PubMed_ArguminSci  

PubMed:24929858 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
T1 67-238 DRI_Background denotes Tortuous carotid arteries are often seen in aged populations and are associated with atherosclerosis, but the underlying mechanisms to explain this preference are unclear.
T2 239-342 DRI_Background denotes Artery buckling has been suggested as one potential mechanism for the development of tortuous arteries.
T3 343-491 DRI_Background denotes The objective of this study, accordingly, was to determine the effect of buckling on cell proliferation and associated NF-κB activation in arteries.
T4 492-676 DRI_Outcome denotes We developed a technique to generate buckling in porcine carotid arteries using long artery segments in organ culture without changing the pressure, flow rate, and axial stretch ratio.
T5 677-825 DRI_Approach denotes Using this technique, we examined the effect of buckling on arterial wall remodeling in 4-day organ culture under normal and hypertensive pressures.
T6 826-960 DRI_Background denotes Cell proliferation, NF-κB p65, IκB-α, ERK1/2, and caspase-3 were detected using immunohistochemistry staining and immunoblot analysis.
T7 961-1186 DRI_Outcome denotes Our results showed that cell proliferation was elevated 5.8-fold in the buckling group under hypertensive pressure (n = 7, P < 0.01) with higher levels of NF-κB nuclear translocation and IκB-α degradation (P < 0.05 for both).
T8 1187-1334 DRI_Approach denotes Greater numbers of proliferating cells were observed on the inner curve side of the buckled arteries compared with the outer curve side (P < 0.01).
T9 1380-1556 DRI_Background denotes Computational simulations using a fluid-structure interaction model showed reduced wall stress on the inner side of buckled arteries and elevated wall stress on the outer side.
T10 1557-1686 DRI_Outcome denotes We conclude that arterial buckling promotes site-specific wall remodeling with increased cell proliferation and NF-κB activation.
T11 1687-1819 DRI_Background denotes These findings shed light on the biomechanical and molecular mechanisms of the pathogenesis of atherosclerosis in tortuous arteries.