LitCovid-sentences  

PMC:7212965 / 40985-42728 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T257 0-91 Sentence denotes Table 3 Gastrointestinal Treatment Adverse Effects of Currently Utilized COVID-19 Therapies
T258 92-168 Sentence denotes Medication type Medication name Adverse effects Major drug–drug interactions
T259 169-193 Sentence denotes Gastrointestinal Hepatic
T260 194-333 Sentence denotes Antimalarial ChloroquineHydroxychloroquine Nausea, vomiting, abdominal pain, and diarrhea reported; frequency not defined Likelihood score:
T261 334-406 Sentence denotes D (possible rare cause of clinically apparent liver injury).Description:
T262 407-444 Sentence denotes Rare elevations in aminotransferases.
T263 445-530 Sentence denotes Most reactions are hypersensitivity with no known cross reactivity to hepatic injury.
T264 531-598 Sentence denotes If this occurs, reasonable to switch between chloroquine therapies.
T265 599-691 Sentence denotes Substrate for CYP2D6 and CYP3A4 substrateSame as above; also substrate for CYP3A5 and CYP2C8
T266 692-768 Sentence denotes Antiviral Remdesivir Not reported (limited data available) Likelihood score:
T267 769-792 Sentence denotes Not scored.Description:
T268 793-842 Sentence denotes Hepatotoxicity reported; frequency not yet known.
T269 843-893 Sentence denotes Not a significant inducer/inhibitor of CYP enzymes
T270 894-934 Sentence denotes Lopinavir/ritonavir Nausea and vomiting:
T271 935-962 Sentence denotes 5%–10% (higher in children:
T272 963-982 Sentence denotes 20%)Abdominal pain:
T273 983-998 Sentence denotes 1%–10%Diarrhea:
T274 999-1064 Sentence denotes 10%–30% + dose-dependentOther: dysguesia in adults <2%, children:
T275 1065-1102 Sentence denotes 25%, increased serum amylase, lipase:
T276 1103-1109 Sentence denotes 3%–8%.
T277 1110-1127 Sentence denotes Likelihood score:
T278 1128-1201 Sentence denotes D (possible, rare cause of clinically apparent liver injury).Description:
T279 1202-1383 Sentence denotes Hepatotoxicity ranges from mild elevations in aminotransferases to acute liver failure.Recovery takes 1–2 mo.Re-challenging may lead to recurrence and should be avoided if possible.
T280 1384-1498 Sentence denotes Substrate for: CYP3A4, CYP2D6P-gpInducer for: CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, UGT1A1Inhibitor for: CYP3A4
T281 1499-1527 Sentence denotes Favipiravir Nausea/vomiting:
T282 1528-1543 Sentence denotes 5%–15%Diarrhea:
T283 1544-1586 Sentence denotes 5%Limited data available Likelihood score:
T284 1587-1609 Sentence denotes Not scoredDescription:
T285 1610-1648 Sentence denotes 3% prevalence, but few data available.
T286 1649-1743 Sentence denotes Inhibitor for: CYP2C8 and aldehyde oxidaseMetabolized by xanthine oxidase and aldehyde oxidase