| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T42 |
0-105 |
Sentence |
denotes |
An in vivo study found that CQ could exert anti-HCoV-OC43 activity transplacentally or via maternal milk. |
| T43 |
106-368 |
Sentence |
denotes |
The data from mouse models showed that 98.6% of the pups survived when pregnant mice were treated with 15 mg/kg of CQ, and survival rates decreased in a dose-dependent manner, with 88% and 13% survival when treated with 5 mg/kg and 1 mg/kg CQ, respectively [14]. |
| T44 |
369-456 |
Sentence |
denotes |
The survival rate of newborn mice via maternal milk was 69.0% with 15 mg/kg of CQ [14]. |
| T45 |
457-606 |
Sentence |
denotes |
In another mouse study, CQ strongly attenuated HCoV-OC43 replication in the brain and prevented the infection from spreading to the spinal cord [15]. |
| T46 |
607-709 |
Sentence |
denotes |
The above studies confirmed that CQ/HCQ have a broad-spectrum anti-HCoV activity in vitro and in vivo. |
