| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T487 |
0-73 |
Sentence |
denotes |
Polyphenols interfere with the inflammatory process in multiple pathways. |
| T488 |
74-294 |
Sentence |
denotes |
For example, they alter the enzymatic processes involved in the proliferation and activation of B- and T-cells, as key components of the inflammatory pathway (by inhibiting tyrosine and serine-threonine protein kinases). |
| T489 |
295-475 |
Sentence |
denotes |
Likewise, polyphenols blunt the synthesis of pro-inflammatory mediators such as cytokines, chemokines (IL-8, IL-6, TNF-α, VCAM-1 and ICAM-1), and angiogenic factors, NF-кB or iNOS. |
| T490 |
476-679 |
Sentence |
denotes |
Further, an inhibitory effect on several pro-inflammatory enzymes was reported, such as COX-2, MAPK or protein kinase-C (PKC) (Alvarez-Suarez et al., 2017; Gasparrini et al., 2017; Hussain et al., 2016). |
| T491 |
680-830 |
Sentence |
denotes |
Thus, studies performed on macrophages proved that resveratrol inhibited the IFN-γ-induced NO production and down-regulated the IFN-γ inducible genes. |
| T492 |
831-998 |
Sentence |
denotes |
In this respect, resveratrol decreased STAT1 activation (an important transcription factor for IFN-γ-induced genes) and hindered JAK-2 activation (Chung et al., 2011). |
