| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T412 |
0-81 |
Sentence |
denotes |
CoV S spikes recognize diverse surface molecules as the attachment or entry site. |
| T413 |
82-238 |
Sentence |
denotes |
Animal and human coronaviruses evolve to acquire the same host receptors and attachment factors and overcome the interspecies barrier from animals to human. |
| T414 |
239-372 |
Sentence |
denotes |
Specifically, S glycoprotein interaction with its binding receptor determines host tropism, pathogenicity and therapeutic clues [80]. |
| T415 |
373-435 |
Sentence |
denotes |
CoVs recognize multiple host receptors via distinct S domains. |
| T416 |
436-522 |
Sentence |
denotes |
The host receptors for β-CoV SARS-CoV includes angiotensin-converting enzyme 2 (ACE2). |
| T417 |
523-598 |
Sentence |
denotes |
As a lineage C β-CoV, the MERS-CoV S glycoprotein binds to DPP4 [81,82,83]. |
| T418 |
599-673 |
Sentence |
denotes |
MERS-CoV S glycoprotein recognizes α2,3-SA over α2,6-SA-bearing receptors. |
| T419 |
674-755 |
Sentence |
denotes |
The N-terminal subunits of the S1/S1A/S1B/S1D complex of MERS-CoV recognize DPP4. |
| T420 |
756-824 |
Sentence |
denotes |
MERS-CoV recognizes CEACAM5 as the attachment factor for entry [78]. |
| T421 |
825-988 |
Sentence |
denotes |
Among the six HCoVs, the α-CoV HCoV-229E S protein recognizes human APN (hAPN) [84]. α-CoV HCoV-NL63 and the lineage B β-CoV SARS-CoV S glycoproteins bind to ACE2. |
| T422 |
989-1101 |
Sentence |
denotes |
Meanwhile the protein receptors specific for lineage A β-CoVs such as HCoV-HKU1 and HCoV-OC43 are not known yet. |
