PMC:7546716 / 43797-44110 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T187 0-313 Sentence denotes NLRP3 inflammasome inhibitors (eg, dapansutrile, CP-456773) NLRP3 Macrophages and other cells Shown to inhibit caspase-1, thereby preventing activation of IL-1β and IL-18; effective in murine models of pulmonary inflammation; and have a potential benefit in heart failure Might be less effective at earlier stages