| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T546 |
0-192 |
Sentence |
denotes |
In order to decide who to treat, and when to start treatment, it is important to define the entity of dysfunctions, probability of treatment success and probability to develop adverse effects. |
| T547 |
193-306 |
Sentence |
denotes |
To promptly intervene in order to prevent severe forms of COVID-19, we need early markers of disease progression. |
| T548 |
307-703 |
Sentence |
denotes |
To this regard, if plasma (free) Zn2+ (or total zinc/albumin molar ratio), albumin, IL-10, Ang (1–9), Ang (1–7), Ang (1–5) and/or bradykinin (1–7) will be proven to be reliable surrogate markers for ACE and/or ACE2 enzymatic activity in vivo, they could be exploited, together with circulating ACE and ACE2 activity evaluation, in order to decide who and when to start treating COVID-19 patients. |
| T549 |
704-802 |
Sentence |
denotes |
Alternatively, eosinopaenia and hypotension may be also exploited as signs of disease progression. |
| T550 |
803-1229 |
Sentence |
denotes |
In any case, since the conditions of some patients can be critical, it is highly recommended to administer the minimal effective dose in order to reduce possible side effects, starting with low and increasing doses, while at the same time monitoring patient status and early signs of disease progression (e.g., blood pressure, eosinophil counts, molecular concentrations of the RAS peptides and other markers of inflammation). |
| T551 |
1230-1630 |
Sentence |
denotes |
The aim of the project was not necessarily to stop viral entry (the epithelial cells take already care of it shedding ACE2) but to block positive feedback loops that follow the cellular response to SARS-CoV-2 infection, which are likely the main cause of the severe symptoms associated with COVID-19, doing so, the disease might hopefully become like a simple flu, a spontaneously eradicable disease. |
