PMC:7102583 / 7789-9359 JSONTXT 14 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T52 0-170 Sentence denotes Melatonin is not viricidal but it has indirect anti-viral actions [3] due to its anti-inflammation, anti-oxidation and immune enhancing features [[21], [22], [23], [24]].
T53 171-255 Sentence denotes There are situations in which melatonin suppresses the features of viral infections.
T54 256-437 Sentence denotes In mice whose central nervous system is infected by virus (e.g., encephalitis), the use of melatonin caused less viremia, reduced paralysis and death, and decreased virus load [25].
T55 438-619 Sentence denotes In previous respiratory syncytial virus models, melatonin caused down-regulation of acute lung oxidative injury, pro-inflammatory cytokine release and inflammatory cell recruitment.
T56 620-751 Sentence denotes These findings, along with those recently summarized by Reiter et al. [3], support a rationale for melatonin use in viral diseases.
T57 752-897 Sentence denotes Also, melatonin's anti-inflammation, anti-oxidation, immune enhancing actions supports its potential attenuation of COVID-19 infection (Fig. 1 ).
T58 898-970 Sentence denotes Fig. 1 Pathogenesis of COVID-19 and potential adjuvant use of melatonin.
T59 971-1178 Sentence denotes We postulated that lungs infected by SARS-CoV-2, and a suppressed immune response, elevated inflammation and excessive oxidation stress proceed unabated, this results in the activation of the cytokine storm.
T60 1179-1309 Sentence denotes ALI/ARDS may ensue, accompanied by a series of complications, the outcomes of which vary according to the severity of the disease.
T61 1310-1503 Sentence denotes Melatonin may play a role of adjuvant medication in the regulation of immune system, inflammation and oxidation stress, and provide support for patients with ALI/ARDS and related complications.
T62 1504-1508 Sentence denotes ALI:
T63 1509-1533 Sentence denotes Acute lung injury; ARDS:
T64 1534-1570 Sentence denotes Acute respiratory distress syndrome.