LitCovid-sentences  

PMC:7247521 / 18071-20556 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T101 0-63 Sentence denotes 3.2 Functional and pathway enrichment analyses of QFPD targets
T102 64-336 Sentence denotes As shown in Fig. 2 , the 11 enriched GO terms of the targets in all five formulae were found, such as oxidoreductase activity, lipid metabolic process, lipid binding, small molecule metabolic process, homeostatic process, signal transducer activity and cell proliferation.
T103 337-707 Sentence denotes Furthermore, the results of pathway enrichment analysis showed that the 7 KEGG pathways were significantly related to more than 4 formula groups, including dteroid biosynthesis, adipocytokine signaling pathway, neuroactive ligand-receptor interaction, steroid hormone biosynthesis, PPAR signaling pathway, arginine and proline metabolism and ABC transporters (Fig. 3 A).
T104 708-938 Sentence denotes In addition, TTD analysis showed that the 8 diseases were significantly association with more than 3 formula groups, such as acne, Behcet'S disease, benign prostate hyperplasia, intrahepatic cholestasis and brain injury (Fig. 3B).
T105 939-1048 Sentence denotes However, the five formulae contained their specific (MSXG, SGMH, XCH, WLS and Others) GO, KEGG and TTD terms.
T106 1049-1442 Sentence denotes For example, neurological system process and beta-Alanine metabolism terms were specific for MXSG; membrane organization and parasitic infections of the eye terms for SGMH; circadian rhythm and hypertension terms for XCH; nucleic acid binding transcription factor activity, ovarian steroidogenesis and chronic inflammatory diseases terms for WLS; fat digestion and absorption terms for Others.
T107 1443-1511 Sentence denotes Fig. 2 Bubble plot of the GO analysis of the five formulae’ targets.
T108 1512-1586 Sentence denotes Fig. 3 Bubble plot of the KEGG/TTD analysis of the five formulae’ targets.
T109 1587-1603 Sentence denotes A: KEGG, B: TTD.
T110 1604-1809 Sentence denotes In the prediction of miRNAs in QFPD targets, MIR-183 and MIR-130A/B/301 were the highest linking terms to bind the five formulae targets and formulae Others was the highest group to bind miRNAs (Fig. 4 A).
T111 1810-1937 Sentence denotes In addition, kinase prediction revealed CDK7 were significantly enriched in formulae MSXG, SGMH, XCH, WLS and Others (Fig. 4B).
T112 1938-2097 Sentence denotes Finally, TF analysis showed that LXR was the highest linking TF to bind the four formulae targets and formulae WLS was the highest group to bind TFs (Fig. 4C).
T113 2098-2183 Sentence denotes Fig. 4 The miRNA, kinase and TF analysis of the five formulae’ targets by WebGestalt.
T114 2184-2293 Sentence denotes Chord plot showing the five formulae’ targets present in the represented enriched miRNA, kinase and TF terms.
T115 2294-2399 Sentence denotes Outer ring shows miRNA/kinase/TF term and log2 enrichment ratio (left) or five formulae grouping (right).
T116 2400-2457 Sentence denotes Chords connect miRNA/kinase/TF term with formulae groups.
T117 2458-2485 Sentence denotes A: miRNA, B: kinase, C: TF.