| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T139 |
0-70 |
Sentence |
denotes |
Ongoing clinical studies assessing the modulation of RAS axis include: |
| T140 |
71-285 |
Sentence |
denotes |
1) the assessment of the relative activity of ACE and ACE2 in patients with diabetes following treatment with candesartan (Non-Insulin Dependent Diabetes Mellitus [NIDDM] and Angiotensin Converting Enzyme 2 [ACE2]: |
| T141 |
286-604 |
Sentence |
denotes |
Diabetic Patients Treated With Antihypertensive Drugs; NCT00192803); and 2) the overexpression of ACE2/Ang 1-7 in cardiac progenitor cells to assess for enhancement in reparative function and the potential to attenuate myocardial ischemia−induced cardiac damage (Cardiovascular Disease Protection Tissue; NCT02348515). |
| T142 |
605-811 |
Sentence |
denotes |
It is evident that targeting the ACE2/Ang1-7/Mas axis is going to be interesting in clinical settings because of the observed cardioprotective effects in the in vivo murine and in vitro cell culture models. |
| T143 |
812-957 |
Sentence |
denotes |
However, further investigation is required to demonstrate whether these favorable experimental effects could be translated into clinical benefit. |
