| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T786 |
0-110 |
Sentence |
denotes |
Table 2 Most frequently evaluated anti-inflammatory/immunomodulatory drugs in clinical trials for COVID-19 a. |
| T787 |
111-176 |
Sentence |
denotes |
Therapy Type Mechanism No. of Interventional Clinical Trials b |
| T788 |
177-256 |
Sentence |
denotes |
Tocilizumab(Actemra) Humanized monoclonal antibody IL-6 receptor blocker ~41 |
| T789 |
257-320 |
Sentence |
denotes |
Ruxolitinib(Jakafi) Small molecule JAK 1 and 2 inhibitor ~15 |
| T790 |
321-429 |
Sentence |
denotes |
Colchicine(Colcrys) Small molecule Inhibition of NLRP3 inflammasome and of microtubule polymerization ~15 |
| T791 |
430-526 |
Sentence |
denotes |
Anakinra(Kineret) Recombinant non-glycosylated human polypeptide IL-1 receptor antagonist ~13 |
| T792 |
527-701 |
Sentence |
denotes |
Methylprednisolone (DEPOMedrol) Small molecule Intracellular receptor-mediated gene expression & suppression of migration of polymorphonuclear leukocytes, among others ~13 |
| T793 |
702-767 |
Sentence |
denotes |
Baricitinib(Olumiant) Small molecule JAK 1 and 2 inhibitor ~12 |
| T794 |
768-841 |
Sentence |
denotes |
Sarilumab(Kevzara) Human monoclonal antibody IL-6 receptor blocker ~10 |
| T795 |
842-1084 |
Sentence |
denotes |
Dexamethasone(Decadron, Active Injection D) Small molecule Stimulation of glucocorticoid receptors, suppression of neutrophil migration, suppression of inflammatory mediators production, and reversal of increased capillary permeability ~10 |
| T796 |
1085-1148 |
Sentence |
denotes |
Sirolimus(Rapamune) Small molecule mTOR pathway inhibitor ~4 |
| T797 |
1149-1217 |
Sentence |
denotes |
Mavrilimumab Human monoclonal antibody GM-CSF receptor blocker ~4 |
| T798 |
1218-1282 |
Sentence |
denotes |
Siltuximab(Sylvant) Chimeric monoclonal antibody Anti-IL-6 ~2 |
| T799 |
1283-1345 |
Sentence |
denotes |
Canakinumab(Ilaris) Human monoclonal antibody Anti-IL-1β ~2 |
| T800 |
1346-1402 |
Sentence |
denotes |
a From clinicaltrials.gov, b No. is as of July 25, 2020. |
| T801 |
1403-1421 |
Sentence |
denotes |
Abbreviations: IL: |
| T802 |
1422-1439 |
Sentence |
denotes |
Interleukin; JAK: |
| T803 |
1440-1584 |
Sentence |
denotes |
Janus kinase; NLRP3: NOD-like receptor protein 3; mTOR: mammalian target of rapamycin; GM-CSF: granulocyte macrophage colony-stimulating factor. |
