| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
119-294 |
DRI_Background |
denotes |
The locus coeruleus (LC) in the brainstem senses alterations in CO(2)/pH and influences ventilatory adjustments that restore blood gas values to starting levels in bullfrogs ( |
| T2 |
317-319 |
DRI_Background |
denotes |
). |
| T3 |
320-475 |
DRI_Challenge |
denotes |
We hypothesized that neurons of the bullfrog LC are sensitive to changes in CO(2)/pH and that chemosensitive responses are intrinsic to individual neurons. |
| T4 |
476-648 |
DRI_Challenge |
denotes |
In addition, we hypothesized putative respiratory control neurons of the bullfrog LC would be stimulated by hypercapnic acidosis within physiological ranges of P(CO(2))/pH. |
| T5 |
649-751 |
DRI_Background |
denotes |
84% of LC neurons depolarized and increased firing rates during exposure to hypercapnic acidosis (HA). |
| T6 |
752-880 |
DRI_Approach |
denotes |
A pH dose response curve shows LC neurons from bullfrogs increase firing rates during physiologically relevant CO(2)/pH changes. |
| T7 |
881-1038 |
DRI_Background |
denotes |
With chemical synapses blocked, half of chemosensitive neurons lost sensitivity to HA; however, gap junction blockade did not alter chemosensitive responses. |
| T8 |
1039-1113 |
DRI_Background |
denotes |
Intrinsically chemosensitive neurons increased input resistance during HA. |
| T9 |
1114-1314 |
DRI_Outcome |
denotes |
These data demonstrate that majority of neurons within the bullfrog LC elicit robust firing responses during physiological ΔCO(2)/pH, likely enabling adjustment of acid-base balance through breathing. |
