| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T325 |
0-47 |
Sentence |
denotes |
The drug is associated with several mechanisms. |
| T326 |
48-220 |
Sentence |
denotes |
The anti-protozoal activity demonstrated by this drug is promoted by the inhibition of pyruvate:ferredoxin oxidoreductase enzyme-dependent electron transfer reaction [137]. |
| T327 |
221-439 |
Sentence |
denotes |
However, in the case of influenza, nitazoxanide and its metabolite inhibit the viral hemagglutinin maturation at the post-translational phase with no effect on the M2 protein or on the neuraminidase glycoprotein [138]. |
| T328 |
440-715 |
Sentence |
denotes |
Furthermore, nitazoxanide modulates other targets and pathways in vitro including glutamate-gated chloride ion channels and glutathione-S-transferase in nematodes, respiration and other pathways in bacterial and cancer cells, and viral and host transcriptional factors [134]. |
| T329 |
716-882 |
Sentence |
denotes |
In fact, nitazoxanide was shown to in vitro inhibit the replication of coronaviruses, including MERS-CoV in cells and the expression of the viral N protein [136,139]. |
| T330 |
883-1027 |
Sentence |
denotes |
The drug was also reported as a non-competitive inhibitor of thiol oxidoreductase ERp57 and thus demonstrated anti-paramyxovirus activity [140]. |
| T331 |
1028-1182 |
Sentence |
denotes |
Moreover, nitazoxanide was reported to inhibit the production of pro-inflammatory cytokines in peripheral blood mononuclear cells and animal models [136]. |
| T332 |
1183-1326 |
Sentence |
denotes |
In peripheral blood mononuclear cells exposed to influenza virus, nitazoxanide potentiated the release of INF-α and INF-β by fibroblasts [135]. |
| T333 |
1327-1476 |
Sentence |
denotes |
In addition, nitazoxanide appears also to act as a bronchodilator in testing models by blocking the calcium-activated chloride channel TMEM16A [141]. |
