PMC:7335494 / 32935-40377 JSONTXT 13 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T165 0-322 Sentence denotes Switching to a very strict low-carb diet was associated with an increase of systemic inflammation in apparently healthy subjects (Rosenbaum et al., 2019), while in subjects with metabolic syndrome or obesity, a short-term ketogenic diet yielded beneficial cardiometabolic effects (Gyorkos et al., 2019; Ruth et al., 2013).
T166 323-449 Sentence denotes In T2DM patients, a one-year nutritional ketosis intervention resulted in a lower cardiovascular risk (Bhanpuri et al., 2018).
T167 450-757 Sentence denotes Importantly, these beneficial effects are amplified by physical exercises (Alves et al., 2016; Asle Mohammadi Zadeh et al., 2018; Myette-Cote et al., 2018), and by the diet supplementation with nuts (Hou et al., 2018), soy (Kani et al., 2017), or even carefully choosing the types of ingested carbohydrates.
T168 758-1032 Sentence denotes In obese and overweight adolescents and adults, a diet based on low glycaemic index food improved inflammation, metabolic as well as cardiovascular risk factors (Rouhani et al., 2016), while the addition of functional foods resulted in further benefits (Izadi et al., 2018).
T169 1033-1177 Sentence denotes Also, the consumption of complex carbohydrates led to a decline of pro-inflammatory molecules’ level in pregnant women (Hernandez et al., 2016).
T170 1178-1317 Sentence denotes The results of most recent clinical studies concerning the link between low-carb diet and systemic inflammation are summarized in Table 3 .
T171 1318-1413 Sentence denotes Table 3 Recent reports regarding the relationship between carbohydrate intake and inflammation.
T172 1414-1467 Sentence denotes Diet type Design Population Intervention Effects Ref.
T173 1468-1584 Sentence denotes Low-carbohydrate versus high-fat diet Randomized crossover study 11 T2DM patients 4-day diet intervention:➢ Group 1:
T174 1585-1618 Sentence denotes Low-fat low-glycaemic index diet,
T175 1619-1629 Sentence denotes ➢ Group 2:
T176 1630-1660 Sentence denotes Low-carbohydrate high-fat diet
T177 1661-1671 Sentence denotes ➢ Group 3:
T178 1672-1840 Sentence denotes Low-carbohydrate high-fat diet +15-min postmeal walks Glycemia and circulating proinsulin were significantly lower in groups 2 and 3 versus 1; Myette-Cote et al. (2018)
T179 1841-1975 Sentence denotes Low-carbohydrate versus low-fat diet Randomized controlled feeding study 33 obese T2DM patients 8-week diet intervention:➢ Normal diet
T180 1976-2005 Sentence denotes ➢ Low-carbohydrate diet (LCD)
T181 2006-2027 Sentence denotes ➢ Low-fat diet (LFD),
T182 2028-2152 Sentence denotes ➢ followed by 12 weeks of high intensity interval training 3 days/week, then a 4-week diet intervention, as presented above.
T183 2153-2325 Sentence denotes After the 24-week period:LCD: ↓ IL-6, resistin, leptin, glucose, insulin, cholesterol, TG, ↑ HDLLFD: ↓ TNF-α, LDL, HOMA-IR, ↑ adiponectin Asle Mohammadi Zadeh et al. (2018)
T184 2326-2463 Sentence denotes Low-carbohydrate versus low-fat diet Randomised controlled trial 51 T2DM patients 6-month diet intervention:➢ Low-carbohydrate diet (LCD)
T185 2464-2539 Sentence denotes ➢ Low-fat diet (LFD) LCD: ↓ sICAM, E-selectinLFD: ↓ CRP Davis et al. (2011)
T186 2540-2677 Sentence denotes Low-carbohydrate versus low-fat diet Randomised controlled trial 51 T2DM patients 6-month diet intervention:➢ Low-carbohydrate diet (LCD)
T187 2678-2750 Sentence denotes ➢ Low-fat diet (LFD) LCD: ↓ IL-1Ra, IL-6 Johansson-Persson et al. (2014)
T188 2751-2918 Sentence denotes Low-carbohydrate versus low-fat diet Clinical trial 148 obese adults (no diabetes and CVD) 12-month diet intervention:➢ low-carbohydrate diet – LCD, n = 75 (<40 g/day)
T189 2919-3039 Sentence denotes ➢ low-fat diet – LFD, n = 73 (<30% kcal/day from total fat, <7% saturated fat) LCD: ↑ adiponectin ↓ICAM Hu et al. (2015)
T190 3040-3169 Sentence denotes Low-carbohydrate + nuts Randomised controlled trial 51 T2DM patients 3-month diet intervention:➢ Low-carbohydrate diet + peanuts:
T191 3170-3206 Sentence denotes 60 g for men, 50 g for women (LCD-P)
T192 3207-3223 Sentence denotes ➢ LCD + almonds:
T193 3224-3379 Sentence denotes 55 g for men, 45 g for women (LCD-A) Improved glycaemic profile versus baseline, no difference between groups regarding IL-5 serum levels Hou et al. (2018)
T194 3380-3512 Sentence denotes Low-Calorie, Low-Carbohydrate Soy Diet Parallel randomized clinical trial 45 patients with NAFLD 8-week diet intervention:➢ Group 1:
T195 3513-3535 Sentence denotes Low-calorie (LC) diet,
T196 3536-3572 Sentence denotes ➢ Group 2: LC, low-carbohydrate diet
T197 3573-3670 Sentence denotes ➢ Group 3: LC, low-carbohydrate diet + soy (LCS) LCS: ↓ glycaemic indices, CRP Kani et al. (2017)
T198 3671-3745 Sentence denotes Switching to an isocaloric ketogenic diet (KD) Clinical study 17 men (BMI:
T199 3746-4106 Sentence denotes 25–35 kg/m2) Transitioning from a normal diet (4 weeks–35% fat, 15% protein, 50% carbohydrate) to 4 weeks of an isocaloric KD (80% fat, 5% carbohydrate, 15% protein) KD: ↑glycerol, free fatty acids, glucagon, adiponectin, gastric inhibitory peptide, TC, LDL, CRP↓Fasting insulin, C-peptide, triglycerides and fibroblast growth factor 21 Rosenbaum et al. (2019)
T200 4107-4325 Sentence denotes Carbohydrate-restricted Paleolithic-based diet Randomized crossover trial 12 subjects with metabolic syndrome 4-week diet intervention:➢ carbohydrate-restricted (<50g) Paleolithic-based diet + sedentary activity (PD-S)
T201 4326-4488 Sentence denotes ➢ PD + high-intensity interval training (PD-Ex) PD-S + PD-Ex: ↓ Glycaemia, TG, fasting insulin, insulin resistance, CRP, TNF-α, IL-6, ICAM-1 Gyorkos et al. (2019)
T202 4489-4639 Sentence denotes Low carbohydrate high fat, diet Randomised controlled trial 55 obese subjects 12-week diet intervention:➢ High-fat, low-carbohydrate diet (HFLC) group
T203 4640-4739 Sentence denotes ➢ Low-fat, high-carbohydrate diet (LFHC) group HFLC: ↓ CRP,TG ↑ adiponectin, HDL Ruth et al. (2013)
T204 4740-4873 Sentence denotes Nutritional ketosis Randomised controlled trial 262 patients with T2DM 12-month diet intervention:➢ Nutritional ketosis (NK, n = 262)
T205 4874-4940 Sentence denotes ➢ Control group, normal diet (n = 87) ↓ CRP Bhanpuri et al. (2018)
T206 4941-5150 Sentence denotes Moderate-carbohydrate versus low-fat diet Randomised controlled trial 122 overweight and obese adults 6-month diet intervention:➢ Group 1: moderate-carbohydrate and high-glycaemic index (GI) diet (HGI), n = 37
T207 5151-5215 Sentence denotes ➢ Group 2: a moderate-carbohydrate and low-GI diet (LGI), n = 36
T208 5216-5439 Sentence denotes ➢ Group 3: a low-fat and high-GI diet (LF), n = 31 LGI vs LF: ↓ fasting insulin, ↑ HOMANo significant differences among groups regarding lipid profiles, inflammatory and metabolic risk markers (IL-6, MCP-1, Leptin, ICAM-1).
T209 5440-5471 Sentence denotes Juanola-Falgarona et al. (2014)
T210 5472-5653 Sentence denotes Low-glycemic-index diet Randomised controlled trial 90 subjects 12-week diet intervention:➢ isocaloric control diet (50% of energy from carbohydrate, 35% from fat, 15% from protein)
T211 5654-5746 Sentence denotes ➢ low-glycaemic-index diet (LGI) (60% from carbohydrate, 25% from fat, and 15% from protein)
T212 5747-5934 Sentence denotes ➢ LGI, rich in functional foods (LGI + FF) (60% from carbohydrate, 25% from fat, and 15% from protein) LGI + FF vs. control: ↓CRP, TNF-αLGI + FF vs. LGI: ↑ adiponectin Izadi et al. (2018)
T213 5935-6102 Sentence denotes Low glycaemic index diet Randomised controlled trial 50 obese and overweight adolescent girls 10-week diet intervention:➢ Healthy nutritional recommendation diet (HNR)
T214 6103-6169 Sentence denotes ➢ Low glycaemic index diet (LGI) ↓ IL-6, CRP Rouhani et al. (2016)
T215 6170-6495 Sentence denotes Low- carbohydrate high-fat diet versus higher-complex carbohydrate lower-fat Randomized controlled feeding study 12 overweight and obese women with gestational (31 weeks) diabetes mellitus 31-week diet intervention:➢ control conventional low-carbohydrate, higher-fat diet (LCHF, 40% carbohydrate, 45% fat, 15% protein; n = 6)
T216 6496-6682 Sentence denotes ➢ higher-complex carbohydrate/lower-fat diet (CHOICE, 60% carbohydrate, 25% fat, 15% protein; n = 6) CHOICE: ↓ expression of proinflammatory genes (IL-1β, TNF- α) Hernandez et al. (2016)
T217 6683-6800 Sentence denotes Regular diet Observational study 95 postmenopausal women Participants classified according to CRP - lower or ≥3 mg/L.
T218 6801-6929 Sentence denotes Sedentary lifestyle was described by walking ≤6000 steps/day; diet was evaluated using a validated food frequency questionnaire.
T219 6930-7025 Sentence denotes CRP was higher for women with sedentary lifestyle and higher glycaemic load Alves et al. (2016)
T220 7026-7304 Sentence denotes Low-fructose diet Comparative study 28 patients with chronic kidney disease 6-week of low-fructose diet (LFD), followed by 6 weeks of regular diet ↓ insulin, CRP sICAM (decrease of insulin and sICAM persistent, while CRP did not when resuming regular diet) Brymora et al. (2012)
T221 7305-7442 Sentence denotes ICAM – intercellular adhesion molecule-1; HOMA – homeostatic model assessment of β cell function; MCP-1 – Monocyte chemotactic protein-1.