| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T218 |
0-684 |
Sentence |
denotes |
Based on previous molecular and clinical studies on SARS-CoV and the recent data on SARS-CoV-2, it is becoming evident that the delay in primary IFN response may be due to multiple factors such as (1) poor overall immune function of a patient with a compromised adaptive response as in older people, (2) patients with comorbidity, (3) genetic factors or epigenetic changes associated with crucial genes and transcriptional factors involved in IFN signaling, and (4) age and sex of the patient, probably making the older individuals and males more susceptible to COVID-19 (Bastard et al., 2020; Li M.Y. et al., 2020; Nguyen et al., 2020; Verdecchia et al., 2020; Zhou F. et al., 2020). |
| T219 |
685-795 |
Sentence |
denotes |
Thus, overall these factors may compromise the host cell immune system and delay the early antiviral response. |
| T220 |
796-950 |
Sentence |
denotes |
Especially in the case of RNA viruses, evasion of host immune response is managed by interfering with PRRs, PLRs, TLRs, and IFN signaling (Kikkert, 2020). |
| T221 |
951-1103 |
Sentence |
denotes |
Additionally, inhibition is also conferred by hijacking host cell biosynthetic machinery and eventually inducing host cell apoptosis as discussed above. |
