| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T42 |
0-220 |
Sentence |
denotes |
The RNA genome of SARS-CoV-2 has more than 29,800 nucleotides which encode for about 29 proteins: nonstructural proteins (NSPs; 16 proteins), structural proteins (4 proteins), and accessory proteins (9 proteins) [18,19]. |
| T43 |
221-401 |
Sentence |
denotes |
The structural proteins are spike S protein, envelope (E) and membrane (M) proteins which form the viral envelope, and nucleocapsid (N) protein which binds to the virus RNA genome. |
| T44 |
402-720 |
Sentence |
denotes |
In the post-entry phase of the virus life cycle (Figure 1), the NSPs domain is expressed as two polypeptides which, after processing, produce papain like protease (PLpro) (NSP3), main protease (Mpro) (also known as 3-chymotrypsin-like protease (3CLpro); NSP5) [20], and RNA-dependent RNA polymerase (RdRp; NSP12) [21]. |
| T45 |
721-861 |
Sentence |
denotes |
Initial processing of the two polypeptides is promoted by host proteases, and then, is propagated by the action of the viral PLpro and Mpro. |
| T46 |
862-955 |
Sentence |
denotes |
The viral RdRp is also responsible for the replication and amplification of the viral genome. |
| T47 |
956-1206 |
Sentence |
denotes |
The viral RNA and the N structural protein are biosynthesized in the host cell cytoplasm, whereas other viral structural proteins including S, M, and E are eventually biosynthesized in the endoplasmic reticulum and transported to the Golgi apparatus. |
| T48 |
1207-1378 |
Sentence |
denotes |
The viral RNA–N complex and S, M, and E proteins are then assembled in the endoplasmic reticulum–Golgi intermediate compartment (ERGIC) to produce a mature virus particle. |
| T49 |
1379-1528 |
Sentence |
denotes |
The mature virus is then released from the Golgi apparatus via a budding process and next from the host cells by exocytosis (Figure 1) [12,22,23,24]. |
