LitCovid-sentences  

PMC:7600245 / 66790-68382 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T516 0-5 Sentence denotes 4.15.
T517 6-34 Sentence denotes N-Acetylcysteine (Acetadote)
T518 35-132 Sentence denotes It is a small molecule in which the amino group of cysteine amino acid is acetylated (Figure S6).
T519 133-174 Sentence denotes N-acetylcysteine was approved by the U.S.
T520 175-280 Sentence denotes FDA in 1963 for the oral use as mucolytic agent and parenteral use to treat acetaminophen overdose [235].
T521 281-377 Sentence denotes Currently, there are about six ongoing clinical trials to evaluate its use in COVID-19 patients.
T522 378-494 Sentence denotes The rationale for these studies is attributed to its potential antiviral, antioxidant, and immunomodulatory effects.
T523 495-635 Sentence denotes In this arena, several experiments have shown that acetylcysteine may eventually inhibit the viral replication of influenza A [236,237,238].
T524 636-739 Sentence denotes Acetylcysteine has also been evaluated for use in the treatment of HIV in two randomized studies [239].
T525 740-948 Sentence denotes Although its effect on the viral load was not consistent, the two studies consistently demonstrated that acetylcysteine substantially increased immunological functions and plasma albumin concentrations [239].
T526 949-1150 Sentence denotes Furthermore, its free sulfhydryl group cleaves the disulfide bonds in mucoproteins which lowers mucous viscosity in patients with cystic fibrosis or chronic obstructive pulmonary disease [240,241,242].
T527 1151-1292 Sentence denotes At higher doses, acetylcysteine can also be used as an antioxidant to mitigate the symptoms of many diseases complicated by oxidative stress.
T528 1293-1433 Sentence denotes In fact, as a component in the synthesis of the antioxidant glutathione, it may reduce the formation of proinflammatory cytokines [243,244].
T529 1434-1592 Sentence denotes Acetylcysteine has also been found to mitigate the oxidative stress and improve the inflammatory response in patients with community acquired pneumonia [245].