| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
85-213 |
DRI_Outcome |
denotes |
The Toll-Like Receptor 2 (TLR2) plays an active and important role in Staphylococcus aureus-induced chronic ocular inflammation. |
| T2 |
214-363 |
DRI_Background |
denotes |
The aim of this study was to investigate the expression and function of TLR2 of corneal stromal cells in ex vivo rabbit model of S. aureus keratitis. |
| T3 |
364-521 |
DRI_Background |
denotes |
Corneal buttons with sclera rims placed in an ex vivo air-interface organ culture were assigned to two groups: corneas with epithelial and stromal abrasions. |
| T4 |
522-651 |
DRI_Approach |
denotes |
Each group was then divided into two sub-groups exposed to UV-killed S. aureus ATCC 6538P and S. aureus ATCC 29213, respectively. |
| T5 |
652-730 |
DRI_Background |
denotes |
TLR2 and IL-8 mRNA expressions were analyzed by quantitative real-time RT-PCR. |
| T6 |
796-938 |
DRI_Outcome |
denotes |
The results demonstrated that TLR2 and IL-8 mRNA were significantly expressed in the stromal cells of the groups exposed to S. aureus strains. |
| T7 |
939-1108 |
DRI_Outcome |
denotes |
Moreover, it has been demonstrated that, after corneal injury, keratocytes differentiated into myofibroblasts became able to express TLR2 only when exposed to S. aureus. |
| T8 |
1109-1260 |
DRI_Challenge |
denotes |
Identification of mechanisms regulation of corneal TLRs may lead to development of therapeutic interventions aimed at controlling corneal inflammation. |
| T9 |
1261-1401 |
DRI_Challenge |
denotes |
This ex vivo model can be used to clarify the molecular events of bacterial-corneal tissue interactions and their inflammatory consequences. |
