Id |
Subject |
Object |
Predicate |
Lexical cue |
T52 |
0-170 |
Sentence |
denotes |
Melatonin is not viricidal but it has indirect anti-viral actions [3] due to its anti-inflammation, anti-oxidation and immune enhancing features [[21], [22], [23], [24]]. |
T53 |
171-255 |
Sentence |
denotes |
There are situations in which melatonin suppresses the features of viral infections. |
T54 |
256-437 |
Sentence |
denotes |
In mice whose central nervous system is infected by virus (e.g., encephalitis), the use of melatonin caused less viremia, reduced paralysis and death, and decreased virus load [25]. |
T55 |
438-619 |
Sentence |
denotes |
In previous respiratory syncytial virus models, melatonin caused down-regulation of acute lung oxidative injury, pro-inflammatory cytokine release and inflammatory cell recruitment. |
T56 |
620-751 |
Sentence |
denotes |
These findings, along with those recently summarized by Reiter et al. [3], support a rationale for melatonin use in viral diseases. |
T57 |
752-897 |
Sentence |
denotes |
Also, melatonin's anti-inflammation, anti-oxidation, immune enhancing actions supports its potential attenuation of COVID-19 infection (Fig. 1 ). |
T58 |
898-970 |
Sentence |
denotes |
Fig. 1 Pathogenesis of COVID-19 and potential adjuvant use of melatonin. |
T59 |
971-1178 |
Sentence |
denotes |
We postulated that lungs infected by SARS-CoV-2, and a suppressed immune response, elevated inflammation and excessive oxidation stress proceed unabated, this results in the activation of the cytokine storm. |
T60 |
1179-1309 |
Sentence |
denotes |
ALI/ARDS may ensue, accompanied by a series of complications, the outcomes of which vary according to the severity of the disease. |
T61 |
1310-1503 |
Sentence |
denotes |
Melatonin may play a role of adjuvant medication in the regulation of immune system, inflammation and oxidation stress, and provide support for patients with ALI/ARDS and related complications. |
T62 |
1504-1508 |
Sentence |
denotes |
ALI: |
T63 |
1509-1533 |
Sentence |
denotes |
Acute lung injury; ARDS: |
T64 |
1534-1570 |
Sentence |
denotes |
Acute respiratory distress syndrome. |