LitCovid-sentences  

PMC:7600245 / 89822-91224 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T723 0-99 Sentence denotes Figure 1 Representation of the viral particle of SARS-CoV-2 demonstrating the structural proteins:
T724 100-153 Sentence denotes S (blue), E (brownish orange), M (red), and N (pink).
T725 154-223 Sentence denotes It also details the post-entry stages of the life cycle of the virus.
T726 224-442 Sentence denotes Following the release of the viral RNA genome to the host cell environment, the nonstructural proteins (NSPs) domain is expressed as two polypeptides and eventually produce PLpro, Mpro (also known as 3CLpro), and RdRp.
T727 443-548 Sentence denotes Initial processing of the two polypeptides is by host proteases and then is propagated by PLpro and Mpro.
T728 549-642 Sentence denotes The viral RdRp is also responsible for the replication and amplification of the viral genome.
T729 643-866 Sentence denotes The viral RNA and the N structural protein are biosynthesized in the host cell cytoplasm, whereas viral structural proteins S, M, and E are biosynthesized in the endoplasmic reticulum and transported to the Golgi apparatus.
T730 867-939 Sentence denotes The viral RNA–N complex and S, M, and E proteins are assembled in ERGIC.
T731 940-992 Sentence denotes The mature virus is produced by the budding process.
T732 993-1034 Sentence denotes The virus is then released by exocytosis.
T733 1035-1040 Sentence denotes Note:
T734 1041-1245 Sentence denotes The virus enters via membrane fusion in the endo/lyso-somes which requires proteolytic activation by cathepsins (a) or via fusion at the cell membrane which requires proteolytic activation by TMPRSS2 (b).
T735 1246-1402 Sentence denotes Furin may also contribute to the entry of the virus, yet its site of action is not fully established. gRNA means genomic RNA and sgRNA means subgenomic RNA.