Id |
Subject |
Object |
Predicate |
Lexical cue |
T296 |
0-217 |
Sentence |
denotes |
Based on ACE2 mechanism of action, there are alternative ways to inhibit ACE2 (and ACE), for example concentration of cation/anion might also targets of intervention to inhibit the zinc metalloprotease ACE2 (and ACE). |
T297 |
218-315 |
Sentence |
denotes |
In this regard, EDTA, a cation chelator, has been shown to be able to inhibit ACE2 activity [79]. |
T298 |
316-610 |
Sentence |
denotes |
Of interest, EDTA binds with 106- and 102-fold higher affinity to Zn2+ than to Ca2+ and Fe2+, respectively [123], and in plasma, free Ca2+ concentration (1.05–1.30 mmol/L) is “only” about 103-fold higher than free Zn2+ (0.1–2.0 µmol/L), while majority of iron in plasma is bound to transferrin. |
T299 |
611-723 |
Sentence |
denotes |
As a consequence, the iron concentration in plasma of healthy subjects is very low on the order of 10−18M [112]. |
T300 |
724-1031 |
Sentence |
denotes |
Among the essential metal ions present in the organisms, the specific affinity of EDTA for systemic Zn2+ in physiologic conditions is highlighted by the evidence that prolonged treatment with CaNa2EDTA results in specific zinc depletion that is believed to mediate the teratogenic effects of the drug [123]. |
T301 |
1032-1361 |
Sentence |
denotes |
As already mentioned, zinc is an important mediator/messenger involved in several cellular activities and excess of free zinc has been shown to be toxic (see also Box 4); however, zinc deficiency has also detrimental effects on growth, neuronal development, and immunity, and in severe cases its consequences can be deadly [102]. |
T302 |
1362-1554 |
Sentence |
denotes |
For these reasons, treatments with CaNa2EDTA require a careful monitoring of the patient for the therapeutic effects as well as possible complications, so as to titrate the appropriate dosage. |