LitCovid-sentences  

PMC:7352545 / 26150-28684 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T251 0-4 Sentence denotes 5.1.
T252 5-57 Sentence denotes Evolutionary Origin and Classification of the CoV HE
T253 58-159 Sentence denotes Certain viruses use glycoproteins such as HA, HE, S and HEF for host receptor binding or destruction.
T254 160-284 Sentence denotes Coronaviridae, Orthomyxoviridae, Paramyxoviridae and Adenoviridae utilize SAs as binding molecules for attachment and entry.
T255 285-341 Sentence denotes However, only limited human pathogens recognize O-Ac SA.
T256 343-349 Sentence denotes 5.1.1.
T257 350-401 Sentence denotes Influenza Virus A and B Spike Proteins of HA and NA
T258 402-479 Sentence denotes Influenza A and B viruses bear two spikes of receptor-binding HA and NA [45].
T259 481-487 Sentence denotes 5.1.2.
T260 488-512 Sentence denotes Influenza C virus HA-HEF
T261 513-566 Sentence denotes HEF is indeed an ancient type of SA-O-acetylesterase.
T262 567-675 Sentence denotes In contrast to A/B, the influenza C virus bears one spike with triple functions of HEF as a homotrimer [46].
T263 676-761 Sentence denotes Each HEF subunit bears two Neu5,9Ac2-binding sites and binds to the 9-O-acetyl group.
T264 762-822 Sentence denotes In parallel, another modification of O-acetylation is found.
T265 823-941 Sentence denotes Indeed, influenza C virus bears SA-O-acetylesterase [47], which converts 5-N-acetyl-9-O-NeuAc (Neu5,9Ac2) to 5-Neu5Ac.
T266 942-1097 Sentence denotes The 9-O-acetyl SA is a unique determinant for the influenza C virus receptor and Neu5,9Ac2 is crucial for receptor activity, but not Neu5Gc or Neu5Ac [48].
T267 1098-1190 Sentence denotes Neu5,9Ac2 is an essential determinant for influenza virus C type-specific host cell tropism.
T268 1191-1250 Sentence denotes NAs cleave the α-ketosidic linkages to the D-Gal or GalNAc.
T269 1251-1318 Sentence denotes SA-O-acetylesterases cleave different O-acetyl linkages (Figure 5).
T270 1319-1421 Sentence denotes The OH-group of Tyr224 and the guanidino group of Arg236 interact with the CH3CO-carbonyl oxygen [49].
T271 1422-1561 Sentence denotes HEF SA-O-acetylesterase is found in several enveloped (+) ssRNA viruses of influenza C virus and also in certain CoVs and toroviruses [47].
T272 1562-1740 Sentence denotes The CoVs are different from the orthomyxoviruses, which hold a segmented (−) ssRNA genome and are instead evolutionary linked to the family Coronaviridae, order Nidovirales [45].
T273 1742-1748 Sentence denotes 5.1.3.
T274 1749-1775 Sentence denotes CoV SA-O-Acetylesterase HE
T275 1776-1864 Sentence denotes CoVs and toroviruses of the Coronaviridae family are specific for the O-Ac SA receptors.
T276 1865-1931 Sentence denotes Their S and HE glycoproteins are similar to influenza C virus HEF.
T277 1932-2089 Sentence denotes CoVs and all toroviruses bear HE gene form class I envelope membrane proteins of about 400 amino acid residues which bear 7 to 12 N-glycosylation sites [50].
T278 2090-2122 Sentence denotes HE multimer forms enter virions.
T279 2123-2241 Sentence denotes Bovine CoV (BCoV) and HCoV-OC43, similar to influenza C virus, recognize Neu5,9Ac2 and bear SA-9-O-acetylesterase [8].
T280 2242-2276 Sentence denotes CoV HEs are all O-acetylesterases.
T281 2277-2470 Sentence denotes The HE enzymes found in torovirus, CoV and influenza C virus are evolutionarily interspecies-mutated with about 30% homology by heterologous RNA recombination [51] and horizontal gene transfer.
T282 2471-2534 Sentence denotes Therefore, viral HEs are diverse and widespread over evolution.