LitCovid-sentences  

PMC:7408073 / 99148-101487 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T480 79-429 Sentence denotes In particular:(a) Chronic administration (about 4 weeks) of C-16/DLM-4760 in combination with ACE2 activating treatments was performed by daily intraperitoneal injection at a dose of 25mg/kg in distilled water (as a solution of 42 mg/mL) or 0.9% sterile saline (as a solution of 84 mg/mL using a 0.5-mL insulin syringe) freshly prepared [52,183,184].
T481 430-761 Sentence denotes (b) Alternatively, chronic administration (about 8 days) of GL1001/DLM-4760 disodium salt in combination with an ACE2 activating treatment was performed by subcutaneous injection (5mL/kg) containing up to a dose of 300 mg/kg, twice a day, formulated in a vehicle solution [15% 2-hydroxypropyl-β-cyclodextrin (HPBDC)/85% H2O] [122].
T482 762-847 Sentence denotes Subchronic doses of GL1001 indicate no adverse effects up to 1,000 mg/kg (see [122]).
T483 848-937 Sentence denotes (c) In humans ORE1001/GL1001/MLN-4760 was already proposed and tested in clinical trials.
T484 938-1106 Sentence denotes Its pharmaceutical indication was for digestive tract inflammations (Inflammatory bowel disease, gastritis and colitis) that are correlated with overexpression of ACE2.
T485 1107-1183 Sentence denotes In a Phase I clinical testing up 14 days dosing, ORE1001 was well tolerated.
T486 1184-1268 Sentence denotes Subjects received drug (dosing up to 2100 mg) with no side adverse effects reported.
T487 1269-1406 Sentence denotes In particular, 47 subjects received single-dose from 2.1 to 2100 mg and 24 subjects received 14 day multiple doses from 50 mg to 1800 mg.
T488 1407-1496 Sentence denotes All doses were well tolerated, with no significant side effects including blood pressure.
T489 1497-1654 Sentence denotes Pharmacokinetics of orally administered capsules was consistent with once-daily dosing. (http://oreholdings.com/wp-content/uploads/2013/06/09.10.09-425.pdf).
T490 1655-1813 Sentence denotes 300 mg (active drug) oral capsules were used in a Phase Ib/IIa clinical trial that was, however, abandoned. (https://clinicaltrials.gov/ct2/show/NCT01039597).
T491 1814-1963 Sentence denotes (d) Finally, MLN-4760 was also administered (2.5 mg/kg per day) by nasal inhalation for 2–3 days in lung-infected mice by Pseudomonas bacteria [185].
T492 1964-2105 Sentence denotes Interestingly, the report underscores the role played by local concentration of molecules (ACE2) in modulating lung inflammation and disease.
T493 2106-2339 Sentence denotes For these reasons, in diseases involving respiratory tract, like SARS, inhalation treatment is preferable, even for the lower concentration (and hopefully lower toxicity) of MLN-4760 needed for this route of treatment administration.