LitCovid-sentences  

PMC:7324763 / 66294-68782 JSONTXT 14 Projects

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Id Subject Object Predicate Lexical cue
T401 0-39 Sentence denotes Immune-Boosting Natural Health Products
T402 40-185 Sentence denotes Ascorbic acid, more commonly known as vitamin C, has been shown to exhibit potent immunomodulatory, antioxidant, and antimicrobial effects (221).
T403 186-374 Sentence denotes Vitamin C has been shown to restore NK cell cytotoxicity in individuals exposed to toxic chemicals through protein kinase C expression, a critical component in lymphocyte metabolism (222).
T404 375-617 Sentence denotes Additional reports have shown that vitamin C also enhances the expression of NKp46, CD69, CD25 and IFN-γ production by NK cells (223) and can increase the expression of IRF3 in lung tissues of influenza infected, pneumonia-induced mice (224).
T405 618-755 Sentence denotes Vitamin C also harbors potent antioxidant attributes which can scavenge reactive oxygen species (ROS) and prevent lung injury (225, 226).
T406 756-940 Sentence denotes Although ROS production is an important component in the host defense response to viruses, they can be harmful to cells and lead to the pathogenesis of viral-induced host injury (227).
T407 941-1223 Sentence denotes The underlying rationale to investigate the therapeutic potential of vitamin C has been based on two key observations: (i) critically ill patients have lower levels of vitamin C (228–230) and (ii) vitamin C has pleiotropic immunomodulatory, antioxidant, and antiviral effects (221).
T408 1224-1357 Sentence denotes It is important to underscore that reports on the clinical outcomes of vitamin C treatment in humans are mixed and context dependent.
T409 1358-1478 Sentence denotes A thorough meta-analysis on vitamin C supplementation for the common cold has been reported by Hemilä and Chalker (231).
T410 1479-1658 Sentence denotes Briefly, they concluded that while the incidence of colds was not reduced, the duration and severity of colds was reduced when assessing studies of regular vitamin C intake (231).
T411 1659-1833 Sentence denotes Interestingly, a separate meta-analysis on vitamin C and cardiac surgery showed a reduction in the length of ICU stay and shortened the need for mechanical ventilation (232).
T412 1834-2011 Sentence denotes This is an important correlation as clinical trials are currently investigating the efficacy of vitamin C to reduce mortality and hospital burden in COVID-19 patients (Table 1).
T413 2012-2159 Sentence denotes A Phase II clinical trial (NCT04264533) was initiated in Wuhan where COVID-19 patients will be given a high dose intravenous infusion of vitamin C.
T414 2160-2488 Sentence denotes Lastly, whether oral dosing of vitamin C can achieve therapeutically relevant concentrations, as described in the above studies, is currently unknown, thus caution should be taken as exceeding the recommended dietary allowance of 100–200 mg/day may lead to mild toxicities including abdominal discomfort and diarrhea (231, 233).