PMC:7600245 / 3332-4610 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T25 0-156 Sentence denotes Considering the current clinical guidelines, remdesivir has been recommended for the treatment of COVID-19 in hospitalized patients with severe disease [9].
T26 157-277 Sentence denotes Furthermore, favipiravir has been approved for the treatment of COVID-19 in the hospital settings in few countries [10].
T27 278-446 Sentence denotes Moreover, dexamethasone as an anti-inflammatory drug has also been recommended in patients with COVID-19 who require mechanical ventilation or supplemental oxygen [11].
T28 447-554 Sentence denotes Despite the above recommendations and/or approvals, the need for effective treatment remains largely unmet.
T29 555-683 Sentence denotes Therefore, a large number of potential therapeutics continue to be developed and others are being advanced into clinical trials.
T30 684-817 Sentence denotes We recently reviewed the chemical and mechanistic aspects of antiviral drugs that block the early phase of the virus life cycle [12].
T31 818-999 Sentence denotes In this article, we review the chemical structures and the mechanisms of action of potential antiviral therapeutics that block/inhibit the post-entry stages of the virus life cycle.
T32 1000-1072 Sentence denotes We only include those therapeutics that are listed in clinicatrials.gov.
T33 1073-1128 Sentence denotes They include both old drugs and new molecular entities.
T34 1129-1211 Sentence denotes Many of the potential therapeutics are small molecules and few are macromolecules.
T35 1212-1278 Sentence denotes Some of these therapeutics also possess anti-inflammatory effects.