Id |
Subject |
Object |
Predicate |
Lexical cue |
T637 |
0-100 |
Sentence |
denotes |
SAs are predominant surface determinants for pathogen attachment, adherence and entry to host cells. |
T638 |
101-213 |
Sentence |
denotes |
Eleven representative vertebrate virus families utilize SAs as initial entry receptors or as attachment factors. |
T639 |
214-342 |
Sentence |
denotes |
Interaction of virus with SA-containing glycans is complex because virus SA-binding lectins are inherently of very low affinity. |
T640 |
343-442 |
Sentence |
denotes |
Viruses acquire enzymes to catalyze virion elution by regional depletion of binding receptors [56]. |
T641 |
443-498 |
Sentence |
denotes |
TM S glycoprotein recognizes oligosaccharide receptors. |
T642 |
499-702 |
Sentence |
denotes |
Using cryo-EM technology and observed structures of S glycoprotein trimers of CoV OC43 complexed with 9-O-acetylated SA, S glycoprotein was demonstrated to mediate virus adhesion and entry to host cells. |
T643 |
703-769 |
Sentence |
denotes |
All CoV S proteins show conservation in binding to 9-O-acetyl-SAs. |
T644 |
770-821 |
Sentence |
denotes |
MERS-CoV also recognizes 9-carbon sugar SA species. |
T645 |
822-856 |
Sentence |
denotes |
MERS-CoV S-1A binds to SA species. |
T646 |
857-987 |
Sentence |
denotes |
For example, SAα2,3- over SAα2,6-linkages expressed in human erythrocytes and mucins are preferentially targeted by MERS-CoV S-1A. |
T647 |
988-1075 |
Sentence |
denotes |
Binding is hence blocked by SA modification to 5-N-NeuGc and 7, 9-O-NeuAc species [73]. |
T648 |
1076-1278 |
Sentence |
denotes |
For example, impairment of ACE2 receptor glycosylation does not influence S-glycoprotein-ACE2 interaction, however, SARS-CoV-2 virus entry into respiratory epithelial host cells was downregulated [133]. |
T649 |
1279-1445 |
Sentence |
denotes |
Changes in ACE2 N-glycans do not apparently influence interaction with the SARS-CoV S glycoprotein, but instead, impair viral S glycoprotein-mediated membrane fusion. |
T650 |
1446-1516 |
Sentence |
denotes |
The receptor glycan structures decide the entry of some human viruses. |
T651 |
1517-1626 |
Sentence |
denotes |
Changes in ACE2 receptor sialylation influences interaction affinity between virus ligands and host receptor. |
T652 |
1627-1724 |
Sentence |
denotes |
Inter-species or individual genetic variations such as drift and mutation may occur in SARS-CoVs. |
T653 |
1725-1829 |
Sentence |
denotes |
This explains currently emerging differences in CoV responses within the same population such as humans. |