| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-107 |
Sentence |
denotes |
Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model. |
| T2 |
108-211 |
Sentence |
denotes |
Star-PAP is a noncanonical poly(A) polymerase and required for the expression of a select set of mRNAs. |
| T3 |
212-289 |
Sentence |
denotes |
However, the pathological role of Star-PAP in cancer largely remains unknown. |
| T4 |
290-390 |
Sentence |
denotes |
In this study, we observed decreased expression of Star-PAP in breast cancer cell lines and tissues. |
| T5 |
391-500 |
Sentence |
denotes |
Ectopic Star-PAP expression inhibited proliferation as well as colony-forming ability of breast cancer cells. |
| T6 |
501-590 |
Sentence |
denotes |
In breast cancer patients, high levels of Star-PAP correlated with an improved prognosis. |
| T7 |
591-748 |
Sentence |
denotes |
Moreover, by regulating the expression of BIK (BCL2-interacting killer), Star-PAP induced apoptosis of breast cancer cells through the mitochondrial pathway. |
| T8 |
749-875 |
Sentence |
denotes |
The growth of breast cancer xenografts in NOD/SCID mice was also inhibited by the doxycycline-induced Star-PAP overexpression. |
| T9 |
876-977 |
Sentence |
denotes |
Furthermore, Star-PAP sensitized breast cancer cells to chemotherapy drugs both in vitro and in vivo. |
| T10 |
978-1128 |
Sentence |
denotes |
In mammary epithelial cells, Star-PAP knockdown partially transformed these cells and induced them to undergo epithelial-mesenchymal transition (EMT). |
| T11 |
1129-1283 |
Sentence |
denotes |
These findings suggested that Star-PAP possesses tumor-suppressing activity and can be a valuable target for developing new cancer therapeutic strategies. |
