| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T407 |
0-282 |
Sentence |
denotes |
The underlying rationale to investigate the therapeutic potential of vitamin C has been based on two key observations: (i) critically ill patients have lower levels of vitamin C (228–230) and (ii) vitamin C has pleiotropic immunomodulatory, antioxidant, and antiviral effects (221). |
| T408 |
283-416 |
Sentence |
denotes |
It is important to underscore that reports on the clinical outcomes of vitamin C treatment in humans are mixed and context dependent. |
| T409 |
417-537 |
Sentence |
denotes |
A thorough meta-analysis on vitamin C supplementation for the common cold has been reported by Hemilä and Chalker (231). |
| T410 |
538-717 |
Sentence |
denotes |
Briefly, they concluded that while the incidence of colds was not reduced, the duration and severity of colds was reduced when assessing studies of regular vitamin C intake (231). |
| T411 |
718-892 |
Sentence |
denotes |
Interestingly, a separate meta-analysis on vitamin C and cardiac surgery showed a reduction in the length of ICU stay and shortened the need for mechanical ventilation (232). |
| T412 |
893-1070 |
Sentence |
denotes |
This is an important correlation as clinical trials are currently investigating the efficacy of vitamin C to reduce mortality and hospital burden in COVID-19 patients (Table 1). |
| T413 |
1071-1218 |
Sentence |
denotes |
A Phase II clinical trial (NCT04264533) was initiated in Wuhan where COVID-19 patients will be given a high dose intravenous infusion of vitamin C. |
| T414 |
1219-1547 |
Sentence |
denotes |
Lastly, whether oral dosing of vitamin C can achieve therapeutically relevant concentrations, as described in the above studies, is currently unknown, thus caution should be taken as exceeding the recommended dietary allowance of 100–200 mg/day may lead to mild toxicities including abdominal discomfort and diarrhea (231, 233). |
