor tissues of the CCR5−/− mice,the tumor tissues of the CCR5−/− mice
R4909 T7215 T7228 themeOf of IL-1Ra,The expression of IL-1Ra
R4910 T7216 T7226 themeOf of IL-1Ra,the expression of IL-1Ra in tumor and spleen tissues was analyzed by immunofluorescence and western
R4911 T7223 T7227 themeOf of IL-1Ra,Upregulation of IL-1Ra in the Tumor and Spleen of CCR5−/− Mice
R4912 T7228 T7225 themeOf The expression of IL-1Ra,The expression of IL-1Ra was upregulated in tumor and spleen tissues of the CCR5−/−
R5871 T8618 T8670 themeOf "− mice in immunity-related organ,","− mice in immunity-related organ,"
R7549 T11499 T11674 causeOf IL-1,IL-1 signaling
R7553 T11508 T11678 themeOf of CCR5,the inhibition of CCR5
R7557 T11511 T11695 themeOf IL-8,IL-8 production
R7559 T11526 T11681 themeOf CCL5,CCL5 production
R7561 T11550 T11688 themeOf of NF-κB,the expression of NF-κB
R7562 T11622 T11676 themeOf constitutively activated NF-κB,constitutively activated NF-κB
R7563 T11629 T11690 themeOf of NF-κB,the activation of NF-κB
R7564 T11554 T11693 themeOf "of cell death inhibitory NF-κB target genes, such as Bcl-2 and cIAP","the expression of cell death inhibitory NF-κB target genes, such as Bcl-2 and cIAP"
R7565 T11631 T11669 causeOf NF-κB,"NF-κB regulates the expression of over 200 genes that control the immune system, cancer cell growth and inflammation [39]"
R7566 T11635 T11675 themeOf of target genes,the expression of target genes
R7567 T11560 T11686 themeOf "the melanoma tumor tissues of the CCR5−/− mice,","the melanoma tumor tissues of the CCR5−/− mice,"
R7568 T11637 T11683 themeOf of NF-κB,Inhibition of NF-κB by the IL-10
R7569 T11638 T11694 causeOf by many cytokines,that NF-κB is activated or inactivated by many cytokines
R7570 T11564 T11684 themeOf NF-κB,regulating NF-κB
R7571 T11569 T11679 causeOf IL-1,of IL-1 signaling
R7572 T11654 T11687 causeOf IL-1,"IL-1 induces the activation of NF-κB in several cancers, and increases cell cycle progression"
R7573 T11596 T11689 causeOf CCR5/CCL5,"of CCR5/CCL5 signaling,"
R7574 T11656 T11682 themeOf of NF-κB,the inactivation of NF-κB in the present study
R7575 T11657 T11670 themeOf activated NF-κB,activated NF-κB
R7576 T11664 T11691 themeOf of NF-κB,Activation of NF-κB
R7577 T11671 T11669 themeOf "the expression of over 200 genes that control the immune system, cancer cell growth and inflammation [39]","NF-κB regulates the expression of over 200 genes that control the immune system, cancer cell growth and inflammation [39]"
R7578 T11679 T11673 themeOf of IL-1 signaling,dysregulation of IL-1 signaling
R7579 T11598 T11683 causeOf by the IL-10,Inhibition of NF-κB by the IL-10
R7580 T11681 T11677 themeOf CCL5 production,reducing CCL5 production by tumor cells
R7581 T11600 T11671 themeOf "of over 200 genes that control the immune system, cancer cell growth and inflammation [39]","the expression of over 200 genes that control the immune system, cancer cell growth and inflammation [39]"
R7582 T11602 T11680 themeOf of IL-1Ra,"The elevated expression of IL-1Ra, without any change of IL-1"
R7583 T11689 T11685 themeOf "of CCR5/CCL5 signaling,","disruption of CCR5/CCL5 signaling, either by reducing CCL5 production by tumor cells or by"
R7584 T11603 T11672 themeOf NF-κB,that NF-κB is activated or inactivated by many cytokines
R7585 T11603 T11694 themeOf NF-κB,that NF-κB is activated or inactivated by many cytokines
R9291 T13583 T13590 themeOf "of the CCR5 gene deleted from the parental strains,","of the CCR5 gene deleted from the parental strains,"
R9971 T14386 T14405 themeOf protein,"with protein extraction solution (PRO-PREPTM, Intron Biotechnology,"