| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T131 |
0-131 |
Sentence |
denotes |
It a thymidine nucleoside analog (Figure 3) that was approved in Korea for the treatment of hepatitis B virus (HBV) infection [60]. |
| T132 |
132-268 |
Sentence |
denotes |
Similar to previous agents, it is a prodrug that requires phosphorylation to form the corresponding active nucleotide, the triphosphate. |
| T133 |
269-420 |
Sentence |
denotes |
Mechanistically, the triphosphate active form appears to noncompetitively inhibit the HBV reverse transcriptase protein priming and DNA synthesis [61]. |
| T134 |
421-589 |
Sentence |
denotes |
Importantly, although clevudine showed a potent antiviral response, its long-term use for more than a year led to the development of viral resistance and myopathy [60]. |
| T135 |
590-690 |
Sentence |
denotes |
The drug is being evaluated in a phase 2 as a treatment for COVID-19 in Korea (NCT04347915; n = 60). |
