Id |
Subject |
Object |
Predicate |
Lexical cue |
T25 |
0-156 |
Sentence |
denotes |
Considering the current clinical guidelines, remdesivir has been recommended for the treatment of COVID-19 in hospitalized patients with severe disease [9]. |
T26 |
157-277 |
Sentence |
denotes |
Furthermore, favipiravir has been approved for the treatment of COVID-19 in the hospital settings in few countries [10]. |
T27 |
278-446 |
Sentence |
denotes |
Moreover, dexamethasone as an anti-inflammatory drug has also been recommended in patients with COVID-19 who require mechanical ventilation or supplemental oxygen [11]. |
T28 |
447-554 |
Sentence |
denotes |
Despite the above recommendations and/or approvals, the need for effective treatment remains largely unmet. |
T29 |
555-683 |
Sentence |
denotes |
Therefore, a large number of potential therapeutics continue to be developed and others are being advanced into clinical trials. |
T30 |
684-817 |
Sentence |
denotes |
We recently reviewed the chemical and mechanistic aspects of antiviral drugs that block the early phase of the virus life cycle [12]. |
T31 |
818-999 |
Sentence |
denotes |
In this article, we review the chemical structures and the mechanisms of action of potential antiviral therapeutics that block/inhibit the post-entry stages of the virus life cycle. |
T32 |
1000-1072 |
Sentence |
denotes |
We only include those therapeutics that are listed in clinicatrials.gov. |
T33 |
1073-1128 |
Sentence |
denotes |
They include both old drugs and new molecular entities. |
T34 |
1129-1211 |
Sentence |
denotes |
Many of the potential therapeutics are small molecules and few are macromolecules. |
T35 |
1212-1278 |
Sentence |
denotes |
Some of these therapeutics also possess anti-inflammatory effects. |