| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T4 |
0-84 |
Sentence |
denotes |
The 2019-novel coronavirus (nCoV) is a major source of disaster in the 21th century. |
| T5 |
85-194 |
Sentence |
denotes |
However, the lack of specific drugs to prevent/treat an attack is a major need at this current point of time. |
| T6 |
195-301 |
Sentence |
denotes |
In this regard, we conducted a systematic review to identify major druggable targets in coronavirus (CoV). |
| T7 |
302-518 |
Sentence |
denotes |
We searched PubMed and RCSB database with keywords HCoV, NCoV, corona virus, SERS-CoV, MERS-CoV, 2019-nCoV, crystal structure, X-ray crystallography structure, NMR structure, target, and drug target till Feb 3, 2020. |
| T8 |
519-722 |
Sentence |
denotes |
The search identified seven major targets (spike protein, envelop protein, membrane protein, protease, nucleocapsid protein, hemagglutinin esterase, and helicase) for which drug design can be considered. |
| T9 |
723-835 |
Sentence |
denotes |
There are other 16 nonstructural proteins (NSPs), which can also be considered from the drug design perspective. |
| T10 |
836-933 |
Sentence |
denotes |
The major structural proteins and NSPs may serve an important role from drug design perspectives. |
| T11 |
934-1073 |
Sentence |
denotes |
However, the occurrence of frequent recombination events is a major deterrent factor toward the development of CoV-specific vaccines/drugs. |
