LitCoin-sentences  

PubMed:20226780 JSONTXT 24 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-112 Sentence denotes Zebrafish chordin-like and chordin are functionally redundant in regulating patterning of the dorsoventral axis.
T2 113-258 Sentence denotes Chordin is the prototype of a group of cysteine-rich domain-containing proteins that bind and modulate signaling of various TGFbeta-like ligands.
T3 259-375 Sentence denotes Chordin-like 1 and 2 (CHL1 and 2) are two members of this group that have been described in human, mouse, and chick.
T4 376-488 Sentence denotes However, in vivo roles for CHL1 and 2 in early development are unknown due to lack of loss-of-function analysis.
T5 489-557 Sentence denotes Here we identify and characterize zebrafish, Danio rerio, CHL (Chl).
T6 558-671 Sentence denotes The chl gene is on a region of chromosome 21 syntenic with the area of murine chromosome 7 bearing the CHL2 gene.
T7 672-859 Sentence denotes Inability to identify a separate zebrafish gene corresponding to the mammalian CHL1 gene suggests that Chl may serve roles in zebrafish distributed between CHL1 and CHL2 in other species.
T8 860-1139 Sentence denotes Chl is a maternal factor that is also zygotically expressed later in development and has spatiotemporal expression patterns that differ from but overlap those of zebrafish chordin (Chd), suggesting differences but also possible overlap in developmental roles of the two proteins.
T9 1140-1250 Sentence denotes Chl, like Chd, dorsalizes embryos upon overexpression and is cleaved by BMP1, which antagonizes this activity.
T10 1251-1425 Sentence denotes Loss-of-function experiments demonstrate that Chl serves as a BMP antagonist with functions that overlap and are redundant with those of Chd in forming the dorsoventral axis.