LitCovid-sentences  

PMC:7600245 / 4612-7674 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T36 0-71 Sentence denotes The Life Cycle of SARS-COV-2 and Potential Targets for Drug Development
T37 72-165 Sentence denotes The life cycle of the virus includes early-stage events and later-stage events (Figure 1a,b).
T38 166-311 Sentence denotes In the first stage, the virus utilizes its spike (S) protein to bind to angiotensin converting enzyme 2 (ACE2) on the host cell membrane [13,14].
T39 312-576 Sentence denotes The virus enters the host cell after the spike S protein-ACE2 complex is proteolytically activated by transmembrane protease serine 2 (TMPRSS2) (see (b) in Figure 1), which eventually permits the virus-host cell fusion and the release of the viral RNA genome [15].
T40 577-676 Sentence denotes Alternatively, the bound virus spike S protein can also be proteolytically activated by furin [16].
T41 677-875 Sentence denotes Further processing is promoted by cathepsins in (endo)lysosomes to ultimately aid in the viral envelope fusion with the host membranes and the release of the viral genome (see (a) in Figure 1) [17].
T42 876-1096 Sentence denotes The RNA genome of SARS-CoV-2 has more than 29,800 nucleotides which encode for about 29 proteins: nonstructural proteins (NSPs; 16 proteins), structural proteins (4 proteins), and accessory proteins (9 proteins) [18,19].
T43 1097-1277 Sentence denotes The structural proteins are spike S protein, envelope (E) and membrane (M) proteins which form the viral envelope, and nucleocapsid (N) protein which binds to the virus RNA genome.
T44 1278-1596 Sentence denotes In the post-entry phase of the virus life cycle (Figure 1), the NSPs domain is expressed as two polypeptides which, after processing, produce papain like protease (PLpro) (NSP3), main protease (Mpro) (also known as 3-chymotrypsin-like protease (3CLpro); NSP5) [20], and RNA-dependent RNA polymerase (RdRp; NSP12) [21].
T45 1597-1737 Sentence denotes Initial processing of the two polypeptides is promoted by host proteases, and then, is propagated by the action of the viral PLpro and Mpro.
T46 1738-1831 Sentence denotes The viral RdRp is also responsible for the replication and amplification of the viral genome.
T47 1832-2082 Sentence denotes The viral RNA and the N structural protein are biosynthesized in the host cell cytoplasm, whereas other viral structural proteins including S, M, and E are eventually biosynthesized in the endoplasmic reticulum and transported to the Golgi apparatus.
T48 2083-2254 Sentence denotes The viral RNA–N complex and S, M, and E proteins are then assembled in the endoplasmic reticulum–Golgi intermediate compartment (ERGIC) to produce a mature virus particle.
T49 2255-2404 Sentence denotes The mature virus is then released from the Golgi apparatus via a budding process and next from the host cells by exocytosis (Figure 1) [12,22,23,24].
T50 2405-2566 Sentence denotes Collectively, the goal of antiviral therapeutics is to inhibit one or more events in the life cycle of the virus in order to impede the propagation of infection.
T51 2567-2714 Sentence denotes Along these lines, any protein or event in the virus life cycle can be considered as a molecular target for anti-COVID-19 drug development efforts.
T52 2715-2883 Sentence denotes In this review, we describe the antiviral agents that are currently being tested in clinical trials to block and/or inhibit the advanced events of the virus life cycle.
T53 2884-3062 Sentence denotes Although the majority of the presented antiviral therapeutics target the viral polymerase or the viral proteases, few other therapeutics target other molecular targets (Table 1).