| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T664 |
0-135 |
Sentence |
denotes |
Many of the above drugs are currently approved therapeutics for other indications; thus, they present a unique repurposing opportunity. |
| T665 |
136-247 |
Sentence |
denotes |
Yet, others are new molecular entities such as AR-527, EIDD-2801, ACS-09, vidofludimus, VERU-111, and BLD-2660. |
| T666 |
248-420 |
Sentence |
denotes |
Interestingly, the reviewed therapeutics exploit a range of mechanisms which will essentially enhance the likelihood of obtaining effective therapeutics in a timely manner. |
| T667 |
421-530 |
Sentence |
denotes |
Furthermore, many of the presented therapeutics promote pharmacological effects beyond the antiviral effects. |
| T668 |
531-649 |
Sentence |
denotes |
Of note are the anti-inflammatory/immune-modulatory effects of selinexor, NSAIDs, VERU-111, leflunomide, and BLD-2660. |
| T669 |
650-769 |
Sentence |
denotes |
These effects are of enormous significance due to the confirmed excessive inflammation in the severe cases of COVID-19. |
| T670 |
770-991 |
Sentence |
denotes |
It is worth mentioning here that testing of the described therapeutics in COVID-19 clinical trials is based on either initial clinical observations or reported activity against previous outbreaks of SARS-CoV and MERS-CoV. |
