| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T59 |
40-104 |
Sentence |
denotes |
Angiotensinogen is converted to angiotensin I (Ang I) via renin. |
| T60 |
105-262 |
Sentence |
denotes |
Ang I is converted to Ang II via angiotensin-converting enzyme (ACE), which also hydrolyzes bradykinin into its inactive metabolites, promoting inflammation. |
| T61 |
263-466 |
Sentence |
denotes |
The pro-inflammatory effects of Ang II are mediated by Ang II type I receptor (AT1), which stimulates aldosterone secretion from the adrenal medulla and antidiuretic hormone from the posterior pituitary. |
| T62 |
467-514 |
Sentence |
denotes |
Aldosterone decreases membrane ACE2 expression. |
| T63 |
515-625 |
Sentence |
denotes |
Endothelin-1 inhibits angiotensin 1-7 (Ang1-7) via extracellular signal-regulated kinase (ERK)1/ERK2 pathways. |
| T64 |
626-779 |
Sentence |
denotes |
Ang II, under favorable conditions (dashed line), can be converted to Ang1-7 via ACE2, whose counter regulatory effects are mediated by the Mas receptor. |
| T65 |
780-932 |
Sentence |
denotes |
Ang1-7 can also be formed via conversion of Ang I to an intermediate Ang1-9 or directly via zinc metallopeptidase neprilysin/prolyl endopeptidase (PEP). |
| T66 |
933-964 |
Sentence |
denotes |
RAS = renin-angiotensin system. |
