PubMed_ArguminSci  

PubMed:25315622 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 139-265 DRI_Outcome denotes Our previous studies show that provinol, a polyphenolic compound, has anti-inflammatory activity during allergic inflammation.
T2 266-477 DRI_Challenge denotes In the present study we investigated the effects of provinol and its combinations with clinically used antiasthmatics: budesonide or theophylline on airway defense mechanisms during experimental allergic asthma.
T3 478-607 DRI_Background denotes Separate groups of guinea pigs were treated during the course of 21-day ovalbumin sensitization with provinol (20 mg/kg/day, p.o.
T4 607-681 DRI_Background denotes ), or budesonide (1 mM by inhalation), or theophylline (10 mg/kg/day, i.p.
T5 681-765 DRI_Background denotes ), and with a half-dose combination of provinol+budesonide or provinol+theophylline.
T6 766-868 DRI_Background denotes Airways defense mechanisms: cough reflex and specific airway resistance (sRaw) were evaluated in vivo.
T7 869-952 DRI_Background denotes Tracheal smooth muscle reactivity and mucociliary clearance were examined in vitro.
T8 953-1146 DRI_Outcome denotes The findings were that provinol caused significant decreases in sRaw and in tracheal smooth muscle contractility, a suppression of cough reflex, and positively modulated ciliary beat frequency.
T9 1147-1261 DRI_Background denotes The bronchodilatory and antitussive effects of provinol were comparable with those of budesonide and theophylline.
T10 1262-1405 DRI_Background denotes Provinol given as add-on treatment significantly potentiated the effects of budesonide or theophylline, although the doses of each were halved.
T11 1406-1562 DRI_Outcome denotes We conclude that provinol not only has bronchodilatory and antitussive effects, but also potentiates similar effects exerted by budesonide and theophylline.