| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T286 |
0-173 |
Sentence |
denotes |
Extensive experiments have been also performed with DX600, a specific peptide ACE2 inhibitor that exhibited a mixed competitive and non-competitive type of inhibition [120]. |
| T287 |
174-271 |
Sentence |
denotes |
Actually, several reports describing Dx600 inhibitor administration in mice suggest its safe use. |
| T288 |
272-552 |
Sentence |
denotes |
Of interest, a report described its (safe) use alone (1 mg/kg per day) by nasal inhalation for 3 days in a mouse model of endotoxin-induced lung inflammation [121]; however, this inhibitor is less efficacious than MLN-4760 in inhibiting the soluble forms of human rACE2 [114,115]. |
| T289 |
553-749 |
Sentence |
denotes |
Altogether these reports on administration of ACE2 inhibitors do not reveal significant adverse impacts or mortality in experimental animals, which suggests their safety in chronic administration. |
| T290 |
750-849 |
Sentence |
denotes |
This was also confirmed in human clinical trials with MLN-4760 (clinical name: ORE1001, see later). |
| T291 |
850-1369 |
Sentence |
denotes |
Of interest, a report showed that on day 28 post-myocardial infarction, adult male Sprague-Dawley rats that had received MLN-4760 (also called C16) 25 mg/mL/day by daily intraperitoneal injection (as a solution of 42 mg/mL in distilled water) tended to have lower left ventricular pulse pressure, mean arterial pressures and left ventricular relaxation time constant-Tau compared to untreated group (see table 2 of the paper) [52], suggesting a possible protective role of ACE2 inhibition in post-myocardial infarction. |
| T292 |
1370-1650 |
Sentence |
denotes |
Therefore, MLN-4760 might be helpful not only for COVID-19 but also in targeted therapies for pathologies correlated with an excessive increase of ACE2 activity that may involve heart, lung, liver, colon or other tissues/organs expressing ACE2 such as blood and endothelial cells. |
| T293 |
1651-1877 |
Sentence |
denotes |
As an example, GL1001 (old name of MLN-4760) showed to produce an anti-inflammatory activity in a mouse model of colitis [122], highlighting the importance of the yin-yang balance of ACE/ACE2 pathways (“in medio stat virtus”). |
